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    Wyświetlanie 1-7 z 7
    Tytuł:
    O POJEDNANIU TRADYCJI I DEMOKRACJI W MYŚLI GILBERTA KEITHA CHESTERTONA
    ON THE RECONCILIATION OF TRADITION AND DEMOCRACY IN THE THOUGHT OF GILBERT KEITH CHESTERTON
    Autorzy:
    Czajka, Łukasz
    Tematy:
    Gilbert K. Chesterton
    John D. Caputo
    Hans G. Gadamer
    democracy of the dead
    Christian orthodoxy
    Pokaż więcej
    Wydawca:
    Akademia Marynarki Wojennej. Wydział Nauk Humanistycznych i Społecznych
    Powiązania:
    https://bibliotekanauki.pl/articles/418684.pdf  Link otwiera się w nowym oknie
    Opis:
    The main aim of this article is to present Chestertonian idea of the tradition as the democracy of the dead. This idea is also critically compare with the political ideas of Hans-Georg Gadamer and John D. Caputo. The article consists of four main parts. The first part contains a reconstruction of Chesterton’s reflection on democracy of the dead, which inclusiveness do not let to forget the voices of our ancestors. In the second part the thought of Chesterton is polemically juxtaposed with philosophical ideas of Hans-Georg Gadamer, who pointed out the need for constant updating of the tradition to the contemporary requirements. Third part contains a critique of the Chestertonian ideas carried out in the spirit of John D. Caputo’s radical hermeneutics. One of the main goal of this hermeneutics is breaking the unity of tradition. In the fourth part they are presented concrete examples of the struggle of Polish (the construction of the Temple of Divine Providence) and Swiss (debate on changing the national anthem) democracy with the traditions of their ancestors.
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Crystallographic characterisation and development of bi-substrate inhibitors of coronavirus nsp14 methyltransferase
    Autorzy:
    Ahmad, Shamshad A.
    Scott, Duncan E.
    Saikatendu, Kumar Singh
    See, Kexin
    Urakova, Nadya
    Wanningen, Patrick
    Kresik, Leanid
    Snijder, Eric J.
    O'Neill, Sandra
    Czarna, Anna
    Gilbert, Ian H.
    Grygier, Przemysław
    Delpal, Adrien
    Post, John M.
    Eadsforth, Thomas
    Norval, Suzanne
    O'Byrne, Sean N.
    Pyrć, Krzysztof
    Wierzbicka, Kinga
    Smith, Craig D.
    Decroly, Etienne
    Matsuda, Alex
    Georgiou, Irene
    Groenewold, Mirjam
    Chang, Edcon
    Plewka, Jacek
    Robinson, Colin
    Opis:
    SARS-CoV-2 non-structural protein 14 (nsp14) is essential for viral mRNA cap guanine-N7 methylation and represents a promising but underexplored antiviral target. Herein we describe a structure-guided campaign based on a hit from a focussed SAM mimetic library. Systematic SAR exploration guided by six X-ray co-crystal structures in complex with SARS-CoV-2 led to compound 26, a bi-substrate inhibitor that bridges the SAM and RNA cap binding sites. Compound 26 achieved nanomolar potency against nsp14 from SARS-CoV-2 ($IC_{50}$ = 53 nM), SARS-CoV-1, and two alphacoronaviruses, with excellent selectivity over human RNMT and flaviviral MTase. In general, the compounds demonstrated favourable metabolic stability, passive permeability, and no HepG2 cytotoxicity. However, cellular antiviral activity was limited, revealing disconnects between enzyme inhibition and phenotypic response. These findings provide a structural framework for optimizing bi-substrate methyltransferase inhibitors against coronaviruses with a view for pan-coronaviral activity.
    Dostawca treści:
    Repozytorium Uniwersytetu Jagiellońskiego
    Artykuł
    Tytuł:
    Minimal information for studies of extracellular vesicles 2018 (MISEV2018) : a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines
    Autorzy:
    Criado, Miria Ferreira
    Russell, Ashley E.
    Giusti, Ilaria
    Camussi, Giovanni
    Isin, Mustafa
    Blenkiron, Cherie
    Meehan, Katie L.
    Scott, Aaron
    Neri, Christian
    Verweij, Frederik J.
    Kim, Kwang Pyo
    Libregts, Sten F.
    Chen, Shuai
    Zocco, Davide
    Archer, Fabienne
    Osteikoetxea, Xabier
    Hoffmann, Karl F.
    Erdbrügger, Uta
    Mertens, Inge
    Driedonks, Tom A. P.
    McVey, Mark J.
    Laitinen, Saara
    Johnson, Suzanne M.
    Schøyen, Tine Hiorth
    Gualerzi, Alice
    Bongiovanni, Antonella
    Lunavat, Taral R.
    Gorski, Sharon M.
    Visnovitz, Tamás
    Soekmadji, Carolina
    van Balkom, Bas W. M.
    Rughetti, Aurelia
    Rouschop, Kasper M. A.
    Giebel, Bernd
    Gustafson, Dakota
    Harrison, Paul
    van Herwijnen, Martijn J. C.
    Watson, Dionysios C.
    Duarte, Filipe V.
    Kawamura, Yumi
    Swift, Simon
    Lemos, Debora S.
    O'Driscoll, Lorraine
    Torrecilhas, Ana Claudia
    Mariscal, Javier
    Vader, Pieter
    Borràs, Francesc E.
    Liao, Ke
    Cheng, Lesley
    Zivkovic, Angela M.
    Minciacchi, Valentina R.
    Myburgh, Kathryn H.
    Klingeborn, Mikael
    Yan, Xiaomei
    Martinez, M. Carmen
    Nolan, John P.
    Vechetti Jr., Ivan J.
    Elie-Caille, Celine
    Wheelock, Asa M.
    Clerici, Stefano P.
    Wehman, Ann M.
    Dhondt, Bert
    Lu, Quan
    Boireau, Wilfrid
    Shekari, Faezeh
    Soares, Rodrigo Pedro
    Rayyan, Morci S.
    Lavieu, Gregory
    Laurent, Louise C.
    Lannigan, Joanne
    Raffai, Robert L.
    Gupta, Gopal N.
    Aikawa, Elena
    Rak, Janusz
    Clayton, Aled
    Jørgensen, Malene Møller
    De Santana Junior, Eliezer F.
    Busatto, Sara
    Sánchez, Catherine
    Ostrowski, Matias
    Gärtner, Kathrin
    Vella, Laura J.
    Jung, Stephanie
    Berardi, Anna C.
    Ibrahim, Ahmed Gamal-Eldin
    Mathieu, Mathilde
    Hochberg, Fred H.
    Kierulf, Peter
    Meckes Jr., David G.
    Zuba-Surma, Ewa
    Leszczynska, Aleksandra
    Najrana, Tanbir
    Dominguez Rubio, Ana Paula
    Baxter, Amy A.
    Jayachandran, Muthuvel
    Ortiz, Luis A.
    Musante, Luca
    Peinado, Hector
    Viñas, Jose L.
    Marcilla, Antonio
    De Wever, Olivier
    Deville, Sarah
    Radeghieri, Annalisa
    Langevin, Scott M.
    Tomasini, Richard
    Chaudhuri, Amrita Datta
    Dieterich, Lothar C.
    Muraca, Mauricio
    Handberg, Aase
    Lombard, Catherine A.
    Fricke, Fabia
    Llorente, Alicia
    Huber, Veronica
    Dolo, Vincenza
    Shatnyeva, Olga
    Lázaro-Ibáñez, Elisa
    Raimondo, Stefania
    Nazarenko, Irina
    Prada, Ilaria
    Jovanovic-Talisman, Tijana
    Inal, Jameel M.
    Buck, Amy H.
    Frelet-Barrand, Annie
    Gabrielsson, Susanne
    Jenster, Guido
    Hooten, Nicole Noren
    Perut, Francesca
    Carter, David R. F.
    Brisson, Alain
    Baldacchino, Shawn
    Linnemannstöns, Karen
    Quesenberry, Peter
    Zhang, Jian-ye
    Bachurski, Daniel
    Lovett, Jason
    Ricklefs, Franz L.
    Boilard, Eric
    Van Deun, Jan
    Krause, Mirja
    Alcaraz, Maria Jose
    Ramirez, Marcel I.
    Zappulli, Valentina
    Zhao, Zezhou
    Ayre, D. Craig
    Weaver, Alissa
    Shelke, Ganesh Vilas
    Anderson, Johnathon D.
    Jiang, Lanzhou Z.
    Devitt, Andrew
    Lenassi, Metka
    Brennan, Meadhbh Á.
    Martin-Jaular, Lorena
    Nejsum, Peter
    Gaudin, Raphael
    McGinnis, Lynda K.
    Nimrichter, Leonardo
    Wahlgren, Jessica
    Toh, Wei Seong
    Buschmann, Dominik
    Bebawy, Mary
    Chen, Chihchen
    Van Keuren-Jensen, Kendall
    Strasser, Erwin F.
    Fuhrmann, Gregor
    Pegtel, D. Michiel
    Tkach, Mercedes
    Lörincz, Ákos M.
    Xu, Jing
    Regev-Rudzki, Neta
    Holder, Beth
    Ikezu, Tsuneya
    Khamari, Delaram
    Ochiya, Takahiro
    Pfaffl, Michael W.
    Haraszti, Reka A.
    Buzás, Edit I.
    Xander, Patricia
    Malhi, Harmeet
    Mussack, Veronica
    Polakovicova, Iva
    Bobis-Wozowicz, Sylwia
    Sharma, Shivani
    Nieuwland, Rienk
    Žėkas, Vytautas
    Antoniou, Anna
    Sódar, Barbara W.
    Bergese, Paolo
    Lötvall, Jan
    van Royen, Martin E.
    Weber, Viktoria
    Zheutlin, Alexander R.
    Tiwari, Swasti
    Huang, Yiyao
    Loyer, Xavier
    Wauben, Marca H. M.
    Möller, Andreas
    Wolfram, Joy
    Yáñez-Mó, Maria
    Bosch, Steffi
    Di Vizio, Dolores
    Rohde, Eva
    Görgens, André
    Webber, Jason P.
    Kano, Shin-ichi
    Morales-Kastresana, Aizea
    Rome, Sophie
    Beckham, Carla
    Falcón-Pérez, Juan M.
    Kusuma, Gina D.
    Shetty, Ashok K.
    Wiener, Zoltán
    Powell, Bonita H.
    Jay, Steven M.
    Silva, Andreia M.
    Wendt, Sebastian
    Bedina Zavec, Apolonija
    Greening, David W.
    Keller, Evan T.
    Fish, Jason E.
    Hegyesi, Hargita
    Lim, Sai Kiang
    Sotillo, Javier
    Breakefield, Xandra
    Flores-Bellver, Miguel
    Gardiner, Chris
    Saul, Meike J.
    Languino, Lucia R.
    Kaur, Sukhbir
    Mariani, Jacopo
    Shahaj, Eriomina
    Brigstock, David R.
    Das, Saumya
    Veit, Tiago D.
    van der Grein, Susanne G.
    Crescitelli, Rossella
    Coffey, Robert J.
    Li, Isaac T. S.
    Duncan, Heather M.
    Atkin-Smith, Georgia K.
    Pisetsky, David S.
    Martens-Uzunova, Elena S.
    Zickler, Antje M.
    Burger, Dylan
    Yin, Hang
    Tixeira, Rochelle
    Eichenberger, Ramon M.
    Raposo, Graca
    Khomyakova, Elena
    Le Lay, Soazig
    Maugeri, Marco
    Schneider, Raphael
    von Strandmann, Elke Pogge
    van Wijnen, Andre J.
    Broekman, Marike L. D.
    van Niel, Guillaume
    O'Loghlen, Ana
    Breglio, Andrew M.
    Roberts, David D.
    Tahara, Hidetoshi
    Coumans, Frank A. W.
    Chin, Andrew R.
    Bromberg, Jacqueline F.
    Dominici, Massimo
    Witwer, Kenneth W.
    Hunt, Stuart
    Robbins, Paul D.
    Holthofer, Harry
    Lowry, Michelle C.
    Jong, Ambrose
    Andaloussi, Samir E. L.
    Jackson, Hannah K.
    Hill, Andrew F.
    Fatima, Farah
    Snyder II, Orman L.
    Xagorari, Angeliki
    Toxavidis, Vasilis
    O'Grady, Tina
    Balaj, Leonora
    Arab, Tanina
    Zheng, Lei
    Nolte-'t Hoen, Esther N. M.
    Försönits, András
    Urbanelli, Lorena
    Andriantsitohaina, Ramaroson
    Gimona, Mario
    Stahl, Philip D.
    Goberdhan, Deborah C. I.
    Velot, Émilie
    Chamley, Lawrence W.
    Stott, Shannon L.
    Gho, Yong Song
    Lee, Myung-Shin
    Salas-Huenuleo, Edison
    Demaret, Tanguy
    Nawaz, Muhammad
    Welsh, Joshua A.
    Chang, Yu-Ting
    Witte, Leonie
    Siljander, Pia R.-M.
    Bryl-Górecka, Paulina
    Couch, Yvonne
    Tewari, Muneesh
    Hendrix, An
    Caruso, Sarah
    Jones, Jennifer C.
    Gilbert, Caroline
    Tosar, Juan Pablo
    Ivanova, Alena
    Muth, Dillon C.
    Zarubova, Jana
    Skowronek, Agata
    Martins, Vilma Regina
    Poon, Ivan K. H.
    Jacobsen, Soren
    Park, Jaesung
    Ekström, Karin
    Kovács, Árpád Ferenc
    Benmoussa, Abderrahim
    Bach, Jean-Marie
    Mathivanan, Suresh
    Dourado, Mauricio R.
    Bielska, Ewa
    Cordeiro-da-Silva, Anabela
    Kuypers, Sören
    Lorenowicz, Magdalena J.
    Saugstad, Julie A.
    Byrd, James Bryan
    Lässer, Cecilia
    Kalluri, Raghu
    Olivier, Martin
    Boulanger, Chantal M.
    Kislinger, Thomas
    Ligeti, Erzsebet
    Lim, Rebecca
    Maas, Sybren L. N.
    Stoorvogel, Willem
    Vasconcelos, M. Helena
    Weiss, Daniel J.
    Mullier, Francois
    Bauer, Natalie N.
    Kurochkin, Igor V.
    Sahoo, Susmita
    Krasemann, Susanne
    Théry, Clotilde
    Ortiz, Alberto
    Vukman, Krisztina V.
    Zimmermann, Pascale
    D'Souza-Schorey, Crislyn
    Gross, Julia Christina
    Buch, Shilpa
    de Candia, Paola
    Morhayim, Jess
    Khvorova, Anastasia
    Baharvand, Hossein
    Hosseinkhani, Baharak
    Lee, Yi Xin Fiona
    Phinney, Donald G.
    Pulliam, Lynn
    Coyle, Beth
    del Portillo, Hernando A.
    Linē, Aija
    Bussolati, Benedetta
    Gámez-Valero, Ana
    Kosanović, Maja M.
    Lukomska, Barbara
    Kornek, Miroslaw
    Neri, Tommaso
    Cocucci, Emanuele
    Schiffelers, Raymond M.
    Hu, Guoku
    Cocks, Alex
    Pink, Ryan C.
    Shiba, Kiyotaka
    Timms, Kate
    Østergaard, Ole
    Pieters, Bartijn C. H.
    Klinke II, David J.
    Vestad, Beate
    Rodrigues, Silvia C.
    Saá, Paula
    Krämer-Albers, Eva-Maria
    Yuana, Yuana
    Opis:
    The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many other names. However, specific issues arise when working with these entities, whose size and amount often make them difficult to obtain as relatively pure preparations, and to characterize properly. The International Society for Extracellular Vesicles (ISEV) proposed Minimal Information for Studies of Extracellular Vesicles ("MISEV") guidelines for the field in 2014. We now update these "MISEV2014" guidelines based on evolution of the collective knowledge in the last four years. An important point to consider is that ascribing a specific function to EVs in general, or to subtypes of EVs, requires reporting of specific information beyond mere description of function in a crude, potentially contaminated, and heterogeneous preparation. For example, claims that exosomes are endowed with exquisite and specific activities remain difficult to support experimentally, given our still limited knowledge of their specific molecular machineries of biogenesis and release, as compared with other biophysically similar EVs. The MISEV2018 guidelines include tables and outlines of suggested protocols and steps to follow to document specific EV-associated functional activities. Finally, a checklist is provided with summaries of key points.
    Dostawca treści:
    Repozytorium Uniwersytetu Jagiellońskiego
    Artykuł
      Wyświetlanie 1-7 z 7

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