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    Wyświetlanie 1-9 z 9
    Tytuł:
    Multifractal detrended fluctuation analysis of heart rate variability
    Autorzy:
    Bębas, Ewelina
    Kasperczuk, Anna
    Oczeretko, Edward
    Bossowski, Artur
    Borowska, Marta
    Tematy:
    fractal dimension
    heart rate variability
    ECG
    diabetes
    children
    multifractal detrended fluctuation analysis
    multifractal
    Pokaż więcej
    Wydawca:
    Politechnika Białostocka. Oficyna Wydawnicza Politechniki Białostockiej
    Powiązania:
    https://bibliotekanauki.pl/chapters/2204804.pdf  Link otwiera się w nowym oknie
    Opis:
    The analysis of heart rate variability can be used to predict cardiovascular state in diabetic children. Studies on HRV are mainly based on RR intervals of the ECG signal and include both linear indices and nonlinear characteristics. The current study aims at applying Multifractal Detrended Fluctuation Analysis to investigate signals of the heart rate variability (HRV) in 50 healthy children (group K), 27 patients suffering from diabetes type 1 without subsequent vascular complications (group A) and 35 patients suffering from diabetes type 1 with subsequent vascular complications (hypertension) (group B). Multifractal features were extracted to quantitatively compare signal complexity between the healthy group and the group of children with diabetes and diabetes with complications. The MFDFA analysis showed the multi-fractional nature of the signals in all groups. The characteristic MFDFA parameters were determined and subjected to statistical analysis. It showed differences in parameters h(1) and h(2) between the control group K and group A. This gives rise to the development of further research in an attempt to distinguish between these groups.
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    CTLA-4 polymorphisms (+49 A/G and -318 C/T) are important genetic determinants of AITD susceptibility and predisposition to high levels of thyroid autoantibodies in Polish children - preliminary study
    Autorzy:
    Pastuszak-Lewandoska, Dorota
    Domańska, Daria
    Rudzińska, Magdalena
    Bossowski, Artur
    Kucharska, Anna
    Sewerynek, Ewa
    Czarnecka, Karolina
    Migdalska-Sęk, Monika
    Czarnocka, Barbara
    Tematy:
    Graves' disease
    Hashimoto's thyroiditis
    autoimmune thyroid disease
    CTLA-4
    single nucleotide polymorphism
    TAb production
    Pokaż więcej
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Powiązania:
    https://bibliotekanauki.pl/articles/1039459.pdf  Link otwiera się w nowym oknie
    Opis:
    Autoimmune thyroid diseases (AITDs), including Hashimoto' s thyroiditis (HT) and Graves' disease (GD), are related to environmental and genetic factors. We analyzed the association of cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) gene two polymorphisms (+49 A/G, -318 C/T) with HT and GD development in Polish children, and correlated both polymorphisms with the production of thyroid autoantibodies (TPOAb and TgAb). The study involved 49 AITD patients (age 10-19) with HT (n=25) or GD (n=24) and 69 healthy controls. SNP genotyping was performed using genomic DNA and TaqMan® probes. The obtained results indicated that CTLA-4 +49 GG genotype was significantly more frequent in both HT and GD patients, whereas the AA genotype was more common in controls. CTLA-4-318 CT genotype was significantly more frequent in AITD, and the CC genotype more often occurred in controls. Significantly higher median TPOAb and TgAb values were associated with G allele in HT, and with T allele in GD patients. Concluding, both studied polymorphisms seem to be important genetic determinants of the risk of HT and GD, and appear to be associated with a predisposition to high levels of TAbs and clinical AITD. The obtained results give more information on the distribution of the CTLA-4 polymorphism in Polish AITD children, and further support the proposal that the CTLA-4 gene plays an important role in a TAb production.
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Response to treatment with recombinant human growth hormone (rhGH) of short stature children born too small for gestational age (SGA) in selected centres in Poland
    Autorzy:
    Pyrżak, Beata
    Paluchowska, Monika
    Petriczko, Elżbieta
    Wikiera, Beata
    Wędrychowicz, Anna
    Starzyk, Jerzy
    Stożek, Karolina
    Antosz, Aleksandra
    Bossowski, Artur
    Walczak, Mieczysław
    Gawlik, Aneta
    Majcher, Anna
    Glińska, Marta
    Kusz, Marcin
    Opis:
    Short stature resulting from SGA is an obligatory indication for treatment with rhGH. The aim of the study was to assess the response to rhGH treatment in patients treated in the years 2016–2020 in six clinical centers in Poland. During the analysis, auxological data were collected, and anthropometrical parameters (Ht, SDS Ht, HV and ΔHV) were reassessed. Subgroups of patients with dysmorphic features (DYSM), fetal alcohol syndrome (FAS) and Silver-Russel syndrome (SRS) were selected. The study group consisted of 235 children (137 boys). The medium initial age was 9.08 years, and 190 patients were in the prepubertal stage. The poor response to treatment was defined as ΔHt SDS < 0.3 and/or ΔHV < 3 cm/year. Seventeen per cent of all patients after the first year and 44% after the second year met the ΔHt SDS < 0.3 criterion, and 56% during the first and 73% during the second year met the ΔHV < 3 cm/year criterion. Our data suggest that patients with SRS may show the best response to treatment, which was sustained throughout the follow-up period. The best response in all subgroups was observed during the first 12 months of therapy. Although the proportion of patients meeting the poor response criteria was high, only a few patients exceeded the 97th percentile for IGF-1 concentration during the first year of treatment. This might suggest that increasing the dose of rhGH in the second treatment year in order to sustain accelerated HV would be safe in these patients.
    Dostawca treści:
    Repozytorium Uniwersytetu Jagiellońskiego
    Artykuł
    Tytuł:
    Difficulties in interpreting IGF-1 levels in short stature children born small for gestational age (SGA) treated with recombinant human growth hormone (rhGH) based on data from six clinical centers in Poland
    Autorzy:
    Wędrychowicz, Anna
    Stożek, Karolina
    Paluchowska, Monika
    Wikiera, Beata
    Kusz, Marcin
    Starzyk, Jerzy
    Pyrżak, Beata
    Petriczko, Elżbieta
    Bossowski, Artur
    Glińska, Marta
    Antosz, Aleksandra
    Walczak, Mieczysław
    Gawlik, Aneta
    Majcher, Anna
    Opis:
    The assessment of IGF-1 concentrations is one of the parameters used for evaluating response to rhGH treatment. An increase in IGF-1 concentration positively correlates with growth improvement, whereas IGF-1 concentrations significantly above the reference range may increase the risk of possible side effects. The aim of this study was to evaluate the IGF-1 local reference ranges for the rhGH treatment centers concerned and to compare these values with the population reference ranges. A retrospective analysis was conducted on auxological data from 229 SGA patients who received rhGH treatment between 2016 and 2020 at six university clinical centers in Poland. The IGF-1 levels were assessed at baseline, after 12 and 24 months, and compared to the reference ranges provided by the local laboratory and to the population reference ranges. After 12 months, 56 patients (24%) presented IGF-1 values > 97th percentile for the local reference range, whereas only 8 (3.5%) did so using the population reference ranges; p < 0.001. After 24 months of treatment, the values were: 47 (33%) > 97th percentile by local vs. 6 (4.2%) by population standards; p < 0.001. Thirty-nine patients had rhGH dose reduced after 12 months, of whom twelve (25%) had IGF-1 > 97th percentile according to the local reference ranges and five (13%) > 97th percentile for the population. Our data suggest that different methods used to determine IGF-1 concentration and the different IGF-1 reference ranges result in a significant proportion of rhGH-treated children with elevated IGF-1 concentration and experiencing dose reductions, which may negatively affect growth rate.
    Dostawca treści:
    Repozytorium Uniwersytetu Jagiellońskiego
    Artykuł
    Autorzy:
    Ruchała, Marek
    Bleizgys, Andrius
    Jackowska, Teresa
    Płudowski, Paweł
    Bossowski, Artur
    Targowski, Tomasz
    Lauterbach, Ryszard
    Pinkas, Jarosław
    Pyrżak, Beata
    Szalecki, Mieczysław
    Kos-Kudła, Beata
    Lewiński, Andrzej
    Konstantynowicz, Jerzy
    Marcinowska-Suchowierska, Ewa
    Zozulińska-Ziółkiewicz, Dorota
    Walczak, Mieczysław
    Fal, Andrzej
    Karras, Spirydon N.
    Pilz, Stefan
    Carlberg, Carsten
    Czech-Kowalska, Justyna
    Misiorowski, Waldemar
    Helwich, Ewa
    Grant, William B.
    Holick, Michael F.
    Peregud-Pogorzelski, Jarosław
    Wielgoś, Mirosław
    Zygmunt, Arkadiusz
    Sieroszewski, Piotr
    Mazur, Artur
    Wójcik, Marek
    Spaczyński, Robert
    Abramowicz, Paweł
    Żmijewski, Michał A.
    Opis:
    Introduction: All epidemiological studies suggest that vitamin D deficiency is prevalent among the Polish general population. Since vitamin D deficiency was shown to be among the risk factors for many diseases and for all-cause mortality, concern about this problem led us to update the previous Polish recommendations. Methods: After reviewing the epidemiological evidence, case-control studies and randomized control trials (RCTs), a Polish multidisciplinary group formulated questions on the recommendations for prophylaxis and treatment of vitamin D deficiency both for the general population and for the risk groups of patients. The scientific evidence of pleiotropic effects of vitamin D as well as the results of panelists’ voting were reviewed and discussed. Thirty-four authors representing different areas of expertise prepared position statements. The consensus group, representing eight Polish/international medical societies and eight national specialist consultants, prepared the final Polish recommendations. Results: Based on networking discussions, the ranges of total serum 25-hydroxyvitamin D concentration indicating vitamin D deficiency [<20 ng/mL (<50 nmol/L)], suboptimal status [20–30 ng/mL (50–75 nmol/L)], and optimal concentration [30–50 ng/mL (75–125 nmol/L)] were confirmed. Practical guidelines for cholecalciferol (vitamin D3) as the first choice for prophylaxis and treatment of vitamin D deficiency were developed. Calcifediol dosing as the second choice for preventing and treating vitamin D deficiency was introduced. Conclusions: Improving the vitamin D status of the general population and treatment of risk groups of patients must be again announced as healthcare policy to reduce a risk of spectrum of diseases. This paper offers consensus statements on prophylaxis and treatment strategies for vitamin D deficiency in Poland.
    Dostawca treści:
    Repozytorium Uniwersytetu Jagiellońskiego
    Artykuł
      Wyświetlanie 1-9 z 9

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