Temat: stimulation - Prolib Integro

Skocz do pozycji: 1.

Tytuł:: Combining rotary wet-spinning biofabrication and electro-mechanical stimulation for the in vitro production of functional myo-substitutes
Autorzy:: Costantini, Marco
Maiullari, Fabio
Rizzi, Roberto
Paradiso, Alessia
Volpi, Marina
Promovych, Yurii
Bearzi, Claudia
Gizynski, Konrad
Fuoco, Claudia
Gargioli, Cesare
Dolinska, Joanna
Presutti, Dario
Swieszkowski, Wojciech
Rinoldi, Chiara
Celikkin, Nehar
Opałło, Marcin
Wiśniewska, Agnieszka
Wydawca:: IOP
Cytata wydawnicza:: Celikkin, Nehar, et al. "Combining rotary wet-spinning biofabrication and electro-mechanical stimulation for the in vitro production of functional myo-substitutes." Biofabrication 15.4 (2023): 045012.
Opis:: This study was supported by the National Science Centre Poland (NCN) within the SONATA 14 2018/31/D/ST8/03647 and PRELUDIUM 19 Project No. 2020/37/N/ST5/03272. This work was also supported by Research Projects CNR Progetti at CNR under the Grant No.: CUP: B93C20046330005. We would like to acknowledge Prof Fabio Domenici at Department of Chemical Science and Technologies, University of Rome "Tor Vergata", Rome, Italy for their support in confocal image acquisition.
In this work, we present an innovative, high-throughput rotary wet-spinning biofabrication method for manufacturing cellularized constructs composed of highly-aligned hydrogel fibers. The platform is supported by an innovative microfluidic printing head (MPH) bearing a crosslinking bath microtank with a co-axial nozzle placed at the bottom of it for the immediate gelation of extruded core/shell fibers. After a thorough characterization and optimization of the new MPH and the fiber deposition parameters, we demonstrate the suitability of the proposed system for the in vitro engineering of functional myo-substitutes. The samples produced through the described approach were first characterized in vitro and then used as a substrate to ascertain the effects of electro-mechanical stimulation on myogenic maturation. Of note, we found a characteristic gene expression modulation of fast (MyH1), intermediate (MyH2), and slow (MyH7) twitching myosin heavy chain isoforms, depending on the applied stimulation protocol. This feature should be further investigated in the future to biofabricate engineered myo-substitutes with specific functionalities.
Dostawca treści:: Repozytorium Centrum Otwartej Nauki

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Tytuł:: 25 years of partial deafness treatment – milestones in the world’s science. Own experience
Autorzy:: Skarżyński, Henryk
Skarżyński, Piotr Henryk
Wydawca:: Uczelnia Łazarskiego
Cytata wydawnicza:: Skarżyński, H., Skarżyński, P.H. (2022). 25 years of partial deafness treatment – milestones in the world’s science. Own experience. Review of Medical Practice, 1-2, 31-39.
Opis:: Over the past 25 years, cochlear implant patients’ inclusion criteria have significantly expanded. Advances in implant technology and surgical techniques allow most patients to maintain good preoperative hearing during and after cochlear implantation. The paper presents the latest concept of partial deafness treatment, including the development and improvement of this method. The course of the surgical procedure is discussed and tips are given regarding the electrode lengths and combinations of acoustic and electrical stimulation; important information is also provided on the preservation of the preoperative structures of the hearing and the inner ear. The work is supplemented by the classification of hearing impairment and the presentation of the development and application of specially designed electrodes used in various types of hearing loss.
Dostawca treści:: Repozytorium Centrum Otwartej Nauki

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Tytuł:: Combined Psycho-physical Neurofeedback Therapy in the Stimulant Addiction Treatment: Clinical-psychological and EEG/FMRI Study
Autorzy:: Yarovyi, O.
Striltsiv, O.
Stebliuk, V.
Omelchenko, O.
Wydawca:: Radomska Szkoła Wyższa w Radomiu
Cytata wydawnicza:: Stebliuk V., Striltsiv O., Omelchenko O. Combined psycho-physical neurofeedback therapy in the stimulant addiction treatment: clinical-psychological and EEG/FMRI study. Journal of Health Sciences. 2013; 3 (10): 325-336.
Opis:: Stimulant usage progressively replaces opiate and cannabis addiction and become substance dependence problem of today. Treatment of stimulant users is traditionally the same as for the opiate addiction. Asthenia, dysphoria and negativism are common causes for psychological dependence. Tranquilizers, antipsychotics, sedatives can quickly help to cope with the negative behavioral disorders that accompany drug usage, but reduced psycho-physical and bio-social activity are common side effects of their use. Thus development of the new replacement therapy methods for stimulant addiction is urgent task for today’s medicine. We propose neurofeedback audiovisual stimulation (AVS) in combination with hypnotic suggestion as a new approach for stimulant addiction treatment. The group of patients was treated with AVS therapy in combination with hypnotic suggestion, which was used as the replacement therapy at the abstinence period. Psychological testing, EEG and fMRI were used for the evaluation of the AVS effects. Psychological tests showed that AVS combined with hypno-suggestive therapy helped to reduce negative psychotic symptoms of the drug withdrawal syndrome. EEG effect of the AVS appeared in predominant delta rhythm displacement by the alpha rhythm after the treatment. fMRI exams showed considerable increase of the volumes of activation after the AVS and almost complete extinction of the deactivation, which is normally present at the time of task execution. The last could be also considered as a marker for prolonged effect of brain stimulation by the AVS therapy. Thus AVS combined with hypno-suggestive therapy is a promising method for the rehabilitation of patients, which are addicted to stimulants.
Walery Zukow
Dostawca treści:: Repozytorium Centrum Otwartej Nauki

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Tytuł:: Wpływ dotacji unijnych na dochodowość gospodarstw agroturystycznych
The impact of EU subsidies on the profitability of agritourism farms
Autorzy:: Brambert, Patryk
Pałka-Łebek, Ewa
Wydawca:: Polskie Towarzystwo Geograficzne, Oddział Katowicki; Uniwersytet Śląski, Wydział Nauk o Ziemi
Cytata wydawnicza:: Pałka-Łebek E., Brambert P., 2018, Wpływ dotacji unijnych na dochodowość gospodarstw agroturystycznych, [w:] Sitek S. (red.) „Stare i nowe” problemy badawcze w geografii społeczno-ekonomicznej, z. 8, Polskie Towarzystwo Geograficzne Oddział Katowicki, Uniwersytet Śląski Wydział Nauk o Ziemi, Sosnowiec, s. 43–54.
Opis:: Tourism, including agritourism has important meaning in new conceptions of rural areas development. The study is the assessment of the impact of European Union subsidies on the profitability of agritourism farms. There is also made a point of the role of agritourism as the phenomenon stimulating revitalization process of rural areas. The authors focused mainly on the economic development stimulants of agritourism in the southeastern Poland. It was built on the analysis of some opinions about these problems of a selected group of agritourist farms. Recognition of the opinions was based on the direct survey of 607 farmers, which was held in 2016. Shapiro and Wilk's test for normality, and Spearman’s R test were applied in the statistical analysis. There is ambiguous correlation between profitability of agritourism farms and sourced funds.
Turystyka, w tym agroturystyka odgrywa dużą rolę w nowych koncepcjach rozwoju obszarów wiejskich. W opracowaniu oceniono wpływ dotacji unijnych na dochodowość gospodarstw agroturystycznych. Zaakcentowano też rolę agroturystyki jako zjawiska stymulującego procesy rewitalizacji obszarów wiejskich. Autorzy skupili się na kwestii głównie ekonomicznych stymulant rozwoju agroturystyki w południowo-wschodniej Polsce. Oparto się na analizie kilku opinii na ten temat w ramach określonej grupy gospodarstw agroturystycznych. Sądy poznano na podstawie bezpośrednich badań ankietowych wśród 607 gospodarzy, które wykonano w 2016 r. W analizie statystycznej zastosowano test normalności W Shapiro-Wilka oraz współczynnik korelacji rangowej R Spearmana. Zależność dochodowości gospodarstw od pozyskanych środków nie jest jednoznaczna.
Dostawca treści:: Repozytorium Centrum Otwartej Nauki

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