Autor: Alvarez, John - Prolib Integro

Skocz do pozycji: 1.

Tytuł:: Biomarkers of response to ibrutinib plus nivolumab in relapsed diffuse large B-cell lymphoma, follicular lymphoma, or Richters transformation
Autorzy:: Hodkinson, Brendan P.
Avivi, Irit
Brody, Joshua D.
Schaffer, Michael
Alvarez, John
Ceulemans, Rob
Fourneau, Nele
Ben-Yehuda, Dina
Forslund, Ann
Younes, Anas
Balasubramanian, Sriram
Jurczak, Wojciech
Carpio, Cecilia
Opis:: We analyzed potential biomarkers of response to ibrutinib plus nivolumab in biopsies from patients with diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), and Richter's transformation (RT) from the LYM1002 phase I/IIa study, using programmed death ligand 1 (PD-L1) immunohistochemistry, whole exome sequencing (WES), and gene expression profiling (GEP). In DLBCL, PD-L1 elevation was more frequent in responders versus nonresponders (5/8 [62.5%] vs. 3/16 [18.8%]; p = 0.065; complete response 37.5% vs. 0%; p = 0.028). Overall response rates for patients with WES and GEP data, respectively, were: DLBCL (38.5% and 29.6%); FL (46.2% and 43.5%); RT (76.5% and 81.3%). In DLBCL, WES analyses demonstrated that mutations in RNF213 (40.0% vs. 6.2%; p = 0.055), KLHL14 (30.0% vs. 0%; p = 0.046), and LRP1B (30.0% vs. 6.2%; p = 0.264) were more frequent in responders. No responders had mutations in EBF1, ADAMTS20, AKAP9, TP53, MYD88, or TNFRSF14, while the frequency of these mutations in nonresponders ranged from 12.5% to 18.8%. In FL and RT, genes with different mutation frequencies in responders versus nonresponders were: BCL2 (75.0% vs. 28.6%; p = 0.047) and ROS1 (0% vs. 50.0%; p = 0.044), respectively. Per GEP, the most upregulated genes in responders were LEF1 and BTLA (overall), and CRTAM (germinal center B-cell–like DLBCL). Enriched pathways were related to immune activation in responders and resistance-associated proliferation/replication in nonresponders. This preliminary work may help to generate hypotheses regarding genetically defined subsets of DLBCL, FL, and RT patients most likely to benefit from ibrutinib plus nivolumab.
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

Artykuł

na półce

Skocz do pozycji: 2.

Artykuł

na półce

Skocz do pozycji: 3.

Tytuł:: Land Management Strategies and their Implications for Mazahua Farmers’ Livelihoods in the Highlands of Central Mexico
Autorzy:: Fajardo, Belina García
Hernández, María Estela Orozco
McDonagh, John
Arteaga, Gustavo Álvarez
Lezama, Patricia Mireles
Tematy:: Rural livelihoods
Mazahua farmers
hillside areas; Pokaż więcej
Wydawca:: Uniwersytet Warszawski. Wydział Geografii i Studiów Regionalnych
Powiązania:: https://bibliotekanauki.pl/articles/1035931.pdf Link otwiera się w nowym oknie
Opis:: This paper presents a case study from a Mazahua indigenous community in the rural Highlands of Central Mexico. It analyses Mazahua farming livelihoods characterised by subsistence agriculture, marginality, poverty and severe land degradation. Mazahua farmers face constrained environmental, socioeconomic and cultural conditions, which influence their local decisions on natural resource management. The results describe the capital assets base used, where land, livestock and crop production are imperative assets to support farmers’ livelihood strategies. It analyses local management practices to achieve livelihood outcomes in the short/long term, and to improve or undermine land characteristics and other related assets. It also presents a farmer typology constructed by local perceptions, a controversial element to drive sustainable development strategies at the local level. Finally, it discusses how local land management practices are adopted and their importance in developing alternatives to encourage positive trade-offs between conservation and production in order to improve rural livelihoods.
Dostawca treści:: Biblioteka Nauki

Artykuł

na półce

Skocz do pozycji: 4.

Tytuł:: Xanthogranulomatous Pyelonephritis: A pooled quantitative analysis of published cases
Autorzy:: Parrill, Allison M.
Tsiyer, Allen
Fogel, Joshua
Gala, Dhir
Politi, Kristen
Patel, Himani
Bhatt, Harshit
Alvarez-Betancourt, Alejandro
Smith, Aaron
Kim, Zae
Cadet, Bair
Nalesnik, Jeffrey
Mahoney, John
Tematy:: Pyelonephritis
Xanthogranulomatous
urology
nephrology
nephrolithiasis; Pokaż więcej
Wydawca:: Polska Akademia Nauk. Czasopisma i Monografie PAN
Powiązania:: https://bibliotekanauki.pl/articles/57112968.pdf Link otwiera się w nowym oknie
Opis:: Xanthogranulomatous Pyelonephritis (XGP) is a serious and rare inflammatory disease of unknown etiology. This systematic review analyzes XGP cases. We performed a literature search for “Pyelonephritis, Xanthogranulomatous.” The primary composite outcome was recovery with post-surgery complications, partial recovery, death, or chronic kidney disease. The secondary outcome was any presentation or treatment complication. Predictor variables consisted of demographics, history, symptoms, and diagnosis/management. Among the 251 patients, the mean age was 36.1 years, and 57.4% were female. The most common symptom and finding were fever (55.0%) and renal stones (53.8%), respectively. There were 15.5% with the composite outcome. There were 51.0% with any presentation or treatment complication. Multivariate logistic regression analysis for the composite outcome showed that kidney of both/horseshoe (OR:3.86, 95% CI:1.01, 14.73, p = 0.048), dialysis required (OR:8.64, 95% CI:2.27, 32.94, p = 0.002), and operative treatment of nephrostomy or nephrostomy followed by nephrectomy (OR:4.57, 95% CI:1.58, 13.17, p = 0.01) were each significantly associated with increased odds. Fever (OR:3.04, 95% CI:1.63, 5.67, p <0.001) and renal stones (OR:2.55, 95% CI:1.35, 4.81, p = 0.004) were each significantly associated with increased odds for any presentation/treatment complication. In conclusion, XGP patients with involvement of both or horseshoe kidneys, dialysis requirements, or treatment of nephrostomy or nephrostomy followed by nephrectomy may require aggressive treatment to mitigate poor patient outcomes.
Dostawca treści:: Biblioteka Nauki

Artykuł

na półce

Skocz do pozycji: 5.

Autorzy:: Ewart, Ian
Kühn, Anna L.
Sievert, Kolja
Hargroves, David
Haldis, Thomas
Bertog, Stefan
Fassbender, Klaus
Routledge, Helen
Comelli, Simone
Siddiqui, Adnan
Hopkins, Nelson L.
Dziadkiewicz, Artur
Pillai, Sanjay
Grunwald, Iris Q.
Alekyan, Bagrat
Niżankowski, Rafał
Witkowski, Adam
Guyler, Paul
Papanagiotou, Panagiotes
Politi, Maria
Alvarez, Carlos A.
Gaikwad, Shailesh
Snyder, Kenneth V.
Sievert, Horst
Pawlowski, Krzysztof
Skrypnik, Dmitry
Houston, John Graeme
Donald-Simspon, Helen
Petrov, Ivo
Hornung, Marius
Podlasek, Anna
Abelson, Mark
Musiałek, Piotr
Mani, Sunithi
Tekieli, Lukasz
Mathias, Klaus
Roffe, Christine
Opis:: Introduction: Today, endovascular treatment (EVT) is the therapy of choice for strokes due to acute large vessel occlusion, irrespective of prior thrombolysis. This necessitates fast, coordinated multi-specialty collaboration. Currently, in most countries, the number of physicians and centres with expertise in EVT is limited. Thus, only a small proportion of eligible patients receive this potentially life-saving therapy, often after significant delays. Hence, there is an unmet need to train a sufficient number of physicians and centres in acute stroke intervention in order to allow widespread and timely access to EVT. Aim: To provide multi-specialty training guidelines for competency, accreditation and certification of centres and physicians in EVT for acute large vessel occlusion strokes. Material and methods: The World Federation for Interventional Stroke Treatment (WIST) consists of experts in the field of endovascular stroke treatment. This interdisciplinary working group developed competency – rather than time-based – guidelines for operator training, taking into consideration trainees' previous skillsets and experience. Existing training concepts from mostly single specialty organizations were analysed and incorporated. Results: The WIST establishes an individualized approach to acquiring clinical knowledge and procedural skills to meet the competency requirements for certification of interventionalists of various disciplines and stroke centres in EVT. WIST guidelines encourage acquisition of skills using innovative training methods such as structured supervised high-fidelity simulation and procedural performance on human perfused cadaveric models. Conclusions: WIST multispecialty guidelines outline competency and quality standards for physicians and centres to perform safe and effective EVT. The role of quality control and quality assurance is highlighted.
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

Artykuł

na półce

Skocz do pozycji: 6.

Autorzy:: Skrypnik, Dimitry
Witkowski, Adam
Kühn, Anna L.
Politi, Maria
Ewart, Ian
Guyler, Paul
Pillai, Sanjay
Houston, John Graeme
Sievert, Horst
Petrov, Ivo
Papanagiotou, Panagiotes
Donald-Simspon, Helen
Fassbender, Klaus
Haldis, Thomas
Alvarez, Carlos A.
Pawlowski, Krzysztof
Siddiqui, Adnan
Podlasek, Anna
Dziadkiewicz, Artur
Hopkins, L. Nelson
Mani, Sunithi
Sievert, Kolja
Alekyan, Bagrat
Q. Grunwald, Iris
Snyder, Samuel K.
Musiałek, Piotr
Tekieli, Lukasz
Gaikwad, Shailesh
Abelson, Mark
Mathias, Klaus
Hargroves, David
Comelli, Simone
Niżankowski, Rafał
Bertog, Stefan
Roffe, Christine
Routledge, Helen
Hornung, Marius
Opis:: Introduction: Today, endovascular treatment (EVT) is the therapy of choice for strokes due to acute large vessel occlusion, irrespective of prior thrombolysis. This necessitates fast, coordinated multi-specialty collaboration. Currently, in most countries, the number of physicians and centres with expertise in EVT is limited. Thus, only a small proportion of eligible patients receive this potentially life-saving therapy, often after significant delays. Hence, there is an unmet need to train a sufficient number of physicians and centres in acute stroke intervention in order to allow widespread and timely access to EVT. Aim: To provide multi-specialty training guidelines for competency, accreditation and certification of centres and physicians in EVT for acute large vessel occlusion strokes. Material and methods The World Federation for Interventional Stroke Treatment (WIST) consists of experts in the field of endovascular stroke treatment. This interdisciplinary working group developed competency – rather than time-based – guidelines for operator training, taking into consideration trainees’ previous skillsets and experience. Existing training concepts from mostly single specialty organizations were analysed and incorporated. Results: The WIST establishes an individualized approach to acquiring clinical knowledge and procedural skills to meet the competency requirements for certification of interventionalists of various disciplines and stroke centres in EVT. WIST guidelines encourage acquisition of skills using innovative training methods such as structured supervised high-fidelity simulation and procedural performance on human perfused cadaveric models. Conclusions:nWIST multispecialty guidelines outline competency and quality standards for physicians and centres to perform safe and effective EVT. The role of quality control and quality assurance is highlighted.
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego