- Tytuł:
- Subsequent event risk in individuals with established coronary heart disease : design and rationale of the GENIUS-CHD consortium
- Autorzy:
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Sun, Yan
Delgado, Graciela
Carpeggiani, Clara
Pilbrow, Anna
Lee, Vei-Vei
Kofink, Daniel
Wallentin, Lars
Fox, Keith
Lang, Chim
Nikus, Kjell
Patel, Riyaz
Mahmoodi, B.
Simon, Tabassome
Gong, Yan
Pare, Guillaume
Al Ali, Lawien
Deloukas, Panos
Mons, Ute
James, Stefan
Laurikka, Jari
Szczeklik, Wojciech
ten Berg, Jurrien
Holmes, Michael
Kaminski, Karol
van der Graaf, Yolanda
Quyyumi, Arshed
Muehlschlegel, Jochen
Stender, Steen
Dube, Marie-Pierre
Stewart, Alexandre
Brenner, Hermann
Hartiala, Jaana
Hovingh, G.
Brugts, Jasper
Jukema, J.
Dudbridge, Frank
Richards, A.
Baranova, Ekaterina
Van de Werf, Frans
Scholz, Markus
Fitzpatrick, Natalie
Cresci, Sharon
Gijsberts, Crystel
Niemcunowicz-Janica, Anna
McPherson, Ruth
Lotufo, Paulo
Tang, W.H.
Drexel, Heinz
Alver, Maris
Danchin, Nicolas
Burkhardt, Ralph
Wilde, Arthur
Anderson, Jeffrey
McCubrey, Raymond
Marziliano, Nicola
Pereira, Alexandre
Pepine, Carl
Pilote, Louise
Saely, Christoph
Carlquist, John
Grobbee, Diederick
Kleber, Marcus
Direk, Kenan
Lindholm, Daniel
Martinelli, Nicola
Sandesara, Pratik
Ardissino, Diego
Girelli, Domenico
Leiherer, Andreas
Johnson, Julie
Bogaty, Peter
Lagerqvist, Bo
Lehtimaki, Terho
Arsenault, Benoit
Levin, Daniel
Bots, Michiel
Kaczor, Marcin
Doughty, Robert
Virani, Salim
Sinisalo, Juha
Siegbahn, Agneta
Boersma, Eric
Wauters, Els
Algra, Ale
Duarte, Nubia
Lokki, Marja-Liisa
Engert, James
Smith, J.
Schmidt, Amand
Trompet, Stella
Marz, Winfried
Kettner, Jiri
van Setten, Jessica
Hagstrom, Emil
Sanak, Marek
Boeckx, Bram
Lenzini, Petra
Klungel, Olaf
Cooper-DeHoff, Rhonda
Body, Simon
Kahonen, Mika
Hingorani, Aroon
Breitling, Lutz
van der Laan, Sander
Tragante, Vinicius
Pitha, Jan
Samman-Tahhan, Ayman
Szpakowicz, Anna
Nelson, Christopher
Tanck, Michael
Deanfield, John
Spertus, John
Held, Claes
Tfelt-Hansen, Jacob
Condorelli, Gianluigi
Horne, Benjamin
Ballantyne, Christie
Sattar, Naveed
Melander, Olle
Metspalu, Andres
Tardif, Jean-Claude
Visseren, Frank
Ford, Ian
Teren, Andrej
Allayee, Hooman
Waltenberger, Johannes
Foco, Luisa
Hoefer, Imo
Maitland-van der Zee, Anke
Jabbari, Reza
Muhlestein, Joseph
Akerblom, Axel
Kuukasjarvi, Pekka
Palmer, Colin
Stott, David
Engstrom, Thomas
Thanassoulis, George
Eriksson, Niclas
de Faire, Ulf
Hubacek, Jaroslav
Lambrechts, Diether
Hazen, Stanley
Boerwinkle, Eric
Glinge, Charlotte
Heydarpour, Mahyar
Pasterkamp, Gerard
Dufresne, Line
Bezzina, Connie
Newton-Cheh, Christopher
Behlouli, Hassan
Anselmi, Chiara
Casu, Gavino
Lyytikainen, Leo-Pekka
Leander, Karin
Vlachopoulou, Efthymia
Gigante, Bruna
Andreassi, Maria
Bergmeijer, Thomas
Cameron, Vicky
Asselbergs, Folkert
Kiliszek, Marek
Carruthers, Kathryn
Thiery, Joachim
Brophy, James
Braund, Peter
Fox, Kim
Almgren, Peter
Hemingway, Harry
Briguori, Carlo
Timmis, Adam
van der Harst, Pim
Opolski, Grzegorz
Samani, Nilesh
Vilmundarson, Ragnar
Howe, Laurence
Ploski, Rafal
Torp-Pedersen, Christian
Olivieri, Oliviero
Kotti, Salma - Opis:
- BACKGROUND: The Genetics of Subsequent Coronary Heart Disease (GENIUS-CHD) consortium was established to facilitate discovery and validation of genetic variants and biomarkers for risk of subsequent CHD events, in individuals with established CHD. METHODS: The consortium currently includes 57 studies from 18 countries, recruiting 185 614 participants with either acute coronary syndrome, stable CHD, or a mixture of both at baseline. All studies collected biological samples and followed-up study participants prospectively for subsequent events. RESULTS: Enrollment into the individual studies took place between 1985 to present day with a duration of follow-up ranging from 9 months to 15 years. Within each study, participants with CHD are predominantly of self-reported European descent (38%-100%), mostly male (44%–91%) with mean ages at recruitment ranging from 40 to 75 years. Initial feasibility analyses, using a federated analysis approach, yielded expected associations between age (hazard ratio, 1.15; 95% CI, 1.14-1.16) per 5-year increase, male sex (hazard ratio, 1.17; 95% CI, 1.13-1.21) and smoking (hazard ratio, 1.43; 95% CI, 1.35-1.51) with risk of subsequent CHD death or myocardial infarction and differing associations with other individual and composite cardiovascular endpoints. CONCLUSIONS: GENIUS-CHD is a global collaboration seeking to elucidate genetic and nongenetic determinants of subsequent event risk in individuals with established CHD, to improve residual risk prediction and identify novel drug targets for secondary prevention. Initial analyses demonstrate the feasibility and reliability of a federated analysis approach. The consortium now plans to initiate and test novel hypotheses as well as supporting replication and validation analyses for other investigators.
- Dostawca treści:
- Repozytorium Uniwersytetu Jagiellońskiego
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