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    Wyświetlanie 1-6 z 6
    Tytuł:
    Migraine-associated common genetic variants confer greater risk of posterior vs. anterior circulation ischemic stroke
    Autorzy:
    Dalca, A.V.
    Thijs, V.
    Ryan, K.
    Frid, P.
    Meschia, J.F.
    Schmidt, R.
    Słowik, Agnieszka
    Kissela, B.M.
    Holmegaard, L.
    Golland, P.
    Broderick, J.P.
    Worrall, B.B.
    Wu, O.
    Rundek, T.
    Giralt-Steinhauer, E.
    Drake, M.
    Mcardle, P.F.
    Woo, D.
    Mocking, S.J.T.
    Bouts, M.J.R.J.
    Lemmens, R.
    Sharma, P.
    Xu, H.
    Jood, K.
    Cole, J.W.
    Lindgren, A.
    Irie, R.
    Kleindorfer, D.O.
    Rost, N.S.
    Schirmer, M.
    Roquer, J.
    Kittner, S.J.
    Donahue, K.L.
    Gaynor, B.
    Mitchell, B.D.
    Sacco, R.L.
    Jern, C.
    Giese, A.K.
    Wasselius, J.
    Rosand, J.
    Mcintosh, E.C.
    Jimenez-Conde, J.
    Petersson, J.
    Opis:
    Objective: To examine potential genetic relationships between migraine and the two distinct phenotypes posterior circulation ischemic stroke (PCiS) and anterior circulation ischemic stroke (ACiS), we generated migraine polygenic risk scores (PRSs) and compared these between PCiS and ACiS, and separately vs. non-stroke control subjects. Methods: Acute ischemic stroke cases were classified as PCiS or ACiS based on lesion location on diffusion-weighted MRI. Exclusion criteria were lesions in both vascular territories or uncertain territory; supratentorial PCiS with ipsilateral fetal posterior cerebral artery; and cases with atrial fibrillation. We generated migraine PRS for three migraine phenotypes (any migraine; migraine without aura; migraine with aura) using publicly available GWAS data and compared mean PRSs separately for PCiS and ACiS vs. non-stroke control subjects, and between each stroke phenotype. Results:Our primary analyses included 464 PCiS and 1079 ACiS patients with genetic European ancestry. Compared to non-stroke control subjects (n=15396), PRSs of any migraine were associated with increased risk of PCiS (p=0.01–0.03) and decreased risk of ACiS (p=0.010–0.039). Migraine without aura PRSs were significantly associated with PCiS (p=0.008–0.028), but not with ACiS. When comparing PCiS vs. ACiS directly, migraine PRSs were higher in PCiS vs. ACiS for any migraine (p=0.001–0.010) and migraine without aura (p=0.032–0.048). Migraine with aura PRS did not show a differential association in our analyses. Conclusions: Our results suggest a stronger genetic overlap between unspecified migraine and migraine without aura with PCiS compared to ACiS. Possible shared mechanisms include dysregulation of cerebral vessel endothelial function.
    Dostawca treści:
    Repozytorium Uniwersytetu Jagiellońskiego
    Artykuł
    Tytuł:
    Enigmatic recurrent pulsational variability of the accreting white dwarf EQ Lyn (SDSS J074531.92+453829.6)
    Autorzy:
    Brockett, T.
    Rodriguez-Gil, P.
    Gänsicke, B. T.
    Southworth, J.
    Mukadam, Anjum S.
    Harrold, S.
    Qian, S.-B.
    Zharikov, S.
    Tovmassian, G.
    Townsley, D. M.
    Montgomery, M. H.
    Henden, A.
    Winget, D. E.
    Aungwerojwit, A.
    Drake, A. J.
    Szymański, Tomasz
    Zoła, Stanisław
    Parsons, S.
    Sion, E. M.
    Szkody, Paula
    Hermes, J. J.
    Pavlenko, E.
    Opis:
    Photometric observations of the cataclysmic variable EQ Lyn (SDSS J074531.92+453829.6), acquired from 2005 October to 2006 January, revealed high-amplitude variability in the range 1166-1290 s. This accreting white dwarf underwent an outburst in 2006 October, during which its brightness increased by at least five magnitudes, and it started exhibiting superhumps in its light curve. Upon cooling to quiescence, the superhumps disappeared and it displayed the same periods in 2010 February as prior to the outburst within the uncertainties of a couple of seconds. This behavior suggests that the observed variability is likely due to nonradial pulsations in the white dwarf star, whose core structure has not been significantly affected by the outburst. The enigmatic observations begin with an absence of pulsational variability during a multi-site campaign conducted in 2011 January-February without any evidence of a new outburst; the light curve is instead dominated by superhumps with periods in the range of 83-87 minutes. Ultraviolet Hubble Space Telescope time-series spectroscopy acquired in 2011 March reveals an effective temperature of 15,400 K, placing EQ Lyn within the broad instability strip of 10,500-16,000 K for accreting pulsators. The ultraviolet light curve with 90% flux from the white dwarf shows no evidence of any pulsations. Optical photometry acquired during 2011 and Spring 2012 continues to reflect the presence of superhumps and an absence of pulsations. Subsequent observations acquired in 2012 December and 2013 January finally indicate the disappearance of superhumps and the return of pulsational variability with similar periods as previous data. However, our most recent data from 2013 March to May reveal superhumps yet again with no sign of pulsations. We speculate that this enigmatic post-outburst behavior of the frequent disappearance of pulsational variability in EQ Lyn is caused either by heating the white dwarf beyond the instability strip due to an elevated accretion rate, disrupting pulsations associated with the He II instability strip by lowering the He abundance of the convection zone, free geometric precession of the entire system, or appearing and disappearing disk pulsations.
    Dostawca treści:
    Repozytorium Uniwersytetu Jagiellońskiego
    Artykuł
    Tytuł:
    Multifrequency studies of the peculiar quasar 4C +21.35 during the 2010 flaring activity
    Autorzy:
    Treves, A.
    Wood, D. L.
    Gurwell, M. A.
    Stamatescu, V.
    Murgia, S.
    Maneva, G.
    Dermer, C. D.
    Saggion, A.
    Porter, T. A.
    Lister, M. L.
    Horan, D.
    Mayer, M.
    Carreto Fidalgo, D.
    Bangale, P.
    Vasileiou, V.
    Hadasch, D.
    Brigida, M.
    Antoranz, P.
    Nikolashvili, M. G.
    Gozzini, S. R.
    Ribó, M.
    Giavitto, G.
    Gehrels, N.
    Morselli, A.
    Prandini, E.
    Homan, D. C.
    Thayer, J. B.
    Vitale, V.
    Krause, J.
    Preziuso, S.
    Chekhtman, A.
    Chiang, J.
    Knödlseder, J.
    Rainò, S.
    Cecchi, C.
    Miranda, J. M.
    Ferenc, D.
    Bonnoli, G.
    Bonamente, E.
    Kushida, J.
    Usher, T. L.
    Sanchez, D. A.
    Colin, P.
    Takahashi, T.
    Lozano, I.
    Ciprini, S.
    Sun, S.
    Efimova, N. V.
    Finke, J.
    López-Coto, R.
    Orienti, M.
    Michelson, P. F.
    Focke, W. B.
    Mariotti, M.
    Dominis Prester, D.
    Reinthal, R.
    Guiriec, S.
    Meucci, M.
    Partini, S.
    Iafrate, G.
    Jordan, B.
    Frantzen, K.
    Mirzoyan, R.
    Bednarek, W.
    Favuzzi, C.
    Blanch, O.
    Reimer, O.
    Fruck, C.
    Moskalenko, I. V.
    Tosti, G.
    Storz, J.
    Conrad, J.
    Larsson, S.
    Paredes-Fortuny, X.
    Shore, S. N.
    Caraveo, P. A.
    Bretz, T.
    Fukazawa, Y.
    Dazzi, F.
    Lindfors, E.
    Schweizer, T.
    Godfrey, G.
    Stamerra, A.
    Mannheim, K.
    Hayashida, M.
    Orito, R.
    Terzić, T.
    Carosi, A.
    Blinov, D. A.
    Overkemping, A.
    Mazziotta, M. N.
    Berger, K.
    Persic, M.
    Babic, A.
    Terrats, D. Garrido
    Caneva, G. De
    Perkins, J. S.
    Sillanpää, A.
    Scapin, V.
    Teshima, M.
    Giordano, F.
    D'Ammando, F.
    Johnson, A. S.
    Stawarz, Łukasz
    Kadenius, V.
    Hose, J.
    López-Oramas, A.
    Lorenz, E.
    Drell, P. S.
    Mizuno, T.
    Troja, E.
    Gasparrini, D.
    Reimer, A.
    Kovalev, Y. Y.
    Hewitt, J. W.
    Spinelli, P.
    Garczarczyk, M.
    Carmona, E.
    Fusco, P.
    Ajello, M.
    Franckowiak, A.
    Mazin, D.
    Buehler, R.
    Giroletti, M.
    Kuss, M.
    Surić, T.
    Takami, H.
    Larionov, V. M.
    Sgrò, C.
    Giglietto, N.
    De Angelis, A.
    Niedzwiecki, A.
    Bellazzini, R.
    Menzel, U.
    Elsaesser, D.
    Ansoldi, S.
    Tibolla, O.
    Toyama, T.
    Paiano, S.
    Piron, F.
    Torres, D. F.
    Spandre, G.
    Donato, D.
    Sitarek, J.
    Snidaric, I.
    Font, L.
    Wagner, R. M.
    Aller, M. F.
    Ros, E.
    Tornikoski, M.
    Cavazzuti, E.
    Pivato, G.
    Rügamer, S.
    Contreras, J. L.
    Ohsugi, T.
    Werner, M.
    Godinović, N.
    Herrero, A.
    Cortina, J.
    Domínguez, A.
    Martínez, M.
    Pesce-Rollins, M.
    Rico, J.
    Satalecka, K.
    Nilsson, K.
    Doert, M.
    Vianello, G.
    Bonnefoy, S.
    Kubo, H.
    Vela, P. Da
    Lombardi, S.
    Sobczynska, D.
    Prada, F.
    Thaele, J.
    González, J. Becerra
    Tescaro, D.
    Antolini, E.
    Marcote, B.
    López, R. J. García
    Einecke, S.
    Kurtanidze, O. M.
    Grenier, I. A.
    Thayer, J. G.
    Almeida, U. Barres de
    Cohen-Tanugi, J.
    Saito, K.
    Lubrano, P.
    Lelas, D.
    Djorgovski, S. G.
    Cutini, S.
    Puljak, I.
    Schulz, A.
    Borracci, F.
    Allafort, A.
    Kodani, K.
    Munar-Adrover, P.
    Lähteenmäki, A.
    Makariev, M.
    Barbiellini, G.
    Nakajima, D.
    Temnikov, P.
    Monzani, M. E.
    Gargano, F.
    Razzano, M.
    Zandanel, F.
    Moroni, P. G. Prada
    Aleksić, J.
    Winer, B. L.
    Eisenacher, D.
    Idec, W.
    Scalzotto, V.
    Vandenbroucke, J.
    Wood, K. S.
    Caliandro, G. A.
    Lewandowska, N.
    Nishijima, K.
    Claus, R.
    Tavecchio, F.
    Steinbring, T.
    Angelakis, E.
    Loparco, F.
    Covino, S.
    Tinivella, M.
    Moralejo, A.
    Drake, A. J.
    Orlando, E.
    Bernardini, E.
    Bregeon, J.
    Silva, E. do Couto e
    Fonseca, M. V.
    Sigua, L. A.
    Ackermann, M.
    Mendez, C. Delgado
    Savolainen, T.
    Buson, S.
    Takahashi, H.
    Bissaldi, E.
    Konno, Y.
    Gaug, M.
    Lovellette, M. N.
    Mallot, K.
    Chiaro, G.
    Kellermann, H.
    Palatiello, M.
    Garcia, J. Rodriguez
    Knoetig, M. L.
    Hughes, R. E.
    Nemmen, R.
    Chaves, R. C. G.
    Lotto, B. De
    Mankuzhiyil, N.
    Bock, R. K.
    Nieppola, E.
    Cameron, R. A.
    Thompson, D. J.
    Schultz, C.
    Zanin, R.
    Lande, J.
    Colombo, E.
    McEnery, J. E.
    Dorner, D.
    Paredes, J. M.
    Muñoz, A. González
    Antonelli, L. A.
    Doro, M.
    Hildebrand, D.
    Barbera, A. La
    Bastieri, D.
    Maraschi, L.
    Takalo, L.
    Vogler, P.
    Salvati, M.
    Latronico, L.
    Longo, F.
    Biland, A.
    Bruel, P.
    de Palma, F.
    López, M.
    Paneque, D.
    Saito, T.
    Spanier, F.
    Nowak, N.
    Rhode, W.
    Kopatskaya, E. N.
    Hrupec, D.
    Barrio, J. A.
    Farina, E.
    Paoletti, R.
    Siskind, E. J.
    Nuss, E.
    Opis:
    The discovery of rapidly variable Very High Energy (VHE; E > 100 GeV) gamma-ray emission from 4C +21.35 (PKS  1222+216) by MAGIC on 2010 June 17, triggered by the high activity detected by the Fermi Large Area Telescope (LAT) in high energy (HE; E > 100 MeV) gamma-rays, poses intriguing questions on the location of the gamma-ray emitting region in this flat spectrum radio quasar. We present multifrequency data of 4C +21.35 collected from centimeter to VHE during 2010 to investigate the properties of this source and discuss a possible emission model. The first hint of detection at VHE was observed by MAGIC on 2010 May 3, soon after a gamma-ray flare detected by Fermi-LAT that peaked on April 29. The same emission mechanism may therefore be responsible for both the HE and VHE emission during the 2010 flaring episodes. Two optical peaks were detected on 2010 April 20 and June 30, close in time but not simultaneous with the two gamma-ray peaks, while no clear connection was observed between the X-ray and gamma-ray emission. An increasing flux density was observed in radio and mm bands from the beginning of 2009, in accordance with the increasing gamma-ray activity observed by Fermi-LAT, and peaking on 2011 January 27 in the mm regime (230 GHz). We model the spectral energy distributions (SEDs) of 4C +21.35 for the two periods of the VHE detection and a quiescent state, using a one-zone model with the emission coming from a very compact region outside the broad line region. The three SEDs can be fit with a combination of synchrotron self-Compton and external Compton emission of seed photons from a dust torus, changing only the electron distribution parameters between the epochs. The fit of the optical/UV part of the spectrum for 2010 April 29 seems to favor an inner disk radius of < six gravitational radii, as one would expect from a prograde-rotating Kerr black hole.
    Dostawca treści:
    Repozytorium Uniwersytetu Jagiellońskiego
    Artykuł
    Tytuł:
    Introducing the CTA concept
    Autorzy:
    Benbow, W.
    Sandaker, H.
    Mahabir, M.
    Niemiec, J.
    Roy, F.
    McHardy, I.
    Stamatescu, V.
    Fontaine, G.
    Boutonnet, C.
    Hidaka, N.
    Kossakowski, R.
    Errando, M.
    Micolon, P.
    Wakely, S. P.
    De Frondat, F.
    Martens, C.
    Ridky, J.
    Naumann, D.
    Tammi, J.
    Lenain, J.-P.
    Puerto-Gimenez, I.
    Okuda, T.
    Ribó, M.
    Giro, E.
    Stringhetti, L.
    Eleftheriadis, C.
    Grygorczuk, J.
    Farakos, K.
    Henault, F.
    de Gouveia Dal Pino, E. M.
    Ibarra, A.
    Marcowith, A.
    Krennrich, F.
    Mottez, F.
    Russo, F.
    Todero Peixoto, C. J.
    Falcone, A.
    Johnson, T.
    Wierzcholska, Alicja
    Darling, J.
    Disset, G.
    Giebels, B.
    Sun, S.
    Lohse, T.
    Mineo, T.
    Bonev, T.
    Mertsch, P.
    Allafort, A. J.
    Melioli, C.
    Bulgarelli, A.
    Martin, J.-M.
    Punch, M.
    Rajda, P. J.
    Reimer, O.
    Saito, Y.
    Firpo Curcoll, R.
    Impiombato, D.
    Dravins, D.
    Umehara, K.
    Conrad, J.
    Grañena, F.
    Hakansson, N.
    Gruev, V.
    Bretz, T.
    Salini, A.
    Busetto, G.
    Botner, O.
    Fukazawa, Y.
    Lindfors, E.
    Ribordy, M.
    Asano, K.
    Daniel, M.
    Bulik, T.
    Actis, M.
    Golev, V.
    Carosi, A.
    Cerruti, M.
    Berger, K.
    Persic, M.
    Hassan, T.
    Armstrong, T.
    Brook, P.
    Granot, J.
    Boettcher, M.
    Barnstedt, J.
    Blake, S.
    Sacco, B.
    Scapin, V.
    Cavazzani, S.
    Drury, L.
    Asorey, H. G.
    López-Oramas, A.
    Yelos, D.
    Tiengo, A.
    Bhat, N.
    Kudryavtsev, V. A.
    Bhattacharyya, S.
    Reitberger, K.
    Toma, K.
    Flores, H.
    Reimer, A.
    Vassiliev, V.
    Prokoph, H.
    Criswell, S. J.
    Mukherjee, R.
    Raue, M.
    Pedaletti, G.
    Neyroud, N.
    Santos, E. M.
    Angüner, E. O.
    Leigui de Oliveira, M. A.
    Rojas, G.
    Shum, E.
    Compin, M.
    Wagner, R. G.
    Garrido, L.
    Yamamoto, H.
    Aghajani, T.
    Tibolla, O.
    Wawer, P.
    Yamamoto, T.
    Kosack, K.
    Depaola, G.
    Zabalza, V.
    Kitamoto, K.
    Martí, J.
    Sowiński, M.
    Baba, H.
    Baushev, A.
    Kieda, D. B.
    Ioka, K.
    Vergani, S.
    Dafonseca, M.
    Markoff, S.
    Prouza, M.
    Billotta, S.
    Smith, N.
    Tsinganos, K.
    Gomez Berisso, M.
    Inoue, Y.
    Tornikoski, M.
    Bigongiari, C.
    Fesquet, M.
    Naumann, C.
    Baby, N.
    Journet, L.
    Ashton, T.
    Allekotte, I.
    Komin, N.
    Ostrowski, Michał
    Stergioulas, N.
    Förster, A.
    Djannati-Ataï, A.
    Dubus, G.
    Lombardi, S.
    Wood, M.
    Finley, C.
    Maya, J.
    Glanzman, T.
    Hermann, G.
    Brunetti, L.
    Vuerli, C.
    Demange, P.
    Cotter, G.
    Della Volpe, D.
    Mori, K.
    Jacholkowska, A.
    Cohen-Tanugi, J.
    Saito, K.
    Fouque, N.
    Suric, T.
    Frei, R.
    Supanitsky, A. D.
    Coppi, P.
    Baixeras, C.
    Crimi, G.
    Paillot, D.
    Munar-Adrover, P.
    Kodani, K.
    Fede, E.
    Schulz, A.
    Emmanoulopoulos, D.
    Pelat, D.
    Bitossi, M.
    Shayduk, M.
    Smith, D.
    Federici, S.
    Bose, R.
    Jablonski, C.
    Peyaud, B.
    Giarrusso, S.
    Ismailova, E.
    Ziółkowski, P.
    Totani, T.
    Nishijima, K.
    Edy, E.
    Rieger, F.
    Sanuy, A.
    Courty, B.
    Berdugo, J.
    Corti, D.
    Lieunard, B.
    Hofmann, W.
    Buanes, T.
    Gaug, M.
    Nikolaidis, A.
    Poutanen, J.
    Kärcher, K.
    Beckmann, V.
    Balbo, M.
    Girard, N.
    Yamazaki, R.
    Spiga, D.
    Blanch Bigas, O.
    Dorner, D.
    Horville, D.
    Takalo, L.
    Braun, I.
    Wetteskind, H.
    Bamba, A.
    Gaweda, J.
    Reville, B.
    Kagaya, M.
    Ueno, H.
    Talbot, G.
    Dale, O.
    Gebremedhin, L.
    Paoletti, R.
    Hrabovsky, M.
    Nellen, L.
    Perez, M. d. C.
    Zacharias, M.
    Inoue, S.
    Leopold, D. J.
    Pichel, A.
    Ohira, Y.
    Usher, T.
    Dyrda, M.
    Osborne, J.
    Mc Comb, L.
    Digel, S.
    Mrusek, I.
    Dournaux, J.-L.
    Madhavan, A.
    Knapp, J.
    Mognet, I.
    Basso, S.
    Chabanne, E.
    Platos, Ł.
    Schwemmer, S.
    Wiśniewski, Ł.
    Bais, A.
    Finley, J. P.
    Dickinson, H.
    Romaszkan, W.
    Rovero, A. C.
    Prandini, E.
    Naumann-Godo, M.
    Kabuki, S.
    Nozato, A.
    Vegas, I.
    Colome, J.
    Chikawa, M.
    Dufour, C.
    Ohm, S.
    Chiappetti, L.
    Miranda, J. M.
    Ferenc, D.
    Segreto, A.
    Veberic, D.
    Bonnoli, G.
    Sakonaka, R.
    Geffroy, N.
    Moore, P.
    Colin, P.
    Corona, P.
    De La Vega, G. A.
    Huan, H.
    Wawrzaszek, R.
    Warda, K.
    De Luca, A.
    López-Coto, R.
    Delagnes, E.
    Gianotti, F.
    Föhr, C.
    Bobkov, A.
    De Caprio, V.
    Steiner, S.
    Yoshida, T.
    Bernardino, T.
    Arnaldi, H.
    Brun, P.
    Díaz, C.
    Carton, P.-H.
    Mirzoyan, R.
    Papyan, G.
    Ripken, J.
    Grasseau, G.
    Lopez, M.
    Vincent, S.
    Vink, J.
    Torii, K.
    Wagner, R.
    Casanova, S.
    Palanque, S.
    Colafrancesco, S.
    Le Padellec, A.
    Rousselle, S.
    Katarzyński, K.
    Tejedor, L. A.
    Schweizer, T.
    Tezier, D.
    Rando, R.
    Briggs, M.
    Bernlöhr, K.
    Gómez-Ortega, J.
    Deleglise, G.
    Kuznetsov, A.
    Houles, J.
    Fillin-Martino, E.
    Kalkuhl, C.
    Manthos, I.
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    Le Flour, T.
    Huber, B.
    Horns, D.
    Kretzschmann, A.
    de Oliveira, Y.
    Molinari, E.
    van Driel, W.
    Sternberger, R.
    Hara, S.
    Covino, S.
    Niedźwiecki, A.
    Rivoire, S.
    Kihm, T.
    Riviére, A.
    Stodulski, M.
    Di Pierro, F.
    Maxfield, S.
    Toussenel, F.
    Buson, S.
    Favill, B.
    Nakamori, T.
    Egberts, K.
    Gougerot, M.
    Gall, D.
    Fantinel, D.
    Lorca, A.
    González, A.
    Gäbele, W.
    Fornasa, M.
    Borgland, A.
    Kawanaka, N.
    Kozioł, Jerzy
    Lande, J.
    Koyama, S.
    Sutcliffe, P.
    Sykes, J.
    Sahakian, V.
    Biland, A.
    Mathieu, A.
    Canestrari, R.
    Decock, G.
    Paneque, D.
    Saito, T.
    Tenzer, C.
    Buckley, J.
    Krueger, P.
    Okumura, A.
    Steenkamp, R.
    Schovanek, P.
    Fresnillo, L.
    Vercellone, S.
    Dostawca treści:
    Repozytorium Uniwersytetu Jagiellońskiego
    Artykuł
      Wyświetlanie 1-6 z 6

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