Temat: protein expression - Prolib Integro

Skocz do pozycji: 1.

Tytuł:: The impacts of cryopreservation and lyophilization methods on the expression of selected acrosomal and mitochondrial proteins in boar spermatozoa
Autorzy:: Kurowska, Patrycja
Samiec, Marcin
Gajda, Lechosław
Rajska, Iwona
Rak, Agnieszka
Bryła, Magdalena
Trzcińska, Monika
Kralka-Tabak, Małgorzata
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

Artykuł

na półce

Skocz do pozycji: 2.

Tytuł:: Actions of methyl-, propyl- and butylparaben on estrogen receptor -\alpha and -\beta and the progesterone receptor in MCF-7 cancer cells and non-cancerous MCF-10A cells
Autorzy:: Gregoraszczuk, Ewa
Wróbel, Anna Maria
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

Artykuł

na półce

Skocz do pozycji: 3.

Tytuł:: Exonic deletions of mismatch repair genes MLH1 and MSH2 correlate with prognosis and protein expression levels in malignant melanomas
Autorzy:: Hasse, Frank Michael
Cordon-Cardo, Carlos
Korabiowska, Monika
Jawień, Jacek
Stachura, Jerzy
Fischer, Gösta
Brinck, Ulrich
Opis:: The mutations of MLH1 and MSH2 have been reported to be responsible for malignant transformation and tumour progression in several sporadic tumours. Eighty-six primary malignant melanomas with known follow-up were investigated. Point mutations of DNA mismatch repair MLH1 and MSH2 in malignant melanomas were not found. Exon 12 (MSH2) was not present in 26 out of the 86 melanomas and exon 13 (MSH2) was lost in 25 of the tumours. The loss of exon 15 (MLH1) was observed in 22 out of the 86 tumours and the loss of exon 16 (MLH1) in 24 melanomas. The loss of exons correlated strongly with the loss of MLH1 and MSH2 protein expression. In multivariate analysis, including all 4 exons and expressions of MLH1 and MSH2, prognostic significance was found only for loss of exon 12 (MSH2) and loss of exon 15 (MLH1).
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

Artykuł

na półce

Skocz do pozycji: 4.

Tytuł:: In vitro interaction between resistin and peroxisome proliferator-activated receptor \gamma in porcine ovarian follicles
Autorzy:: Drwal, Eliza
Rak, Agnieszka
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

Artykuł

na półce

Skocz do pozycji: 5.

Tytuł:: DLC3 expression in hepatocellular carcinoma
Autorzy:: Wolosz, D.
Szparecki, G.
Wolinska, E.
Gornicka, B.
Tematy:: DLC3 protein
protein expression
hepatocellular carcinoma
Rho protein
human disease
liver disease; Pokaż więcej
Wydawca:: Instytut Medycyny Wsi
Powiązania:: https://bibliotekanauki.pl/articles/3292.pdf Link otwiera się w nowym oknie
Opis:: Introduction and objective. Deleted in Liver Cancer (DLC) proteins belong to the family of RhoGAPs and thus are believed to operate as negative regulators of the Rho family of small GTPases. Rho proteins are considered to be significant links between numerous cellular pathways. So far, DLC1 – the first identified member from Deleted in Liver Cancer family – has been established as a tumour suppressor in hepatocellular carcinoma. As shown by many studies, DLC1 expression is reduced by gene loss or epigenetic silencing in this type of cancer. The expression and function of its close family relative DLC3 is less known. The presented study determined the expression and cellular localization of DLC3 protein in hepatocellular carcinoma tissue. Materials and methods. The protein level in two types of hepatocellular carcinoma: typical and fibrolamellar, were assessed by the immunohistochemical approach. Results. DLC3 immunoreactivity was found to be present in the cytoplasm of normal hepatocytes. In hepatocellular carcinoma sections, DLC3 was detected primarily in the cytoplasm of cancer cells, although in a small percentage of cancer cells cell nuclei were also positively stained. Morphometric analysis followed by statistical evaluation showed that the DLC3 immunoreactivity in the tumour sections was comparable to the one observed in non-cancerous liver specimens. Conclusions. The results obtained indicate that DLC3 protein, contrary to DLC1, is commonly expressed in hepatocellular carcinoma. It appears that members of the DLC family, although structurally highly related, may function differently during HCC development.
Dostawca treści:: Biblioteka Nauki