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Wyszukujesz frazę "Beiske, L." wg kryterium: Autor


Wyświetlanie 1-2 z 2
Tytuł:
Prospects for a survey of the galactic plane with the Cherenkov Telescope Array
Autorzy:
Beshley, V.
Curtis-Ginsberg, Z.
Seglar Arroyo, M.
Castrejon, N.
Steppa, C.
Barrio, J.A.
Viana, A.
Sangiorgi, P.
Slowikowska, A.
Bolmont, J.
Font Guiteras, L.
Kostunin, D.
del Peral, L.
Abe, S.
López-Moya, M.
Reimer, A.
Sizun, P.
Ferrand, G.
Tibolla, O.
Alves Batista, R.
Biland, A.
Green, D.
Kagaya, M.
Kornecki, P.
Kieda, D.B.
Leuschner, F.
Dörner, J.
Hernández Cadena, S.
Boisson, C.
Stolarczyk, T.
Palatiello, M.
Vitale, V.
Ambrosino, F.
Zaharijas, G.
Morcuende, D.
van Eldik, C.
Reichherzer, P.
Pierre, E.
Holder, J.
Agudo, I.
Luque-Escamilla, P.L.
Fröse, S.
Sano, H.
Iarlori, M.
Kosack, K.
Dubus, G.
Dumora, D.
Vignatti, J.
Vacula, M.
Yoshikoshi, T.
Coimbra Araujo, C.H.
Balbo, M.
Vovk, I.
Mukherjee, R.
Janecek, P.
Regeard, M.
Crestan, S.
Gaug, M.
Orlando, S.
Nikolić, L.
Siejkowski, H.
Bhattacharjee, P.
Gréaux, L.
Miener, T.
Macias, O.
Beiske, L.
Tian, W.W.
Wierzcholska, A.
Braiding, C.
Augusto Stuani, L.
Dubos, C.
Leone, F.
Nickel, L.
Stanič, S.
Travnicek, P.
Zacharias, M.
de Menezes, R.
Cifuentes, A.
Grasso, D.
Moralejo, A.
Renaud, M.
Rhode, W.
Greenshaw, T.
Bernardini, E.
Bordas, P.
De Frondat Laadim, F.
Olive, J.-F.
Nosek, D.
López-Coto, R.
Leto, G.
Sapienza, V.
Sánchez-Conde, M.
Feijen, K.
Holler, M.
Ruiter, A.J.
Mizuno, T.
Cascone, E.
Wohlleben, F.
Marsella, G.
Vodeb, V.
Rodríguez-Vázquez, J.J.
Lombardi, S.
Chernyakova, M.
Salzmann, H.
Dournaux, J.-L.
Novosyadlyj, B.
Vecchi, M.
Ventura, S.
Ziętara, Krzysztof
Lazendic-Galloway, J.
Lozano Bahilo, J.
Chen, A.W.
de Naurois, M.
Brose, R.
Duffy, S.
Orlando, E.
Suda, Y.
Miceli, M.
Burmistrov, L.
Bronzini, E.
Dalchenko, M.
Caraveo, P.
Pantaleo, F.R.
Quirrenbach, A.
Tripodo, G.
Jankowsky, F.
Carrasco, M.-S.
Pumo, M.L.
Terada, Y.
Foffano, L.
Liodakis, I.
Tsiahina, A.
Brunelli, G.
Jarnot, C.
Calisse, P.G.
Horan, D.
Ponti, G.
de Martino, D.
Mas-Aguilar, A.
Khélifi, B.
Chadwick, P.M.
Rigoselli, M.
Errando, M.
Inoue, S.
Rosales de Leon, A.
Garczarczyk, M.
Bonnoli, G.
Siqueira, C.
Cotter, G.
Hnatyk, B.
Di Tria, R.
Nozaki, S.
Asano, K.
Takeishi, R.
De la Torre Luque, P.
Menchiari, S.
Maurin, G.
Martínez, M.
Marcowith, A.
Muraczewski, A.
Bosnjak, Z.
Giesbrecht, J.
Prokhorov, D.
Lucarelli, F.
dos Anjos, R.D.C.
Olmi, B.
Gallozzi, S.
Giglietto, N.
Markoff, S.
Amans, J.-P.
Russo, F.
Suomijärvi, T.
Fiandrini, E.
Spencer, S.T.
Marinos, P.
Pérez-Romero, J.
Rando, R.
Vaclavek, L.
Kubo, H.
Schipani, P.
Della Valle, M.
Pech, M.
Komin, N.
Tanaka, S.J.
Feng, Q.
Adam, R.
Mariotti, M.
Djuvsland, J.
Pagliaro, A.
La Palombara, N.
Maier, G.
Villanueva, J.
Ferrarotto, F.
Vazquez Acosta, M.L.
Rico, J.
Lyard, E.
Zuriaga-Puig, J.
Gallant, Y.A.
Bylund, T.
de Ona Wilhelmi, E.
Vigorito, C.F.
Vuillaume, T.
Caroff, S.
della Volpe, D.
Meunier, J.-L.
Carquin, E.
Yamazaki, R.
Hara, S.
Ohishi, M.
Jurysek, J.
Horvath, P.
Kalekin, O.
Ribó, M.
Rieger, F.
Rodriguez Fernandez, G.
Jiménez Martínez, I.
Ravel, T.
Fioretti, V.
Gueta, O.
Guillemot, L.
Cristofari, P.
Sarkar, S.
Hermann, G.
Duangchan, C.
Okumura, A.
Arcaro, C.
Burtovoi, A.
Acharyya, A.
Schiavone, F.
Remy, Q.
Cantlay, B.K.
Richtler, T.
Iocco, F.
Cerruti, M.
Scherer, A.
Fontaine, G.
Incardona, F.
Kerszberg, D.
Fattorini, A.
Manicò, G.
Ballet, J.
Voutsinas, G.
Kataoka, J.
Baxter, J.
Molero, M.
Eckner, C.
Hinton, J.
Ascasíbar, Y.
Toussenel, F.
Nemmen, R.
Piano, G.
Petrucci, P.-O.
Vorobiov, S.
Malyshev, D.
Berti, A.
Orienti, M.
Mastropietro, M.
Blazek, J.
Jamrozy, Marek
Wechakama, M.
Funk, S.
Moya Zamanillo, V.
Heckmann, L.
Laporte, P.
Marquez, P.
Aschersleben, J.
Tavecchio, F.
Voisin, V.
Baquero Larriva, A.
Zampieri, L.
Ambrosi, G.
Conte, F.
Biederbeck, N.
Morselli, A.
Marty, C.
Escudero, J.
Knödlseder, J.
Egberts, K.
Di Piano, A.
Alvarez-Crespo, N.
Furniss, A.
Saha, L.
Amato, E.
Belmont, R.
Muraishi, H.
Stamerra, A.
Romeo, G.
Vink, J.
Queiroz, F.
Williams, D.A.
Domínguez, A.
Yoshida, T.
Reimer, O.
Nakamori, T.
Hrabovsky, M.
Giordano, F.
Bernlöhr, K.
Brown, A.M.
Green, J.G.
Pueschel, E.
Reposeur, T.
Viaux, N.
Lindfors, E.
Steinmassl, S.
Meyer, D.M.-A.
Goldoni, P.
Mello, A.J.T.S.
Arrabito, L.
Fukazawa, Y.
Paoletti, R.
Gasbarra, C.
Sliusar, V.
Di Pierro, F.
Depaoli, D.
Backes, M.
Esposito, P.
Kluźniak, W.
Persic, M.
Escarate, P.
Barbosa Martins, V.
Mestre, E.
Ohtani, Y.
Umana, G.
Balazs, C.
Touzard, V.
Rudak, B.
Terrier, R.
Sguera, V.
Peresano, M.
Bucciantini, N.
Tajima, H.
Grenier, I.
Servillat, M.
Tothill, N.
Michałowski, J.
Prandini, E.
Jin, W.
Lenain, J.-P.
Orlandini, M.
Panebianco, G.
Lazarević, S.
Iori, M.
Martin, P.
Doro, M.
Burelli, I.
Batzofin, R.
Carosi, A.
Juramy-Gilles, C.
Orito, R.
de Souza, V.
Parmiggiani, N.
Burton, M.
Giuffrida, R.
Tutone, A.
Smith, D.A.
Bonollo, A.
Blanch, O.
Pintore, F.
Dominik, R.M.
Delgado, C.
Schussler, F.
D'Aì, A.
Falceta-Goncalves, D.
Alfaro, J.
Costa, A.
Fiori, M.
Torradeflot, F.
Schubert, J.L.
Delgado Giler, A.G.
Nieto, D.
Teshima, M.
Ong, R.A.
Hassan, T.
Ostrowski, Michał
Schwanke, U.
Schwefer, G.
Zavrtanik, M.
Romano, P.
Ebr, J.
Caproni, A.
Moulin, E.
Patricelli, B.
Verna, G.
Kaufmann, S.
Santangelo, A.
Chambery, P.
Fegan, S.
Morik, K.
Produit, N.
Tavernier, T.
Paredes, J.M.
Kobayashi, Y.
Gaggero, D.
Karas, V.
Grondin, M.-H.
Emery, G.
Flores, H.
Munari, K.
Beck, G.
de Gouveia Dal Pino, E.M.
Heller, M.
Harvey, V.M.
Biteau, J.
Contreras, J.L.
Roache, E.
Batković, I.
Einecke, S.
Fiasson, A.
López-Oramas, A.
Miranda, J.M.
Loporchio, S.
Molfese, C.
Priyadarshi, C.
Dinesh, A.
Yang, L.
Kushida, J.
Bocchino, F.
Razzaque, S.
Hovatta, T.
Martínez, G.A.
Hadasch, D.
González, J.M.
Jean, P.
Costantini, H.
Campoy-Ordaz, A.
Diebold, S.
Bhattacharyya, S.
Mohrmann, L.
Kantzas, D.
Dell'aiera, M.
Wagner, S.J.
Murach, T.
Capuzzo-Dolcetta, R.
Niemiec, J.
Linhoff, M.
Petruk, O.
Cuevas, O.
Nikołajuk, M.
Noda, K.
Acero, F.
Aguasca-Cabot, A.
Zavrtanik, D.
Cortina, J.
Podobnik, F.
Stawarz, Łukasz
David, L.
Spiga, D.
Barres de Almeida, U.
Molina, E.
Paneque, D.
Tibaldo, L.
Pagano, I.
Abhir, J.
Conforti, V.
Kohri, K.
Mandat, D.
Hnatyk, R.
D'Ammando, F.
Díaz, C.
Martí, J.
Waegebaert, V.
Pecimotika, M.
Zanin, R.
Novotny, V.
Sol, H.
Vercellone, S.
Kleiner, T.
de Bony de Lavergne, M.
Oya, I.
Rulten, C.B.
Bonneau Arbeletche, L.
Trois, A.
Glombitza, J.
Cassol, F.
Schleicher, B.
Dadina, M.
Fukui, Y.
Kazanas, D.
Granot, J.
McKeague, S.
Bi, B.
Nagataki, S.
Pohl, M.
Dazzi, F.
Evoli, C.
Schovanek, P.
Hayashi, K.
Grau, R.
Saturni, F.G.
Brun, F.
Vallania, P.
Giuliani, A.
Carosi, R.
Montaruli, T.
Lapington, J.
Filipovic, M.
Pühlhofer, G.
Benbow, W.
Kissmann, R.
Miceli, D.
Mazin, D.
Godinovic, N.
De Caprio, V.
Hofmann, W.
Hervet, O.
Di Venere, L.
Pietropaolo, E.
Goulart Coelho, J.
Kowal, G.
Bertucci, B.
Pérez-Torres, M.A.
Sergijenko, O.
Saito, T.
Giarrusso, M.
Zhdanov, V.I.
Walter, R.
Šarić, T.
Donini, A.
Escanuela, C.
Ribeiro, D.
Grolleron, G.
Rowell, G.
Santander, M.
Starling, R.
Pons, E.
Inada, T.
Principe, G.
Torres, D.F.
Morlino, G.
Dwarkadas, V.V.
Zech, A.
Mackey, J.
White, R.
Chaty, S.
Angüner, E.O.
Michailidis, M.
D'Amico, G.
Hackfeld, J.
Seitenzahl, I.
De Lucia, M.
Pittori, C.
Aramo, C.
Sharma, P.
Mereghetti, S.
Galanti, G.
Bulgarelli, A.
Gammaldi, V.
Ghalumyan, A.
Vigliano, A.
Becerra González, J.
Sadeh, I.
Kluge, G.
Martinez, O.
Gasparrini, D.
Castro-Tirado, A.J.
Zdziarski, A.A.
Aguirre-Santaella, A.
Láinez, M.
Peron, G.
La Barbera, A.
Patel, S.R.
Gunji, S.
Katagiri, H.
Escobar Godoy, M.
Rizi, V.
Pihet, M.
Punch, M.
Mitchell, A.
Cerasole, D.
De Lotto, B.
Galaz, G.
Bissaldi, E.
Živec, M.
Bernete, J.
Chiavassa, A.
Hanlon, W.
Vassiliev, V.
Moderski, R.
Santos-Lima, R.
Djannati-Ataï, A.
Elsässer, D.
Di Girolamo, T.
Pavlović, D.
Glicenstein, J.-F.
Rosado, J.
Nievas Rosillo, M.
Longo, F.
Chytka, L.
Hiroshima, N.
Lamastra, A.
Plard, C.
Lemoine-Goumard, M.
Abhishek, A.
Bottacini, E.
Opis:
Approximately one hundred sources of very-high-energy (VHE) gamma rays are known in the Milky Way, detected with a combination of targeted observations and surveys. A survey of the entire Galactic Plane in the energy range from a few tens of GeV to a few hundred TeV has been proposed as a Key Science Project for the upcoming Cherenkov Telescope Array Observatory (CTAO). This article presents the status of the studies towards the Galactic Plane Survey (GPS). We build and make publicly available a sky model that combines data from recent observations of known gamma-ray emitters with state-of-the-art physically-driven models of synthetic populations of the three main classes of established Galactic VHE sources (pulsar wind nebulae, young and interacting supernova remnants, and compact binary systems), as well as of interstellar emission from cosmic-ray interactions in the Milky Way. We also perform an optimisation of the observation strategy (pointing pattern and scheduling) based on recent estimations of the instrument performance. We use the improved sky model and observation strategy to simulate GPS data corresponding to a total observation time of 1620 hours spread over ten years. Data are then analysed using the methods and software tools under development for real data. Under our model assumptions and for the realisation considered, we show that the GPS has the potential to increase the number of known Galactic VHE emitters by almost a factor of five. This corresponds to the detection of more than two hundred pulsar wind nebulae and a few tens of supernova remnants at average integral fluxes one order of magnitude lower than in the existing sample above 1 TeV, therefore opening the possibility to perform unprecedented population studies. The GPS also has the potential to provide new VHE detections of binary systems and pulsars, to confirm the existence of a hypothetical population of gamma-ray pulsars with an additional TeV emission component, and to detect bright sources capable of accelerating particles to PeV energies (PeVatrons). Furthermore, the GPS will constitute a pathfinder for deeper follow-up observations of these source classes. Finally, we show that we can extract from GPS data an estimate of the contribution to diffuse emission from unresolved sources, and that there are good prospects of detecting interstellar emission and statistically distinguishing different scenarios. Thus, a survey of the entire Galactic plane carried out from both hemispheres with CTAO will ensure a transformational advance in our knowledge of Galactic VHE source populations and interstellar emission.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
Frequency and prognostic impact of ALK amplifications and mutations in the European Neuroblastoma Study Group (SIOPEN) High-Risk Neuroblastoma Trial (HR-NBL1)
Autorzy:
Popovic-Beck, Maja
Bown, Nick
Font de Mora, Jaime
Noguera, Rosa
Taschner-Mandl, Sabine
Muhlethaler-Mottet, Annick
Laureys, Genevieve
Malis, Josef
Pierron, Gaelle
Kogner, Per
Rossing, Maria
Combaret, Valerie
Chesler, Louis
Castel, Victoria
Luksch, Roberto
Tweddle, Deborah A.
Bellini, Angela
de Preter, Katleen
Ladenstein, Ruth
George, Sally L.
Ambros, Peter F.
Baulande, Sylvain
Beiske, Klaus
Marques, Barbara
Ash, Shifra
Clement, Nathalie
van Roy, Nadine
Valteau-Couanet, Dominique
Balwierz, Walentyna
Schleiermacher, Gudrun
Martinsson, Tommy
Vicha, Ales
Delattre, Olivier
Auger, Nathalie
Jeison, Marta
Morini, Martina
Betts, David R.
Bhalshankar, Jaydutt
Lapouble, Eve
Elliott, Martin
Bernkopf, Marie
Mazzocco, Katia
Potschger, Ulrike
Bernard, Virginie
Jimenez, Irene
Opis:
Purpose: In neuroblastoma (NB), the ALK receptor tyrosine kinase can be constitutively activated through activating point mutations or genomic amplification. We studied ALK genetic alterations in high-risk (HR) patients on the HR-NBL1/SIOPEN trial to determine their frequency, correlation with clinical parameters, and prognostic impact. Materials and Methods: Diagnostic tumor samples were available from 1,092 HR-NBL1/SIOPEN patients to determine ALK amplification status (n = 330), ALK mutational profile (n = 191), or both (n = 571). Results: Genomic ALK amplification (ALKa) was detected in 4.5% of cases (41 out of 901), all except one with MYCN amplification (MNA). ALKa was associated with a significantly poorer overall survival (OS) (5-year OS: ALKa [n = 41] 28% [95% CI, 15 to 42]; no-ALKa [n = 860] 51% [95% CI, 47 to 54], [P < .001]), particularly in cases with metastatic disease. ALK mutations (ALKm) were detected at a clonal level (> 20% mutated allele fraction) in 10% of cases (76 out of 762) and at a subclonal level (mutated allele fraction 0.1%-20%) in 3.9% of patients (30 out of 762), with a strong correlation between the presence of ALKm and MNA (P < .001). Among 571 cases with known ALKa and ALKm status, a statistically significant difference in OS was observed between cases with ALKa or clonal ALKm versus subclonal ALKm or no ALK alterations (5-year OS: ALKa [n = 19], 26% [95% CI, 10 to 47], clonal ALKm [n = 65] 33% [95% CI, 21 to 44], subclonal ALKm (n = 22) 48% [95% CI, 26 to 67], and no alteration [n = 465], 51% [95% CI, 46 to 55], respectively; P = .001). Importantly, in a multivariate model, involvement of more than one metastatic compartment (hazard ratio [HR], 2.87; P < .001), ALKa (HR, 2.38; P = .004), and clonal ALKm (HR, 1.77; P = .001) were independent predictors of poor outcome. Conclusion: Genetic alterations of ALK (clonal mutations and amplifications) in HR-NB are independent predictors of poorer survival. These data provide a rationale for integration of ALK inhibitors in upfront treatment of HR-NB with ALK alterations.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
    Wyświetlanie 1-2 z 2

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