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Wyszukujesz frazę "Dong, David" wg kryterium: Autor


Tytuł:
Connectedness and cycle spaces of friends-and-strangers graphs
Autorzy:
Defant, Colin
Dong, David
Lee, Alan
Wei, Michelle
Tematy:
friends-and-strangers graph
spider
dandelion
cycle space
Coxeter move
Pokaż więcej
Wydawca:
Uniwersytet Zielonogórski. Wydział Matematyki, Informatyki i Ekonometrii
Powiązania:
https://bibliotekanauki.pl/articles/59898621.pdf  Link otwiera się w nowym oknie
Opis:
If $X=(V(X),E(X))$ and $Y=(V(Y),E(Y))$ are $n$-vertex graphs, then their friends-and-strangers graph $\mathsf{FS}(X,Y)$ is the graph whose vertices are the bijections from $V(X)$ to $V(Y)$ in which two bijections $\sigma$ and $\sigma^' $ are adjacent if and only if there is an edge $\{a,b\}\in E(X)$ such that $\{\sigma(a),\sigma(b)\}\in E(Y)$ and $\sigma^'=\sigma\circ (a b)$, where $(a b)$ is the permutation of $V(X)$ that swaps $a$ and $b$. We prove general theorems that provide necessary and/or sufficient conditions for $\mathsf{FS}(X,Y)$ to be connected. As a corollary, we obtain a complete characterization of the graphs $Y$ such that \( \mathsf{FS}(\mathsf{Dand}_{k,n},Y) \) is connected, where \( \mathsf{Dand}_{k,n} \) is a dandelion graph; this substantially generalizes a theorem of the first author and Kravitz in the case $k=3$. For specific choices of $Y$, we characterize the spider graphs $X$ such that $\mathsf{FS}(X,Y)$ is connected. In a different vein, we study the cycle spaces of friends-and-strangers graphs. Naatz proved that if $X$ is a path graph, then the cycle space of $\mathsf{FS}(X,Y)$ is spanned by $4$-cycles and $6$-cycles; we show that the same statement holds when $X$ is a cycle and $Y$ has domination number at least $3$. When $X$ is a cycle and $Y$ has domination number at least $2$, our proof sheds light on how walks in $\mathsf{FS}(X,Y)$ behave under certain Coxeter moves.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Paths to low-carbon development in China: The role of government environmental target constraints
Autorzy:
Bai, Tingting
Xu, Dong
Yang, Qianyi
Dudás Piroska, Vargáné
Dénes Dávid, Lóránt
Zhu, Kai
Tematy:
government environmental target constraints
carbon emissions
energy consumption
industrial structure optimization
green technology innovation
Pokaż więcej
Wydawca:
Instytut Badań Gospodarczych
Powiązania:
https://bibliotekanauki.pl/articles/39830406.pdf  Link otwiera się w nowym oknie
Opis:
Research background: To achieve the targets for carbon peak and air quality improvement, local governments should propose environmental targets and develop realization paths that are tailored to their unique local conditions. They then promote low-carbon development through the implementation of multiple measures. Purpose of the article: As the government performance appraisal system im-proves, the question arises as to whether governments take the initiative to com-bine environmental policies with government target constraints to reduce carbon emissions. Methods: The announcement of environmental target constraints by local governments in government work reports is considered a quasi-natural experiment. This study examines the effect of government environmental target constraints (GETC) on carbon emissions (CEs) using differences-in-differences (DID), propensity score matching-DID (PSM-DID), and spatial-DID (SDID) with data from 241 Chinese cities from 2003 to 2019. Findings & value added: The results demonstrate that GETC can effectively reduce local CEs, with the inhibitory effect being most effective in the first two years after setting environmental targets, but diminishing in the third year. GETC can reduce local CEs through three paths: reducing energy consumption, promoting industrial structure optimization, and encouraging green technology innovation. Spatial spillover effects show that GETC reduces local CEs while exacerbating CEs in neighboring cities, indicating a beggar-thy-neighbor effect in conventional environmental regulation policy. This effect is observed mainly in the geographic matrix and the economic-geographic matrix, but not in the economic matrix. According to heterogeneity analysis, GETC in the eastern and central cities can significantly reduce CEs. The inhibitory effect of GETC on local CEs is stronger in cities where secretaries and mayors have longer tenures and higher levels of education. The paper's theoretical value lies in exploring the reduction of CEs through the combination of government self-restraint and environmental policies, providing a new solution for local governments to achieve CEs reduction. Furthermore, it offers practical insights into the improvement of the Chinese government assessment system.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Rap1b in smooth muscle and endothelium is required for maintenance of vascular tone and normal blood pressure
Autorzy:
Mattson, David L.
Lund, Hayley
Momotani, Ko
Ge, Zhi-Dong
Zhang, David X.
Somlyo, Avril V.
Zheng, Xiaodong
Lakshmikanthan, Sribalaji
Maas, Jason E.
Auchampach, John A.
Zięba, Bartosz J.
Artamonov, Mykhaylo V.
Chrzanowska-Wodnicka, Magdalena
Szabo, Aniko
Opis:
Objective—Small GTPase Ras-related protein 1 (Rap1b) controls several basic cellular phenomena, and its deletion in mice leads to several cardiovascular defects, including impaired adhesion of blood cells and defective angiogenesis. We found that Rap1b−/− mice develop cardiac hypertrophy and hypertension. Therefore, we examined the function of Rap1b in regulation of blood pressure. Approach and Results—Rap1b−/− mice developed cardiac hypertrophy and elevated blood pressure, but maintained a normal heart rate. Correcting elevated blood pressure with losartan, an angiotensin II type 1 receptor antagonist, alleviated cardiac hypertrophy in Rap1b−/− mice, suggesting a possibility that cardiac hypertrophy develops secondary to hypertension. The indices of renal function and plasma renin activity were normal in Rap1b−/− mice. Ex vivo, we examined whether the effect of Rap1b deletion on smooth muscle–mediated vessel contraction and endothelium-dependent vessel dilation, 2 major mechanisms controlling basal vascular tone, was the basis for the hypertension. We found increased contractility on stimulation with a thromboxane analog or angiotensin II or phenylephrine along with increased inhibitory phosphorylation of myosin phosphatase under basal conditions consistent with elevated basal tone and the observed hypertension. Cyclic adenosine monophosphate–dependent relaxation in response to Rap1 activator, Epac, was decreased in vessels from Rap1b−/− mice. Defective endothelial release of dilatory nitric oxide in response to elevated blood flow leads to hypertension. We found that nitric oxide–dependent vasodilation was significantly inhibited in Rap1b-deficient vessels. Conclusions—This is the first report to indicate that Rap1b in both smooth muscle and endothelium plays a key role in maintaining blood pressure by controlling normal vascular tone.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
Safer and efficient base editing and prime editing via ribonucleoproteins delivered through optimized lipid-nanoparticle formulations
Autorzy:
Palczewski, Krzysztof
Chen, Paul Z.
Kiser, Philip D.
Risalit,i Eleonora
Rodrigues Menezes, Carolline
Hołubowicz, Rafał
Smidak, Roman
Griffo Alessandra
Caprettini Valeria
Felgner, Philip L.
Dong, Zhiqian
Liu, David R.
Almeida Filipe
Lyon, David C.
Cheifet Barbara
Salom, David
Felgner, Jiin
Choi, Elliot H.
Palczewska, Grazyna
Bassetto, Marco
Du, Samuel W.
Haskell Jennifer
Gao, Fangyuan
Medani, Omar
Yan, Alexander L.
Hołubowicz, Maria W.
Newby, Gregory A.
Foik, Andrzej T.
Workman, J. Noah
Współwytwórcy:
Caprettini Valeria
Almeida Filipe
Cheifet Barbara
Griffo Alessandra
Haskell Jennifer
Wydawca:
Nature Portfolio
Cytata wydawnicza:
Hołubowicz, R., Du, S.W., Felgner, J. et al. Safer and efficient base editing and prime editing via ribonucleoproteins delivered through optimized lipid-nanoparticle formulations. Nat. Biomed. Eng 9, 57–78 (2025). https://doi.org/10.1038/s41551-024-01296-2
Opis:
Delivering ribonucleoproteins (RNPs) for in vivo genome editing is safer than using viruses encoding for Cas9 and its respective guide RNA. However, transient RNP activity does not typically lead to optimal editing outcomes. Here we show that the efficiency of delivering RNPs can be enhanced by cell-penetrating peptides (covalently fused to the protein or as excipients) and that lipid nanoparticles (LNPs) encapsulating RNPs can be optimized for enhanced RNP stability, delivery efficiency and editing potency. Specifically, after screening for suitable ionizable cationic lipids and by optimizing the concentration of the synthetic lipid DMG-PEG 2000, we show that the encapsulation, via microfluidic mixing, of adenine base editor and prime editor RNPs within LNPs using the ionizable lipid SM102 can result in in vivo editing-efficiency enhancements larger than 300-fold (with respect to the delivery of the naked RNP) without detectable off-target edits. We believe that chemically defined LNP formulations optimized for RNP-encapsulation stability and delivery efficiency will lead to safer genome editing.
Dostawca treści:
Repozytorium Centrum Otwartej Nauki
Artykuł
Autorzy:
Jankowski, Piotr
Shiba, Mariko H.
Almahmeed, Wael
Wood, David
Lloyd-Jones, Donald
Puri, Raman
Alonso, Rodrigo
Perel, Pablo
Ray, Kausik K.
Pinto, Fausto
Zhao, Dong
Olmo, Rosa Fernandez
Ference, Brian A.
Ezhov, Marat
Mehta, Roopa
Nicholls, Stephen J.
Blom, Dirk
Daccord, Magdalena
Lanas, Fernando
Virani, Salim S.
Santos, Raul D.
Gidding, Samuel S.
Severin, Tania
Wong, Nathan D.
Opis:
Background: Atherosclerotic cardiovascular diseases (ASCVD) including myocardial infarction, stroke and peripheral arterial disease continue to be major causes of premature death, disability and healthcare expenditure globally. Preventing the accumulation of cholesterol-containing atherogenic lipoproteins in the vessel wall is central to any healthcare strategy to prevent ASCVD. Advances in current concepts about reducing cumulative exposure to apolipoprotein B (apo B) cholesterol-containing lipoproteins and the emergence of novel therapies provide new opportunities to better prevent ASCVD. The present update of the World Heart Federation Cholesterol Roadmap provides a conceptual framework for the development of national policies and health systems approaches, so that potential roadblocks to cholesterol management and thus ASCVD prevention can be overcome. Methods: Through a review of published guidelines and research papers since 2017, and consultation with a committee composed of experts in clinical management of dyslipidaemias and health systems research in low-and-middle income countries (LMICs), this Roadmap identifies (1) key principles to effective ASCVD prevention (2) gaps in implementation of these interventions (knowledge-practice gaps); (3) health system roadblocks to treatment of elevated cholesterol in LMICs; and (4) potential strategies for overcoming these. Results: Reducing the future burden of ASCVD will require diverse approaches throughout the life-course. These include: a greater focus on primordial prevention; availability of affordable cholesterol testing; availability of universal cholesterol screening for inherited dyslipidaemias; risk stratification moving beyond 10-year risk to look at lifetime risk with adequate risk estimators; wider availability of affordable cholesterol-lowering therapies which should include statins as essential medications globally; use of adequate doses of potent statin regimens; and combination therapies with ezetimibe or other therapies in order to attain and maintain robust reductions in LDL-C in those at highest risk. Continuing efforts are needed on health literacy for both the public and healthcare providers, utilising multi-disciplinary teams in healthcare and applications that quantify both ASCVD risk and benefits of treatment as well as increased adherence to therapies. Conclusions: The adverse effects of LDL-cholesterol and apo B containing lipoprotein exposure are cumulative and result in ASCVD. These are preventable by implementation of different strategies, aimed at efficiently tackling atherosclerosis at different stages throughout the human life-course. Preventive strategies should therefore be updated to implement health policy, lifestyle changes and when needed pharmacotherapies earlier with investment in, and a shift in focus towards, early preventive strategies that preserve cardiovascular health rather than treat the consequences of ASCVD.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
A combination treatment based on drug repurposing demonstrates mutation-agnostic efficacy in pre-clinical retinopathy models
Autorzy:
Kolesnikov, Alexander V.
Petersen-Jones, Simon M.
Leinonen, Henri
Palczewski, Krzysztof
Lewandowski, Dominik
Kiser, Philip D.
Tabaka, Marcin
Querubin, Janice
Marinho, Luis Felipe L.P.
Einstein, David E.
Dong, Zhiqian
Kordecka, Katarzyna
Seemab, Umair
Choi, Elliot H.
Occelli, Laurence M.
Kefalov, Vladimir J.
Blackshaw, Seth
Zhang, Jianye
Galinska, Anna
Hoang, Thanh
Zhao Yuan
Lee, Timothy
Foik, Andrzej T.
Einstein, Elliott E.
Współwytwórcy:
Zhao Yuan
Wydawca:
Nature Portfolio
Cytata wydawnicza:
Leinonen, H., Zhang, J., Occelli, L.M. et al. A combination treatment based on drug repurposing demonstrates mutation-agnostic efficacy in pre-clinical retinopathy models. Nat Commun 15, 5943 (2024). https://doi.org/10.1038/s41467-024-50033-5
Opis:
Inherited retinopathies are devastating diseases that in most cases lack treatment options. Disease-modifying therapies that mitigate pathophysiology regardless of the underlying genetic lesion are desirable due to the diversity of mutations found in such diseases. We tested a systems pharmacology-based strategy that suppresses intracellular cAMP and Ca2+ activity via G protein-coupled receptor (GPCR) modulation using tamsulosin, metoprolol, and bromocriptine coadministration. The treatment improves cone photoreceptor function and slows degeneration in Pde6βrd10 and RhoP23H/WT retinitis pigmentosa mice. Cone degeneration is modestly mitigated after a 7-month-long drug infusion in PDE6A-/- dogs. The treatment also improves rod pathway function in an Rpe65-/- mouse model of Leber congenital amaurosis but does not protect from cone degeneration. RNA-sequencing analyses indicate improved metabolic function in drug-treated Rpe65-/- and rd10 mice. Our data show that catecholaminergic GPCR drug combinations that modify second messenger levels via multiple receptor actions provide a potential disease-modifying therapy against retinal degeneration.
Dostawca treści:
Repozytorium Centrum Otwartej Nauki
Artykuł
Tytuł:
Apophis planetary defense campaign
Autorzy:
Sonbas, Eda
Bressi, Terry H.
Farnocchia, Davide
Falco, Carmelo
Morate, David
Weryk, Robert
Yim, Hong-Suh
Chastel, Serge
Marsset, Michael
Larsen, Jeffrey A.
Mastaler, Ron A.
Licandro, Javier
Taylor, Patrick A.
Pérez-Toledo, Fabricio
Warner, Elizabeth
Heinze, Aren N.
Cantillo, David
Kamiński, Krzysztof
Weiland, Henry J.
Kokina, Tatiana
Kaplan, Murat
Perminov, Alexander
Reddy, Vishnu
Kim, Myung-Jin
Chingis, Omarov
Kelley, Michael S.
Brozovic, Marina
Kamińska, Monika K.
Lees, Robert C.
Micheli, Marco
Bauer, James
Mathias, Donovan L.
Satpathy, Akash
Michel, Patrick
Moon, Hong-Kyu
Alarcon, Miguel R.
Serebryanskiy, Aleksander
de León, Julia
Elenin, Leonid
Kim, Dong-Heun
Ogłoza, Waldemar
Choi, Young-Jun
Kaiser, Galina
Mainzer, Amy
Szakáts, Robert
Christensen, Eric
Janse van Rensburg, Petro
Nastasi, Alessandro
Scotti, James V.
Cennamo, Ramona
Jacques, Cristovao
Glamazda, Dmitry
Ivanov, Alexander
McMillan, Robert S.
Lee, Hee-Jae
Serra-Ricart, Miquel
Novichonok, Artem
Pál, András
Marciniak, Anna
Buzzi, Luca
Popescu, Marcel
Tubbiolo, Andrew F.
Brucker, Melissa J.
Graziani, Filippo
Medeiros, Hissa
Schmalz, Sergei
Kuznetsov, Eduard
Dróżdż, Marek
Holman, Matthew J.
Kiss, Csaba
Read, Mike T.
Mokhnatkin, Artem
Zoła, Stanisław
Bell, David
Zhornichenko, Anastasiya
Faggioli, Laura
Roh, Dong-Goo
Veres, Peter
Reva, Inna
Erasmus, Nicolas
Polishook, David
Naidu, Shantanu P.
Benner, Lance A. M.
Wiebe, Yulia
Wheeler, Lorien F.
Petrescu, Elisabeta
Tonry, John L.
Masiero, Joseph
Rumpf, Clemens
Erece, Orhan
Reichart, Daniel E.
Barnardi, Fabrizio
Denneau, Larry
Balam, David
Żejmo, Michał
Cano, Juan
Wells, Guy
Dotson, Jessie
Wainscoat, Richard
Bamberger, Daniel
Opis:
We describe results of a planetary defense exercise conducted during the close approach to Earth by the near-Earth asteroid (99942) Apophis during 2020 December–2021 March. The planetary defense community has been conducting observational campaigns since 2017 to test the operational readiness of the global planetary defense capabilities. These community-led global exercises were carried out with the support of NASA's Planetary Defense Coordination Office and the International Asteroid Warning Network. The Apophis campaign is the third in our series of planetary defense exercises. The goal of this campaign was to recover, track, and characterize Apophis as a potential impactor to exercise the planetary defense system including observations, hypothetical risk assessment and risk prediction, and hazard communication. Based on the campaign results, we present lessons learned about our ability to observe and model a potential impactor. Data products derived from astrometric observations were available for inclusion in our risk assessment model almost immediately, allowing real-time updates to the impact probability calculation and possible impact locations. An early NEOWISE diameter measurement provided a significant improvement in the uncertainty on the range of hypothetical impact outcomes. The availability of different characterization methods such as photometry, spectroscopy, and radar provided robustness to our ability to assess the potential impact risk.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
Search for topological defect dark matter with a global network of optical magnetometers
Autorzy:
Dailey, Conner
Kornack, Thomas
Wang, Tao
Masia-Roig, Hector
Hamilton, Paul S.
Sheng, Dong
Smiga, Joseph A.
Weis, Antoine
Buchler, Ben C.
Jackson Kimball, Derek F.
Grujić, Zoran D.
Stalnaker, Jason E.
Monroy, Madeline
Sulai, Ibrahim
Pustelny, Szymon
Peng, Xiang
Khamis, Sami
Kim, Dongok
Wilson, Tatum
Lebedev, Victor
Wickenbrock, Arne
Hedges, Morgan
Paul, Karun V.
Zhang, Jianwei
Pospelov, Maxim
Padniuk, Mikhail
Budker, Dmitry
Palm, Christopher A.
Derevianko, Andrei
Tandon, Dhruv
Figueroa, Nataniel L.
Gerhardt, Ilja
Segura, Perrin C.
Lu, Zheng-Tian
Afach, Samer
Semertzidis, Yannis K.
Penaflor, Alexander
Wu, Teng
Wurm, David
Yu, Dongrui
Yang, Yucheng
Scholtes, Theo
Dumont, Vincent
Shin, Yun Chang
Park, Sun Yool
Hao, Chuanpeng
Guo, Hong
Preston, Rayshaun
Xiao, Wei
Opis:
Ultralight bosons such as axion-like particles are viable candidates for dark matter. They can form stable, macroscopic field configurations in the form of topological defects that could concentrate the dark matter density into many distinct, compact spatial regions that are small compared with the Galaxy but much larger than the Earth. Here we report the results of the search for transient signals from the domain walls of axion-like particles by using the global network of optical magnetometers for exotic (GNOME) physics searches. We search the data, consisting of correlated measurements from optical atomic magnetometers located in laboratories all over the world, for patterns of signals propagating through the network consistent with domain walls. The analysis of these data from a continuous month-long operation of GNOME finds no statistically significant signals, thus placing experimental constraints on such dark matter scenarios.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł

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