Temat: Angiotensinogen - Prolib Integro

Skocz do pozycji: 1.

Tytuł:: Human AGT-p.Met268Thr and coronary heart disease risk: a case-control study and meta-analysis
Autorzy:: Hanieh, Mohammadi
Narges, Razavi
Abbasi, Ali
Babaei, Faezeh
Seyedrezazadeh, Ensiyeh
Hosseinzade, Abasalt
Tematy:: coronary disease
angiotensinogen
genetic polymorphism
meta-analysis.; Pokaż więcej
Data publikacji:: 2018
Powiązania:: https://bibliotekanauki.pl/articles/551649.pdf Link otwiera się w nowym oknie
Źródło:: Family Medicine & Primary Care Review; 2018, 1; 17-24
1734-3402
Pojawia się w:: Family Medicine & Primary Care Review
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: LC/MS/MS assessment of changes in placental angiotensin I metabolism in preeclampsia
Autorzy:: Stettner-Kołodziejska, Dominika
Bujak-Giżycka, Beata
Wiśniewska, Anna
Łomnicka, Magdalena
Kołodziejski, Michał
Wiecheć, Marcin
Rytlewski, Krzysztof
Huras, Hubert
Olszanecki, Rafał
Tematy:: angiotensinogen metabolism
placenta
preeclampsia
angiotensin II
RAS; Pokaż więcej
Data publikacji:: 2022-10-21
Powiązania:: https://bibliotekanauki.pl/articles/56993044.pdf Link otwiera się w nowym oknie
Źródło:: Folia Medica Cracoviensia; 2022, 62, 1; 71-88
0015-5616
Pojawia się w:: Folia Medica Cracoviensia
Opis:: Background: Preeclampsia (PE) is a condition characterized by high blood pressure and significant proteinuria in pregnant women. It affects about 7% pregnancies and can be cause of fetal and maternal morbidity and mortality. During pregnancy, a physiological overexpression of the Renin-An-giotensin System (RAS) components is observed, including increased plasma Ang II level. Dysregulation of RAS in placenta may contribute to preeclampsia and uterine growth retardation. The aim of the study was to evaluate the Ang I metabolism in human preeclamptic placentas and to compare to normal pregnancies condition. Method: Fragments of placental tissues were collected right after ceasarian section from PE and physiological pregnancies. Tissues were incubated in Krebs buffer in the presence of Ang I. Evaluation of Ang I metabolites in incubating fluid was performed by LC/MS/MS method. mRNA expression of main RAS components was measured by RT-PCR. Results: Pattern of angiotensin metabolites did not differ between groups. The main products were Ang 1–7 and Ang II. Comparing to control group, more than 3-fold lower production of Ang II and Ang 1–7 in preeclampsia was observed. mRNA expressions of ACE and AT1 were significantly decreased in pre-eclamptic placentas, whereas higher expression of mRNA of ACE2 and MAS receptor were observed. Conclusions: Production of Ang 1–7 by PE placentas was significantly lower than in control group. Significantly decreased mRNA expression of ACE and AT1 receptor and lower production of Ang II in placentas of PE patients suggest that placental Ang II/ACE/AT1r pathway could be less important than Ang 1–7/ACE-2/MASr pathway in development of preeclampsia, but this requires further investigations.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: Computational study of ACE and AGT gene of RAAS pathway
Autorzy:: Nisha, Nisha
Kaur, Satbir
Kaur, Sumanpreet
Kumar, Sandeep
Galhna, Kiranjeet Kaur
Kaur, Kamaljeet
Tematy:: Angiotensin converting enzyme
Angiotensinogen
Hypertension
Renin angiotensin aldosterone system
Single nucleotide polymorphism; Pokaż więcej
Data publikacji:: 2018
Powiązania:: https://bibliotekanauki.pl/articles/1112240.pdf Link otwiera się w nowym oknie
Źródło:: World News of Natural Sciences; 2018, 19; 65-77
2543-5426
Pojawia się w:: World News of Natural Sciences
Opis:: Renin angiotensin aldosterone system (RAAS) is a hormone regulatory hormone system that regulate blood pressure. The two major genes ACE and AGT are the players of RAAS pathway. These genes codes for angiotensin convertase enzyme and angiotensinogen protein respectively. The angiotensin convertase enzyme convert inactive angiotensinogen into active angiotensin which further helps in the regulation of blood pressure. Due to imbalance in this pathway may cause hypertension. So in the present study we decided to perform the computational study of ACE and AGT gene. We evaluated the deleterious/damaging effect of SNPs of ACE and AGT gene by SIFT and I-Mutant2.0. The total number of SNPs predicted to be deleterious by both tools were 5 (1.83%) and 22 (6.07%) for AGT and ACE genes respectively. We also studied subcellular location of ACE and AGT genes and drugs targeting these genes from database GeneCards. Further the result output of both the softwares were also compared.
Dostawca treści:: Biblioteka Nauki

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