Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Wyszukujesz frazę "liver" wg kryterium: Temat


Tytuł:
Early results of liver resection using laparoscopic technique
Autorzy:
Stranek, Maciej
Pędziwiatr, Michał
Radkowiak, Dorota
Zychowicz, Anna
Budzyński, Piotr
Major, Piotr
Budzyński, Andrzej
Tematy:
laparoscopy
liver resection
liver metastases
Pokaż więcej
Data publikacji:
2016
Powiązania:
https://bibliotekanauki.pl/articles/1394071.pdf  Link otwiera się w nowym oknie
Źródło:
Polish Journal of Surgery; 2016, 88, 1; 20-25
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Opis:
The aim of the study was to present early outcomes of liver resection using laparoscopic technique. Material and methods. Retrospective analysis of patients who underwent liver resection using laparoscopic method was conducted. The analyzed group included 23 patients (11 women and 12 men). An average patient age was 61.3 years (37 – 83 years). Metastases of the colorectal cancer to the liver were the cause for qualification to the procedure of 15 patients, metastasis of breast cancer in 1 patient and primary liver malignancy in 5 patients. The other 2 patients were qualified to the liver resection to widen the surgical margins due to gall-bladder cancer diagnosed in the pathological assessment of the specimen resected during laparoscopic cholecystectomy, initially performed for other than oncology indications. Results. Hemihepatectomy was performed in 11 patients (9 right and 2 left), while the other 12 patients underwent minor resection procedures (5 metastasectomies, 4 nonanatomical liver resections, 1 bisegmentectomy, 2 resections of the gall-bladder fossa). An average duration of the surgical procedure was 275 minutes 65 – 600). An average size of the resected tumors was 28 mm (7 – 55 mm). In three cases conversion to laparotomy occurred, caused by excessive bleeding from the liver parenchyma. Postoperative complications were found in 4 patients (17.4%). Median hospitalization duration was 6 days (2 – 130 days). One patient (4.3%) was rehospitalized due to subhepatic abscess and required reoperation. Histopathology assessment confirmed radical resection (R0) in all patients in our group. Conclusion. Laparoscopic liver resections seem to be an interesting alternative in the treatment of focal lesions in the liver.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
History of liver transplantation in Poland
Autorzy:
Krawczyk, Marek
Tematy:
liver transplantations
history of liver transplantation
liver transplant centers in Poland
liver transplantation technique
Pokaż więcej
Data publikacji:
2018
Powiązania:
https://bibliotekanauki.pl/articles/1392651.pdf  Link otwiera się w nowym oknie
Źródło:
Polish Journal of Surgery; 2018, 90, 3; 60-68
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Opis:
Experimental research on liver transplantation was introduced in Poland by Waldemar Olszewski and his team in 1972. Not until 15 years later, in 1987, did Stanisław Zieliński in Szczecin and Marian Pardela in Katowice make an attempt of transplanting liver in humans. In 1989 another attempt was made by Jacek Pawlak and Marek Krawczyk in Warsaw. The first successful liver transplantation in Poland was performed in 1990 by Piotr Kaliciński at the Children’s Memorial Health Institute, Warsaw. Also, in early 1990s the attempts were made by Jerzy Polański in Warsaw and Piotr Szyber in Wrocław. In the next years, liver transplantations were connected with three centers in Szczecin and were associated with the following persons: Roman Kostryka, Maciej Wójcicki and Samir Zeaira. In Warsaw, 1994, Jacek Pawlak, Bogdan Michałowicz and Krzysztof Zieniewicz performed another successful liver transplantation. The program started to develop rapidly and is still up and running. In 2000, Wojciech Rowiński and Marek 
Pacholczyk created another liver transplant center in Warsaw, while in 2005 Lech Cierpka and Robert Król did the same in Katowice. In the following years, liver transplantation was initiated by Maciej Słupski in Bydgoszcz (2017) and Zbigniew Śledziński in Gdańsk (2018). In the developing liver transplant centers, an exceptional contribution was made by Paweł Nyckowski, Jacek Pawlak, Krzysztof Zieniewicz, Waldemar Patkowski, Tadeusz Wróblewski, Rafał Paluszkiewicz, Marek Pacholczyk, Andrzej Chmura, Maciej Kosieradzki and Marek Krawczyk – all employed by the Medical University of Warsaw. In Wrocław, Dariusz Patrzałek and Paweł Chudoba were very active in the field of liver transplantations. In 1996, the Organizing-Coordinating Center for Transplantation POLTRANSPLANT was brought to life and at first was directed by Janusz Wałaszewski, then by Roman Danielewicz and Artur Kamiński. In 1999, Piotr Kaliciński and Marek Krawczyk started the program for liver fragment harvesting and transplantation from living donors. Until the end of 2016, 4186 liver transplantations including 314 liver transplants from living donors were performed in Poland. Currently there are three active centres in Warsaw, namely Pediatric Surgery and Transplantation Surgery, Children’s Memorial Health Institute; Department of General, Transplant and Liver Surgery, Medical University of Warsaw; 
Department of General and Transplant Surgery, Medical University of Warsaw. Other active centres in Poland are Department of General and Transplant Surgery, Provincial Hospital in Szczecin, Department of General, Vascular and Transplant Surgery, Medical University of Silesia, Katowice, Department of Vascular, General and Transplant Surgery in Wrocław. Liver transplant programs have also been initiated at the Department of Liver and General Surgery, Bydgoszcz, and Department of General, Endocrine and Transplant Surgery, Medical University of Gdańsk.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Is there a rationale for aggressive breast cancer liver metastases resections in Polish female patients? Analysis of overall survival following hepatic resection at a single centre in Poland
Autorzy:
Kobryń, Eliza
Kobryń, Konrad
Wróblewski, Tadeusz
Kobryń, Krzysztof
Pietrzak, Radosław
Rykowski, Paweł
Ziarkiewicz-Wróblewska, Bogna
Lamparski, Krzysztof
Zieniewicz, Krzysztof
Patkowski, Waldemar
Krawczyk, Marek
Paluszkiewicz, Rafał
Tematy:
liver metastases
breast cancer
liver surgery
Pokaż więcej
Data publikacji:
2016
Powiązania:
https://bibliotekanauki.pl/articles/991146.pdf  Link otwiera się w nowym oknie
Źródło:
Annals of Agricultural and Environmental Medicine; 2016, 23, 4
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Opis:
Introduction. Breast cancer (BC) makes up nearly 26% of malignant tumours worldwide and is the leading cause of cancerrelated deaths in European women. With approximately 18,000 new cases of BC diagnosed in Polish women annually, breast cancer liver metastasis (BCLM) is respectively an increasing issue. Recent data found in literature indicates improved survival following liver resection with systemic therapy. Objective. The aim of study was to evaluate surgical treatment in patients with isolated BCLM. Materials and method. During 2009–2013, a retrospective study was undertaken and 30 cases analysed. From nearly 2,000 liver resections performed, 11 female patients at the mean age of 59.18 years with BCLM were qualified for surgery. Results. The median time between primary and secondary treatment was 3.5 years (1–7). One patient (9.1%) presented an extrahepatic lesion – bone metastasis. The left lobe, right lobe and both lobes of the liver were affected, respectively, in 3 (27.3%), 4 (36.4%) and 4 (36.4%) patients. 5 patients (45.5%) presented single hepatic lesion, in contrast to the maximum number of lesions which equalled 6 in the right lobe. Average hospitalisation period was 13.27 days and discharge on the 11.3 postoperative day. One-year survival was 72.7% (8 patients); therefore, three-year survival was 36.4% (4 patients). Conclusions. Oncological centres should assess BCLM patients more openly and qualify them for hepatic resection along with adjuvant systemic treatment in order to improve overall survival. This, however, needs to be studied in a multicentre randomized trial.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Alcohol-associated liver disease — a current overview
Autorzy:
Mirowski, Krystian
Balicka-Ślusarczyk, Barbara
Hydzik, Piotr
Zwolińska-Wcisło, Małgorzata
Tematy:
alcohol-associated liver disease
alcohol-related liver disease
ALD
ARLD
alcoholic steatosis
alcoholic fatty liver
alcoholic hepatitis
alcoholic liver cirrhosis
Pokaż więcej
Data publikacji:
2024-10-17
Powiązania:
https://bibliotekanauki.pl/articles/57114025.pdf  Link otwiera się w nowym oknie
Źródło:
Folia Medica Cracoviensia; 2024, 64, 2; 93-104
0015-5616
Pojawia się w:
Folia Medica Cracoviensia
Opis:
Alcohol-associated liver disease (ALD) remains a major and increasingly pressing concern in hepatology. ALD includes spectrum of conditions, each with unique diagnostic and therapeutic challenges. Excessive alcohol intake is a leading preventable cause of physical harm, including ALD. The pathogenesis of ALD involves oxidative stress, inflammation, and lipid metabolism disruptions, with genetic predispositions playing a major role. ALD progresses from hepatic steatosis to steatohepatitis, and finally liver cirrhosis, which is marked by severe fibrosis and impaired liver function. Advanced ALD stages, particularly alcoholic hepatitis and liver cirrhosis, are characterized by high mortality rates. Management of ALD primarily involves strict abstinence from alcohol, which can reverse early-stage disease or halt progression. Nutritional support, vitamin supplementation, and symptomatic treatment are also essential. Liver transplantation is the only definitive treatment for alcoholic liver cirrhosis, but it is difficult for patients with a history of alcohol abuse to qualify for the procedure. Epidemiological data indicate a growing burden of ALD, especially among younger populations, exacerbated by increased alcohol consumption trends and the COVID-19 pandemic’s influence on drinking behaviors. Despite ALD’s significant impact, current therapies are limited, highlighting the need for innovative treatments and comprehensive patient management strategies. Individualized care, enhanced epidemiological research, and new therapeutic approaches are crucial to improving outcomes for ALD patients.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Comparison of Total Tumor Volume, Size and Number of Colorectal Liver Metastases in Prediction of Survival in Patients after Liver Resection
Autorzy:
Hołówko, Wacław
Grąt, Michał
Wronka, Karolina Maria
Stypułkowski, Jan
Roszkowski, Rafał
Studnicki, Paweł
Krawczyk, Marek
Tematy:
colorectal liver metastases
liver resection
total tumor volume
Pokaż więcej
Data publikacji:
2015-02-01
Powiązania:
https://bibliotekanauki.pl/articles/1395543.pdf  Link otwiera się w nowym oknie
Źródło:
Polish Journal of Surgery; 2015, 87, 2; 53-58
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Opis:
Liver is the most common location of the colorectal cancer metastases occurrence. Liver resection is the only curative method of treatment. Unfortunately it is feasible only in 25% of patients with colorectal liver metastases, often because of the extensiveness of the disease. The aim of the study was to evaluate the predictive value of total tumor volume, size and number of colorectal liver metastases in patients treated with right hemihepatectomy. Material and methods. A retrospective analysis was performed in a group of 135 patients with colorectal liver metastases, who were treated with right hemihepatectomy. Total tumor volume was estimated based on the formula (4/3)πr3. Moreover, the study included an analysis of data on the number and size of tumors, radicality of the resection, time between primary tumor resection and liver resection, pre-operative blood serum concentration of carcinoembryonal antigen (CEA) and carcinoma antigen Ca19-9. The predictive value of the factors was evaluated by applying a Cox proportional hazards model and the area under the ROC curve. Results. The univariate analysis has shown the predictive value of size of the largest tumor (p=0.033; HR=1.065 per each cm) on the overall survival, however no predictive value of number of tumors (p=0.997; HR=1.000) and total tumor volume (p=0.212; HR=1.002) was observed. The multivariate analysis did not confirm the predictive value of the size of the largest tumor (p=0.141; HR=1.056). In the analysis of ROC curves, AUROC for the total tumor volume, the size of the largest tumor and the number of tumors were 0.629, 0.608, 0.520, respectively. Conclusions. Total tumor volume, size and number of liver metastases are not independent risk factors for the worse overall survival of patients with colorectal liver metastases treated with liver resection, therefore increased values of these factors should not be a contraindication for surgical treatment
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The effect and clinical significance of using nathanson liver retractor on liver function tests in laparoscopic gastric cancer surgery
Autorzy:
Gojayev, Afig
Yüksel, Cemil
Mercan, Ümit
Çaparlar, Mehmet Ali
Çetindağ, Özhan
Akbulut, Serkan
Ünal, Ali Ekrem
Bayar, Sancar
Demirci, Salim
Tematy:
gastrectomy
gastric cancer
laparoscopy
liver enzymes
liver dysfunciton
Pokaż więcej
Data publikacji:
2021-10-08
Powiązania:
https://bibliotekanauki.pl/articles/58461446.pdf  Link otwiera się w nowym oknie
Źródło:
Polish Journal of Surgery; 2022, 94, 1; 1-7
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Opis:
Aim: There are very few studies in the literature investigating the changes caused by the Nathanson retractors in liver function tests (LFT) after LG and their clinical significance. The present study investigated the changes made by the Nathanson retractor used during laparoscopic gastrectomy (LG) in LFT and their clinical significance. Material and methods: The data of 236 patients who underwent radical gastrectomy for primary gastric cancer at Surgical Oncology Unit in the period between January 2015 and January 2020 were retrospectively studied. The patients were divided into two groups: laparoscopic gastrectomy (LG; 136 cases) and open gastrectomy (OG; 106 cases). Patients after cholecystectomy, with primary or secondary liver tumors, with chronic hepatic disease, with high preoperative ALT, AST and bilirubin values were excluded from the study. LFT were measured preoperatively and on postoperative day 1 (LFT1), LFT3, LFT5 and LFT7. LFT: ALT, AST and Total bilirubin (BIL). Results: ALT1, ALT3, ALT5, ALT7 ALT values and AST1, AST3, AST5 AST values of patients in the LG group were found to be significantly higher (P < 0.001). Mean total bilirubin values of the groups were similar (P > 0.05). In order to evaluate how the increase in LFT due to the use of the Nathanson retractors reflected on the patients' clinic, we divided the patients who underwent LG into two groups based on ALT increase in ALT1: Normal and Elevated. The in-hospital mortality rates (P = 0.080) and oral nutrition time (P = 0.913) of the groups were similar. No liver infarction developed in any of the groups. The duration of stay in the ICU was significantly longer in individuals with elevated LFT (P = 0.019). Conclusion: Although the use of the Nathanson retractor during LG causes an increase in liver function test results, this does not cause major clinical problems in patients
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Neutrophil-lymphocyte ratio and mean platelet volume as predictive factors for liver fibrosis and steatosis in patients with chronic hepatitis B
Autorzy:
Pokora-Rodak, A.
Kiciak, S.
Tomasiewicz, K.
Tematy:
neutrophil-lymphocyte ratio
hepatitis B
liver fibrosis
liver steatosis
Pokaż więcej
Data publikacji:
2018
Powiązania:
https://bibliotekanauki.pl/articles/2081973.pdf  Link otwiera się w nowym oknie
Źródło:
Annals of Agricultural and Environmental Medicine; 2018, 25, 4; 690-692
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Opis:
Objective. Evaluation of the neutrophil-lymphocyte ratio and mean platelet volume as predictive factors for liver fibrosis and steatosis in HBV patients qualified for antiviral treatment. Materials and method. The study comprised 38 CHB patients who had commenced antiviral treatment, and 20 healthy volunteers who constituted the clinical control group. All patients had their blood count taken and underwent hepatic assessment using transient elastography with CAP (controlled attenuation parameter). Results. It was found that the mean hepatic fibrosis was 8.7 kPa (±8.8) and the mean liver steatosis – 286 db/m (±64). Mean NLR – 2.78(±1.1), whereas in the control group the mean NLR value was 1.64(±0.98). A negative linear correlation (r= -0.34; p=0.035) was found between liver fibrosis and the NLR value in the study group. No correlation was observed between hepatic steatosis and the NLR. Mean MPV – 12.6fl (±3.1), which was considerably higher in the CBH patients than in the control group. A positive correlation (r= 0.79, p= 0.001) was found between MPV and disease severity evaluated with transient elastography. Conclusions. The NLR and the MPV were significantly higher in the CHB patients than in the healthy volunteers. Both the NLR and the MPV can be treated as predictive factors for liver fibrosis in this group of patients.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A prospective, interventional clinical study to evaluate the safety and efficacy of Liv.52 DS in the management of non-alcoholic fatty liver disease
Autorzy:
Siregar, Gontar
Paramesh, Rangesh
Kumawat, Rajesh
D, Palaniyamma
HA, Srikrishna
Tematy:
ALT/AST
fatty liver
fibrosis
non-alcoholic fatty liver disease
Pokaż więcej
Data publikacji:
2021-06-30
Powiązania:
https://bibliotekanauki.pl/articles/2038171.pdf  Link otwiera się w nowym oknie
Źródło:
European Journal of Clinical and Experimental Medicine; 2021, 2; 129-136
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Opis:
Introduction. Non-alcoholic fatty liver disease (NAFLD) is excessive fat build-up in the liver due to causes other than alcohol use. Aim. To evaluate the clinical efficacy and safety of Liv.52 DS tablets in the management of NAFLD. Material and methods. Prospective, interventional clinical study conducted on 60 patients of both sex, aged between 18-65 years, confirmed with NAFLD from clinical examination, laboratory test, ultrasound findings and those willing to give informed consent. All patients received Liv.52 DS at a dose of 2 tablets twice daily for 2 months. All patients were evaluated at baseline, end of 1st month, and end of 2nd month for liver function tests, hepatomegaly by ultrasound, NAFLD Fibrosis Score, lipid profile, hematology and biochemical investigations. Results. Study data was analyzed with GraphPad Prism Software Version 6.07. Data of those patients who completed the study was considered for analysis. Significant improvement in hepatomegaly, liver enzymes was observed. NAFLD fibrosis score revealed no progression of liver fibrosis due to NAFLD during the study period. No abnormal lab values were recorded and there were no adverse events reported during the study. Conclusion. Study concludes that Liv.52 DS is safe and beneficial in individuals suffering from NAFLD.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Influence of the zearalenone on the activity of chosen liver enzymes in a rat
Autorzy:
Stadnik, A
Borzecki, A.
Tematy:
rat
liver
enzyme
enzyme activity
zearalenone
mycotoxin
Fusarium
liver cell
Pokaż więcej
Data publikacji:
2009
Powiązania:
https://bibliotekanauki.pl/articles/51110.pdf  Link otwiera się w nowym oknie
Źródło:
Annals of Agricultural and Environmental Medicine; 2009, 16, 1; 31-35
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Influence of oleic acid in different solvent media on BRL 3A cell growth and viability
Autorzy:
Liu, Runqi
Yang, Wei
Xia, Cheng
Chen, Yuanyuan
Gao, Sansi
Dong, Zhihao
Huang, Baoyin
Li, Ruirui
He, Ping
Xu, Chuang
Tematy:
oleic acid
non-alcoholic fatty liver disease
liver lipid deposition
Pokaż więcej
Data publikacji:
2018
Powiązania:
https://bibliotekanauki.pl/articles/1038377.pdf  Link otwiera się w nowym oknie
Źródło:
Acta Biochimica Polonica; 2018, 65, 3; 443-447
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Opis:
Oleic acid (OA) is widely used in pathology studies of hepatocellular lipid deposition. Identifying the effects of different solvents on OA-induced liver lipid deposition would be beneficial for studies on hepatocytes. We treated BRL 3A cells with OA dissolved in different solvents. After 12 h incubation, cell viability was assessed using MTT assays. Reactive oxygen species (ROS), triglyceride (TG) and total cholesterol (TC) counts, and the expression level of glucose regulated protein (GRP78), sterol regulatory element binding protein (SREBP-1C) and fatty acid synthase (FAS) were analyzed. Water, PBS and DMSO were disadvantageous to the dissolution of OA and did not cause an OA-induced response in hepatocytes. In the alcohol+OA-treated cells, the severe ER stress, oxidative stress and cellular fat deposition were significantly increased. BSA promoted cell growth and the cells treated with 1.2% BSA+OA showed a lower grade TG and endoplasmic reticulum stress compared with KOH+OA and alcohol+OA treatments. KOH had no significant influence on BRL 3A cells viability. When treated with OA dissolved in KOH, BRL 3A cells showed a typical hepatocyte damage. KOH was considered the suitable choice for an OA solvent for BRL 3A cells in hepatic lipidosis research.
Dostawca treści:
Biblioteka Nauki
Artykuł

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies