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    Tytuł:
    Rationale and design of the PeriOperative ISchemic Evaluation-3 (POISE-3) : a randomized controlled trial evaluating tranexamic acid and a strategy to minimize hypotension in noncardiac surgery
    Autorzy:
    Cheong, Chao Chia
    Balasubramanian, Kumar
    Copland, Ingrid
    Kurz, Andrea
    Guyatt, Gordon
    Short, Timothy G.
    Lomivorotov, Vladimir V.
    Parlow, Joel L.
    Chan, Matthew T.V.
    Ofori, Sandra N.
    Torres, David
    Ayad, Sabry
    Whitlock, Richard P.
    Duceppe, Emmanuelle
    Schmartz, Denis
    Eikelboom, John
    Tandon, Vikas
    Conen, David
    Garg, Amit X.
    Yusuf, Salim
    Borges, Lavia K.
    Vanhelder, Tomas
    Lamy, Andre
    Jayaram, Raja
    Wu, William K.K.
    Richards, Toby
    Biccard, Bruce
    Devereaux, P.J.
    Meyhoff, Christian S.
    Gross, Peter L.
    Zapata, Maria J. Martínez
    Efremov, Sergey
    de Nadal, Miriam
    Srinathan, Sadeesh
    Stillo, David
    Petit, Shirley
    Amir, Mohammed
    Mcintyre, William
    Abubakirov, Marat
    Wang, Michael K.
    Painter, Thomas W.
    Polanczyk, Carisi A.
    Kirov, Mikhail
    Marcucci, Maura
    Xavier, Denis
    Sessler, Daniel
    Likhvantsev, Valery
    Patel, Ameen
    Kleinlugtenbelt, Ydo V.
    Szczeklik, Wojciech
    Landoni, Giovanni
    Alfonsi, Pascal
    Spence, Jessica
    Rao, Mangala
    Leslie, Kate
    Belley-Cote, Emily
    Wittmann, Maria
    Ruetzler, Kurtz
    Wang, C.Y.
    Fleischmann, Edith
    Astrakov, Sergey V.
    Bhatt, Keyur
    Mcgillion, Michael
    Roshanov, Pavel
    Aguado, Hector J.
    Bangdiwala, Shrikant I.
    Iglesisas, Pilar Paniagua
    Vincent, Jessica
    Opis:
    Background: For patients undergoing noncardiac surgery, bleeding and hypotension are frequent and associated with increased mortality and cardiovascular complications. Tranexamic acid (TXA) is an antifibrinolytic agent with the potential to reduce surgical bleeding; however, there is uncertainty about its efficacy and safety in noncardiac surgery. Although usual perioperative care is commonly consistent with a hypertension-avoidance strategy (i.e., most patients continue their antihypertensive medications throughout the perioperative period and intraoperative mean arterial pressures of 60 mmHg are commonly accepted), a hypotension-avoidance strategy may improve perioperative outcomes. Methods: The PeriOperative Ischemic Evaluation (POISE)-3 Trial is a large international randomized controlled trial designed to determine if TXA is superior to placebo for the composite outcome of life-threatening, major, and critical organ bleeding, and non-inferior to placebo for the occurrence of major arterial and venous thrombotic events, at 30 days after randomization. Using a partial factorial design, POISE-3 will additionally determine the effect of a hypotension-avoidance strategy versus a hypertension-avoidance strategy on the risk of major cardiovascular events, at 30 days after randomization. The target sample size is 10,000 participants. Patients ≥45 years of age undergoing noncardiac surgery, with or at risk of cardiovascular and bleeding complications, are randomized to receive a TXA 1 g intravenous bolus or matching placebo at the start and at the end of surgery. Patients, health care providers, data collectors, outcome adjudicators, and investigators are blinded to the treatment allocation. Patients on ≥ 1 chronic antihypertensive medication are also randomized to either of the two blood pressure management strategies, which differ in the management of patient antihypertensive medications on the morning of surgery and on the first 2 days after surgery, and in the target mean arterial pressure during surgery. Outcome adjudicators are blinded to the blood pressure treatment allocation. Patients are followed up at 30 days and 1 year after randomization. Discussion: Bleeding and hypotension in noncardiac surgery are common and have a substantial impact on patient prognosis. The POISE-3 trial will evaluate two interventions to determine their impact on bleeding, cardiovascular complications, and mortality.
    Dostawca treści:
    Repozytorium Uniwersytetu Jagiellońskiego
    Artykuł
    Tytuł:
    Comparative study of cooling of automobile LED headlights without and with fins and finding comfortable operating conditions
    Autorzy:
    Mishra, Manbodh Kumar
    Chandramohan, V. P.
    Balasubramanian, Karthik
    Tematy:
    LED lights
    automobile headlight
    finite element method
    junction temperature
    safe working conditions
    Pokaż więcej
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Powiązania:
    https://bibliotekanauki.pl/articles/139930.pdf  Link otwiera się w nowym oknie
    Opis:
    LED light must be cooled to avoid reaching a certain temperature. Two different 3D practical domains of LED light are modelled, (i) square aluminium plate with a cylindrical plate and an LED module (model I), (ii) the same provision of model I with 25 fins (model II). ANSYS 16.0 is used for solving the problem. Temperature distribution, junction temperature (Tj ) and heat flux are estimated. Analyses are carried out for various ambient temperatures (Ta) and for different LED power dissipations (Q) to identify the safe operating conditions. In model I, it is found that 38% of working conditions go beyond the critical limit of Tj and it is reduced to 21.4% in model II. In model II, for low Ta of 30 and 40 C with all Q considered in this analysis are safer. If Ta is between 30 and 80 C, then Q must be maintained at 0.5 to 1.25 W. Beyond this, conditions are not safe.
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-10 z 10

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