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    Wyświetlanie 1-4 z 4
    Tytuł:
    The Reaction of Rat Kidney to Acute Stress Solution of Sodium Chloride in Normal and Occasional Abuse of Thyroid Status
    Autorzy:
    Zukow, Walery
    Dolomatov, Sergey
    Kubyshkin, Аnatoliy
    Sataieva, Tatiana
    Opis:
    Walery Zukow
    Objective: To study the effectiveness of osmoregulation of renal function in rats with occasional violation of thyroid status in the acute intragastric load of sodium chloride solutions. Materials and Methods: The study was carried out on white male rats, thyroxine was administered once intraperitoneally, 50 mg/100 g body weight. Kidney function was studied in conditions induced diuresis after intragastric administration of stress testing water or 0.3%, 0.8%, 2% and 3% sodium chloride solution in a volume of 5% of body weight. Results: It was found that thyroxin causes a decrease in creatinine clearance and increased renal excretion of endogenous nitrates and nitrites. In control solutions, increasing concentrations of sodium chloride cause progressive increase in glomerular filtration rate values and excretion of osmotically active substances. Discovered a more complex dependence of the values of diuresis and the concentration of NaCl. Minimum performance diuresis recorded using a solution of 0.8% NaCl, and the maximum - in load and aqueous 3% solution of NaCl. Conclusions: 1. The kidneys of rats administered once T4 retain the ability excretion of excessive amounts of liquid and OAB, protecting the internal tissues and organs from hypoosmia and hyperosmotic stress. 2. A single dose of T4 rats can induce switching mechanisms of renal volume regulation and osmoregulation in the phylogenetically ancient tubular type of regulation of fluid excretion by the kidneys and the OAB. 3. For short abuse thyroid status changes in GFR and tubular transport OAB are reversible.
    Dostawca treści:
    Repozytorium Centrum Otwartej Nauki
    Artykuł
    Tytuł:
    Determinants of long-term outcome in patients after percutaneous stent-assisted intervention on renal artery steno-occlusive atherosclerotic disease
    Autorzy:
    Rosławiecka, Agnieszka
    Przewłocki, Tadeusz
    Kabłak-Ziembicka, Anna
    Trystuła, Mariusz
    Odrowąż-Pieniążek, Piotr
    Rzeźnik, Daniel
    Badacz, Rafał
    Opis:
    Introduction: The effect of stent-assisted percutaneous transluminal angioplasty (PTA) for renal artery stenosis (RAS) on systolic (SBP) and diastolic blood pressure (DBP) as well as renal function, in comparison with medical therapy, is still debatable. Data on determinants of cardiovascular (CV) outcome after PTA are lacking. Objectives: We aimed to identify determinants of major cardiac and cerebral events (MACCEs) following PTA for RAS. Patients and methods: A total of 248 PTAs for RAS were performed in 211 patients with difficult-to-treat hypertension and/or progressive renal impairment. The primary outcomes were procedural success, in-hospital complications, renal function (estimated glomerular filtration rate [eGFR]), change in SBP or DBP, and an incidence of MACCEs during a median of 47 months (interquartile range [IQR], 18–78 months). Results: Procedural success and complication rates were 99.2% and 4.7%, respectively. We observed significant differences in SBP, DBP, and eGFR at 12 months as compared with baseline. A total of 63 MACCEs (30.6%) were noted in 206 patients with available follow-up data. The receiver operating characteristic curve analysis indicated the following best cutoff values for the risk of CV death: an increase in eGFR by at least 11 ml/min/1.73 m2 and a decrease in SBP and DBP by at least 20 mm Hg and 5 mm Hg, respectively. At 12-month follow-up, an increase in eGFR of at least 11 ml/min/1.73 m2 was independently associated with a reduced risk of death (hazard ratio [HR], 0.42; 95% CI, 0.19–0.90; P = 0.02) and MACCEs (HR, 0.54; 95% CI, 0.32–0.93; P = 0.03), while a decrease of DBP by 5 mm Hg or higher, with a reduced risk of stroke (HR, 0.1; 95% CI, 0.02–0.39; P = 0.001). Conclusions: This study confirms the efficacy and safety of PTA as well as its significant effect on changes in blood pressure and eGFR values. Patients with an increase in eGFR of at least 11 ml/min/1.73 m2 have a significant risk reduction of MACCEs and CV death, while those with a decrease in DBP of at least 5 mm Hg, of stroke.
    Dostawca treści:
    Repozytorium Uniwersytetu Jagiellońskiego
    Artykuł
      Wyświetlanie 1-4 z 4

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