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    Wyświetlanie 1-8 z 8
    Tytuł:
    Air pollution and IgE sensitization in four European birth cohorts : the MeDALL project
    Autorzy:
    Thiering, Elisabeth
    Bousquet, Jean
    Kull, Inger
    Markevych, Iana
    Koppelman, Gerard H
    Bergström, Anna
    Wijga, Alet
    Berdel, Dietrich
    Heinrich, Joachim
    Melén, Erik
    Wickman, Magnus
    Gruzieva, Olena
    Lupinek, Christian
    Standl, Marie
    von Berg, Andrea
    Antó, Josep Maria
    van Hage, Marianne
    Valenta, Rudolf
    Gehring, Ulrike
    Vonk, Judith M
    Altug, Hicran
    Schikowski, Tamara
    Opis:
    Background: whether long-term exposure air to pollution has effects on allergic sensitization is controversial. Objective: our aim was to investigate associations of air pollution exposure at birth and at the time of later biosampling with IgE sensitization against common food and inhalant allergens, or specific allergen molecules, in children aged up to 16 years. Methods: a total of 6163 children from 4 European birth cohorts participating in the Mechanisms of the Development of ALLergy [MeDALL] consortium were included in this metaanalysis of the following studies: Children, Allergy, Milieu, Stockholm, Epidemiology (BAMSE) (Sweden), Influences of Lifestyle-Related Factors on the Human Immune System and Development of Allergies in Childhood (LISA)/German Infant Study on the Influence of Nutrition Intervention PLUS Environmental and Genetic Influences on Allergy Development (GINIplus) (Germany), and Prevention and Incidence of Asthma and Mite Allergy (PIAMA) (The Netherlands). The following indicators were modeled by land use regression: individual residential outdoor levels of particulate matter with aerodynamic diameters less than 2.5 mm, less than 10 mm, and between 2.5 and 10 mm; PM2.5 absorbance (a measurement of the blackness of PM2.5 filters); and nitrogen oxides levels. Blood samples drawn at ages 4 to 6 (n 5 5989), 8 to 10 (n 5 6603), and 15 to 16 (n 5 5825) years were analyzed for IgE sensitization to allergen extracts by ImmunoCAP. Additionally, IgE against 132 allergen molecules was measured by using the MedALL microarray chip (n 5 1021). Results: air pollution was not consistently associated with IgE sensitization to any common allergen extract up to age 16 years. However, allergen-specific analyses suggested increased risks of sensitization to birch (odds ratio [OR] 5 1.12 [95% CI 5 1.01-1.25] per 10-mg/m3 increase in NO2 exposure). In a subpopulation with microarray data, IgE to the major timothy grass allergen Phleum pratense 1 (Phl p 1) and the cat allergen Felis domesticus 1 (Fel d 1) greater than 3.5 Immuno Solid-phase Allergen Chip standardized units for detection of IgE antibodies were related to PM2.5 exposure at birth (OR 5 3.33 [95% CI 5 1.40-7.94] and OR 5 4.98 [95% CI 5 1.59-15.60], respectively, per 5-mg/m3 increase in exposure). Conclusion: air pollution exposure does not seem to increase the overall risk of allergic sensitization; however, sensitization to birch as well as grass pollen Phl p 1 and cat Fel d 1 allergen molecules may be related to specific pollutants.
    Dostawca treści:
    Repozytorium Uniwersytetu Jagiellońskiego
    Artykuł
    Tytuł:
    Singlet Fission in a New Series of Systematically Designed Through-space Coupled Tetracene Oligomers
    Autorzy:
    Yang, Shang-Da
    Chen, Bo-Han
    Hsu, Chao-Hsien
    Majdecki, Maciej
    Zakrocka, Magdalena
    Chou, Pi-Tai
    Wang, Chih-Hsing
    Shi, Emily Hsue-Chi
    Wei, Yu-Chen
    Lu, Chih-Hsuan
    Gaweł, Przemysław
    Wydawca:
    Wiley
    Cytata wydawnicza:
    Angew. Chem. Int. Ed. 2024, e202401103 ; https://doi.org/10.1002/anie.202401103
    Opis:
    Polish National Science Centre (SONATA 2020/39/D/ST4/00560); National Agency for Academic Exchange (Polish Returns PPN_PPO_2020_1_00012); Poland’s high-performance Infrastructure PLGrid (HPC Centers: ACK Cyfronet AGH, PCSS, CI TASK, WCSS) grant no.: PLG/2021/014515, PLG/2022/01539 and PLG/2023/016125; National Science and Technology Council (grant no. NSTC-112-2639-M-002-007-ASP)
    Singlet fission (SF) holds great promise for current photovoltaic technologies, where tetracenes, with their relatively high triplet energies, play a major role for application in silicon-based solar cells. However, the SF efficiencies in tetracene dimers are low due to the unfavorable energetics of their singlet and triplet energy levels. In the solid state, tetracene exhibits high yields of triplet formation through SF, raising great interest about the underlying mechanisms. To address this discrepancy, we designed and prepared a novel molecular system based on a hexaphenylbenzene core decorated with 2 to 6 tetracene chromophores. The spatial arrangement of tetracene units, induced by steric hindrance in the central part, dictates through-space coupling, making it a relevant model for solid-state chromophore organization. We then revealed a remarkable increase in SF quantum yield with the number of tetracenes, reaching quantitative (196 %) triplet pair formation in hexamer. We observed a short-lived correlated triplet pair and limited magnetic effects, indicating ineffective triplet dissociation in these through-space coupled systems. These findings emphasize the crucial role of the number of chromophores involved and the interchromophore arrangement for the SF efficiency. The insights gained from this study will aid designing more efficient and technology-compatible SF systems for applications in photovoltaics.
    Dostawca treści:
    Repozytorium Centrum Otwartej Nauki
    Artykuł
    Tytuł:
    Between Successful and Unsuccessful Ageing: Selected Aspects and Contexts
    Autorzy:
    Tomczyk, Łukasz
    Klimczuk, Andrzej
    Współwytwórcy:
    Tomczyk, Łukasz
    Klimczuk, Andrzej
    Wydawca:
    Uniwersytet Pedagogiczny w Krakowie
    Cytata wydawnicza:
    Ł. Tomczyk, A. Klimczuk (eds.), Between Successful and Unsuccessful Ageing: Selected Aspects and Contexts, Uniwersytet Pedagogiczny w Krakowie, Kraków 2019, 208pp. https://doi.org/10.24917/9788395373718
    Opis:
    We provide to readers the 11th volume of the "Czech-Polish-Slovak Studies in Andragogy and Social Gerontology" series. We are delighted to announce that the presented study is the result of the work of scientists from seven countries: Austria, China, Ghana, Hungary, Japan, Poland, and Russia. This international collection of texts is part of the global discourse on the determinants of adult education and the functioning of people in late adulthood. The 11th volume is a collection of research results that show both the positive and negative dimensions of ageing through the prism of research experience from various geographical and cultural areas. The researchers invited to the presented volume tried to illustrate the issues assigned to the following topics: ageing with dignity; retirement age; assumptions and conditions resulting from living in the home; the relationship between challenges concerning life expectancy and needs; care and ageing services; and foundations and potential changes in pension systems. The research results presented in this volume have a common denominator, which is caring for the quality of life of the older people regardless of their place of residence. Thus, the study "Between Successful and Unsuccessful Ageing: Selected Aspects and Contexts" brings new insights from scientists who scrupulously characterize the complexity of processes that affect the positive and negative conditions of functioning in old age, which is a mosaic of various nuances. Inviting readers to familiarize themselves with the content of the monograph, we would like to thank the reviewers who contributed to the improvement of the quality of the texts and open new fields for participation in further joint publishing projects.
    Dostawca treści:
    Repozytorium Centrum Otwartej Nauki
    Książka
      Wyświetlanie 1-8 z 8

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