Temat: thyroid - Prolib Integro

Skocz do pozycji: 1.

Tytuł:: The influence of sucralose on thyroid gland function
Wpływ sukralozy na stan funkcjonalny gruczołu tarczycy
Autorzy:: Oliynyk, O.
Tematy:: thyroid hormones
thyroid gland
sucralose; Pokaż więcej
Data publikacji:: 2021
Powiązania:: https://bibliotekanauki.pl/articles/2048845.pdf Link otwiera się w nowym oknie
Źródło:: Health Problems of Civilization; 2021, 15, 1; 12-16
2353-6942
2354-0265
Pojawia się w:: Health Problems of Civilization
Opis:: Background. Recently, an increasing number of scientific studies have reported on the adverse effects of sweeteners on the body. The aim of this work was to study the effect of sucralose on the production of thyroid hormones. Material and methods. The study involved 30 women (average age 24.5±5.2 years) who considered themselves to be healthy. Blood levels of free and total triiodothyronine, free and total thyroxine, as well as thyroid-stimulating hormone were determined. The women were then prescribed sucralose for a month, taken daily at a dose of 15 mg/kg. At the end of this period, levels of thyroid hormones were measured again. Results. After the sucralose regimen, free and total triiodothyronine and total thyroxine were found to be 2.0, 1.58 and 1.46 times lower, respectively, than before sucralose intake (P
Wprowadzenie. W ostatnim czasie coraz więcej badań naukowych porusza kwestię szkodliwego wpływu słodzików na organizm. Celem niniejszej pracy było przebadanie związku sukralozy z produkcją hormonów tarczycowych. Materiał i metody. Badanie objęło 30 kobiet (średnia wieku 24,5±5,2 roku), które określiły siebie jako zdrowe. Ustalono poziomy wolnej i całkowitej trijodotyroniny, wolnej i całkowitej tyroksyny oraz hormonu stymulującego hormon tarczycy we krwi. Następnie zalecono pacjentkom przyjmowanie sukralozy codziennie przez miesiąc (w dawce 15 mg/kg). Po tym okresie ponownie zbadano wartości hormonów tarczycy. Wyniki. Po reżimie dawkowania sukralozy, zaobserwowano znaczący spadek wolnej i całkowitej trijodotoroniny oraz całkowitej tyroksyny o odpowiednio 2,0, 1,58 i 1,46 (P
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Impact of tobacco smoking on thyroid ultrasound image assessed among random population of spa patients in Kołobrzeg, Poland
Autorzy:: Łożyńska-Podsadna, Ewelina
Andrzejewska, Magdalena
Czarnywojtek, Agata
Tematy:: cigarette smoking
goiter
thyroid
thyroid nodules
thyroid volume
tobacco; Pokaż więcej
Data publikacji:: 2018
Powiązania:: https://bibliotekanauki.pl/articles/1164235.pdf Link otwiera się w nowym oknie
Źródło:: World Scientific News; 2018, 108; 229-236
2392-2192
Pojawia się w:: World Scientific News
Opis:: Tobacco smoking increases the risk of many diseases, but its association with thyroid disorders remains unclear. Most studies show higher incidence of thyroid nodularity in the populations of smokers. Due to its pro-inflammatory effect, tobacco is said to play an important role also in the development of thyroid inflammation. However, our study showed opposite results. We performed a research on a population of 75 spa guests in Poland. The study was based on surveys and ultrasound thyroid examination. Among examined patients, thyroid nodularity was more common in non-smokers than in smokers. Focal changes were detected in 25,00% of smokers and in 48,00% of non-smokers. Examined smokers presented also less abnormalities in the thyroid echogenicity. Heterogenous thyroid echogenicity was detected in 40,00% of smokers and in 52% of non-smokers. 49,21% of the examined population had enlarged thyroid gland. Among the group with enlarged thyroid gland only 24,30% were smokers and 75,70% were non-smokers. Such results can be explained by a small study group of patients. Another aspect is the type of the group- it turned out, that most of the patients who were interested in participation in the study, presented thyroid diseases in the past.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: Cervical thyroid remnant consistent with papillary carcinoma as an incidental finding in a patient with benign total thyroidectomy ten years prior
Autorzy:: Ruano Campos, Adriana
Rivera Alonso, Daniel
Ochagavía Cámara, Santiago
Tematy:: benign thyroidectomy
cervical thyroid remnant
papillary thyroid carcinoma; Pokaż więcej
Data publikacji:: 2020
Powiązania:: https://bibliotekanauki.pl/articles/1391852.pdf Link otwiera się w nowym oknie
Źródło:: Polish Journal of Surgery; 2020, 92, 1; 52-54
0032-373X
2299-2847
Pojawia się w:: Polish Journal of Surgery
Opis:: Background: Differential diagnosis of a cervical lesion corresponding with papillary thyroid carcinoma (PTC) after benign total thyroidectomy can be a real challenge. Methods: A cervical thyroid remnant compatible with papillary carcinoma was incidentally found ten years after total thyroidectomy for a non-functional multinodular goitre. Histological analysis of fine needle puncture aspiration (FNPA) was highly suggestive for PTC. Surgical excision of the cervical lesion was performed. Specimen study demonstrated a classic variant of PTC contacting a peripheral margin, applying ablative treatment with radioactive iodine postoperatively. Results: The patient did not present signs of recurrence during follow-up. Small thyroid remnants after benign thyroidectomy are often left behind, although their risk of malignancy is exceptional. Conclusions: It is important to individualize therapeutic approach when facing this rare entity. We decided to treat the patient by removing the lesion followed by ablation therapy with successful results. PTC: Papillary thyroid carcinoma FNPA: Fine needle puncture aspiration
Dostawca treści:: Biblioteka Nauki

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Tytuł:: Clinical and Metabolic Changes Following Complicated Thyroid Resection Procedures
Autorzy:: Sławeta, Norbert
Głuszek, Stanisław
Heciak, Jacek
Tematy:: thyroid surgery
thyroid surgery complications
hypoparathyroidism
vocal cord paralysis; Pokaż więcej
Data publikacji:: 2013-05-01
Powiązania:: https://bibliotekanauki.pl/articles/1396347.pdf Link otwiera się w nowym oknie
Źródło:: Polish Journal of Surgery; 2013, 85, 5; 235-246
0032-373X
2299-2847
Pojawia się w:: Polish Journal of Surgery
Opis:: Clinical and metabolic consequences of complicated thyroid resection procedures are rarely an object of complex analysis, and teams participating in treatment may have a very limited knowledge of them. The aim of the study was to assess clinical and metabolic consequences of complicated thyroid surgical procedures. Material and methods. In the years 2002-2007, 756 patients underwent surgery due to non-neoplastic thyroid diseases. Sixty-nine (9.1%) patients experienced complications manifesting as vocal cord paralysis and/or hypoparathyroidism. Follow-up examination was conducted in a group of 42 persons, which amounted to 61% of patients who experienced complications following thyroid surgical procedures. Follow-up examination, comprising assessment of morphotic blood elements, electrolyte, lipid and parathormone blood concentrations, thyroid hormone activity, respiratory function, vocal cord mobility, bone mineralization and ultrasound examination of the pocket left after thyroid resection, was conducted after the mean period of 43 months following surgery. Results. In the analyzed group, no significant differences in plasma electrolyte content were found (sodium, potassium, magnesium, calcium and phosphorus ions). In the group of patients with chronic hypoparathyroidism, no hypophosphatemia was observed, and there were no reports of concomitant nephrolithiasis or cataract. Increased cholesterol concentration was observed in the group of patients with chronic hypoparathyroidism and without hypoparathyroidism (p = 0.07). In 35% of patients with chronic vocal cord paralysis, abnormal results of spirometry tests were obtained. In the group of patients with chronic hypoparathyroidism, densitometry examination revealed higher T-score values compared with patients with transient hypoparathyroidism and vocal cord paralysis (p = 0.07). No bone mineralization disorders manifesting as pathological fractures were noted. Conclusions. The knowledge of clinical and metabolic consequences of complicated thyroid surgical procedures, due to their complexity, may be very limited among the members of both surgical teams and teams involved in management of complications. Development of a complication following thyroid surgery may be associated with significant homeostasis disorders, especially as regards calcium-phosphate metabolism, the skeletal system and the respiratory system. Such disorders can manifest long after the disease onset, only properly intensified and long-term management allows limitation of their extent.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 5.

Tytuł:: A sight into the pathogenesis and treatment of thyroid-associated ophthalmopathy
Autorzy:: Krzemienowska-Cebulla, Aleksandra
Puziewicz-Krzemienowska, Małgorzata
Dorochowicz, Mateusz
Matus, Iwona
Tematy:: Graves’ disease
TAO
thyroid-associated ophthalmopathy
thyroid eye disease; Pokaż więcej
Data publikacji:: 2024-06-30
Powiązania:: https://bibliotekanauki.pl/articles/40614535.pdf Link otwiera się w nowym oknie
Źródło:: European Journal of Clinical and Experimental Medicine; 2024, 22, 2; 432-438
2544-2406
2544-1361
Pojawia się w:: European Journal of Clinical and Experimental Medicine
Opis:: Introduction and aim. Thyroid-associated ophthalmopathy (TAO), often referred to as thyroid eye disease or Graves’ ophthalmopathy, is a syndrome characterized by autoimmune inflammation affecting the eye muscles, connective tissue, and orbital fat. The aim of this literature review is to present TAO and integrate the available data in the literature regarding the pathogenesis and treatment methods. Based on these, the authors aim to examine whether, despite the extensive knowledge already available on TAO, there are still issues to be investigated. Material and methods. In this literature review, books and scientific publications in both Polish and English languages have been assessed. The search criteria included keywords such as TAO, Graves’ disease, thyroid-associated ophthalmopathy. The evaluation covered the following databases: PubMed, Scopus, Google Scholar. Analysis of the literature. Typically, the eyeball is not involved, but in exceptional cases, corneal ulceration may occur, or inflammation of the optic nerve may ensue. TAO most commonly occurs in the course of hyperthyroidism in Graves’ disease, involving up to 25–50% of cases. The coexistence of autoantigens shared between the thyroid and orbital tissues is considered the primary cause of TAO when it occurs concurrently with hyperthyroidism, later in its course, or even preceding the manifestation of hyperthyroidism, with or without concurrent thyroid dysfunction. TAO is generally bilateral, although dominance on one side is often observed. Common symptoms include eye pain, photophobia, diplopia, varying degrees of proptosis, and impaired vision. The cornerstone of treatment lies in managing hyperthyroidism, as TAO cannot be cured without it. Conclusion. First-line treatment involves glucocorticoids, with radiation therapy as a supplementary option, and in cases unresponsive to pharmacological treatment, surgical intervention may be necessary.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 6.

Tytuł:: Skin changes in the neck and selenium content in patients with thyroid diseases
Autorzy:: Dziemianowicz, M
Markiewicz-Żukowska, R
Socha, K
Soroczyńska, J
Borawska, MH
Tematy:: Thyroid shadow
selenium
smoking; Pokaż więcej
Data publikacji:: 2014
Powiązania:: https://bibliotekanauki.pl/articles/1916517.pdf Link otwiera się w nowym oknie
Źródło:: Progress in Health Sciences; 2014, 4, 2; 31-36
2083-1617
Pojawia się w:: Progress in Health Sciences
Opis:: Purpose: Occurrence of skin changes, in the form of discolouration on neck and in form of a so-called ”thyroid shadow”, was observed in patients with: Hashimoto’s disease, Graves´ disease, struma nodosa euthyrotica or hyperthyreosis. Effects of selenium status and smoking on the risk of those skin changes were investigated. Materials and methods: The study group consisted of 267 patients with different kinds of thyroid disease. The control group included 34 healthy people. Selenium concentrations in serum were determined by electrothermal absorption spectrometry method. Results: Thyroid shadow was observed in 70 percent of the subject. Selenium levels in serum were lower in patients with thyroid disease (65.051±16.70 µg/L), especially in smokers (62.477±15.21 µg/L) than in the control group (75.162±19.92 µg/L). Conclusions: Thyroid shadow syndrome would be the diagnostic signal of thyroid diseases, especially Hashimoto disease. Selenium status is important in the studied thyroid diseases. Cigarette smoking decreases the concentration of selenium in the serum of patients with thyroid diseases.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 7.

Tytuł:: Correlation of fine needle aspiration cytology with histopathology in patients undergoing thyroid surgery
Autorzy:: Singh, Parampreet
Gupta, Nitin
Dass, Arjun
Handa, Uma
Singhal, Surinder
Tematy:: FNAC
histopathology
thyroid swelling; Pokaż więcej
Data publikacji:: 2021
Powiązania:: https://bibliotekanauki.pl/articles/1397291.pdf Link otwiera się w nowym oknie
Źródło:: Polish Journal of Otolaryngology; 2021, 75, 4; 33-39
0030-6657
2300-8423
Pojawia się w:: Polish Journal of Otolaryngology
Opis:: Introduction: Thyroid swellings are one of the most common swellings in the neck. They pose a major problem in developing countries like India, considering the high endemicity for iodine deficiency disorders. Thyroid gland is affected in many conditions. Out of these, majority are benign while less than 5% are malignant. Multiple noninvasive and invasive diagnostic tests are available for the diagnosis of thyroid swelling. However, at present, FNAC is considered the gold standard investigation. Despite the high sensitivity and specificity, FNAC has its limitations. Histopathological examination of surgically excised thyroid swelling is the confirmatory gold standard to determine the pathology of the thyroid gland. Material and method: This prospective and observational study was conducted in the Department of Otorhinolaryngology (ENT) in collaboration with the Department of Pathology in a tertiary care hospital and medical school. A total of seventy patients were included. Results: The diagnosis on FNAC was correlated with histopathology. Statistical analysis showed FNAC had a sensitivity of 83.3%, specificity of 100%, positive predictive value of 100%, negative predictive value of 96.7%. However, the overall accuracy in this study was determined to be 95.71%. Results were found to be statistically significant (P < 0.05). Conclusions: The diagnostic role of FNAC in thyroid lesions is of utmost importance in making preoperative diagnosis. FNAC was found to be highly sensitive and specific for diagnosing thyroid lesions but the final HPE is considered as a gold standard.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 8.

Tytuł:: Overdiagnosis of Thyroid Cancer
Autorzy:: Machała, Ewa
Tematy:: fine needle aspiration biopsy
overdiagnosis
papillary thyroid cancer
throidectomy
thyroid cancer; Pokaż więcej
Data publikacji:: 2018
Powiązania:: https://bibliotekanauki.pl/articles/1177715.pdf Link otwiera się w nowym oknie
Źródło:: World Scientific News; 2018, 101; 120-131
2392-2192
Pojawia się w:: World Scientific News
Opis:: Overdiagnosis of thyroid cancers contributes to increased incidence of thyroid cancers worldwide, which is already a serious public health problem. A great number of medical tests, helping to detect thyroid cancer, may result in an epidemic of diagnosis. A dramatic increase in the number of detected cases of thyroid cancer may be associated with a great number of neck ultrasounds, fine- needle aspirations and incidental findings during examination. Unfortunately, in response to overdiagnosis, more and more surgeries are being performed. It is important to differentiate stationary cancers from potentially aggressive diseases. Detection of cancer contributes to saving lives. However, in some instances it can be harmful, particularly if the disease is overdiagnosed. The aim of this review is to give a balanced view of thyroid cancer epidemic and controversies arising out of overdiagnosis.
Dostawca treści:: Biblioteka Nauki

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Tytuł:: Wole guzowate olbrzymie – opis przypadku
Giant nodular goitre – case report
Autorzy:: Dec, Małgorzata
Przybylska-Kuć, Sylwia
Ryczak, Elżbieta
Bartoszek, Elżbieta
Mosiewicz, Jerzy
Tematy:: tarczyca
wole
biopsja cienkoigłowa
hormony tarczycy
thyroid gland
goitre
fine-needle biopsy
thyroid hormones; Pokaż więcej
Data publikacji:: 2014
Powiązania:: https://bibliotekanauki.pl/articles/437637.pdf Link otwiera się w nowym oknie
Źródło:: Medical Review; 2014, 4; 388-395
2450-6761
Pojawia się w:: Medical Review
Opis:: Wole guzowate nietoksyczne to choroba tarczycy, w której dominują ogniskowe zaburzenia jej budowy, wynikające najczęściej z rozrostu oraz ze zmian zwyrodnieniowych lub zwłóknienia, bez zaburzeń czynności tarczycy. O wolu mówimy wówczas, gdy jego objętość w obrazie ultrasonograficznym wynosi > 20ml u kobiet i > 25ml u mężczyzn. Schorzenie to postępuje powoli i latami może nie powodować zaburzeń czynności tego narządu. Oznaczenie stężenia hormonu tyreotropowego (TSH) jest pierwszorzutowym i podstawowym badaniem w ocenie czynności tego gruczołu. Natomiast objawy dużego wola mogą być związane z przesunięciem i uciskiem tarczycy na tchawicę, przełyk czy naczynia szyjne. Podstawowym badaniem weryfikującym zmiany w obrębie gruczołu jest ultrasonografia jako nieinwazyjna i powszechnie dostępna metoda obrazowa w połączeniu z biopsją aspiracyjną cienkoigłową. Pacjenci z wolem guzowatym nadczynnym lub objawami uciskowymi powinni być leczeni radykalnie – operacyjnie lub przy pomocy radiojodu. W artykule przedstawiony jest opis przypadku pacjentki, która została przyjęta do szpitala z powodu wola olbrzymiego z objawami uciskowymi. Choroba postępowała u chorej przez wiele lat, ale dopiero ograniczona ruchomość szyi i duszność nasilająca się w pozycji leżącej na wznak spowodowały, iż pacjentka zgłosiła się do lekarza. W badaniu fizykalnym uwagę zwracała asymetryczna szyja, ze znacznie powiększonym obwodem, o guzowatej powierzchni i z widocznymi poszerzonymi naczyniami żylnymi. U opisywanej pacjentki z uwagi na występujące objawy uciskowe, bardzo dużą masę gruczołu oraz eutyreozę zdecydowano o radykalnym leczeniu operacyjnym, które przyniosło znaczną poprawę jakości życia pacjentki.
Nodular goitre of the thyroid is associated with focal structure abnormalities such as hyperplasia, degeneration or fibrosis with no functional disorders of the gland. The goitre is recognised when the volume of the thyroid measured in ultrasonography is more than 20 ml in women and more than 25 ml in men. This disease develops slowly and may not cause any functional disorders for years. Thyrotropic hormone concentration (TSH) in blood serum is a basic test in the functional assessment of the gland. However, symptoms of giant nodular goitre can be connected with modelling trachea, oesophagus and blood vessels of the neck. The basic investigation verifying changes in the gland is ultrasonography, which is non-invasive and available diagnostic procedure, in connection with fine-needle biopsy. Patients with toxic goitre or pressure symptoms should be treated with radical surgery or radioactive iodine. In the article there was presented a case report of a female patient who was admitted to the hospital due to giant nodular goitre with pressure symptoms. The disease had been developing for many years until restricted mobility of the neck and dyspnea made her seek for medical advice. Assymetry of the neck with significantly increased circumference and nodular surface with enlarged veins were observed in the physical examination. In the described patient there was radical surgery performed due to pressure symptoms, large mass of the gland and euthyreosis. The treatment significantly improved patient’s quality of life.
Dostawca treści:: Biblioteka Nauki

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Tytuł:: Correlation of Fine Needle Aspiration Cytology of Thyroid Gland with Histopathological Results
Autorzy:: Machała, Ewa
Sopiński, Jan
Iavorska, Iulia
Kołomecki, Krzysztof
Tematy:: fine needle aspiration biopsy
fine needle aspiration cytology
thyroid cancer
papillary thyroid cancer
throidectomy; Pokaż więcej
Data publikacji:: 2018
Powiązania:: https://bibliotekanauki.pl/articles/1392909.pdf Link otwiera się w nowym oknie
Źródło:: Polish Journal of Surgery; 2018, 90, 6; 13-19
0032-373X
2299-2847
Pojawia się w:: Polish Journal of Surgery
Opis:: Fine needle aspiration cytology (FNAC) is considered as the gold-standard diagnostic test in the diagnostics of thyroid nodules. It is a cost-effective procedure that provides specific diagnosis rapidly with minimal complications. It plays an important role in the determination of treatment - patients with suspected malignancy diagnosis can be subjected to surgery. On the other hand, it can decrease the rate of unnecessary surgeries. Aim: The aim of this study was to evaluate and compare the correlation, accuracy of fine needle aspiration cytology (FNAC) in the diagnostics of thyroid lesions with the final histopathologic diagnosis based on the surgical specimens. Materials and Methods: In our study we performed a retrospective analysis of a case series of patients who had been admitted to the Department of Endocrine, General and Oncological Surgery of the Hospital of M. Kopernik in Łodź (Poland) between May 2016 and December 2017 and underwent FNAC with subsequent surgery. Cytological diagnosis was classified into six Bethesda categories. Results: On cytological examination, 1070/1262 cases were reported as benign, 49 as malignant and 143 as suspicious. On histopathological examination, 956/1070 cases were confirmed as benign but there were 114 discordant cases. Among the other cases histopathology diagnosis confirmed malignancy in 45/49 cases and 128/143 suspicious cases. The sensitivity and specificity were 60,28% and 98,05% respectively. False positive rate was 1.95% and false negative rate was 39.72%. The positive predictive value was 90.1% and negative predictive value was 89.35%. Accuracy of FNA in differentiating benign from malignant thyroid lesions was 89.46%.
Dostawca treści:: Biblioteka Nauki

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