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Tytuł:
Effectiveness of chronic obstructive pulmonary disease (COPD) treatment with a combination of tiotropium / olodaterol in Polish standard clinical practice as measured by the improvement of the Clinical COPD Questionnaire score : an observational study
Autorzy:
Barczyk, Adam
Kania, Aleksander
Celejewska-Wójcik, Natalia
Żurowska, Katarzyna
Opis:
Introduction: Health-related quality of life in patients with chronic obstructive pulmonary disease (COPD) can be measured by the Clinical COPD Questionnaire (CCQ). In this study, the CCQ was used to assess the therapeutic success of a fixed-dose tiotropium / olodaterol combination treatment in Polish COPD patients. Objectives: We aimed to evaluate the changes in the CCQ score in Polish patients with COPD after 6 weeks of treatment with tiotropium / olodaterol and to assess the predictors of response to this treatment. Patients and methods: Data of the Polish subgroup of the NIS-CCQ observational study (NCT03663569) were extracted. COPD patients who had received a new tiotropium / olodaterol prescription were included. The primary end point was therapeutic success predefined as a 0.4-point reduction in the CCQ score after 6 weeks of tiotropium / olodaterol treatment. Post-hoc logistic regression analysis was performed to identify the predictors of response to the treatment. Results: After 6 weeks of treatment, 72.4% of patients achieved therapeutic success. The therapy was successful in 83.4% of treatment-naïve patients, as compared with 62.6% and 73.3% of those previously treated with long-acting muscarinic antagonists or long-acting β2 agonists in monotherapy and in combination with inhaled corticosteroids, respectively. Therapeutic success was achieved by at least 50% of patients regardless of the COPD severity and exacerbation history but it was more frequent in patients with more severe disease. The airflow limitation severity grades 2 to 4, modified Medical Research Council Dyspnea Scale classes 2 to 4, exacerbations within the last year before the study, and treatment-naïve status predicted a better response to tiotropium / olodaterol. Conclusions: Tiotropium / olodaterol treatment improved clinical control in Polish COPD patients. Therapeutic success was the most pronounced in individuals with more severe COPD and in the treatment-naïve group but occurred also in those with moderate disease and in previously treated participants.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
Validation of the Polish-language version of the COPD Assessment Test
Autorzy:
Barczyk, Adam
Czajkowska.Malinowska, Ma.gorzata
Brożek, Grzegorz
Celejewska-Wójcik, Natalia
Kania, Aleksander
Trzaska.Sobczak, Marzena
Połtyn, Beata
Kuziemski, Krzysztof
Miszczuk, Marta
Farnik, Małgorzata
Krenke, Rafał
Opis:
INTRODUCTION The COPD Assessment Test (CAT) is a standardized patient–completed tool dedicated to assessment of symptom severity. While the Polish CAT version has been used for a few years, it has not been validated so far. OBJECTIVES The aim of the study was to validate the Polish‑language version of the CAT questionnaire by assessing its reproducibility and reliability. PATIENTS AND METHODS Validation of the Polish‑language version of the CAT questionnaire was a substudy of the international multicenter observational cross‑sectional POPE survey of patients with chronic obstructive pulmonary disease (COPD) in Central and Eastern European countries. The study was completed in 395 outpatients with stable disease at least 4 weeks before the survey. Validation was performed with the use of the Spearman correlation and Cronbach α coefficients, Cohen κ test, and the Bland–Altman procedure. RESULTS The internal consistency assessed by the Cronbach α coefficient was 0.87 for the questionnaire and 0.84 to 0.86 for its separate items. The repeatability of the questionnaire was good to very good (Cohen κ, 0.76–0.85; P <0.01). The Spearman coefficient for the sum of scores of test–retest responses was 0.95 (P <0.01). The Bland–Altman analysis revealed very good test–retest and interrater reliability, with the mean difference between test I and test II results of –0.556 (95% CI, –0.345 to 0.767). CONCLUSIONS The Polish version of the CAT questionnaire is a reproducible and reliable instrument for evaluation of patients with COPD and should be recommended for use in clinical practice.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Wyświetlanie 1-10 z 18

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