Autor: Blom, A. - Prolib Integro

Skocz do pozycji: 1.

Tytuł:: Population parameters of fallow deer at Dońana National Park (SW Spain)
Autorzy:: Blom, A.
Garcia, J. E.
Braza, F.
Cases, V.
San José, C.
Powiązania:: Acta Theriologica
Opis:: In order to know the reproductive and social status of fallow deer Dama dama (Linnaeus, 1758) populations at Dońana National Park and analyze the infuence of climatic factors and population density on the reproductive performance of females and males, periodic counts were conducted from September 1982 to September 1988.
Dostawca treści:: RCIN - Repozytorium Cyfrowe Instytutów Naukowych

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Skocz do pozycji: 2.

Tytuł:: Serum complement activation by C4BP-IgM fusion protein can restore susceptibility to antibiotics in Neisseria gonorrhoeae
Autorzy:: Bettoni, Serena
Ram, Sanjay
Blom, Anna M.
Unemo, Magnus
Stone, M. Rhia L.
Maziarz, Karolina
Bazzo, Maria Luiza
Potempa, Jan
Blaskovich, Mark A. T.
Opis:: Neisseria gonorrhoeae is the etiological agent of gonorrhea, the second most common bacterial sexually transmitted infection worldwide. Reproductive sequelae of gonorrhea include infertility, ectopic pregnancy and chronic pelvic pain. Most antibiotics currently in clinical use have been rendered ineffective due to the rapid spread of antimicrobial resistance among gonococci. The developmental pipeline of new antibiotics is sparse and novel therapeutic approaches are urgently needed. Previously, we utilized the ability of N. gonorrhoeae to bind the complement inhibitor C4b-binding protein (C4BP) to evade killing by human complement to design a chimeric protein that linked the two N-terminal gonococcal binding domains of C4BP with the Fc domain of IgM. The resulting molecule, C4BP-IgM, enhanced complement-mediated killing of gonococci. Here we show that C4BP-IgM induced membrane perturbation through complement deposition and membrane attack complex pore insertion facilitates the access of antibiotics to their intracellular targets. Consequently, bacteria become more susceptible to killing by antibiotics. Remarkably, C4BP-IgM restored susceptibility to azithromycin of two azithromycin-resistant clinical gonococcal strains because of overexpression of the MtrC-MtrD-MtrE efflux pump. Our data show that complement activation can potentiate activity of antibiotics and suggest a role for C4BP-IgM as an adjuvant for antibiotic treatment of drug-resistant gonorrhea.
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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Skocz do pozycji: 3.

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Skocz do pozycji: 4.

Autorzy:: Jankowski, Piotr
Shiba, Mariko H.
Almahmeed, Wael
Wood, David
Lloyd-Jones, Donald
Puri, Raman
Alonso, Rodrigo
Perel, Pablo
Ray, Kausik K.
Pinto, Fausto
Zhao, Dong
Olmo, Rosa Fernandez
Ference, Brian A.
Ezhov, Marat
Mehta, Roopa
Nicholls, Stephen J.
Blom, Dirk
Daccord, Magdalena
Lanas, Fernando
Virani, Salim S.
Santos, Raul D.
Gidding, Samuel S.
Severin, Tania
Wong, Nathan D.
Opis:: Background: Atherosclerotic cardiovascular diseases (ASCVD) including myocardial infarction, stroke and peripheral arterial disease continue to be major causes of premature death, disability and healthcare expenditure globally. Preventing the accumulation of cholesterol-containing atherogenic lipoproteins in the vessel wall is central to any healthcare strategy to prevent ASCVD. Advances in current concepts about reducing cumulative exposure to apolipoprotein B (apo B) cholesterol-containing lipoproteins and the emergence of novel therapies provide new opportunities to better prevent ASCVD. The present update of the World Heart Federation Cholesterol Roadmap provides a conceptual framework for the development of national policies and health systems approaches, so that potential roadblocks to cholesterol management and thus ASCVD prevention can be overcome. Methods: Through a review of published guidelines and research papers since 2017, and consultation with a committee composed of experts in clinical management of dyslipidaemias and health systems research in low-and-middle income countries (LMICs), this Roadmap identifies (1) key principles to effective ASCVD prevention (2) gaps in implementation of these interventions (knowledge-practice gaps); (3) health system roadblocks to treatment of elevated cholesterol in LMICs; and (4) potential strategies for overcoming these. Results: Reducing the future burden of ASCVD will require diverse approaches throughout the life-course. These include: a greater focus on primordial prevention; availability of affordable cholesterol testing; availability of universal cholesterol screening for inherited dyslipidaemias; risk stratification moving beyond 10-year risk to look at lifetime risk with adequate risk estimators; wider availability of affordable cholesterol-lowering therapies which should include statins as essential medications globally; use of adequate doses of potent statin regimens; and combination therapies with ezetimibe or other therapies in order to attain and maintain robust reductions in LDL-C in those at highest risk. Continuing efforts are needed on health literacy for both the public and healthcare providers, utilising multi-disciplinary teams in healthcare and applications that quantify both ASCVD risk and benefits of treatment as well as increased adherence to therapies. Conclusions: The adverse effects of LDL-cholesterol and apo B containing lipoprotein exposure are cumulative and result in ASCVD. These are preventable by implementation of different strategies, aimed at efficiently tackling atherosclerosis at different stages throughout the human life-course. Preventive strategies should therefore be updated to implement health policy, lifestyle changes and when needed pharmacotherapies earlier with investment in, and a shift in focus towards, early preventive strategies that preserve cardiovascular health rather than treat the consequences of ASCVD.
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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Skocz do pozycji: 5.

Tytuł:: Measurement of the electron structure function $F_{2}^{e}$ at LEP energies
Autorzy:: Fuster, J.
Zalewska, A.
Veloso, F.
Benvenuti, A.
Cavallo, F.
Pukhaeva, N.
Todorovova, S.
Petrolini, A.
Benekos, N.
Mazzucato, F.
Moenig, K.
Treille, D.
Begalli, M.
Rovelli, T.
Meroni, C.
Sokolov, A.
Abdallah, J.
Wicke, D.
Siebel, M.
Van Vulpen, I.
Spassov, T.
Zavrtanik, D.
Ferrer, A.
Szumlak, T.
Wickens, J.
Sander, C.
Jarry, P.
Muryn, B.
Borisov, G.
Crennell, D.
De Maria, N.
Tonazzo, A.
Barker, G. J.
Garcia, C.
Berat, C.
Mandl, F.
Amato, S.
Nikolenko, M.
Ferro, F.
Ruhlmann-Kleider, V.
Asman, B.
Lesiak, T.
Adzic, P.
Liebig, W.
Tobin, M.
Matorras, F.
Mazzucato, M.
Lyons, L.
Fernandez, J.
van Remortel, N.
Andreazza, A.
Tzamarias, S.
Katsoufis, E.
Ballestrero, A.
Flagmeyer, U.
Stugu, B.
Zupan, M.
Di Ciaccio, L.
Rivero, M.
Behrmann, A.
De Boer, W.
Contri, R.
Mulders, M.
Myklebust, T.
Bertrand, D.
Blom, M.
Augustin, J. E.
Jonsson, P.
Brenner, R.
Myatt, G.
Romero, A.
Ouraou, A.
Tortosa, P.
Della Ricca, G.
Oyanguren, A.
Kapusta, F.
da Silva, T.
Parkes, C.
Ellert, M.
Ryabtchikov, D.
Abreu, P.
Piotto, E.
Orava, R.
Vitale, L.
Zimin, N. I.
Drees, J.
Vrba, V.
Winter, M.
Lutz, P.
Kouznetsov, O.
Jackson, J. N.
Sosnowski, R.
Szczekowski, M.
Moa, T.
Arnoud, Y.
Mueller, U.
Smadja, G.
Krumstein, Z.
Bonesini, M.
Augustinus, A.
Camporesi, T.
Ben-Haim, E.
Johansson, E. K.
Jungermann, L.
Grosdidier, G.
Muenich, K.
Besancon, M.
Mariotti, C.
Ask, S.
Pimenta, M.
Salmi, L.
Anjos, N.
Boyko, I.
Renton, P.
Belous, K.
Chudoba, J.
Palacios, J. P.
Castro, N.
Allport, P. P.
Trochimczuk, M.
Moreno, S.
Sisakian, A.
Eigen, G.
Liko, D.
Bowcock, T. J. W.
Cuevas, J.
Haug, S.
Rodriguez, D.
Apel, W-D.
MacNaughton, J.
Ledroit, F.
Moraes, D.
Baroncelli, A.
De Clercq, C.
Buschmann, P.
Martinez-Rivero, C.
Tome, B.
Bambade, P.
Di Simone, A.
Polok, G.
Leinonen, L.
Carena, F.
Bouquet, B.
Booth, P. S. L.
Leder, G.
Elsing, M.
Holmgren, S-O.
Podobnik, T.
Yushchenko, O.
Stanitzki, M.
Kerzel, U.
Antilogus, P.
Uvarov, V.
Gavillet, Ph.
Cossutti, F.
Vilanova, D.
Lepeltier, V.
Poireau, V.
Pozdniakov, V.
Olshevski, A.
Botner, O.
Gomez-Ceballos, G.
Reid, D.
Mundim, L.
Albrecht, T.
Van Eldik, J.
Battaglia, M.
Haag, C.
de Paula, L.
Smirnova, O.
Margoni, M.
Papadopoulou, Th. D.
Chierici, R.
Marin, J-C.
Migliore, E.
Brunet, J. M.
Tkatchev, L.
Cieslik, K.
Mastroyiannopoulos, N.
Fokitis, E.
Maltezos, S.
Costa, M. J.
Katsanevas, S.
Pierre, F.
Bluj, M.
Malek, A.
Berggren, M.
Barbier, R.
D'Hondt, J.
Nawrocki, K.
Brodet, E.
Hedberg, V.
King, B. T.
Zintchenko, A.
Passon, O.
Buschbeck, B.
Nicolaidou, R.
Hauler, F.
Turluer, M-L.
Verzi, V.
Marechal, B.
Sopczak, A.
Richard, F.
Hallgren, A.
Fanourakis, G.
Pape, L.
Hennecke, M.
Radojicic, D.
Guy, J.
Parodi, F.
Washbrook, A. J.
Onofre, A.
Salt, J.
Adam, W.
Paganoni, M.
Baillon, P.
Loukas, D.
Tabarelli, T.
Marco, J.
Doroba, K.
Wilkinson, G.
Kucharczyk, M.
Gokieli, R.
Ronchese, P.
Nemecek, S.
Oblakowska-Mucha, A.
Verdier, P.
Nassiakou, M.
Valenti, G.
Kluit, P.
Passeri, A.
Markou, A.
Chapkin, M.
Foeth, H.
Gazis, E.
De Lotto, B.
Vegni, G.
Fulda-Quenzer, F.
Leitner, R.
Matteuzzi, C.
Hamilton, K.
Hamacher, K.
Weiser, C.
Jeans, D.
Cosme, G.
Bloch, D.
Pieri, L.
Ridky, M.
Amapane, N.
Murray, W.
Baubillier, M.
Kernel, G.
Szwed, Jerzy
Allmendinger, T.
Bruckman, P.
Perrotta, A.
Jarlskog, G.
Zhuravlov, V.
Mjoernmark, U.
Montenegro, J.
Ekelof, T.
Checchia, P.
Witek, M.
Sekulin, R.
Stocchi, A.
Tyapkin, I. A.
Piedra, J.
Mitaroff, W.
Chung, S. U.
Bracko, M.
Obraztsov, V.
Schwickerath, U.
Goncalves, P.
Parzefall, U.
Chliapnikov, P.
Marco, R.
Mc Nulty, R.
Espirito Santo, M. C.
Troncon, C.
Becks, K-H.
Osterberg, K.
Fassouliotis, D.
Collins, P.
Lamsa, J.
Pol, M. E.
Rebecchi, P.
Zalewski, P.
Roudeau, P.
Venus, W.
Da Silva, W.
Palka, H.
Savoy-Navarro, A.
Graziani, E.
Morettini, P.
Perepelitsa, V.
Grzelak, K.
Wahlen, H.
Bardin, D.
Kourkoumelis, C.
Moch, M.
Feindt, M.
Kjaer,N. J.
Lipniacka, A.
Golob, B.
Sadovsky, A.
Rehn, J.
Andringa, S.
Navarria, F.
De Min, A.
Strauss, J.
Besson, N.
VanDam, P.
Timmermans, J.
Charpentier, Ph.
Szeptycka, M.
Alemany-Fernandez, R.
Peralta, L.
Tegenfeldt, F.
Houlden, M. A.
Masik, J.
Hoffman, J.
Lopes, J. H.
Lemonne, J.
Travnicek, P.
Joram, C.
Monge, R.
Kersevan, B. P.
Tristram, G.
Boonekamp, M.
Gandelman, M.
Holt, P. J.
Amaldi, U.
Kokkinias, P.
Pullia, A.
Anashkin, E.
Lopez, J. M.
Reinhardt, R.
Canale, V.
Paiano, S.
Słomiński, Wojciech
De Angelis, A.
Calvi, M.
Opis:: The hadronic part of the electron structure function $F_{2}^{e}$ has been measured for the first time, using $e^{+}e^{-} $ data collected by the DELPHI experiment at LEP, at centre-of-mass energies of $\sqrt{s}$=91.2-209.5 GeV. The data analysis is simpler than that of the measurement of the photon structure function. The electron structure function $F_{2}^{e}$ data are compared to predictions of phenomenological models based on the photon structure function. It is shown that the contribution of large target photon virtualities is significant. The data presented can serve as a cross-check of the photon structure function $F_{2}^{\gamma}$ analyses and help in refining existing parameterisations.
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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