- Tytuł:
- Advances in targeting signal transduction pathways
- Autorzy:
-
Tafuri, Agostino
Laidler, Piotr
Donia, Marco
Mazzarino, Maria C.
Mijatovic, Sanja
Martelli, Alberto M.
Steelman, Linda S.
D'Assoro, Antonio B.
Libra, Massimo
Polesel, Jerry
Chappell, William H.
Abrams, Stephen L.
Maksimovic-Ivanic, Danijela
Montalto, Giuseppe
Umezawa, Kazuo
Sun, Lin
Candido, Severio
Malaponte, Grazia
Cervello, Melchiorre
Davis, Nicole M.
Drobot, Lyudmyla
Demidenko, Zoya N.
Cocco, Lucio
Fagone, Paolo
Franklin, Richard A.
McCubrey, James A.
Milella, Michele
Chiarini, Francesca
Dulińska-Litewka, Joanna
Talamini, Renato
Evangelisti, Camilla
Nicoletti, Ferdinando
Basecke, Jorg
Ligresti, Giovanni - Opis:
- Over the past few years, significant advances have occurred in both our understanding of the complexity of signal transduction pathways as well as the isolation of specific inhibitors which target key components in those pathways. Furthermore critical information is being accrued regarding how genetic mutations can affect the sensitivity of various types of patients to targeted therapy. Finally, genetic mechanisms responsible for the development of resistance after targeted therapy are being discovered which may allow the creation of alternative therapies to overcome resistance. This review will discuss some of the highlights over the past few years on the roles of key signaling pathways in various diseases, the targeting of signal transduction pathways and the genetic mechanisms governing sensitivity and resistance to targeted therapies.
- Dostawca treści:
- Repozytorium Uniwersytetu Jagiellońskiego
Artykuł