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    Wyświetlanie 1-8 z 8
    Tytuł:
    Kinetics of a nucleoside release from lactide-caprolactone and lactide-glycolide polymers in vitro.
    Autorzy:
    Kryczka, Tomasz
    Grieb, Paweł
    Bero, Maciej
    Kasperczyk, Janusz
    Dobrzynski, Piotr
    Tematy:
    biodegradable polymers
    adenosine
    Pokaż więcej
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Powiązania:
    https://bibliotekanauki.pl/articles/1044392.pdf  Link otwiera się w nowym oknie
    Opis:
    We assessed the rate of release of a model nucleoside (adenosine, 5%, w/w) from nine different lactide-glycolide or lactide-caprolactone polymers. The polymer discs were eluted every second day with an artificial cerebrospinal fluid at the elution rate roughly approximating the brain extracellular fluid formation rate. Adenosine in eluate samples was assayed by HPLC. Three polymers exhibited a relatively constant release of adenosine for over four weeks, resulting in micromolar concentrations of nucleoside in the eluate. This points to the neccessity of further development of polymers of this types as intracerebral nucleoside delivery systems for local treatment of brain tumors.
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    In vitro release of cytotoxic nucleoside analogs from lactide-caprolactone and lactide-glycolide copolymers.
    Autorzy:
    Kryczka, Tomasz
    Bero, Maciej
    Kasperczyk, Janusz
    Dobrzyński, Piotr
    Marciniec, Barbara
    Popierzal-Brzezińska, Maria
    Grieb, Paweł
    Tematy:
    sterilization
    cladribine
    5-fluorouracil
    biodegradable copolymers
    Pokaż więcej
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Powiązania:
    https://bibliotekanauki.pl/articles/1043828.pdf  Link otwiera się w nowym oknie
    Opis:
    The aims of our study were to assess the release of cytotoxic nucleoside analogs 5-fluorouracil and 2-chloro-2'-deoxyadenosine from different lactide-glycolide or lactide-caprolactone biodegradable copolymers and the effects of sterilization on this release. The polymers were sterilized either with ethylene oxide at 37°C, or with gamma radiation (15 kGy, 20 kGy, or 25 kGy). The kinetics of nucleoside release from the copolymers were measured over 50 days. Four copolymers exhibited relatively constant release of nucleosides in micromolar concentrations during the entire observation period. Sterilization with either ethylene oxide or gamma radiation only slightly influenced nucleoside release. Further development of these copolymers as an intracerebral nucleoside delivery system for local treatment of brain tumors is indicated.
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Low-intensity whole-body oxidative stress in patients with parotid gland tumors
    Autorzy:
    Sowa, Paweł
    Kasperczyk, Sławomir
    Dadok, Adam
    Misiołek, Maciej
    Adamczyk-Sowa, Monika
    Tematy:
    enzyme
    gland
    immunology
    parotid
    tumor
    Pokaż więcej
    Wydawca:
    Index Copernicus International
    Powiązania:
    https://bibliotekanauki.pl/articles/58511058.pdf  Link otwiera się w nowym oknie
    Opis:
    Introduction: Recently, there has been a significant increase in the number of patients hospitalized and undergoing surgery due to parotid gland tumors. Etiological factors of salivary gland tumors are still unknown. Oxidative stress (OS) has been suggested to be an important indicator of carcinogenesis in some tumors. Aim: The aim of our study was to assess the state of OS in patients with selected benign and malignant parotid gland tumors. Material and method: Results: We found an increase in plasma lipofuscin levels in patients with all investigated parotid gland tumors. Furthermore, the activity of Cu/Zn-SOD in Warthin’s tumor patients was statistically lower compared to the controls, pleomorphic adenoma or mucoepidermoid carcinoma. Conclusions: In conclusion, we sustain the hypothesis on the presence of low-intensity whole-body OS in patients with parotid gland tumors. Furthermore, LPS may be a useful marker of OS in patients with benign and malignant tumors. Moreover, pathological mechanisms connected with WT seem to be different compared to malignant neoplasms and other benign tumors. It seems that Cu/Zn-SOD, as an antioxidative enzyme, may play an important role in those mechanisms taking part in WT.
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Analysis of the impact of sex and age on the variation in the prevalence of antinuclear autoantibodies in Polish population : a nationwide observational, cross-sectional study
    Autorzy:
    Mikhailidis, Dimitri P.
    Catapano, Alberico
    Mastej, Mirosław
    Toth, Peter P.
    Lip, Gregory Y.H.
    Banach, Maciej
    Krzemien, Paweł
    Charchar, Fadi J.
    Windak, Adam
    Tomasik, Tomasz
    Howard, George
    Penson, Peter E.
    MacDonald, Thomas M.
    Sattar, Naveed
    Tomaszewski, Maciej
    Kasperczyk, Sławomir
    Kasperczyk, Aleksandra
    Ray, Kausik K.
    Williams, Bryan
    Jóźwiak, Jacek J.
    Dobrakowski, Michał
    Opis:
    The detection of antinuclear autoantibody (ANA) is dependent on many factors and varies between the populations. The aim of the study was first to assess the prevalence of ANA in the Polish adult population depending on age, sex and the cutoff threshold used for the results obtained. Second, we estimated the occurrence of individual types of ANA-staining patterns. We tested 1731 patient samples using commercially available IIFA using two cutoff thresholds of 1:100 and 1:160. We found ANA in 260 participants (15.0%), but the percentage of positive results strongly depended on the cutoff level. For a cutoff threshold 1:100, the positive population was 19.5% and for the 1:160 cutoff threshold, it was 11.7%. The most prevalent ANA-staining pattern was AC-2 Dense Fine speckled (50%), followed by AC-21 Reticular/AMA (14.38%) ANA more common in women (72%); 64% of ANA-positive patients were over 50 years of age. ANA prevalence in the Polish population is at a level observed in other highly developed countries and is more prevalent in women and elderly individuals. To reduce the number of positive results released, we suggest that Polish laboratories should set 1:160 as the cutoff threshold.
    Dostawca treści:
    Repozytorium Uniwersytetu Jagiellońskiego
    Artykuł
      Wyświetlanie 1-8 z 8

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