Temat: aggregation - Prolib Integro

Skocz do pozycji: 1.

Tytuł:: Amyloid β interaction with model cell membranes – What are the toxicity-defining properties of amyloid β?
Autorzy:: Pieta, Izabela S.
Pieta, Piotr
Lipkowski, Jacek
Mrdenovic, Dusan
Nowakowski, Robert
Kutner, Wlodzimierz
Wydawca:: Elsevier B.V.
Cytata wydawnicza:: International Journal of Biological Macromolecules 200 (2022) 520–531. https://doi.org/10.1016/j.ijbiomac.2022.01.117
Opis:: Disruption of the neuronal membrane by toxic amyloid β oligomers is hypothesized to be the major event associated with Alzheimer's disease's neurotoxicity. Misfolding of amyloid β is followed by aggregation via different pathways in which structurally different amyloid β oligomers can be formed. The respective toxic actions of these structurally diverse oligomers can vary significantly. Linking a particular toxic action to a structurally unique kind of amyloid β oligomers and resolving their toxicity-determining feature remains challenging because of their transient stability and heterogeneity. Moreover, the lipids that make up the membrane affect amyloid β oligomers' behavior, thus adding to the problem's complexity. The present review compares and analyzes the latest results to improve understanding of amyloid β oligomers' interaction with lipid bilayers.
P.P. acknowledges the support of the Polish National Science Centre , grant No. OPUS12 2016/23B/ST4/02791 . The research activity of D. M. was supported by funds from the European Union's Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No. 711859 and by financial resources for science in the years 2017–2021 awarded by the Polish Ministry of Science and Higher Education for the implementation of an international co-financed project. J.L. acknowledges the support of the Natural Sciences and Engineering Research Council of Canada (NSERC) grant ( RG-03958 ).
Dostawca treści:: Repozytorium Centrum Otwartej Nauki

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Skocz do pozycji: 2.

Tytuł:: Probing E/Z Isomerism Using Pillar[4]pyridinium/Gold Nanoparticle Ensembles and Their Photoresponsive Behavior
Autorzy:: Misztalewska-Turkowicz, Iwona
Kravets, Mykola
Sashuk, Volodymyr
Wydawca:: ACS
Cytata wydawnicza:: Langmuir 2022, 38, 16, 4942–4947 // https://doi.org/10.1021/acs.langmuir.2c00342
Opis:: Despite the fundamental importance and broad applicability of E/Z dicarboxylic acids, their discrimination remains challenging and greatly unexplored. Herein, we present a general approach for the recognition of E/Z diacids using supramolecular interactions coupled with plasmonic response. The method allows detecting both single isomers and their light-induced interconversion, which ultimately entails multiple reversible nanoparticle aggregations. Such a molecular recognition-coupled responsive nanoscale self-assembly resembles natural mechanisms and can be a versatile means of building artificial complexity.
Dostawca treści:: Repozytorium Centrum Otwartej Nauki

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Skocz do pozycji: 3.

Tytuł:: Zarządzanie środowiskiem glebowym przy użyciu biowęgla i zeolitu w różnych kombinacjach: wpływ na stan gleby i aspekty ekonomiczne
Management of the soil environment using biochar and zeolite in various combinations: impact on soil condition and economical aspects
Autorzy:: Szewczuk-Karpisz, Katarzyna
Kukowska, Sylwia
Wydawca:: Springer Nature
Cytata wydawnicza:: Kukowska Sylwia, Szewczuk-Karpisz Katarzyna, Management of the soil environment using biochar and zeolite in various combinations: impact on soil condition and economical aspects, Volume 25, Pages 77-102, (2025), https://doi.org/10.1007/s11368-024-03927-2
Opis:: Purpose Both biochar (BC) and zeolite (Z) are defined as soil conditioners affecting various parameters of soil environment significantly. In most cases, BCs and Zs are characterized by well-developed specific surface area, high porosity, and excellent sorption properties, which is highly helpful in soil reclamation or conditioning. This literature review compares impact of BCs and Zs on the physicochemical properties of various soils as well as economic aspects of their synthesis. Materials and methods The review was prepared based on the articles published in the last 5 years (2018-2023). The articles were selected from the ScienceDirect® database using the keywords: ‘biochar/zeolite impact on soil physicochemical properties’, ‘biochar/zeolite impact on water retention of soil’ and ‘biochar/zeolite economic aspects’. Results and discussion Based on the available data, it can be stated that both biochars and zeolites have good sorptive properties, which usually contributes to better growth of crops. Comparing biochar and zeolites and choosing which one is more promising depends on the specific purpose and type of soil to which they are to be applied. Biochar usage contributes mainly to providing organic matter and improving soil structure, while zeolites are applied for enhancing water retention. The profitability of zeolite and biochar production depends largely on the precursor as well as the synthesis method. Conclusions Due to the fact that impact of synthetic zeolites on the soil environment is much less frequently investigated than that of biochars, the research using Zs and various types of soil is especially needed. During soil reclamation, in some cases, it is advisable to apply biochar and zeolite simultaneously. Combinations of these materials may provide benefits in soil structure and water retention. Such mixed techniques should be investigated in the near future.
Uploaded file is the preprint of publication: Kukowska Sylwia, Szewczuk-Karpisz Katarzyna, Management of the soil environment using biochar and zeolite in various combinations: impact on soil condition and economical aspects, Volume 25, Pages 77-102, (2025), https://doi.org/10.1007/s11368-024-03927-2
National Science Centre, Poland - grant no. 2021/41/B/NZ9/03059
Dostawca treści:: Repozytorium Centrum Otwartej Nauki

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Skocz do pozycji: 4.

Tytuł:: Sterically Tuned Ortho-Phenylene-Linked Donor–Acceptor Benzothiazole-Based Boron Difluoride Complexes as Thermally-Activated Delayed Fluorescence Emitters for Organic Light-Emitting Diodes
Autorzy:: Baryshnikov, Glib V.
Kutsiy, Stepan
Ranjan Sahoo, Smruti
Ceborska, Magdalena
Wisniewska, Agnieszka
Volyniuk, Dmytro
Stakhira, Pavlo
Grazulevicius, Juozas Vidas
Potopnyk, Mykhaylo A.
Wydawca:: American Chemical Society
Cytata wydawnicza:: ACS Appl. Mater. Interfaces 2024, 16, 44, 60633–60647 // https://doi.org/10.1021/acsami.4c12662
Opis:: “Long-term program of support of the Ukrainian research teams at the Polish Academy of Sciences carried out in collaboration with the U.S. National Academy of Sciences with the financial support of external partners”; National Supercomputer Centre (NSC) through the project LiU-compute-2024-14, funded by the Linköping University; Research Council of Lithuania (S-MIP-24-2)
Two donor–acceptor dyes with an ortho-phenylene-linked carbazole electron donor and a benzothiazole-fused boron heterocyclic acceptor were designed, synthesized, and spectroscopically investigated. Due to the steric effects of boron heterocyclic units, the dyes demonstrate different conformations in the crystalline state. The presence of numerous hydrogen-bonding intermolecular interactions and the very weak π–π stacking in the molecular packing results in intense solid-state emission with photoluminescence quantum yields of 40 and 18% for crystals and 50 and 42% for host-based light-emitting layers. The compounds show aggregation-induced emission and thermally activated delayed fluorescence (TADF). The received ionization potential and electron affinity values suggested good charge-injecting ability and bipolar charge-transporting properties of the developed dyes. Transport of holes and electrons was detected in layers of one dye by the time-of-flight measurements. The benzothiazole-based boron difluoride complexes showed high electron mobility of 1.5 × 10–4 and 0.7 × 10–4 cm2 V–1 s–1 at an electric field of 1.35 × 106 V cm–1. Therefore, these dyes were successfully applied as emitters in organic light-emitting diodes with external quantum efficiencies of 15 and 13%, respectively. Our study marks a critical advancement in the area of solid-state emissive boron difluoride dyes, which can be applied as TADF emitters into organic light-emitting diodes. The obtained results reveal that the orientation of the acceptor unit in the ortho-phenylene-linked donor–acceptor dyes makes a significant impact on the TADF activity.
Dostawca treści:: Repozytorium Centrum Otwartej Nauki

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Skocz do pozycji: 5.

Tytuł:: Ambient-temperature porogen-free method for preparation of silica-based macroporous materials
Autorzy:: Sedlářová, Ivona
Trunov, Dan
Dendisová, Marcela
Hassouna, Fatima
Muzika, František
Šoóš, Miroslav
Kříž, Anita
Štětina, Jiří
Wydawca:: Elsevier
Cytata wydawnicza:: Dan Trunov, František Muzika, Anita Kříž, Jiří Štětina, Ivona Sedlářová, Marcela Dendisová, Fatima Hassouna and Miroslav Šoóš, Ambient-temperature porogen-free method for preparation of silica-based macroporous materials, Colloids and Surfaces A: Physicochemical and Engineering Aspects, (2021) doi:https://doi.org/10.1016/j.colsurfa.2021.128033
Opis:: The presented work focuses on the synthesis of silica-based macroporous aggregates composed of silica nanoparticles using a template-free method. To improve the mechanical strength of the prepared fractal-like aggregates, the silica precursor tetraethyl orthosilicate (TEOS) is used during nanoparticle aggregation. The obtained results confirm the possibility to tailor the pore size distribution (PSD) simply by using primary particles of various sizes. The prepared porous materials have a porosity ranging from 60 to 74 % with a specific surface area between 10 to 200 m2/g and an average pore diameter from 30 to 1300 nm. Functionalization of the aggregate surface was done by replacing part of TEOS with a silica precursor that contained desired functional groups. This was demonstrated by preparing macroporous aggregates with carboxyl, amine and epoxy functional groups. The application of prepared aggregates was demonstrated by immobilization of urease from Canavalia ensiformis resulting in high enzyme activity compare to free enzymes.
This work was supported by a Czech Science Foundation (GACR) grant 16-22997S and a specific university research – grant No A1_FCHI_2021_005. This publication is part of a project that has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No. 847413. Scientific work published as part of an international co-financed project founded from the program of the Minister of Science and Higher Education entitled "PMW" in the years 2020 - 2024; agreement no. 5005/H2020-MSCA-COFUND/2019/2.
Dostawca treści:: Repozytorium Centrum Otwartej Nauki

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Skocz do pozycji: 6.

Tytuł:: Ambient-temperature porogen-free method for preparation of silica-based macroporous materials
Autorzy:: Sedlářová, Ivona
Trunov, Dan
Dendisová, Marcela
Hassouna, Fatima
Muzika, František
Šoóš, Miroslav
Kříž, Anita
Štětina, Jiří
Wydawca:: Elsevier
Cytata wydawnicza:: Dan Trunov, František Muzika, Anita Kříž, Jiří Štětina, Ivona Sedlářová, Marcela Dendisová, Fatima Hassouna and Miroslav Šoóš, Ambient-temperature porogen-free method for preparation of silica-based macroporous materials, Colloids and Surfaces A: Physicochemical and Engineering Aspects, (2021) doi:https://doi.org/10.1016/j.colsurfa.2021.128033
Opis:: The presented work focuses on the synthesis of silica-based macroporous aggregates composed of silica nanoparticles using a template-free method. To improve the mechanical strength of the prepared fractal-like aggregates, the silica precursor tetraethyl orthosilicate (TEOS) is used during nanoparticle aggregation. The obtained results confirm the possibility to tailor the pore size distribution (PSD) simply by using primary particles of various sizes. The prepared porous materials have a porosity ranging from 60% to 74% with a specific surface area between 10 and 200 m2/g and an average pore diameter from 30 to 1300 nm. Functionalization of the aggregate surface was done by replacing part of TEOS with a silica precursor that contained desired functional groups. This was demonstrated by preparing macroporous aggregates with carboxyl, amine and epoxy functional groups. The application of prepared aggregates was demonstrated by immobilization of urease from Canavalia ensiformis resulting in high enzyme activity compare to free enzymes.
This work was supported by a Czech Science Foundation (GACR) grant 16-22997S and a Specific University Research – grant No A1_FCHI_2021_005. This publication is part of a project that has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie Grant agreement No. 847413. Scientific work published as part of an international co-financed project founded from the program of the Minister of Science and Higher Education entitled "PMW" in the years 2020 - 2024; agreement no. 5005/H2020-MSCA-COFUND/2019/2.
Dostawca treści:: Repozytorium Centrum Otwartej Nauki

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Skocz do pozycji: 7.

Tytuł:: Inhibition of Amyloid β-Induced Lipid Membrane Permeation and Amyloid β Aggregation by K162
Autorzy:: Kutner, Robert
Mrdenowic, Dusan
Pieta, Izabela S.
Zarzycki, Piotr
Pieta, Piotr
Majewska, Marta
Lipkowski, Jacek
Nowakowski, Robert
Wydawca:: American Chemical Society
Cytata wydawnicza:: ACS Chem. Neurosci. 2021, 12, 3, 531–541. https://doi.org/10.1021/acschemneuro.0c00754
Opis:: This research was supported by receiving funding from the Polish National Science Centre, grant No. OPUS12 2016/23B/ST4/02791, awarded to P.P. The research activity of D.M. was supported by funds from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No. 711859 and by financial resources for science in the years 2017–2021 awarded by the Polish Ministry of Science and Higher Education for the implementation of an international cofinanced project. P.Z. acknowledges support from the US Department of Energy (DOE) Chemical Sciences, Geosciences, and Biosciences Division under Contract DE-AC02-05CH11231. The collaboration between the Polish Academy of Sciences and the Lawrence Berkeley National Laboratory was supported by grant NCN Sonata-Bis (DEC-2016/22/E/ST4/00446). J.L. acknowledges support of Natural Sciences and Engineering Research Council of Canada (NSERC) grant (RG-03958).
Alzheimer’s disease (AD) is characterized by progressive neurodegeneration associated with amyloid β (Aβ) peptide aggregation. The aggregation of Aβ monomers (AβMs) leads to the formation of Aβ oligomers (AβOs), the neurotoxic Aβ form, capable of permeating the cell membrane. Here, we investigated the effect of a fluorene-based active drug candidate, named K162, on both Aβ aggregation and AβO toxicity toward the bilayer lipid membrane (BLM). Electrochemical impedance spectroscopy (EIS), atomic force microscopy (AFM), and molecular dynamics (MD) were employed to show that K162 inhibits AβOs-induced BLM permeation, thus preserving BLM integrity. In the presence of K162, only shallow defects on the BLM surface were formed. Apparently, K162 modifies Aβ aggregation by bypassing the formation of toxic AβOs, and only nontoxic AβMs, dimers (AβDs), and fibrils (AβFs) are produced. Unlike other Aβ toxicity inhibitors, K162 preserves neurologically beneficial AβMs. This unique K162 inhibition mechanism provides an alternative AD therapeutic strategy that could be explored in the future.
Dostawca treści:: Repozytorium Centrum Otwartej Nauki

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