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Wyszukujesz frazę "DAscenzo, Fabrizio" wg kryterium: Autor


Tytuł:
Long-term outcomes following drug-eluting balloons versus thin-strut drug-eluting stents for treatment of recurrent restenosis in drug-eluting stents
Autorzy:
Dobrzycki, Sławomir
Chudzik, Magdalena
Januszek, Rafał
Wańha, Wojciech
Bil, Jacek
Hrymniak, Bruno
Jaguszewski, Miłosz
Kowalik, Ilona
Tomasiewicz, Brunon
Wojakowski, Wojciech
Bartuś, Stanisław
Kralisz, Paweł
Witkowski, Adam
Desperak, Piotr
Reczuch, Krzysztof
Hudziak, Damian
Figatowski, Tomasz
Kubica, Jacek
Milewski, Marek
Dascenzo, Fabrizio
Wolny, Rafał
Walczak, Tomasz
Niezgoda, Piotr
Kuźma, Łukasz
Ochała, Andrzej
Gąsior, Mariusz
Gil, Robert J.
Opis:
Background: There is limited data on the optimal revascularization strategy in patients with recurrent in-stent restenosis (R-ISR). Aims: To compare the long-term outcomes of patients treated with either a thin-strut drug-eluting stent (thin-DES) or a drug-eluting balloon (DEB) for R-ISR in a drug-eluting stent (DES). Methods: A multicenter DEB-DRAGON registry was used to retrospectively identify patients with R-ISR who received either a thin-DES or a DEB. Propensity score matching was applied to adjust for baseline differences. The primary outcome was target lesion revascularization (TLR). Results: Out of 311 patients (mean age, 67 years; 63% male) with R-ISR, 86 (27.7%) were treated with a thin-DES and 225 (72.3%) with a DEB. Median follow-up was 2.6 years. TLR occurred in 18 (20.9%) patients who received thin-DES and 61 (27.1%) patients treated with DEB (hazard ratio [HR], 0.57; 95% confidence interval [CI], 0.33–0.98; log-rank P = 0.04). The difference remained significant in a propensity score-matched cohort of 57 patients treated with thin-DES and 57 patients treated with a DEB (17.5 vs. 33.3%, respectively; HR, 0.38; 95% CI, 0.17–0.86; P = 0.01). The risks of device-oriented adverse cardiac events and all-cause mortality were similar after thin-DES or DEB in both unadjusted and propensity score-matched cohorts. In a multivariable Cox proportional hazard model, the treatment with a thin-DES was an independent predictor of a TLR-free survival (HR, 0.33; 95% CI 0.13–0.84; P = 0.02). Conclusions: In patients with R-ISR implantation of a thin-DES is associated with a lower risk of repeated revascularization compared with angioplasty with a DEB.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
Long-term outcomes following drug-eluting balloon or thin-strut drug-eluting stents for treatment of in-stent restenosis stratified by duration of dual antiplatelet therapy (DEB-Dragon Registry)
Autorzy:
Mielczarek, Maksymilian
Chudzik, Magdalena
Januszek, Rafał
Wańha, Wojciech
Bil, Jacek
Hrymniak, Bruno
Pawlik, Artur
Staszczak, Bartłomiej
Gilis-Malinowska, Natasza
Jaguszewski, Miłosz
Tomasiewicz, Brunon
Wojakowski, Wojciech
Bartuś, Stanisław
Witkowski, Adam
Kedhi, Elvin
Desperak, Piotr
Figatowski, Tomasz
Smolka, Grzegorz
Kubler, Piotr
Dylewski, Łukasz
Milewski, Marek
Reczuch, Krzysztof
Kubica, Jacek
Balan, Robert
Hudziak, Damian
Wybraniec, Maciej
Dascenzo, Fabrizio
Wolny, Rafał
Walczak, Tomasz
Niezgoda, Piotr
Ochała, Andrzej
Ciećwierz, Dariusz
Gąsior, Mariusz
Gruchała, Marcin
Gil, Robert J.
Opis:
Introduction: Data regarding the duration of dual antiplatelet therapy (DAPT) in patients with drug-eluting stent restenosis (DES-ISR) treated with percutaneous coronary intervention (PCI) and drug-eluting balloons (DEB) or DES are not unambiguous. Aim: To evaluate the relationship between long-term outcomes and the length of DAPT in patients treated with PCI due to DES-ISR with DEB or DES. Material and methods: Overall, a total of 1,367 consecutive patients with DES-ISR, who underwent PCI with DEB or DES between 2008 and 2019 entered the study. The mean length of the follow-up was 1,298.7 ±794 days. We assessed study endpoints according to the duration of DAPT (≤ 3 vs. > 3 and ≤ 6 vs. > 6 months) before and after propensity score matching (PSM): stroke, target lesion revascularisation (TLR), target vessel revascularisation (TVR), myocardial infarction (MI), death and device oriented composite endpoints (DOCE). Kaplan-Meier estimates were created to differentiate long-term outcomes. Results: Pairwise contrast analysis considering type of PCI (DES vs. DEB) and duration of DAPT (≤ 6 vs. > 6 months) before PSM revealed superiority of DES + DAPT > 6 months vs. DEB + DAPT > 6 months for DOCE (p < 0.001), TVR (p = 0.02) and TLR (p = 0.01). Also, DES+DAPT ≤ 6 months was found to be superior compared to DEB + DAPT ≤ 6 months for DOCE (p < 0.001), TVR (p = 0.02) and TLR (p = 0.01). Kaplan-Meier estimate analysis confirmed that DAPT > 6 months is related to a higher stroke rate (p = 0.01) when compared to ≤ 6 months. Conclusions: Treatment with DAPT in patients with DES-ISR is related to better long-term outcomes in the case of PCI with DES than DEB. DAPT > 6 months is related to the greater rate of strokes, independently of the type of treatment (DES and DEB) than DAPT ≤ 6 months.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł

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