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    Wyświetlanie 1-6 z 6
    Tytuł:
    Cross-oncopanel study reveals high sensitivity and accuracy with overall analytical performance depending on genomic regions
    Autorzy:
    Ma, Charles
    Supplee, Julianna
    Zhang, Sa
    Kreil, David Philip
    Blomquist, Thomas M.
    Tom, Nikola
    Xiao, Chunlin
    Li, Weihua
    LoCoco, Jennifer S.
    Jones, Wendell
    Megherbi, Dalila B.
    Hipp, Jennifer
    Horvath, Kyle
    Strahl, Maya
    Marella, Narasimha
    Silla-Castro, Juan Carlos
    López, Mario Solís
    Qu, Wubin
    Liang, Yu
    Verma, Suman
    Eterovic, Agda Karina
    Pirooznia, Mehdi
    Pabón-Peña, Carlos
    Ghosal, Abhisek
    Craig, Daniel J.
    Chen, Tao
    Hennigan, Brittany
    Deveson, Ira W.
    Qiu, Fujun
    Chang, Chia-Jung
    del Pozo, Angela
    Tang, Lin-ya
    Yip, Shun H.
    Duncan, Daniel
    Hu, Jianhong
    Stetson, Daniel
    Shi, Tieliu
    Li, Quan-Zhen
    Shaknovich, Rita
    Chin, Christopher R.
    Richmond, Todd A.
    Willey, James C.
    Bhandari, Ambica
    Sebra, Robert
    Zhang, Guangliang
    Burgess, Daniel
    Tichý, Boris
    Jarosz, Mirna
    Liu, Liang-Chun
    Fan, Xiaohui
    Szankasi, Philippe
    Bushel, Pierre R.
    Haseley, Nathan
    Gong, Binsheng
    Scherer, Andreas
    Glenn, Sean
    Crawford, Erin
    Hong, Huixiao
    Martín-Arenas, Rubén
    Hung, Li-Yuan
    Wirta, Valtteri
    Chaubey, Alka
    Bao, Wenjun
    Li, Zhiguang
    Shi, Leming
    Zhou, Xiaoyan
    Kerkhof, Jennifer
    Lader, Eric
    Garcia, Elena Vallespin
    Chierici, Marco
    Xu, Shibei
    Li, Dan
    Xu, Joshua
    Liu, Zhichao
    Morrison, Tom
    Walker, Kimbley
    Tan, Haowen
    Mason, Christopher E.
    Johann, Donald J.
    Łabaj, Paweł
    Butler, Daniel J.
    Wang, Junwen
    Best, Hunter
    Ning, Baitang
    Parsons, Barbara L.
    Arib, Hanane
    Thierry-Mieg, Danielle
    Lapunzina, Pablo
    Blackburn, James
    Tao, Yonghui
    Wang, Charles
    Thomas, David
    Zhao, Meiru
    Happe, Scott
    Cai, Wanshi
    Zheng, Yuanting
    Stuart, Alan
    Shi, Qiang
    Sadikovic, Bekim
    Giorda, Kristina
    Boardman, Lisa
    Wen, Zhining
    Kusko, Rebecca
    Xu, Chang
    Raymond, Amelia
    Chen, Guangchun
    Mittal, Vinay K.
    Hang, Xinyi
    Meng, Qingchang
    Zhang, Yifan
    Li, Peng
    Wang, Yexun
    Thakkar, Shraddha
    Thodima, Venkat J.
    Wilkins, Katherine
    Tong, Weida
    Mieczkowski, Piotr A.
    Lucas, Anne Bergstrom
    Cooley Coleman, Jessica
    Liu, Shaoqing
    Ringler, Rebecca
    Lai, Kevin
    Schulze, Egbert
    Yu, Ying
    Mercer, Timothy
    Muzny, Donna
    Guan, Meijian
    Yang, Mary
    Rindler, Paul
    Song, Ping
    Paweletz, Cloud P.
    Wu, Leihong
    Bao, Longlong
    Kipp, Benjamin
    Attwooll, Claire
    Wang, Shangzi
    Haag, Christine
    Smith, Melissa
    Thierry-Mieg, Jean
    Furlanello, Cesare
    Bisgin, Halil
    Ying, Jianming
    Novoradovskaya, Natalia
    Zhang, Zhihong
    Babson, Kevin
    Close, Devin
    Conroy, Jeffrey
    Burgher, Blake
    Xiao, Wenzhong
    Cawley, Simon
    Foox, Jonathan
    Opis:
    Targeted sequencing using oncopanels requires comprehensive assessments of accuracy and detection sensitivity to ensure analytical validity. By employing reference materials characterized by the U.S. Food and Drug Administration-led SEquence Quality Control project phase2 (SEQC2) effort, we perform a cross-platform multi-lab evaluation of eight Pan-Cancer panels to assess best practices for oncopanel sequencing.
    Dostawca treści:
    Repozytorium Uniwersytetu Jagiellońskiego
    Artykuł
    Tytuł:
    Multirate delivery of multiple therapeutic agents from metal-organic frameworks
    Autorzy:
    Gil, Barbara
    Charrier, Cedric
    Düren, Tina
    Mercer, Derry K.
    Teat, Simon J.
    Ashbrook, Sharon E.
    Wheatley, Paul S.
    Renouf, Catherine L.
    Warrender, Steward J.
    Allan, Phoebe K.
    Dawson, Daniel
    Morris, Russell E.
    McKinlay, Alistair C.
    Williams, Jenifer J.
    Duncan, Morven J.
    Marszałek, Bartosz
    Opis:
    The highly porous nature of metal-organic frameworks (MOFs) offers great potential for the delivery of therapeutic agents. Here, we show that highly porous metal-organic frameworks can be used to deliver multiple therapeutic agents—a biologically active gas, an antibiotic drug molecule, and an active metal ion—simultaneously but at different rates. The possibilities offered by delivery of multiple agents with different mechanisms of action and, in particular, variable timescales may allow new therapy approaches. Here, we show that the loaded MOFs are highly active against various strains of bacteria.
    Dostawca treści:
    Repozytorium Uniwersytetu Jagiellońskiego
    Artykuł
    Tytuł:
    Same data, different analysts : variation in effect sizes due to analytical decisions in ecology and evolutionary biology
    Autorzy:
    Thawley, Christopher J.
    Ferreira-Arruda, Thalita
    Rugemalila, Deusdedith
    Taff, Conor Claverie
    Hager, Heather A.
    Schmoll, Tim
    Ke, Alison
    Fisher, David N.
    Payo-Payo, Ana
    Mos, Benjamin
    Abbey-Lee, Robin N.
    Martin, Charles A.
    Manrique-Garzon, Laura Milena
    Michelangeli, Marcus
    Shapiro, Julie Teresa
    Rosenberg, Michael S.
    Schroeder, Julia
    Cox, Murray P.
    Novotny, Jessie Lanterman
    Santos, Leticia Pereira
    Kačergytė, Ineta
    Muraina, Taofeek Olatunbosun
    Griffith, Frances J.
    Riva, Federico
    Paterson, John Harold
    García-Cervigón, Ana I.
    Camerlenghi, Ettore
    Macphie, Kirsty H.
    Schmidt, Marcus
    Youngflesh, Casey
    Palacio, Facundo Xavier
    Campbell, Sara E.
    Skupien, Fabrício Luiz
    Keogan, Katharine
    Perry, Kayla I.
    Bell, Kristian
    Good, Megan Kate
    Harrison, Natasha Dean
    Paquet, Matthieu
    Zilio, Giacomo
    Pottier, Patrice
    Organ, Chris L.
    Döbert, Timm Fabian
    Greenler, Skye M.
    Marchand, Philippe
    Smith, Jeremy A.
    Elmore, Jared Alan
    Turnell, Biz R.
    Jucker, Tommaso
    Gandy, Sara L.
    Verrelli, Brian C.
    Atkins, Jeff W.
    Razafindratsima, Onja H.
    Vélez, Juliana
    Johnsson, Martin
    Crouch, Connor Davidson
    de Sousa, Alexandra Allison
    Martin, Dominic Andreas
    Tanentzap, Andrew J.
    Walker, Xanthe J.
    Wolfson, David William
    Bradham, Jennifer
    Ross, Jessica
    Atkinson, Joe
    Barrett, Meghan
    Gould, Elliot
    Shearer, Caroline L.
    Wood, Andrew
    Law, Alan
    Kaltz, Oliver
    Gliksman, Daniel
    Drobniak, Szymon
    Hagan, James G.
    van Oordt, Francis
    Hsu, Bin-Yan
    Billman, Peter D.
    de Lima, Daniela Oliveira
    Blake, Shannon
    Finch, Elizabeth A.
    Kothari, Shan
    Griffith, Daniel M.
    Herrera-Chaustre, María Laura
    Slinn, Heather Lea
    Ramananjato, Veronarindra
    Zimmer, Cédric
    Meiners, Scott J.
    Martinig, April Robin
    Goslee, Sarah C.
    Campos, Leonardo L. F.
    Gilles, Marc
    Duffy, Alexandra Grace
    Baker, Christopher M.
    Vergara-Florez, Diana Carolina
    Santostefano, Francesca
    Tompkins, Emily M.
    Dunn, Robert P.
    Dobson, Adam J.
    Salazar, Stephen M.
    Eberhart-Hertel, Luke
    Kochan, David P.
    Takola, Elina
    Géron, Charly
    Freund, Cathryn A.
    Blake, Charlie K.
    Chik, Heung Ying Janet
    Telford, Richard J.
    Magellan, Kit
    Zimmerman, Gregory Mark
    Bertram, Michael Grant
    Luquet, Martin
    Roast, Michael James
    Nooten, Sabine S.
    Hamilton, Daniel G.
    D’Amelio, Pietro B.
    Goldspiel, Harrison B.
    Mortensen, Jennifer
    Vanderwel, Mark C.
    Yen, Jian D. L.
    Niemelä, Petri
    McCallum, Erin S.
    Malm, Lisa E.
    Trlica, Andrew
    Christie, Alec Philip
    Mair, Magdalena M.
    Weaver, Ryan J.
    Salmón, Pablo
    Caravaggi, Anthony
    Harris, Jonathan Philo
    Elsherif, Mahmoud Medhat
    Vitali, Valerio
    Murphy, Penelope Wrenn
    Aloni, Irith
    Havird, Justin Chase
    Sánchez-Tójar, Alfredo
    English, Holly M.
    Pedersen, Karen Marie
    Clark, Bethany L.
    Walker, Jeffrey
    Brand, Jack A.
    Schtickzelle, Nicolas
    Zitomer, Rachel A.
    Kusch, Jillian M.
    Larson, Courtney L.
    Haesen, Stef
    Chunco, Amanda J.
    Moiron, Maria
    Heaton, Andrew J.
    Schilling, Hayden T.
    Killion, Alexander K.
    Lagisz, Malgorzata
    Bulla, Martin
    Tarjuelo, Rocío
    Hasnain, Sarah Syedia
    Sollmann, Rahel
    Fidler, Fiona
    Merkling, Thomas
    Grebe, Nicholas M.
    Román-Palacios, Cristian
    Frank, Graham S.
    Gomes, Dylan G. E.
    Kelly, Clint D.
    Simón, Diego
    Olin, Agnes Birgitta
    Bradfer-Lawrence, Tom
    Manhart, Michael
    Whelan, Shannon
    Villamil, Nora
    Cressman, Kimberly A.
    Alcaraz, Carles
    Griffioen, Maaike
    Fernandez-Juricic, Esteban
    Cardoso, Pedro
    Russell, Avery L.
    Jung, Martin
    Girndt, Antje
    Fiorenza, Evan A.
    Bordes, Camille Nina Marion
    McCauley, Mark
    Saccone, Patrick
    Gratton, Paolo
    Tortorelli, Claire Marie
    Crotti, Marco
    Dobler, Ralph
    Fourcade, Yoan
    Griffith, Simon C.
    Rocha, Felipe Pereira
    Nelli, Luca
    Sutton, Guy F.
    Ensminger, David C.
    Beltrán, Iván
    Martin, Jake Mitchell
    Keppeler, Friedrich Wolfgang
    Boyd, Melissa Anna
    Gosnell, J. Stephen
    Waryszak, Pawel
    Brengdahl, Martin I.
    Lindsay, Shane
    Chuang, Angela
    Forstmeier, Wolfgang
    Tidau, Svenja
    Fieberg, John
    Johnson, Douglas H.
    Perez, Grégoire
    Lauterbur, M. Elise
    Kuppler, Jonas
    Mäntylä, Elina
    Thierry, Hugo
    Catanach, Therese A.
    Vanderwel, K. Michelle
    Bonisoli-Alquati, Andrea
    Sadeh, Asaf
    Iranzo, Esperanza C.
    Aguirre, Luis A.
    L’Herpiniere, Kiara
    Parker, Timothy H.
    Smith, Grania Polly
    Whitney, Kaitlin Stack
    Lembrechts, Jonas J.
    Choy, Emily Sarah
    Léandri-Breton, Don-Jean
    Bonnet, Timothée
    Dutta, Trishna
    Dunning, Jamie
    Garretson, Alexis C.
    Mandeville, Caitlin P.
    Iverson, Erik N. K.
    Nightingale, Josh
    Still, Shannon Michael
    Abbott, Jessica K.
    Parker, Darren James
    Ruuskanen, Suvi
    Fontaine, Amélie
    Scott, Drew A.
    Vanderwolf, Karen J.
    Ostevik, Kate L.
    Lievens, Eva J. P.
    Botterill-James, Thomas
    Berauer, Bernd J.
    Mammola, Stefano
    Geary, William L.
    Jimoh, Saheed Olaide
    Duncan, Alison B.
    Fraser, Hannah S.
    White, Rachel Louise
    Ge, Xuezhen
    Van de Vondel, Stijn
    Chen, Xuan
    Carroll, Charles J. W.
    Rowland, Freya E.
    Grames, Eliza M.
    Nakagawa, Shinichi
    Pascall, David J.
    Covernton, Garth A.
    Thomson, Jacqueline
    Pasquarella, Valerie J.
    Swallow, Ben
    Bliard, Louis
    Stuber, Erica F.
    Bello, Suleiman Kehinde
    Lauck, Katherine S.
    Grossman, Jake J.
    Urban, Lara
    Proulx, Raphaël
    Weller, Daniel L.
    Roche, Dominique G.
    Larkin, Daniel J.
    Boyle, Sarah A.
    Korsten, Peter
    Contina, Andrea
    Proulx, Michael J.
    Van Eeckhoven, Jens
    Ferguson, Stephen M.
    Sharma, Nitika
    Marshall, Benjamin Michael
    Nolazco, Sergio
    Schultz, Nick L.
    Kim, Dongmin
    Lalla, Kristen Marianne
    Ernst, Ulrich Rainer
    Rennison, Diana J.
    Güncan, Ali
    Riyahi, Sepand
    Moreira, Bruno
    Iannarilli, Fabiola
    Wedegärtner, Ronja E. M.
    Yanco, Scott W.
    Randimbiarison, Finaritra Tolotra
    Vollering, Julien
    Schneider, Adam C.
    Vesk, Peter A.
    McNew, Sabrina M.
    Arekar, Kunal
    Nilsonne, Gustav
    Bose, Aneesh P. H.
    Walter, Jonathan A.
    Gannon, Dustin G.
    Howard, Tanner J.
    Scroggie, Michael Peter
    Doherty, Tim S.
    Sitvarin, Michael I.
    Vieira, Marcus Vinícius
    Altschul, Drew
    Fuentes-Lillo, Eduardo
    Pruett, Jessica L
    Schrock, Allie E.
    Sales, Kris
    MacLeod, Ross
    Jorna, Jesse
    Bussière, Luc
    van der Wal, Jessica Eva Megan
    Opis:
    Although variation in effect sizes and predicted values among studies of similar phenomena is inevitable, such variation far exceeds what might be produced by sampling error alone. One possible explanation for variation among results is differences among researchers in the decisions they make regarding statistical analyses. A growing array of studies has explored this analytical variability in different fields and has found substantial variability among results despite analysts having the same data and research question. Many of these studies have been in the social sciences, but one small “many analyst” study found similar variability in ecology. We expanded the scope of this prior work by implementing a large-scale empirical exploration of the variation in effect sizes and model predictions generated by the analytical decisions of different researchers in ecology and evolutionary biology. We used two unpublished datasets, one from evolutionary ecology (blue tit, Cyanistes caeruleus, to compare sibling number and nestling growth) and one from conservation ecology (Eucalyptus, to compare grass cover and tree seedling recruitment). The project leaders recruited 174 analyst teams, comprising 246 analysts, to investigate the answers to prespecified research questions. Analyses conducted by these teams yielded 141 usable effects (compatible with our meta-analyses and with all necessary information provided) for the blue tit dataset, and 85 usable effects for the Eucalyptus dataset. We found substantial heterogeneity among results for both datasets, although the patterns of variation differed between them. For the blue tit analyses, the average effect was convincingly negative, with less growth for nestlings living with more siblings, but there was near continuous variation in effect size from large negative effects to effects near zero, and even effects crossing the traditional threshold of statistical significance in the opposite direction. In contrast, the average relationship between grass cover and Eucalyptus seedling number was only slightly negative and not convincingly different from zero, and most effects ranged from weakly negative to weakly positive, with about a third of effects crossing the traditional threshold of significance in one direction or the other. However, there were also several striking outliers in the Eucalyptus dataset, with effects far from zero. For both datasets, we found substantial variation in the variable selection and random effects structures among analyses, as well as in the ratings of the analytical methods by peer reviewers, but we found no strong relationship between any of these and deviation from the meta-analytic mean. In other words, analyses with results that were far from the mean were no more or less likely to have dissimilar variable sets, use random effects in their models, or receive poor peer reviews than those analyses that found results that were close to the mean. The existence of substantial variability among analysis outcomes raises important questions about how ecologists and evolutionary biologists should interpret published results, and how they should conduct analyses in the future.
    Dostawca treści:
    Repozytorium Uniwersytetu Jagiellońskiego
    Artykuł
    Tytuł:
    Health effects of overweight and obesity in 195 countries over 25 years
    Autorzy:
    Moradi-Lakeh, Maziar
    Wesana, Joshua
    Biadgilign, Sibhatu
    Afshin, Ashkan
    Naghavi, Mohsen
    Noubiap, Jean J.
    Salomon, Joshua A.
    Kosen, Soewarta
    Vlassov, Vasiliy V.
    Tonelli, Marcello
    Zenebe, Zerihun M.
    Carrero, Juan J.
    Reitsma, Marissa B.
    Boneya, Dube J.
    Weiderpass, Elisabete
    Vaezghasemi, Masoud
    Amberbir, Alemayehu
    Owolabi, Mayowa O
    Cornaby, Leslie
    Hay, Simon I.
    Shiue, Ivy
    Shamsizadeh, Moretza
    Bjertness, Espen
    Mirrakhimov, Erkin M.
    Vos, Theo
    Barac, Aleksandra
    Kinfu, Yohannes
    Ku, Tiffany
    Westerman, Ronny
    Tyrovolas, Stefanos
    Tadese, Fentaw
    Kesavachandran, Chandrasekharan N.
    Tedla, Bemnet A.
    Liang, Xiaofeng
    Mengistu, Desalegn T.
    Liu, Patrick
    Hafezi-Nejad, Nima
    Khader, Yousef S.
    Murray, Christopher J. L.
    Vollset, Stein E.
    Yano, Yuichiro
    Thakur, J. S.
    Amini, Erfan
    Beyene, Addisu S.
    Schutte, Aletta E.
    Werdecker, Andrea
    Mokdad, Ali
    Cecilio, Pedro
    Yonemoto, Naohiro
    Lopez, Alan D.
    Ahmed, Muktar B.
    Obermeyer, Carla M.
    Shiri, Rahman
    Ogbo, Felix A.
    Rai, Rajesh K.
    Topór-Mądry, Roman
    Kumar, G Anil
    Ärnlöv, Johan
    Feigin, Valery L.
    Forouzanfar, Mohammad H.
    Baye, Estifanos
    Santos, Itamar S.
    Tabarés-Seisdedos, Rafael
    Kim, Daniel
    Gona, Philimon N.
    Larson, Heidi J.
    Lozano, Rafael
    McAlinden, Colm
    Ukwaja, Kingsley N.
    Mensink, Gert B. M.
    Dharmaratne, Samath D.
    Yonga, Gerald
    McGarvey, Stephen T.
    Sawhney, Monika
    Silverberg, Jonathan I.
    Amrock, Stephen M.
    Mensah, George A.
    Tegegne, Balewgizie S.
    Gebrehiwot, Tsegaye T.
    Schmidt, Maria I.
    Ciobanu, Liliana G.
    Fürst, Thomas
    Rafay, Anwar
    Abbafati, Cristiana
    Sur, Patrick
    Esteghamati, Alireza
    Kasaeian, Amir
    Anjana, Ranjit M.
    Marczak, Laurie
    Eshrati, Babak
    Goto, Atsushi
    Mueller, Ulrich O.
    Ranabhat, Chhabi L.
    Schmidhuber, Josef
    Katikireddi, Srinivasa V.
    Swaminathan, Soumya
    Silva, Diego A. S.
    Duncan, Bruce B.
    Alkerwi, Ala’a
    Banerjee, Amitava
    Khang, Young-Ho
    Salama, Joseph S.
    Al-Aly, Ziyad
    Biryukov, Stan
    Malekzadeh, Reza
    Sheikhbahaei, Sara
    Safiri, Saeid
    Singh, Jasvinder A
    Terkawi, Abdullah S.
    Fernandes, Joao
    Uthman, Olalekan A.
    Majeed, Azeem
    Stranges, Saverio
    Lee, Alex
    Mazidi, Mohsen
    Kim, Yun J.
    Lim, Stephen S.
    Zaidi, Zoubida
    Campos-Nonato, Ismael
    Kamal, Ritul
    Amegah, Adeladza K.
    Shin, Min-Jeong
    Dandona, Lalit
    Zipkin, Ben
    Patton, George C.
    Khubchandani, Jagdish
    Pourmalek, Farshad
    Sartorius, Benn
    Dandona, Rakhi
    Kengne, Andre P.
    Roba, Hirbo S.
    Horino, Masako
    Gold, Audra
    Islami, Farhad
    Mezgebe, Haftay B.
    Habtewold, Tesfa D.
    Al-Raddadi, Rajaa
    Damtew, Solomon A.
    Bennett, Derrick A.
    Qorbani, Mostafa
    Sepanlou, Sadaf G.
    Leinsalu, Mall
    Hadush, Kokeb T.
    Sanabria, Juan R.
    Estep, Kara
    Abate, Kalkidan Hassen
    Amare, Azmeraw T.
    Defo, Barthelemy Kuate
    Asayesh, Hamid
    Vasankari, Tommi
    Cercy, Kelly
    Malta, Deborah C.
    Reinig, Nikolas
    Opis:
    BACKGROUND: Although the rising pandemic of obesity has received major attention in many countries, the effects of this attention on trends and the disease burden of obesity remain uncertain. METHODS: We analyzed data from 68.5 million persons to assess the trends in the prevalence of overweight and obesity among children and adults between 1980 and 2015. Using the Global Burden of Disease study data and methods, we also quantified the burden of disease related to high body-mass index (BMI), according to age, sex, cause, and BMI in 195 countries between 1990 and 2015. RESULTS: In 2015, a total of 107.7 million children and 603.7 million adults were obese. Since 1980, the prevalence of obesity has doubled in more than 70 countries and has continuously increased in most other countries. Although the prevalence of obesity among children has been lower than that among adults, the rate of increase in childhood obesity in many countries has been greater than the rate of increase in adult obesity. High BMI accounted for 4.0 million deaths globally, nearly 40% of which occurred in persons who were not obese. More than two thirds of deaths related to high BMI were due to cardiovascular disease. The disease burden related to high BMI has increased since 1990; however, the rate of this increase has been attenuated owing to decreases in underlying rates of death from cardiovascular disease. CONCLUSIONS: The rapid increase in the prevalence and disease burden of elevated BMI highlights the need for continued focus on surveillance of BMI and identification, implementation, and evaluation of evidence-based interventions to address this problem. (Funded by the Bill and Melinda Gates Foundation.).
    Dostawca treści:
    Repozytorium Uniwersytetu Jagiellońskiego
    Artykuł
    Tytuł:
    Minimal information for studies of extracellular vesicles 2018 (MISEV2018) : a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines
    Autorzy:
    Criado, Miria Ferreira
    Russell, Ashley E.
    Giusti, Ilaria
    Camussi, Giovanni
    Isin, Mustafa
    Blenkiron, Cherie
    Meehan, Katie L.
    Scott, Aaron
    Neri, Christian
    Verweij, Frederik J.
    Kim, Kwang Pyo
    Libregts, Sten F.
    Chen, Shuai
    Zocco, Davide
    Archer, Fabienne
    Osteikoetxea, Xabier
    Hoffmann, Karl F.
    Erdbrügger, Uta
    Mertens, Inge
    Driedonks, Tom A. P.
    McVey, Mark J.
    Laitinen, Saara
    Johnson, Suzanne M.
    Schøyen, Tine Hiorth
    Gualerzi, Alice
    Bongiovanni, Antonella
    Lunavat, Taral R.
    Gorski, Sharon M.
    Visnovitz, Tamás
    Soekmadji, Carolina
    van Balkom, Bas W. M.
    Rughetti, Aurelia
    Rouschop, Kasper M. A.
    Giebel, Bernd
    Gustafson, Dakota
    Harrison, Paul
    van Herwijnen, Martijn J. C.
    Watson, Dionysios C.
    Duarte, Filipe V.
    Kawamura, Yumi
    Swift, Simon
    Lemos, Debora S.
    O'Driscoll, Lorraine
    Torrecilhas, Ana Claudia
    Mariscal, Javier
    Vader, Pieter
    Borràs, Francesc E.
    Liao, Ke
    Cheng, Lesley
    Zivkovic, Angela M.
    Minciacchi, Valentina R.
    Myburgh, Kathryn H.
    Klingeborn, Mikael
    Yan, Xiaomei
    Martinez, M. Carmen
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    Vasconcelos, M. Helena
    Weiss, Daniel J.
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    Kurochkin, Igor V.
    Sahoo, Susmita
    Krasemann, Susanne
    Théry, Clotilde
    Ortiz, Alberto
    Vukman, Krisztina V.
    Zimmermann, Pascale
    D'Souza-Schorey, Crislyn
    Gross, Julia Christina
    Buch, Shilpa
    de Candia, Paola
    Morhayim, Jess
    Khvorova, Anastasia
    Baharvand, Hossein
    Hosseinkhani, Baharak
    Lee, Yi Xin Fiona
    Phinney, Donald G.
    Pulliam, Lynn
    Coyle, Beth
    del Portillo, Hernando A.
    Linē, Aija
    Bussolati, Benedetta
    Gámez-Valero, Ana
    Kosanović, Maja M.
    Lukomska, Barbara
    Kornek, Miroslaw
    Neri, Tommaso
    Cocucci, Emanuele
    Schiffelers, Raymond M.
    Hu, Guoku
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    Pink, Ryan C.
    Shiba, Kiyotaka
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    Pieters, Bartijn C. H.
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    Saá, Paula
    Krämer-Albers, Eva-Maria
    Yuana, Yuana
    Opis:
    The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many other names. However, specific issues arise when working with these entities, whose size and amount often make them difficult to obtain as relatively pure preparations, and to characterize properly. The International Society for Extracellular Vesicles (ISEV) proposed Minimal Information for Studies of Extracellular Vesicles ("MISEV") guidelines for the field in 2014. We now update these "MISEV2014" guidelines based on evolution of the collective knowledge in the last four years. An important point to consider is that ascribing a specific function to EVs in general, or to subtypes of EVs, requires reporting of specific information beyond mere description of function in a crude, potentially contaminated, and heterogeneous preparation. For example, claims that exosomes are endowed with exquisite and specific activities remain difficult to support experimentally, given our still limited knowledge of their specific molecular machineries of biogenesis and release, as compared with other biophysically similar EVs. The MISEV2018 guidelines include tables and outlines of suggested protocols and steps to follow to document specific EV-associated functional activities. Finally, a checklist is provided with summaries of key points.
    Dostawca treści:
    Repozytorium Uniwersytetu Jagiellońskiego
    Artykuł
      Wyświetlanie 1-6 z 6

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