Autor: Chen, Jessica - Prolib Integro

Skocz do pozycji: 1.

Tytuł:: Pirtobrutinib in relapsed or refractory B-cell malignancies (BRUIN) : a phase 1/2 study
Autorzy:: Cheah, Chan Y.
Woyach, Jennifer A.
Flinn, Ian W.
Alencar, Alvaro
Gerson, James N.
Wallin, Johan
Ghia, Paolo
Abdel-Wahab, Omar
Fenske, Timothy S.
Ku, Nora C.
Tan, Xuan Ni
Taylor, Justin
Fakhri, Bita
Shah, Nirav N.
Chen, Jessica
Lewis, Katharine L.
Yin, Ming
Nair, Binoj
Schuster, Stephen J.
Marella, Narasimha
Brown, Jennifer R.
Ebata, Kevin
Lamanna, Nicole
Cohen, Jonathon B.
Patel, Manish R.
Jurczak, Wojciech
Eyre, Toby A.
Barve, Minal A.
Kuss, Bryone
Palomba, M. Lia
Sundaram, Suchitra
Coombs, Catherine C.
Wang, Michael
Mato, Anthony R.
Lech-Maranda, Ewa
Le Gouill, Steven
Roeker, Lindsey E.
Tsai, Donald E.
Pagel, John M.
Wierda, William G.
Davids, Matthew S.
Lewis, David John
Zhu, Edward
Tam, Constantine S.
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

Artykuł

na półce

Skocz do pozycji: 2.

Tytuł:: AXL targeting by a specific small molecule or monoclonal antibody inhibits renal cell carcinoma progression in an orthotopic mice model
Autorzy:: Blø, Magnus
Lorens, James
Osman, Tarig
Gausdal, Gro
Kamińska, Marta
Chen, Tony J.
Furriol, Jessica
Kalucka, Urszula
Marti, Hans-Peter
Benedyk-Machaczka, Małgorzata
Mydel, Piotr
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

Artykuł

na półce

Skocz do pozycji: 3.

Tytuł:: Network analysis of neuropsychiatric, cognitive, and functional complications of stroke : implications for novel treatment targets
Autorzy:: Lam, Ben
Sachdev, Perminder S.
Chen, Christopher
Traykov, Latchezar
Oestreich, Lena K.L.
Desmond, David W.
Klimkowicz-Mrowiec, Aleksandra
Wright, Paul
Di Biase, Maria A.
Mok, Alice H.
van Oostenbrugge, Robert
Crawford, John D.
Bordet, Régis
Yu, Kyung‐Ho
O'Sullivan, Michael J.
Lee, Minwoo
Staals, Julie E.A.
Lo, Jessica W.
Köhler, Sebastian
Zalesky, Andrew
Opis:: Aim: Recovery from stroke is adversely affected by neuropsychiatric complications, cognitive impairment, and functional disability. Better knowledge of their mutual relationships is required to inform effective interventions. Network theory enables the conceptualization of symptoms and impairments as dynamic and mutually interacting systems. We aimed to identify interactions of poststroke complications using network analysis in diverse stroke samples. Methods: Data from 2185 patients were sourced from member studies of STROKOG (Stroke and Cognition Consortium), an international collaboration of stroke studies. Networks were generated for each cohort, whereby nodes represented neuropsychiatric symptoms, cognitive deficits, and disabilities on activities of daily living. Edges characterized associations between them. Centrality measures were used to identify hub items. Results: Across cohorts, a single network of interrelated poststroke complications emerged. Networks exhibited dissociable depression, apathy, fatigue, cognitive impairment, and functional disability modules. Worry was the most central symptom across cohorts, irrespective of the depression scale used. Items relating to activities of daily living were also highly central nodes. Follow-up analysis in two studies revealed that individuals who worried had more densely connected networks than those free of worry (CASPER [Cognition and Affect after Stroke: Prospective Evaluation of Risks] study: S = 9.72, P = 0.038; SSS [Sydney Stroke Study]: S = 13.56, P = 0.069). Conclusion: Neuropsychiatric symptoms are highly interconnected with cognitive deficits and functional disabilities resulting from stroke. Given their central position and high level of connectedness, worry and activities of daily living have the potential to drive multimorbidity and mutual reinforcement between domains of poststroke complications. Targeting these factors early after stroke may have benefits that extend to other complications, leading to better stroke outcomes.
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego