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    Wyświetlanie 1-6 z 6
    Tytuł:
    Assessment of application of the new 2019 European Society of Cardiology/European Atherosclerosis Society Guidelines for the Management of Dyslipidaemias in daily clinical practice — one center study
    Autorzy:
    Cecha, Patrycja
    Chromik, Anna
    Piotrowska, Ilona
    Zabojszcz, Michał
    Dolecka-Ślusarczyk, Magdalena
    Siudak, Zbigniew
    Tematy:
    cardiovascular risk
    ESC/EAS guidelines
    lipid-lowering therapy
    PCSK9 inhibitors
    statins
    Pokaż więcej
    Wydawca:
    Polska Akademia Nauk. Czasopisma i Monografie PAN
    Powiązania:
    https://bibliotekanauki.pl/articles/56985284.pdf  Link otwiera się w nowym oknie
    Opis:
    Background: Cardiovascular diseases are the first cause of death globally. Hypercholesterolemia is the most important factor responsible for atherosclerotic plaque formation and increasing cardiovascular risk. Reduction of LDL-C level is the most relevant goal for reduction of cardiovascular risk. Aims: Real life adherence to guidelines concerning statin therapy in one center study population. Methods: We analyzed data collected in the Department of Internal Diseases from September 2019 to February 2020, obtained from 238 patients hospitalized in this time period. We assessed application of the new 2019 ESC/EAS Guidelines for the Management of Dyslipidaemias in daily clinical practice and compared effectiveness of LLT according to 2016 and 2019 guidelines. Results: Only 1 in 5 patients with dyslipideamia achieve the 2019 ESC/EAS guideline-recommended levels of LDL-C with relation to their TCVR. We noticed that 20 of patients who did not achieve proper 2019 LDL level, meet the therapy targets established in year 2016. We observed that higher patient TCVR resulted in better compliance with guidelines and ordination of proper LLT. Most patients were on monotherapy with statins. Conclusions: It could be beneficial to start treatment with double or even triple therapy especially in group with the highest LDL-C levels.
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Diabetes mellitus is still a strong predictor of periprocedural outcomes of primary percutaneous coronary interventions in patients presenting with ST-segment elevation myocardial infarction (from the ORPKI Polish National Registry)
    Autorzy:
    Zdzierak, Barbara
    Zabojszcz, Michał
    Surdacki, Andrzej
    Dudek, Dariusz
    Rakowski, Tomasz
    Dziewierz, Artur
    Zasada, Wojciech
    Tokarek, Tomasz
    Bartuś, Stanisław
    Siudak, Zbigniew
    Malinowski, Krzysztof
    Dolecka-Ślusarczyk, Magdalena
    Opis:
    The impact of diabetes mellitus (DM) on outcomes of patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI) was confirmed by several studies. However, it is unclear whether this effect is still present in large groups of unselected patients undergoing up-to-date treatment. Thus, we sought to assess the impact of DM on periprocedural outcomes of primary PCI in STEMI using data from the Polish National Registry of PCI. Data on 150,782 STEMI patients undergoing primary PCI were collected. Of them, 26,360 (17.5%) patients had DM. Patients with DM were higher-risk individuals who experienced longer reperfusion delays and were less likely to have closed infarct-related artery at baseline (TIMI 0 + 1 flow: 73.2% vs. 72.0%; p < 0.0001) and achieve optimal reperfusion after PCI (TIMI 3 flow: 91.8% vs. 88.5%; p < 0.0001). The periprocedural mortality (1.1% vs. 1.9%; p < 0.0001) was higher in patients with DM and DM was identified as an independent predictor of periprocedural death. In conclusion, despite continuous progress in STEMI treatment, DM remains a strong predictor of periprocedural mortality. However, this detrimental effect of DM may be partially explained by the overall higher risk profile of diabetic patients.
    Dostawca treści:
    Repozytorium Uniwersytetu Jagiellońskiego
    Artykuł
    Tytuł:
    Clinical outcomes in patients with acute myocardial infarction treated with primary percutaneous coronary intervention stratified according to duration of pain-to-balloon time and type of myocardial infarction
    Autorzy:
    Staszczak, Bartłomiej
    Janion-Sadowska, Agnieszka
    Jędrychowska, Magdalena
    Zabojszcz, Michał
    Surdacki, Andrzej
    Januszek, Rafał Adam
    Pawlik, Artur
    Bartuś, Joanna B.
    Tokarek, Tomasz
    Bartuś, Stanisław
    Siudak, Zbigniew
    Malinowski, Krzysztof
    Susuł, Michał
    Socha, Sylwia
    Dolecka-Ślusarczyk, Magdalena
    Opis:
    Background: Based on the clinical outcomes of patients with ST-segment elevation myocardial infarction(STEMI) and non-ST-segment elevation myocardial infarction (NSTEMI), treated with primary percutaneouscoronary intervention (pPCI), this study intended to assess mortality and major adverse cardiac andcerebrovascular event (MACCE) rates according to duration of pain-to-balloon (PTB) time and type of MI.Methods: This is a retrospective cohort study based on the prospectively collected ORPKI registry whichcovers PCIs performed in Poland chosen between January 2014 and December 2017. Under assessmentwere 1,994 STEMI and 923 NSTEMI patients. Study endpoints included mortality and MACCE rates(in-hospital, 30-day, 12- and 36-month). Predictors of all-cause mortality in the overall group, STEMIand NSTEMI were assessed by multivariable analysis.Results: Kaplan-Meier survival curve analysis did not reveal significant differences between theSTEMI and NSTEMI group for all-cause mortality or MACCE at the 36-month follow-up. While inthe long PTB time group, MACCE rate was significantly greater in STEMI patients when compared toNSTEMI (p = 0.004). Among STEMI patients, the short, medium and long PTB time groups differedsignificantly in the rate of all-cause mortality (p = 0.006) and MACCE (p = 0.04) at 1,095 days offollow-up, which were the greatest in the long PTB time group.Conclusions: Before considering the length of PTB time, there were no statistically significant differencesin mortality or MACCE frequency between the STEMI and NSTEMI group at 36-month follow-up.Longer PTB times are related to significantly greater mortality at the 36-month follow-up in the STEMI,but not in the NSTEMI group.
    Dostawca treści:
    Repozytorium Uniwersytetu Jagiellońskiego
    Artykuł
      Wyświetlanie 1-6 z 6

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