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Wyświetlanie 1-10 z 43
Tytuł:
Clinical value of cholinesterase in patients treated with radical nephroureterectomy for upper urinary tract carcinoma
Autorzy:
von Deimling, Markus
Singla, Nirmish
Chłosta, Piotr
Shariat, Shahrokh F.
Majdoub, Muhammad
Soria, Francesco
Rajwa, Pawel
Teoh, Jeremy Yuen-Chun
Margulis, Vitaly
Pallauf, Maximilian
Laukhtina, Ekaterina
Moschini, Marco
Fisch, Margit
D'Andrea, David
Yanagisawa, Takafumi
Pradere, Benjamin
Rink, Michael
Kawada, Tatsushi
Lotan, Yair
Roupret, Morgan
Karakiewicz, Pierre I.
Opis:
Purpose To evaluate the prognostic value and the clinical impact of preoperative serum cholinesterase (ChoE) levels on decision-making in patients treated with radical nephroureterectomy (RNU) for clinically non-metastatic upper tract urothelial cancer (UTUC). Methods A retrospective review of an established multi-institutional UTUC database was performed. We evaluated preoperative ChoE as a continuous and dichotomized variable using a visual assessment of the functional form of the association of ChoE with cancer-specific survival (CSS). We used univariable and multivariable Cox regression models to establish its association with recurrence-free survival (RFS), CSS, and overall survival (OS). Discrimination was evaluated using Harrell's concordance index. Decision curve analysis (DCA) was used to assess the impact on clinical decision-making of preoperative ChoE. Results A total of 748 patients were available for analysis. Within a median follow-up of 34 months (IQR 15-64), 191 patients experienced disease recurrence, and 257 died, with 165 dying of UTUC. The optimal ChoE cutoff identified was 5.8 U/l. ChoE as continuous variable was significantly associated with RFS (p < 0.001), OS (p < 0.001), and CSS (p < 0.001) on univariable and multivariable analyses. The concordance index improved by 8%, 4.4%, and 7% for RFS, OS, and CSS, respectively. On DCA, including ChoE did not improve the net benefit of standard prognostic models. Conclusion Despite its independent association with RFS, OS, and CSS, preoperative serum ChoE has no impact on clinical decision-making. In future studies, ChoE should be investigated as part of the tumor microenvironment and assessed as part of predictive and prognostic models, specifically in the setting of immune checkpoint-inhibitor therapy.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
Positive family history as a predictor for disease outcomes after radical prostatectomy for nonmetastatic prostate cancer
Autorzy:
Chłosta, Piotr
Shariat, Shahrokh F.
Haydter, Martin
Korn, Stephan
Quhal, Fahad
Sari Motlagh, Reza
Karakiewicz, Pierre I.
König, Frederik
Briganti, Alberto
Pallauf, Maximilian
Ye, Ding-wei
Nyirady, Peter
Comperat, Eva
Gandaglia, Giorgio
Enikeev, Dmitry
Aydh, Abdulmajeed
Mostafaei, Hadi
Rajwa, Paweł
Petrov, Patrik
D'Andrea, David
Yanagisawa, Takafumi
Pradere, Benjamin
Marra, Giancarlo
Kawada, Tatsushi
Abufaraj, Mohammad
Laukhtina, Ekaterina
Opis:
Background While family history (FHx) of prostate cancer (PCa) increases the risk of PCa, comparably less is known regarding the impact of FHx on pathologic and oncologic outcomes after radical prostatectomy (RP). Methods We retrospectively reviewed our multicenter database comprising 6,041 nonmetastatic PCa patients treated with RP. Patients with a FHx of PCa in one or more first-degree relatives were considered as FHx positive. We examined the association of FHx with pathologic outcomes and biochemical recurrence (BCR) using logistic and Cox regression models, respectively. Results In total, 1,677 (28%) patients reported a FHx of PCa. Compared to patients without FHx, those with, were younger at RP (median age of 59 vs. 62 years, p < 0.01), and had significantlymore favorable biopsy and RP histopathologic findings. On multivariable logistic regression analysis, positive FHx was associated with extracapsular extension (odds ratio [OR] 0.77, 95% confidence interval [CI] 0.66–0.90, p < 0.01; model AUC 0.73) and upgrading (OR 0.70, 95% CI 0.62–0.80, p < 0.01; model AUC 0.68). Incorporating FHx significantly improved the AUC of the base model for upgrading (p < 0.01). Positive FHx was not associated with BCR in pre- and postoperative multivariable models (p = 0.1 and p = 0.7); c-indexes of Cox multivariable models were: 0.73 and 0.82, respectively. Conclusions We found that patients with clinically nonmetastatic PCa who have positive FHx of PCa undergo RP at a younger age and have more favorable pathologic outcomes. Nevertheless, FHx of PCa did not confer better BCR rates, suggesting that FHx leads to potentially early detection and treatment without impact on BCR.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
Modeling morphological learning, typology, and change : What can the neural sequence-to-sequence framework contribute?
Autorzy:
Elsner, Micha
Sims, Andrea D.
Erdmann, Alexander
Hernandez, Antonio
Jaffe, Evan
Jin, Lifeng
Booker Johnson, Martha
Karim, Shuan
King, David L.
Lamberti Nunes, Luana
Oh, Byung-Doh
Rasmussen, Nathan
Shain, Cory
Antetomaso, Stephanie
Dickinson, Kendra V.
Diewald, Noah
McKenzie, Michelle
Stevens-Guille, Symon
Tematy:
morphology
computational modeling
typology
Pokaż więcej
Wydawca:
Polska Akademia Nauk. Instytut Podstaw Informatyki PAN
Powiązania:
https://bibliotekanauki.pl/articles/103835.pdf  Link otwiera się w nowym oknie
Opis:
We survey research using neural sequence-to-sequence models as computational models of morphological learning and learnability. We discuss their use in determining the predictability of inflectional exponents, in making predictions about language acquisition and in modeling language change. Finally, we make some proposals for future work in these areas.
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-10 z 43

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