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Wyświetlanie 1-10 z 11
Autorzy:
Nęcka, Edward
Wydawca:
Academic Press/Elsevier
Opis:
Insight is a sudden realization of the gist of a problem. The notion was introduced by Gestalt psychologists in opposition to the trial-and-error model of problem solving. This article describes three typical features of insight, that is, the experience of suddenness, the incubational break, and the change of configuration of the problem's elements (restructuring). Relevant empirical data are provided to illustrate these features. Then, three theoretical models of insight are discussed: selectivity of cognitive processes, simplification of the problem structure, and assimilation of external cues. These models have been formulated in order to account for the typical features of the phenomenon of insight.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
Fingerprint sąsiadujących podstruktur jako nowa metoda reprezentacji związków chemicznych oraz jego wykorzystanie w poszukiwaniu związków selektywnych dla wybranych receptorów serotoninowych
Neighboring substructures fingerprint as a new method of compound representation and its application in screening for novel selective compounds for selected serotonin receptors
Autorzy:
Rataj, Krzysztof
Współwytwórcy:
Bojarski, Andrzej J.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Książka
Tytuł:
Nanoscale Halide Perovskites for Photocatalytic CO2 Reduction: Product Selectivity, Strategies Implemented, and Charge-carrier Separation
Autorzy:
Hsu, Hsien-Yi
Feng, Jianpei
Colmenares, Juan Carlos
Mak, Chun Hong
Wang, Zhe
Lee, Duu-Jong
Song, Haisheng
Shen, Hsin-Hu
Han, Bin
Santoso, Shella Permatasari
Li, Fang-Fang
Yuan, Mingjian
Wydawca:
Royal Society of Chemistry
Cytata wydawnicza:
H. Hsu, Z. Wang, C. H. Mak, J. Feng, H. Shen, B. Han, S. P. Santoso, M. Yuan, F. Li, H. Song, D. Lee and J. C. Colmenares, J. Mater. Chem. A, 2024, DOI: 10.1039/D4TA02446J.
Opis:
Research Grants Council of Hong Kong (grant no. CityU 21203518 and F-CityU106/18) Innovation and Technology Commission (grant no. MHP/104/21) Shenzhen Science Technology and Innovation Commission (grant no. JCYJ20210324125612035, R-IND12303 and R-IND12304) City University of Hong Kong (grant no. 9360140, 7005289, 7005580, 7005720, 9667213, 9667229, 9680331 and 9678291) National Natural Science Foundation of China (51901119, 22071070, 61874165, and 21833009) Major State Basic Research Development Program of China (2019YFB1503401)
The over-use of fossil fuels leads to a sharp increase in atmospheric concentrations of carbon dioxide (CO2), which seriously contributes to the energy crisis and climate problems. The direct transformation of CO2 into high-value chemicals through photocatalysis offers an effective way to mitigate these problems. The key to achieving this goal is to discover a cost-effective, highly efficient, and durable photocatalyst. Due to their straightforward synthesis, high light absorption capacity, rapid exciton production efficiency, and long carrier diffusion length, nanoscale halide perovskites (NHPs) have great potential for solar photocatalysis. However, several crucial problems, like poor long-term stability, low product selectivity, and severe charge recombination, have become bottlenecks in the development of NHP photocatalysts. Therefore, this review aims to summarize the principles of CO2 reduction reaction (CO2RR), the structural features of halide perovskites nanocrystals (NCs) in the system, and the principal approaches to enhancing their photocatalytic activity. Factors that influence the selectivity of CO2RR final products are also discussed. Moreover, this review pays special attention to the techniques for studying photogenerated carrier transport processes and photocatalytic intermediates, which make a significant contribution to the insight into the reaction mechanism of photocatalytic CO2 reduction. Finally, the main challenges and prospects for NHP’s further development are also presented. This review will offer instructions for the design of NHP photocatalysts to further enhance the photocatalytic performance and product selectivity for CO2 reduction. It will also offer insights into studying the charge transport process and mechanism for the CO2 photocatalytic reduction reaction.
Dostawca treści:
Repozytorium Centrum Otwartej Nauki
Artykuł
Tytuł:
The structural determinants for α1-adrenergic/serotonin receptors activity among phenylpiperazine-hydantoin derivatives
Autorzy:
Dela, Anna
Czarnota-Łydka, Kinga
Siwek, Agata
Podlewska, Sabina
Kieć-Kononowicz, Katarzyna
Satała, Grzegorz
Handzlik, Jadwiga
Bednarski, Marek
Kucwaj-Brysz, Katarzyna
Opis:
Several studies confirmed the reciprocal interactions between adrenergic and serotoninergic systems and the influence of these phenomena on the pathogenesis of anxiety. Hence, searching for chemical agents with a multifunctional pharmacodynamic profile may bring highly effective therapy for CNS disorders. This study presents a deep structural insight into the hydantoin-arylpiperazine group and their serotonin/α-adrenergic activity. The newly synthesized compounds were tested in the radioligand binding assay and the intrinsic activity was evaluated for the selected derivatives. The computer-aided SAR analysis enabled us to answer questions about the influence of particular structural fragments on selective vs. multifunctional activity. As a result of the performed investigations, there were two leading structures: (a) compound 12 with multifunctional adrenergic-serotonin activity, which is a promising candidate to be an effective anxiolytic agent; (b) compound 14 with high α1A/α1D affinity and selectivity towards α1B, which is recommended due to the elimination of probable cardiotoxic effect. The structural conclusions of this work provide significant support for future lead optimization in order to achieve the desired pharmacodynamic profile in searching for new CNS-modulating agents.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
Benzimidazole-2-one : a novel anchoring principle for antagonizing p53-Mdm2
Autorzy:
Wang, Wei
Camacho-Horvitz, Miguel S.
Dömling, Alexander
Holak, Tadeusz
Cao, Haiping
Wolf, Siglinde
Opis:
Herein we propose the benzimidazole-2-one substructure as a suitable tryptophan mimic and thus a reasonable starting point for the design of p53 Mdm2 antagonists. We devise a short multicomponent reaction route to hitherto unknown 2-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)acetamides by reacting mono N-carbamate protected phenylenediamine in a Ugi-3CR followed by base induced cyclisation. Our preliminary synthesis and screening results are presented here. The finding of the benzimidazolone moiety as a tryptophan replacement in mdm2 is significant as it offers access to novel scaffolds with potentially higher selectivity and potency and improved biological activities. Observing low μM affinities to mdm2 by NMR and fluorescence polarization we conclude that the 2-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)acetamide scaffold might be a good starting point to further optimize the affinities to Mdm2.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Wyświetlanie 1-10 z 11

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