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Wyszukujesz frazę "André, Philippe" wg kryterium: Autor


Tytuł:
PRISM (Polarized Radiation Imaging and Spectroscopy Mission) : an extended white paper
Autorzy:
Negrello, Mattia
Tartari, Andrea
Naselsky, Pavel
Comis, Barbara
Silva, Antonio Da
Piacentini, Francesco
Rosset, Cyrille
Nati, Federico
Fosalba, Pablo
Perrotta, Francesca
Petris, Marco de
Cuttaia, Francesco
Battye, Richard
Ghribi, Adnan
Chluba, Jens
Trombetti, Tiziana
Lattanzi, Massimiliano
Verde, Licia
Maino, Davide
Avillez, Miguel de
Bouchet, François
Mangilli, Anna
Macias-Perez, Juan
Bucher, Martin
Stompor, Radek
Fuller, Gary
Enßlin, Torsten
Bendo, George
Boulanger, François
Davis, Richard
Liguori, Michele
Bartolo, Nicola
Grainge, Keith
Béthermin, Matthieu
Barreiro, Belen
Falgarone, Edith
Martinez-Gonzalez, Enrique
Errard, Josquin
André, Philippe
Ponthieu, Nicolas
Banday, Anthony
Bonaldi, Anna
Lesgourgues, Julien
Natoli, Paolo
Tristram, Matthieu
Castex, Guillaume
Pollo, Agnieszka
Wandelt, Ben
Zotti, Gianfranco de
Watson, Robert
Liuzzo, Elisabetta
Trappe, Neil
Challinor, Anthony
Hamilton, Jean-Christophe
Schillaci, Alessandro
Bernard, Jean-Philippe
Noviello, Fabio
Paladino, Rosita
Rubino-Martin, Jose-Alberto
Delabrouille, Jacques
Ganga, Ken
Lopez-Caniego, Marcos
Burigana, Carlo
Massardi, Marcella
Casasola, Viviana
Mennella, Aniello
Rosa, Adriano de
Ferrière, Katia
Camus, Philippe
Miville-Deschênes, Marc-Antoine
Silk, Joseph
Murphy, Anthony
Shellard, Paul
Cai, Zhen-Yi
Palanque-Delabrouille, Nathalie
Jackson, Mark
Khatri, Rishi
Bartlett, James
Martins, Carlos J. A. P.
Paoletti, Daniela
Casas, Francisco
Piccirillo, Lucio
Giard, Martin
Herranz, Diego
Melchiorri, Alessandro
Bersanelli, Marco
Hernandez-Monteagudo, Carlos
Chon, Gayoung
Hall, Alex
Dunkley, Joanna
Barbosa, Domingos
Galli, Silvia
Ferreira, Pedro
Colafrancesco, Sergio
Monfardini, Alessandro
Bernardis, Paolo de
Maffei, Bruno
Matarrese, Sabino
Polenta, Gianluca
Lamagna, Luca
Jaffe, Andrew
Benoȋt, Alain
García-Bellido, Juan
Masi, Silvia
Dickinson, Clive
Toffolatti, Luigi
Tucci, Marco
Weijgaert, Rien Van de
Paci, Francesco
Ricciardi, Sara
Finelli, Fabio
Gonzalez-Nuevo, Joaquin
Gruppuso, Alessandro
Kunz, Martin
Fletcher, Andrew
Giraud-Héraud, Yannick
Roman, Matthieu
Baccigalupi, Carlo
Désert, François-Xavier
Peiris, Hiranya
Vielva, Patricio
Terenzi, Luca
Salatino, Maria
Bielewicz, Pawel
O'Sullivan, Créidhe
Tent, Bartjan Van
Leahy, Paddy
Brand, Jan
Remazeilles, Mathieu
Pisano, Giampaolo
Sunyaev, Rashid
Withington, Stafford
Starobinsky, Alexei
Melin, Jean-Baptiste
Tomasi, Maurizio
Pagano, Luca
Haverkorn, Marijke
D'Alessandro, Giuseppe
Piat, Michel
Battistelli, Elia
Diego, Jose Maria
Mignano, Arturo
Opis:
PRISM (Polarized Radiation Imaging and Spectroscopy Mission) was proposed to ESA in May 2013 as a large-class mission for investigating within the framework of the ESA Cosmic Vision program a set of important scientific questions that require high resolution, high sensitivity, full-sky observations of the sky emission at wavelengths ranging from millimeter-wave to the far-infrared. PRISM's main objective is to explore the distant universe, probing cosmic history from very early times until now as well as the structures, distribution of matter, and velocity flows throughout our Hubble volume. PRISM will survey the full sky in a large number of frequency bands in both intensity and polarization and will measure the absolute spectrum of sky emission more than three orders of magnitude better than COBE FIRAS. The data obtained will allow us to precisely measure the absolute sky brightness and polarization of all the components of the sky emission in the observed frequency range, separating the primordial and extragalactic components cleanly from the galactic and zodiacal light emissions. The aim of this Extended White Paper is to provide a more detailed overview of the highlights of the new science that will be made possible by PRISM, which include: (1) the ultimate galaxy cluster survey using the Sunyaev-Zeldovich (SZ) effect, detecting approximately 10^{6} clusters extending to large redshift, including a characterization of the gas temperature of the brightest ones (through the relativistic corrections to the classic SZ template) as well as a peculiar velocity survey using the kinetic SZ effect that comprises our entire Hubble volume; (2) a detailed characterization of the properties and evolution of dusty galaxies, where the most of the star formation in the universe took place, the faintest population of which constitute the diffuse CIB (Cosmic Infrared Background); (3) a characterization of the B modes from primordial gravity waves generated during inflation and from gravitational lensing, as well as the ultimate search for primordial non-Gaussianity using CMB polarization, which is less contaminated by foregrounds on small scales than the temperature anisotropies; (4) a search for distortions from a perfect blackbody spectrum, which include some nearly certain signals and others that are more speculative but more informative; and (5) a study of the role of the magnetic field in star formation and its interaction with other components of the interstellar medium of our Galaxy. These are but a few of the highlights presented here along with a description of the proposed instrument.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
CIAO1 and MMS19 deficiency : a lethal neurodegenerative phenotype caused by cytosolic Fe-S cluster protein assembly disorders
Autorzy:
van Weeghel, Michel
Garavaglia, Barbara
Labrune, Philippe
van der Wel, Nicole N.
Pena, Izabella A.
Dobritzsch, Doreen
Moeschler, John B.
Filiano, James J.
Dyment, David
Prykhozhij, Sergey V.
Houtkooper, Riekelt H.
Kochan, Jakub
Berman, Jason N.
Leen, René
van Kuilenburg, André B. P.
Roseboom, Winfried
Weschke, Bernhard
McIntyre, Rebecca L.
Riva, Daria
Willemsen, Michèl A.
Vaz, Frédéric M.
Roelofsen, Jeroen
Pras-Raves, Mia L.
Ferreira, Carlos R.
Ekker, Marc
Jansen-Meijer, Judith
Schomakers, Bauke V.
Jaspers, Yorrick R.J.
Correard, Solenne
van Karnebeek, Clara D.M.
van Klinken, Jan B.
van der Lee, Robin
Drögemöller, Britt I.
Tarailo-Graovac, Maja
Saxena, Vishal
Schock, Sarah
Grootemaat, Anita E.
Ban, Kevin
Kramer, Gertjan
Ross, Colin J.
Zoetekouw, Lida
Meinsma, Rutger
Wassermann, Wyeth W.
Opis:
Purpose The functionality of many cellular proteins depends on cofactors, yet they have only been implicated in a minority of Mendelian diseases. Here, we describe the first two inherited disorders of the cytosolic iron-sulfur protein assembly system. Methods Genetic testing via genome sequencing was applied to identify the underlying disease cause in 3 patients with microcephaly, congenital brain malformations, progressive developmental and neurologic impairments, recurrent infections, and a fatal outcome. Studies in patient-derived skin fibroblasts and zebrafish models were performed to investigate the biochemical and cellular consequences Results Metabolic analysis showed elevated uracil and thymine levels in body fluids but no pathogenic variants in DPYD. Genome sequencing identified compound heterozygosity in two patients for missense variants in CIAO1 and homozygosity for an in-frame 3-nucleotide deletion in MMS19 in the third patient. Profound alterations in the proteome, metabolome and lipidome were observed in patient-derived fibroblasts. We confirmed the detrimental effect of deficiencies in CIAO1 and MMS19 in zebrafish models. Conclusion A general failure of cytosolic and nuclear iron-sulfur protein maturation caused pleiotropic effects. The critical function of the cytosolic iron-sulfur protein assembly machinery for antiviral host defense may well explain the recurrent severe infections occurring in our patients.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
PCSK9 genetic variants and risk of type 2 diabetes : a mendelian randomisation study
Autorzy:
Bots, Michiel L.
Froguel, Philippe
Hypponen, Elina
Price, Jackie F.
Smart, Melissa
van Iperen, Erik
Hakonarson, Hakon
Lange, Leslie A.
Ridker, Paul M.
Moldovan, Max
Kiechl, Stefan
Kumari, Meena
Husemoen, Lise Lotte Nystrup
Liu, Tian
Patel, Riyaz S.
Mahajan, Anubha
Larson, Eric B.
Sanchez-Galvez, Adelaida
Ritchie, Marylyn D.
Pikhart, Hynek
Kitchner, Terrie
Willeit, Karin
Demuth, Juri
Verweij, Niek
Balkau, Beverley
Cariou, Bertrand
de Andrade, Mariz
Sacerdote, Carlotta
Morris, Richard
Matullo, Giuseppe
Young, Robin
Lerch, Markus M.
Kubinova, Ruzena
Christen, Tim
Malyutina, Sofia
Wareham, Nicholas J.
Chasman, Daniel I.
O' Donnell, Martin
Fairhurst-Hunter, Zammy
Uitterlinden, Andre
Scott, Robert
Hingorani, Aroon D.
Whincup, Peter
Power, Christine
Hancock, Stephen
Grarup, Niels
van der Schouw, Yvonne T.
Mason, Dan
Pająk, Andrzej
Tamosiunas, Abdonas
Guarrera, Simonetta
Mook-Kanamori, Dennis O.
Dorr, Marcus
Ward, Joey
Pare, Guillaume
Bobak, Martin
Pell, Jill P.
Hovingh, G. Kees
Bertram, Lars
Pedersen, Oluf
Kirchner, H. Lester
Gustafsson, Stefan
Linneberg, Allan
Carrell, David S.
Snieder, Harold
Baumeister, Sebastian
Hartwig, Fernando Pires
Ford, Ian
Casas, Juan-Pablo
Preiss, David
Ben-Shlomo, Yoav
Swerdlow, Daniel I.
Willeit, Johann
Fiorito, Giovanni
Holmes, Michael V.
Yusuf, Salim
Volker, Uwe
Denny, Joshua C.
Meade, Tom
Maitland-van der Zee, Anke H.
Panayiotou, Andrie G.
McLachlan, Stela
Lyall, Donald M.
Grobbee, Diederick E.
Coassin, Stefan
Wanamethee, Goya
Volzke, Henry
Kivimaki, Mika
Wright, John
Carty, Cara
Nicolaides, Andrew
Asselbergs, Folkert W.
Eppinga, Ruben N.
Langenberg, Claudia
Attia, John
Welch, Catherine
Padmanabhan, Sandosh
Brilliant, Murray
Marques-Vidal, Pedro
Bonnefond, Amélie
Franco, Oscar
Baranova, Ekaterina V.
Reiner, Alex P.
Teumer, Alexander
Keating, Brendan J.
Thuillier, Dorothee
Horta, Bernardo Lessa
Ingelsson, Erik
Humphries, Steve E.
Smith, Daniel J.
Lind, Lars
Hansen, Torben
Holliday, Elizabeth
van der Harst, Pim
Schmidt, Amand F.
Cooper, Jackie
Steinhagen-Thiessen, Elisabeth
Hofman, Albert
Dehghan, Abbas
Onland-Moret, N. Charlotte
Demuth, Ilja
Chong, Michael
Roden, Dan M.
Said, M. Abdullah
McCarty, Catherine A.
Crosslin, David R.
Campbell, Archie
Simonsen, Kenneth Starup
Luan, Jian'an
Bao, Yanchun
Sattar, Naveed
Pazoki, Raha
Norman, Kristina
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9
Autorzy:
Denaxas, Spiros
Lester, Kirchner H.
Bondy, Melissa
Casas, Juan P.
Kitchner, Terrie
Fiorito, Giovanni
Roden, Dan M.
Hovingh, Kees
Swerdlow, Daniel I.
Hemminki, Kari
Nicolaides, Andrew
Mahajan, Anubha
Linneberg, Allan
Lill, Christina M.
Pazoki, Raha
Wright, John
Morris, Richard
Pare, Guillaume
Law, Philip
Price, Jackie F.
Welch, Catherine
Hakonarson, Hakon
Campbell, Archie
Panayiotou, Andrie G.
Eppinga, Ruben N.
Uitterlinden, Andre
Wareham, Nicholas J.
Cooper, Jackie
Malyutina, Sofia
Valentine, Dennis
Fairhurst-Hunter, Zammy
Christen, Tim
Ingelsson, Erik
Hopewell, Jemma C.
Lerch, Markus M.
Franco, Oscar
Costa, Rui Providencia E.
Sanchez-Galvez, Adelaida
Guarrera, Simonetta
Kiechl, Stefan
Asselbergs, Folkert W.
Hancock, Stephen
Speedy, Helen
Scott, Robert A.
Hansen, Torben
Goldschmidt, Hartmut
Meade, Tom
Froguel, Philippe
Brilliant, Murray
Lange, Leslie A.
Demuth, Ilja
McLachlan, Stela
Faraway, Rupert
Grobbee, Diederick E.
Bao, Yanchun
Engert, Andreas
Mason, Dan
ODonnell, Martin
Bertram, Lars
Roussel, Ronan
Luan, Jianan
Crosslin, David R.
Ward, Joey
Hansson, Markus
Hartwig, Fernando Pires
Chong, Michael
Dorr, Marcus
Ritchie, Marylyn D.
Pikhart, Hynek
Holliday, Elizabeth
Li, Ni
Padmanabhan, Sandosh
Houlston, Richard
McCarty, Catherine A.
Moldovan, Max
Langenberg, Claudia
Smart, Melissa
Snieder, Harold
Kinnersley, Ben
Cornish, Alex J.
Chasman, Daniel I.
van Iperen, Erik
Pell, Jill P.
Schmidt, Amand F.
Willeit, Johann
Morgan, Gareth
Humphries, Steve E.
Young, Robin
Whincup, Peter
Bonnefond, Amelie
Labreche, Karim
Volzke, Henry
Finan, Chris
Ridker, Paul M.
Wanamethee, Goya
Dale, Caroline
Went, Molly
Attia, John
Ben-Shlomo, Yoav
Hingorani, Aroon D.
Tamosiunas, Abdonas
van der Schouw, Yvonne T.
Seshadri, Sudha
Kumari, Meena
Carrell, David S.
Denny, Joshua C.
Maitland-van der Zee, Anke H.
Matullo, Giuseppe
Patel, Riyaz S.
Sacerdote, Carlotta
Sattar, Naveed
Norman, Kristina
Power, Christine
Ford, Ian
Pająk, Andrzej
Lind, Lars
Schofield, Peter
Yusuf6, Salim
Holmes, Michael V.
Baumeister, Sebastian
Volker, Uwe
Christophersen, Ingrid E.
Scott, Rodney
Onland-Moret, N. Charlotte
Allan, James
Weinhold, Niels
Nilsson, Bjorn
Steinhagen-Thiessen, Elisabeth
Preiss, David
Verweij, Niek
Coassin, Stefan
Cariou, Bertrand
Bobak, Martin
Sanson, Marc
Jess, Tine
Baranova, Ekaterina V.
Bots, Michiel L.
Kivimaki, Mika
Willeit, Karin
Thuillier, Dorothee
Sonneveld, Pieter
Hofman, Albert
Teumer, Alexander
Hypponen, Elina
Simon, Matthias
Sud, Amit
de Andrade, Mariza
Larson, Eric B.
Carty, Cara
Grarup, Niels
Reiner, Alex P.
Said, M. Abdullah
Marques-Vidal, Pedro
Demuth, Juri
Fatemifar, Ghazaleh
Keating, Brendan J.
Hemingway, Harry
van der Harst, Pim
Mook-Kanamori, D. O.
Dobbins, Sara E.
Kubinova, Ruzena
Horta, Bernardo Lessa
Dehghan, Abbas
Pedersen, Oluf
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł

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