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Wyświetlanie 1-10 z 11
Tytuł:
A standard convention for particle-level Monte Carlo event-variation weights
Autorzy:
Plätzer, Simon
Siódmok, Andrzej
Schönherr, Marek
Gignac, Matthew
Kretzschmar, Jan
Singh Chahal, Gurpreet
Schumann, Steffen
Bothmann, Enrico
Kar, Deepak
Höche, Stefan
McFayden, Josh
Lönnblad, Leif
Siegert, Frank
Andersen, Jeppe R.
Gütschow, Christian
Gellersen, Leif
Buckley, Andy
Prestel, Stefan
Krauss, Frank
Skands, Peter
Butterworth, Jonathan Mark
Seymour, Michael H.
Corpe, Louie
Papaefstathiou, Andreas
Bhattacharya, Saptaparna
Opis:
Streams of event weights in particle-level Monte Carlo event generators are a convenient and immensely CPU-efficient approach to express systematic uncertainties in phenomenology calculations, providing systematic variations on the nominal prediction within a single event sample. But the lack of a common standard for labelling these variation streams across different tools has proven to be a major limitation for event-processing tools and analysers alike. Here we propose a well-defined, extensible community standard for the naming, ordering, and interpretation of weight streams that will serve as the basis for semantically correct parsing and combination of such variations in both theoretical and experimental studies.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
A retrospective cohort study comparing differences in 30-day mortality among critically ill patients aged ? 70 years treated in European tax-based healthcare systems (THS) versus social health insurance systems
Autorzy:
Moreno, Rui
Wernly, Bernhard
Sigal, Sviri
Oeyen, Sandra
Artigas, Antonio
Jung, Christian
Perings, Stefan
Pinto, Bernardo Bollen
Wernly, Sarah
Leaver, Susannah
Rezar, Richard
Marsh, Brian
Wolff, Georg
Fjolner, Jesper
Andersen, Finn H.
Joannidis, Michael
Elhadi, Muhammed
Bruno, Raphael Romano
Guidet, Bertrand
Szczeklik, Wojciech
Boumendil, Ariane
Schefold, Joerg C.
Flaatten, Hans
Beil, Michael
van Heerden, Peter Vernon
de Lange, Dylan W.
Kelm, Malte
Opis:
In Europe, tax-based healthcare systems (THS) and social health insurance systems (SHI) coexist. We examined differences in 30-day mortality among critically ill patients aged ≥ 70 years treated in intensive care units in a THS or SHI. Retrospective cohort study. 2406 (THS n = 886; SHI n = 1520) critically ill ≥ 70 years patients in 129 ICUs. Generalized estimation equations with robust standard errors were chosen to create population average adjusted odds ratios (aOR). Data were adjusted for patient-specific variables, organ support and health economic data. The primary outcome was 30-day-mortality. Numerical differences between SHI and THS in SOFA scores (6 ± 3 vs. 5 ± 3; p = 0.002) were observed, but clinical frailty scores were similar (> 4; 17% vs. 14%; p = 0.09). Higher rates of renal replacement therapy (18% vs. 11%; p < 0.001) were found in SHI (aOR 0.61 95%CI 0.40–0.92; p = 0.02). No differences regarding intubation rates (68% vs. 70%; p = 0.33), vasopressor use (67% vs. 67%; p = 0.90) and 30-day-mortality rates (47% vs. 50%; p = 0.16) were found. Mortality remained similar between both systems after multivariable adjustment and sensitivity analyses. The retrospective character of this study. Baseline risk and mortality rates were similar between SHI and THS. The type of health care system does not appear to have played a role in the intensive care treatment of critically ill patients ≥ 70 years with COVID-19 in Europe.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
Relationship between the Clinical Frailty Scale and short-term mortality in patients > or = 80 years old acutely admitted to the ICU : a prospective cohort study
Autorzy:
Watson, Ximena
De Lange, Dylan W.
Valentin, Andreas
Moreno, Rui
Flaatten, Hans
Agvald-Ohman, Christina
Guidet, Bertrand
Polok, Kamil
Górka, Jacek
Artigas, Antonio
Szczeklik, Wojciech
Andersen, Finn H.
Leaver, Susannah
Zafeiridis, Tilemachos
Fjolner, Jesper
Cecconi, Maurizio
Joannidis, Michael
Pinto, Bernardo Bollen
Walther, Sten
Marsh, Brian
Oeyen, Sandra
Schefold, Joerg C.
Christensen, Steffen
Beil, Michael
Sviri, Sigal
van Heerden, Peter Vernon
Jung, Christian
Morandi, Alessandro
Rhodes, Andrew
Fronczek, Jakub
Opis:
Background: The Clinical Frailty Scale (CFS) is frequently used to measure frailty in critically ill adults. There is wide variation in the approach to analysing the relationship between the CFS score and mortality after admission to the ICU. This study aimed to evaluate the influence of modelling approach on the association between the CFS score and short-term mortality and quantify the prognostic value of frailty in this context. Methods: We analysed data from two multicentre prospective cohort studies which enrolled intensive care unit patients ≥ 80 years old in 26 countries. The primary outcome was mortality within 30-days from admission to the ICU. Logistic regression models for both ICU and 30-day mortality included the CFS score as either a categorical, continuous or dichotomous variable and were adjusted for patient’s age, sex, reason for admission to the ICU, and admission Sequential Organ Failure Assessment score. Result: The median age in the sample of 7487 consecutive patients was 84 years (IQR 81–87). The highest fraction of new prognostic information from frailty in the context of 30-day mortality was observed when the CFS score was treated as either a categorical variable using all original levels of frailty or a nonlinear continuous variable and was equal to 9% using these modelling approaches (p < 0.001). The relationship between the CFS score and mortality was nonlinear (p < 0.01). Conclusion: Knowledge about a patient’s frailty status adds a substantial amount of new prognostic information at the moment of admission to the ICU. Arbitrary simplification of the CFS score into fewer groups than originally intended leads to a loss of information and should be avoided.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
Survey of third-party parenting options associated with fertility preservation available to patients with cancer around the globe
Autorzy:
Rodrigues, Jhenifer K.
Ataman, Lauren M.
Anazodo, Antoinette
Chehin, Mauricio Barbour
Silva, Adelino Amaral
Jach, Robert
Bourlon, Maria T.
Woodruff, Teresa K.
Zand, Elnaz
Fontoura, Paula
Suk Suh, Chang
Rashedi, Alexandra S.
Terrado, Guillermo
Marinho, Ricardo M.
Azambuja, Ricardo
Almeida-Santos, Teresa
Edmonds, Maxwell E.
Andersen, Claus Yding
Jayasinghe, Yasmin
Horbaczewska, Anna
Greenblatt, Ellen M.
Mitchell, Rod
Almeida Campos-Junior, Paulo Henrique
Nelen, Willianne
Diaz-Garcia, Cesar
Arvas, Ayse
Beerendonk, Catharina C.M.
Mallmann, Peter
Anderson, Richard A.
Grieco, Silvana Chedid
Motta, Eduardo
Reis, Fernando M.
Furui, Tatsuro
Smith, Kristin
Shaulov, Talya
Medrano, Jose
Lee, Jung Ryeol
de Carvalho, Bruno Ramalho
Azmy, Osama
De Vos, Michel
Takae, Seido
Romero, Sergio
Khrouf, Mohamed
Suzuki, Nao
Vega, Mario
Adiga, Satish Kumar
Sanchez, Flor
Salama, Mahmoud
de Meneses e Silva, Joao Marcos
Van Moer, Ellen
Melo, Claudia
Winkler-Crepaz, Katharina
de Roo, Saskia F.
Scarella, Anibal
Sartorio, Cassio
del Mar Andres, Maria
Fathi, Rouhollah
Wildt, Ludwig
de A. Antunes, Roberto
Smitz, Johan
Sugishita, Yodo
Ferreira Melo e Silva, Ligia Helena
Kim, Seok Hyun
Opis:
bstract PURPOSE In the accompanying article, “Survey of Fertility Preservation Options Available to Patients With Cancer Around the Globe,” we showed that specific fertility preservation services may not be offered at various sites around the world because of cultural and legal barriers. We assessed global and regional experiences as well as the legal status of third-party reproduction and adoption to serve as a comprehensive international data set and resource for groups that wish to begin oncofertility interventions. METHODS We provide data on the legalities of third-party assisted reproductive technologies and other familybuilding options in the 28 oncofertility-practicing countries surveyed. RESULTS We found regional and country differences that will be important in the development of tailored resources for physicians and for patient brochures that are sensitive to these local restrictions and cultural norms. CONCLUSION Because many patients first consult Web-based materials, the formal assessment of the availability of these options provides members of the global oncofertility community with data to which they might otherwise not have ready access to better serve their patients.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Wyświetlanie 1-10 z 11

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