- Tytuł:
- Determination of N-nitrosodiethanolamine in trolamine by GC-FID method
- Autorzy:
-
Rykowska, I.
Wasiak, W. - Tematy:
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N-nitrosodiethanolamine
GC-FID
GC-MS - Pokaż więcej
- Wydawca:
- Politechnika Bydgoska im. Jana i Jędrzeja Śniadeckich. Wydział Technologii i Inżynierii Chemicznej
- Powiązania:
- https://bibliotekanauki.pl/articles/347009.pdf Link otwiera się w nowym oknie
- Opis:
- This study investigated the possibility of determination of N-nitrosodiethanolamine in triethanolamine by GC-FID methods. Triethanolamine is a component of many pharmaceuticals, including Lamiderm and Ketoprofen. According to the 5th European Pharmacopoeia, the maximum permissible concentration of N-nitrosodiethanolamine is 25 ppb. N-nitrosodiethanolamine is characterized by high volatility and low concentration in real samples. Thus, vacuum distillation was applied for the preconcentration of an analyte. Chromatographic separation was performed using a J&W Scientific DB-WAX (30 m x 0.251 mm; DF = 0.25 µm) capillary column. The method was linear from 8 ppb to 1 ppm (R2 = 0.9995). According to the definition of the International Union of Pure Applied Chemistry (IUPAC), the detection limit (S/N = 3) of the present method for N-nitrosodiethanolamine is 7 ppm. The proposed GC-FID method is an efficient method for the separation and quantitative determination of N-nitrosodiethanolamine.
- Dostawca treści:
- Biblioteka Nauki
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