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Przejdź do strony domowej biblioteki Pedagogiczna Biblioteka Wojewódzka im. Komisji Edukacji Narodowej w Lublinie Link otwiera się w nowym oknie Logo biblioteki Prolib Integro - strona głównaPedagogiczna Biblioteka Wojewódzka im. Komisji Edukacji Narodowej w Lublinie
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    Wyświetlanie 1-7 z 7
    Tytuł:
    Prediction of individual lifetime cardiovascular risk and potential treatment benefit : development and recalibration of the LIFE-CVD2 model to four European risk regions
    Autorzy:
    Westbury, Leo
    Giampaoli, Simona
    Dennison, Elaine
    Shea, Steven
    Matsushita, Kunihiro
    Rosengren, Annika
    Brenner, Hermann
    Wareham, Nicholas J.
    Malyutina, Sofia
    Pennells, Lisa
    Gillum, Richard F
    Panagiotakos, Demosthenes
    Schmidt, Börge
    Kiechl, Stefan
    Pamieri, Luigi
    Zhou, Bin
    Muilwijk, Mirthe
    Ikram, M. Arfan
    Hansson, Per-Olof
    Di Angelantonio, Emanuele
    Harms, Peter
    Davidson, Karina
    Shipley, Martin J
    Kucharska-Newton, Anna
    Pikhart, Hynek
    Bakker, Stephan J L
    Hageman, Steven H J
    Bolton, Thomas R
    Brunner, Eric J.
    Erbel, Raimund
    Cook, Nancy R
    Kist, Janet M
    Humphries, Steve E.
    Läll, Kristi
    Bonnefond, Amélie
    Stang, Andreas
    Packard, Chris
    Providencia, Rui
    Gómez-de-la-Cámara, Agustín
    Pablos, David Lora
    Ridker, Paul M.
    Nordestgaard, Borge G.
    Dörr, Marcus
    Psaty, Bruce M.
    Tamosiunas, Abdonas
    Moons, Karel G M
    Schwartz, Joseph E
    Numans, Mattijs E
    Sattar, Naveed
    Schöttker, Ben
    Meyer, Haakon E
    Blaha, Michael
    Ford, Ian
    Pająk, Andrzej
    Völzke, Henry
    Boer, Jolanda M A
    Kaptoge, Stephen
    Peters, Annette
    Lu, Wentian
    Mortensen, Martin Bødtker
    Gansevoort, Ron T
    Bobak, Martin
    Thorand, Barbara
    Potier, Louis
    Sofat, Reecha
    Schramm, Sara
    Visseren, Frank L.J.
    Willeit, Peter
    Dorresteijn, Jannick A N
    Rodriguez, Beatriz
    Kavousi, Maryam
    Danesh, John
    Os, Hendrikus J A
    Donfrancesco, Chiara
    Spackman, Sarah
    Vries, Tamar I
    Floyd, James S
    Jukema, J. Wouter
    Verschuren, W.M. Monique
    Håheim, Lise Lund
    Kubinova, Ruzena
    Fu, Michael
    Dostawca treści:
    Repozytorium Uniwersytetu Jagiellońskiego
    Artykuł
    Tytuł:
    Contribution of common genetic variants to risk of early-onset ischemic stroke
    Autorzy:
    Jimenez-Conde, Jordi
    Ryan, Kathleen A.
    Luke, Sothear
    Gieger, Christian
    Pera, Joanna
    Thijs, Vincent
    Smith, Jennifer A.
    Mitchell, Braxton D.
    Chong, Michael
    Rexrode, Kathryn
    Cruchaga, Carlos
    Torres-Aguila, Nuria P.
    Markus, Hugh S.
    Heitsch, Laura
    Walters, Robin G.
    Li, Jiang
    Rosand, Jonathan
    Jaworek, Thomas
    Kamatani, Yoichiro
    Meschia, James F.
    Holliday, Elizabeth
    Mcardle, Patrick F.
    Anderson, Christopher D.
    Ilinca, Andreea
    Bell, Steven
    Cushman, Mary
    Gaynor, Brady J.
    Muller-Nurasyid, Martina
    Putaala, Jukka
    Cole, John W.
    Engstrom, Gunnar
    Grittner, Ulrike
    Strbian, Daniel
    Kardia, Sharon L.R.
    Levi, Christopher R.
    Hong, Charles C.
    O'Donnell, Martin
    Pare, Guillaume
    Zand, Ramin
    Tuladhar, Anil M.
    Faul, Jessica D.
    Havulinna, Aki S.
    Sacco, Ralph L.
    Mcdonough, Caitrin W.
    Jern, Christina
    Boncoraglio, Giorgio B.
    Hu, Jie
    Rothwell, Peter M.
    Metso, Tiina
    Lin, Kuang
    Giese, Anne-Katrin
    Fecteau, Natalie S.
    Jackson, Rebecca D.
    Johnson, Julie A.
    Ribases, Marta
    Attia, John
    Veldink, Jan H.
    de Leeuw, Frank-Erik
    Lemmens, Robin
    O'Connor, Timothy D.
    Danesh, John
    Irvin, Marguerite R.
    Perry, James A.
    Hochberg, Marc C.
    Stine, O. Colin
    Fernandez-Cadenas, Israel
    Tomppo, Liisa
    Abedi, Vida
    Grewal, Raji P.
    Li, Liming
    Sanchez-Mora, Cristina
    Lange, Leslie
    Ross, Owen A.
    Chen, Zhengming
    Debette, Stephanie
    Wassertheil-Smoller, Sylvia
    Stanne, Tara M.
    Jacob, Mina A.
    Smith, Nicholas L.
    Dichgans, Martin
    Sudlow, Cathie L.M.
    Kittner, Steven J.
    Rannikmae, Kristiina
    Peddareddygari, Leema R.
    Lopez, Haley
    Peters, Annette
    Benavente, Oscar R.
    Weir, David R.
    Salomaa, Veikko
    Enzinger, Chris
    Lindgren, Arne G.
    Tatlisumak, Turgut
    Durda, Jon Peter
    Ray, Debashree
    Xu, Huichun
    Lee, Jin-Moo
    Worrall, Bradford B.
    Butterworth, Adam
    Słowik, Agnieszka
    Soderholm, Martin
    Woo, Daniel
    Carcel-Marquez, Jara
    Duggan, David J.
    Maguire, Jane
    Koido, Masaru
    Sharma, Pankaj
    Terao, Chikashi
    Malik, Rainer
    Schmidt, Reinhold
    Amouyel, Philippe
    Kubo, Michiaki
    Rabionet, Raquel
    Tregouet, David-Alexandre
    Armstrong, Nicole D.
    Rundek, Tatjana
    Opis:
    Background and Objectives:Current genome-wide association studies of ischemic stroke have focused primarily on late-onset disease. As a complement to these studies, we sought to identify the contribution of common genetic variants to risk of early-onset ischemic stroke: Methods: We performed a meta-analysis of genome-wide association studies of early-onset stroke (EOS), ages 18–59 years, using individual-level data or summary statistics in 16,730 cases and 599,237 nonstroke controls obtained across 48 different studies. We further compared effect sizes at associated loci between EOS and late-onset stroke (LOS) and compared polygenic risk scores (PRS) for venous thromboembolism (VTE) between EOS and LOS. Results: We observed genome-wide significant associations of EOS with 2 variants in ABO, a known stroke locus. These variants tag blood subgroups O1 and A1, and the effect sizes of both variants were significantly larger in EOS compared with LOS. The odds ratio (OR) for rs529565, tagging O1, was 0.88 (95% confidence interval [CI]: 0.85–0.91) in EOS vs 0.96 (95% CI: 0.92–1.00) in LOS, and the OR for rs635634, tagging A1, was 1.16 (1.11–1.21) for EOS vs 1.05 (0.99–1.11) in LOS; p-values for interaction = 0.001 and 0.005, respectively. Using PRSs, we observed that greater genetic risk for VTE, another prothrombotic condition, was more strongly associated with EOS compared with LOS (p = 0.008). Discussion: The ABO locus, genetically predicted blood group A, and higher genetic propensity for venous thrombosis are more strongly associated with EOS than with LOS, supporting a stronger role of prothrombotic factors in EOS.
    Dostawca treści:
    Repozytorium Uniwersytetu Jagiellońskiego
    Artykuł
    Tytuł:
    Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes
    Autorzy:
    Psaty, Bruce M.
    Longstreth Jr, W. T.
    Chen, Wei-Min
    Amouyel, Philippe
    Schmidt, Reinhold
    Lange, Leslie A.
    Maguire, Jane
    Cole, John W.
    Ridker, Paul M.
    Cotlarciuc, Ioana
    Salomaa, Veikko
    Bartz, Traci M.
    Havulinna, Aki S.
    den Hoed, Marcel
    Chambers, John C.
    Anderson, Christopher D.
    Nalls, Michael A.
    Kooperberg, Charles
    Kleindorfer, Dawn O.
    Ikram, M. Arfan
    Markus, Hugh S.
    Seshadri, Sudha
    Thorsteinsdottir, Unnur
    Gottesman, Rebecca F.
    Ninomiya, Toshiharu
    Mosley, Thomas H.
    Malik, Rainer
    Takeuchi, Fumihiko
    Correa, Adolfo
    Hata, Jun
    Manichaikul, Ani
    Carrera, Caty
    Hassan, Ahamad
    van Duijn, Cornelia M.
    Trompet, Stella
    Lubitz, Steven A.
    Engelter, Stefan T.
    Taylor, Kent D.
    Tregouet, David A.
    Duan, Qing
    Kooner, Jaspal S.
    Benavente, Oscar R.
    Mitchell, Braxton D.
    Smith, Nicholas L.
    Okada, Yukinori
    Kissela, Brett M.
    Rexrode, Kathryn M.
    Bis, Joshua C.
    Grewal, Raji P.
    Rundek, Tatjana
    Chasman, Daniel I.
    Holliday, Elizabeth G.
    Jimenez-Conde, Jordi
    Wareham, Nicholas J.
    Tzourio, Christophe
    Pulit, Sara L.
    Mishra, Aniket
    Wilson, James G.
    Lemmens, Robin
    Howson, Joanna M. M.
    Christophersen, Ingrid E.
    Kamatani, Yoichiro
    Magnusson, Patrik K.
    Rosand, Jonathan
    DeStefano, Anita L.
    Tatlisumak, Turgut
    Jern, Christina
    Kato, Norihiro
    Carty, Cara L.
    Danesh, John
    de Bakker, Paul I. W.
    Boncoraglio, Giorgio B.
    McArdle, Patrick F.
    Reiner, Alexander P.
    Rutten-Jacobs, Loes
    Tai, E. Shyong
    Hopewell, Jemma C.
    Kittner, Steven J.
    Tanislav, Christian
    Traylor, Matthew
    Pare, Guillaume
    Gustafsson, Stefan
    Irvin, Marguerite R.
    Lindgren, Arne G.
    Launer, Lenore J.
    Giese, Anne-Katrin
    Haessler, Jeffrey
    Strbian, Daniel
    Sharma, Pankaj
    Fernandez-Cadenas, Israel
    Dichgans, Martin
    Cruchaga, Carlos
    Chauhan, Ganesh
    Sacco, Ralph L.
    Yusuf, Salim
    Sale, Michele M.
    Lee, Jin-Moo
    Rannikmae, Kristiina
    Gudnason, Vilmundur
    Lin, Wei-Yu
    Rice, Kenneth
    Johnson, Andrew D.
    Rothwell, Peter M.
    Walters, Matthew
    Ay, Hakan
    Lewis, Cathryn M.
    Leys, Didier
    van der Laan, Sander W.
    Sargurupremraj, Muralidharan
    Schadt, Eric E.
    Rolfs, Arndt
    Słowik, Agnieszka
    Debette, Stephanie
    Hyacinth, Hyacinth I.
    Heckbert, Susan R.
    Thijs, Vincent N. S.
    Sakaue, Saori
    Almgren, Peter
    Saleheen, Danish
    Langenberg, Claudia
    Hsu, Fang-Chi
    Rich, Stephen S.
    Sudlow, Cathie L.M.
    Ruusalepp, Arno
    Falcone, Guido J.
    Jian, Xueqiu
    Meschia, James F.
    Pastinen, Tomi
    Melander, Olle
    Codoni, Veronica
    Civelek, Mete
    Harris, Tamara B.
    Ellinor, Patrick T.
    Wiggins, Kerri L.
    Wassertheil-Smoller, Sylvia
    Ingelsson, Erik
    Schminke, Ulf
    Roselli, Carolina
    Langefeld, Carl D.
    Sanghera, Dharambir K.
    Brown Jr, Robert D.
    Kanai, Masahiro
    O'Donnell, Martin J.
    van der Harst, Pim
    Lorentzen, Erik
    Rost, Natalia S.
    Stefansson, Kari
    Bjorkegren, Johan L. M.
    Johnson, Julie A.
    Bevan, Steve
    Thorleifsson, Gudmar
    Worrall, Bradford B.
    Chong, Michael
    Kubo, Michiaki
    Tiedt, Steffen
    Butterworth, Adam S.
    Howard, George
    Jukema, J. Wouter
    Adams, Hieab H. H.
    Rotter, Jerome I.
    Keene, Keith L.
    Koplev, Simon
    Woo, Daniel
    Yang, Qiong
    Sapkota, Bishwa R.
    He, Jiang
    Fornage, Myriam
    Ago, Tetsuro
    Schmidt, Carsten O.
    Gretarsdottir, Solveig
    Elliott, Paul
    Dostawca treści:
    Repozytorium Uniwersytetu Jagiellońskiego
    Artykuł
      Wyświetlanie 1-7 z 7

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