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Wyświetlanie 1-10 z 13
Tytuł:
A multicarotenoid beadlet for human nutrition - proof of concept of in vitro timed release
Autorzy:
Gellenbeck, Kevin
Salter-Venzon, Dawna
Lala, Rajendra
Chavan, Jayanthi
Tematy:
dissolution
carotenoid
bioavailability
controlled release
Pokaż więcej
Wydawca:
Polskie Towarzystwo Biochemiczne
Powiązania:
https://bibliotekanauki.pl/articles/1039766.pdf  Link otwiera się w nowym oknie
Opis:
Since the 1980's when the predominate focus of study and use of carotenoids in human nutritional formulations was solely on beta-carotene, there has been a steady increase in research aimed to understand the role of a wide variety of carotenoids in human health. This work has increasingly demonstrated the benefits of a number of carotenoids, and there has been a corresponding increase in the number of carotenoids provided in nutritional supplements (multicarotenoids). Numerous published observations in both human and animal studies suggest significant interaction and competition between various carotenoids during absorption and metabolism, resulting in the inhibition of uptake of one over the other. This competition has the end result of reducing the beneficial effects of the inhibited carotenoid. To limit such competition and maximize carotenoid uptakes, a layered beadlet was designed to release a defined ratio of carotenoids sequentially. Preliminary dissolution testing is presented showing the release profile in simulated digestive conditions of a combination of beta-carotene, alpha carotene, lutein, zeaxanthin, lycopene and astaxanthin derived from natural sources. Comparison is made to an immediate release beadlet formulation using the same combination of carotenoids. These results will be used to guide proof of concept clinical testing for effectiveness in humans.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Ethylcellulose as a coating material in controlled-release fertilizers
Autorzy:
Lubkowski, Krzysztof
Smorowska, Aleksandra
Sawicka, Marta
Wróblewska, Elwira
Dzienisz, Alicja
Kowalska, Małgorzata
Sadłowski, Marcin
Tematy:
mineral fertilizers
controlled release
ethylcellulose
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Wydawca:
Zachodniopomorski Uniwersytet Technologiczny w Szczecinie. Wydawnictwo Uczelniane ZUT w Szczecinie
Powiązania:
https://bibliotekanauki.pl/articles/778115.pdf  Link otwiera się w nowym oknie
Opis:
Ethylcellulose polymer was used as a coating material in the preparation of controlled release fertilizers. The materials have been prepared with the use of an immersion method. The mass ratio of polymer to fertilizer was in the range of 0.165–0.285 and the layer thickness was in the range of 204–244 μm. Mechanical properties of the prepared materials were significantly better in comparison with the initial fertilizer. Measurements of time and the degree of release of mineral components from the obtained materials were determined with a standard method. Ethylcellulose-coated materials have met the requirements of controlled release fertilizers.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Coated NPK Fertilizer Based on Citric Acid-Crosslinked Chitosan/Alginate Encapsulant
Autorzy:
Mesias, Vince St. D.
Agu, Anne Bernadette S.
Benablo, Precious Japheth L.
Chen, Chun-Hu
Penaloza Jr., David P.
Tematy:
controlled release
crosslinking
encapsulation
NPK fertilizer
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Wydawca:
Polskie Towarzystwo Inżynierii Ekologicznej
Powiązania:
https://bibliotekanauki.pl/articles/124714.pdf  Link otwiera się w nowym oknie
Opis:
A coated nitrogen-phosphorus-potassium (NPK) fertilizer was prepared via crosslinking chitosan and alginate using citric acid. Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), particle size analysis, and zeta potential measurement showed the successful crosslinking, appropriate size, and colloidal stability of the coated NPK fertilizer. The encapsulation capability of the crosslinked chitosan/alginate (Chi/Alg) was studied using fluorescence spectroscopy and NPK analysis. The release behavior studies under various pH conditions showed that Chi/Alg NPK conformed to the standards of controlled release fertilizer with a maximum release rate of 40% for 30 days. The investigation of the release mechanism using Korsemeyer-Peppas mathematical model showed that the release of nutrients is governed by both coating material relaxation and diffusion process.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Preparation of micro-encapsulated strawberry fragrance and its application in the aromatic wallpaper
Autorzy:
Xiao, Z.
Zhang, Y.
Zhu, G.
Niu, Y.
Xue, Z.
Zhu, J.
Tematy:
micro-encapsulation
fragrance
wallpaper
controlled release
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Wydawca:
Zachodniopomorski Uniwersytet Technologiczny w Szczecinie. Wydawnictwo Uczelniane ZUT w Szczecinie
Powiązania:
https://bibliotekanauki.pl/articles/778533.pdf  Link otwiera się w nowym oknie
Opis:
Micro-encapsulated strawberry fragrance was successfully prepared with wall materials including maltodextrin, sodium octenylsuccinate and gum Arabic. The micro-capsule was added to wallpaper and aromatic wallpaper with strawberry characteristics was obtained. The particle distribution, surface morphology, chemical structure, thermal property and controlled release performance of micro-encapsulated fragrance and aromatic wallpaper were investigated using laser particle size analyzer, scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-TR), thermal gravity analysis (TGA) and chromatography-mass spectrometer (GC-MS). The results showed that the average diameter of micro-capsule was 2 μm and the particles mainly distributed in the tissues of wallpaper. The result of TGA showed that the micro-capsule had a good stability. Meanwhile, the aromatic wallpaper had strawberry aroma more than 3 months and took on excellent controlled release performance.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Modified dibutyrylchitin films as matrices for controlled ibuprofen release
Autorzy:
Mucha, Maria
Michalak, Iwona
Draczyński, Zbigniew
Tematy:
controlled release
dibutyrylchitin
ibuprofen
nanoclay
transdermal systems
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Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Powiązania:
https://bibliotekanauki.pl/articles/1035223.pdf  Link otwiera się w nowym oknie
Opis:
In view of ongoing interest in biodegradable polymers, dibutyrylchitin was used as a matrix for controlled release of a model substance. Transdermal systems (films) are presently more commonly used as an alternative to standard forms of drug delivery. The presented results are concerned with the release of ibuprofen from dibutyrylchitin film. The obtained transdermal films were modified by applying a control layer to slow down the release process. The matrices were also modified by adding nanoclay (Nanofil 2). Dibutyrylchitin matrices were tested for swelling and release kinetics using UV-Vis spectrophotometer. The drug kinetics release was studied in phosphorus buffer of pH=5.5 at the temperature of 35˚C. Structural investigations of the obtained matrices were carried out by optical microscopy and FTIR spectrophotometry. An appropriate mathematical model was also fitted to the obtained experimental data
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Encapsulation of hydroxycitronellal in β-cyclodextrin and the characteristics of the inclusion complex
Autorzy:
Zhu, Guangyong
Xiao, Zuobing
Zhou, Rujun
Liu, Junhua
Zhu, Guangxu
Tematy:
food additives
encapsulation
aroma
controlled release
flavor
Pokaż więcej
Wydawca:
Zachodniopomorski Uniwersytet Technologiczny w Szczecinie. Wydawnictwo Uczelniane ZUT w Szczecinie
Powiązania:
https://bibliotekanauki.pl/articles/2204143.pdf  Link otwiera się w nowym oknie
Opis:
Hydroxycitronellal has been widely used in foods, beverages, perfumery and cosmetics. It can also be used to treat anxiety. The major drawbacks regarding the use of hydroxycitronellal are related to water insolubility, volatility, instability, and sensitization. To overcome these concerns, β-cyclodextrin was adopted as wall material to encapsulate hydroxycitronellal in this work. Hydroxycitronellal-β-cyclodextrin inclusion complex was prepared and the product was characterized. The interaction of hydroxycitronellal and β-cyclodextrin, and the assembly of hydroxycitronellal-β-cyclodextrin inclusion complex were investigated by molecular simulation (MM). The results showed that hydroxycitronellal loading capacity was 8.5%. The thermal stability and lastingness of hydroxycitronellal were im-proved by the formation of the inclusion complex. The minimum binding energy was –151.2 kJ/mol. Among the perpendicular, staggered parallel and ideally parallel orientation of the inclusion complexes, the minimum energy value was found for the staggered parallel arrangement. These basic data are useful to understand the interaction between hydroxycitronellal and β-cyclodextrin.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
RELEASE AND PERMEATION OF INDOMETHACIN FROM PHOSPHOLIPID COMPLEX FILM GENERATED FROM SPRAY FORMULATIONS
Autorzy:
Buatong, Wilaiporn
Nakpheng, Titpawan
Dechraksa, Janwit
Saisamuth, Sao-ake
Kongkhao, Wipatcha
Srichana, Teerapol
Tematy:
thin film
controlled release
indomethacin
Topical spray
phospholipid complex
Pokaż więcej
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Powiązania:
https://bibliotekanauki.pl/articles/895442.pdf  Link otwiera się w nowym oknie
Opis:
An indomethacin topical spray was prepared using lecithin and a cholesterol derivative as a phospholipid complex in a film. Polyvinylpyrrolidone (PVP) was used as a film-forming agent. Drug penetration through keratinocytes was evaluated as well as cytotoxicity to the keratinocytes and fibroblast cells. The results reveal that the PVP concentration provided fine droplets under a microscope with a low contact angle (12.07°-22.53°). Incorporating PVP in the formulation reduced the hydrodynamic radius or size by 20 times. The SEM and TEM results showed smoother surfaces of the thin film for larger quantities of the PVP film-forming agent in the formulations. It also gave the highest drug penetration when the PVP was 0.5%. However, the film-forming agent can also act as a control release barrier. The percent viabilities of the human keratinocytes and fibroblasts were higher in the indomethacin spray phospholipid complex thin film formulation than the pure drug.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Sustain release Formulation and Evaluation of Ofloxacin floating delivery system
Autorzy:
Patel, A. J.
Naik, D. R.
Raval, J. R.
Tematy:
ofloxacin
ethyl cellulose
xanthum gum
floating drug delivery System
controlled release
Pokaż więcej
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Powiązania:
https://bibliotekanauki.pl/articles/412207.pdf  Link otwiera się w nowym oknie
Opis:
Floating tablets has been accepted as a process to achieve controlled drug delivery by prolonging the residence time of the dosage form at the site of absorption, thereby improving and enhancing the bioavailability of drug. The objective of present study outlines the development and characterization the floating drug delivery system of Ofloxacin to enhance its bioavailability and therapeutic efficacy, using different grades of polymer along with effervescent agent sodium bicarbonate and citric acid. Ofloxacin is a synthetic chemotherapeutic second-generation antibiotic of the fluoroquinolone class. Different tablet formulations were formulated by wet granulation technique and were evaluated for physical parameters like Tablet Thickness, Hardness, % Friability, Weight variation, Content uniformity, In vitro buoyancy, Swelling index, In vitro dissolution study and drug release mechanisms. As the concentration of the polymer in the formulations increased the release of drug decreased. Hence it was considered as suitable candidate for formulation as floating drug delivery system. Different kinetic models were applied to drug release data in order to evaluate release mechanisms and kinetics. The optimized formula F4 showed better sustained drug release with good floating properties and fitted best to be Korsmeyer-Peppas model with R2 value of 0.9575. As the n value for the Korsmeyer- Peppas model was found be more than 0.5 it follows Non-Fickian diffusion mechanism. FTIR result showed that there is no drug excipients interaction.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Procesy adsorpcyjne w tworzeniu hybrydowych układów do kontrolowanego uwalniania preparatów farmaceutycznych
Adsorption processes in forming of hybrid structures for controlled release of pharmaceuticals
Autorzy:
Zarzycki, R.
Modrzejewska, Z.
Nawrotek, K.
Skwarczyńska, A.
Tematy:
adsorpcja
kontrolowane uwalnianie
chitozan
równowaga adsorpcyjna
kinetyka
adsorption
controlled release
chitosan
equilibrium
kinetics
Pokaż więcej
Wydawca:
Towarzystwo Chemii i Inżynierii Ekologicznej
Powiązania:
https://bibliotekanauki.pl/articles/106372.pdf  Link otwiera się w nowym oknie
Opis:
Przedstawiono możliwości wytwarzania układów hybrydowych do kontrolowanego uwalniania środków farmakologicznych przy wykorzystaniu nośników hydrożelowych i struktury w skali mikro i nano. Szczególną uwagę zwrócono na wytwarzanie takich układów w procesie adsorpcji, korzystając z nośnika chitozanowego. Przedstawiono modele opisujące stan równowagi oraz kinetykę w procesie sorpcji substancji modelowych.
Possibilities of formation of hybrid systems for controlled drug release from hydrogel carriers and structures in micro- and nanoscale are discussed in the study. Attention is focussed on the formation of such systems in the adsorption process from a chitosan carrier. Models which describe the equilibrium state and sorption kinetics of model substances are presented.
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-10 z 13

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