Autor: Eppinga, Ruben N. - Prolib Integro

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Wyszukujesz frazę "Eppinga, Ruben N." wg kryterium: Autor

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Tytuł:: PCSK9 genetic variants and risk of type 2 diabetes : a mendelian randomisation study
Autorzy:: Bots, Michiel L.
Froguel, Philippe
Hypponen, Elina
Price, Jackie F.
Smart, Melissa
van Iperen, Erik
Hakonarson, Hakon
Lange, Leslie A.
Ridker, Paul M.
Moldovan, Max
Kiechl, Stefan
Kumari, Meena
Husemoen, Lise Lotte Nystrup
Liu, Tian
Patel, Riyaz S.
Mahajan, Anubha
Larson, Eric B.
Sanchez-Galvez, Adelaida
Ritchie, Marylyn D.
Pikhart, Hynek
Kitchner, Terrie
Willeit, Karin
Demuth, Juri
Verweij, Niek
Balkau, Beverley
Cariou, Bertrand
de Andrade, Mariz
Sacerdote, Carlotta
Morris, Richard
Matullo, Giuseppe
Young, Robin
Lerch, Markus M.
Kubinova, Ruzena
Christen, Tim
Malyutina, Sofia
Wareham, Nicholas J.
Chasman, Daniel I.
O' Donnell, Martin
Fairhurst-Hunter, Zammy
Uitterlinden, Andre
Scott, Robert
Hingorani, Aroon D.
Whincup, Peter
Power, Christine
Hancock, Stephen
Grarup, Niels
van der Schouw, Yvonne T.
Mason, Dan
Pająk, Andrzej
Tamosiunas, Abdonas
Guarrera, Simonetta
Mook-Kanamori, Dennis O.
Dorr, Marcus
Ward, Joey
Pare, Guillaume
Bobak, Martin
Pell, Jill P.
Hovingh, G. Kees
Bertram, Lars
Pedersen, Oluf
Kirchner, H. Lester
Gustafsson, Stefan
Linneberg, Allan
Carrell, David S.
Snieder, Harold
Baumeister, Sebastian
Hartwig, Fernando Pires
Ford, Ian
Casas, Juan-Pablo
Preiss, David
Ben-Shlomo, Yoav
Swerdlow, Daniel I.
Willeit, Johann
Fiorito, Giovanni
Holmes, Michael V.
Yusuf, Salim
Volker, Uwe
Denny, Joshua C.
Meade, Tom
Maitland-van der Zee, Anke H.
Panayiotou, Andrie G.
McLachlan, Stela
Lyall, Donald M.
Grobbee, Diederick E.
Coassin, Stefan
Wanamethee, Goya
Volzke, Henry
Kivimaki, Mika
Wright, John
Carty, Cara
Nicolaides, Andrew
Asselbergs, Folkert W.
Eppinga, Ruben N.
Langenberg, Claudia
Attia, John
Welch, Catherine
Padmanabhan, Sandosh
Brilliant, Murray
Marques-Vidal, Pedro
Bonnefond, Amélie
Franco, Oscar
Baranova, Ekaterina V.
Reiner, Alex P.
Teumer, Alexander
Keating, Brendan J.
Thuillier, Dorothee
Horta, Bernardo Lessa
Ingelsson, Erik
Humphries, Steve E.
Smith, Daniel J.
Lind, Lars
Hansen, Torben
Holliday, Elizabeth
van der Harst, Pim
Schmidt, Amand F.
Cooper, Jackie
Steinhagen-Thiessen, Elisabeth
Hofman, Albert
Dehghan, Abbas
Onland-Moret, N. Charlotte
Demuth, Ilja
Chong, Michael
Roden, Dan M.
Said, M. Abdullah
McCarty, Catherine A.
Crosslin, David R.
Campbell, Archie
Simonsen, Kenneth Starup
Luan, Jian'an
Bao, Yanchun
Sattar, Naveed
Pazoki, Raha
Norman, Kristina
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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Skocz do pozycji: 2.

Tytuł:: Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9
Autorzy:: Denaxas, Spiros
Lester, Kirchner H.
Bondy, Melissa
Casas, Juan P.
Kitchner, Terrie
Fiorito, Giovanni
Roden, Dan M.
Hovingh, Kees
Swerdlow, Daniel I.
Hemminki, Kari
Nicolaides, Andrew
Mahajan, Anubha
Linneberg, Allan
Lill, Christina M.
Pazoki, Raha
Wright, John
Morris, Richard
Pare, Guillaume
Law, Philip
Price, Jackie F.
Welch, Catherine
Hakonarson, Hakon
Campbell, Archie
Panayiotou, Andrie G.
Eppinga, Ruben N.
Uitterlinden, Andre
Wareham, Nicholas J.
Cooper, Jackie
Malyutina, Sofia
Valentine, Dennis
Fairhurst-Hunter, Zammy
Christen, Tim
Ingelsson, Erik
Hopewell, Jemma C.
Lerch, Markus M.
Franco, Oscar
Costa, Rui Providencia E.
Sanchez-Galvez, Adelaida
Guarrera, Simonetta
Kiechl, Stefan
Asselbergs, Folkert W.
Hancock, Stephen
Speedy, Helen
Scott, Robert A.
Hansen, Torben
Goldschmidt, Hartmut
Meade, Tom
Froguel, Philippe
Brilliant, Murray
Lange, Leslie A.
Demuth, Ilja
McLachlan, Stela
Faraway, Rupert
Grobbee, Diederick E.
Bao, Yanchun
Engert, Andreas
Mason, Dan
ODonnell, Martin
Bertram, Lars
Roussel, Ronan
Luan, Jianan
Crosslin, David R.
Ward, Joey
Hansson, Markus
Hartwig, Fernando Pires
Chong, Michael
Dorr, Marcus
Ritchie, Marylyn D.
Pikhart, Hynek
Holliday, Elizabeth
Li, Ni
Padmanabhan, Sandosh
Houlston, Richard
McCarty, Catherine A.
Moldovan, Max
Langenberg, Claudia
Smart, Melissa
Snieder, Harold
Kinnersley, Ben
Cornish, Alex J.
Chasman, Daniel I.
van Iperen, Erik
Pell, Jill P.
Schmidt, Amand F.
Willeit, Johann
Morgan, Gareth
Humphries, Steve E.
Young, Robin
Whincup, Peter
Bonnefond, Amelie
Labreche, Karim
Volzke, Henry
Finan, Chris
Ridker, Paul M.
Wanamethee, Goya
Dale, Caroline
Went, Molly
Attia, John
Ben-Shlomo, Yoav
Hingorani, Aroon D.
Tamosiunas, Abdonas
van der Schouw, Yvonne T.
Seshadri, Sudha
Kumari, Meena
Carrell, David S.
Denny, Joshua C.
Maitland-van der Zee, Anke H.
Matullo, Giuseppe
Patel, Riyaz S.
Sacerdote, Carlotta
Sattar, Naveed
Norman, Kristina
Power, Christine
Ford, Ian
Pająk, Andrzej
Lind, Lars
Schofield, Peter
Yusuf6, Salim
Holmes, Michael V.
Baumeister, Sebastian
Volker, Uwe
Christophersen, Ingrid E.
Scott, Rodney
Onland-Moret, N. Charlotte
Allan, James
Weinhold, Niels
Nilsson, Bjorn
Steinhagen-Thiessen, Elisabeth
Preiss, David
Verweij, Niek
Coassin, Stefan
Cariou, Bertrand
Bobak, Martin
Sanson, Marc
Jess, Tine
Baranova, Ekaterina V.
Bots, Michiel L.
Kivimaki, Mika
Willeit, Karin
Thuillier, Dorothee
Sonneveld, Pieter
Hofman, Albert
Teumer, Alexander
Hypponen, Elina
Simon, Matthias
Sud, Amit
de Andrade, Mariza
Larson, Eric B.
Carty, Cara
Grarup, Niels
Reiner, Alex P.
Said, M. Abdullah
Marques-Vidal, Pedro
Demuth, Juri
Fatemifar, Ghazaleh
Keating, Brendan J.
Hemingway, Harry
van der Harst, Pim
Mook-Kanamori, D. O.
Dobbins, Sara E.
Kubinova, Ruzena
Horta, Bernardo Lessa
Dehghan, Abbas
Pedersen, Oluf
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

Artykuł

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Skocz do pozycji: 3.

Tytuł:: Genetic insights into resting heart rate and its role in cardiovascular disease
Autorzy:: Newton-Cheh, Christopher H.
Strachan, David P.
Assimes, Themistocles
Gudnason, Vilmundur
Stolarz-Skrzypek, Katarzyna
Lorentzon, Mattias
Morris, Andrew P.
Hicks , Andrew A.
Nikus, Kjell
Linneberg, Allan
Ntalla, Ioanna
Smith, Albert V.
Perola, Markus
Lecoeur, Cecile
Launer, Lenore J.
Riese, Harriette
van de Vegte, Yordi J.
Ulivi, Sheila
Campbell, Archie
Zhao, Wei
Arnar, David O.
Rizzi, Federica
Sabanayagam, Charumathi
Eppinga, Ruben N.
Bielak, Lawrence F.
Sever, Peter
Ormel, Johan
Pina Concas, Maria
Lindgren, Cecilia M.
Kleber, Marcus E.
Smith, Jennifer A.
Wareham, Nicholas J.
Guo, Xiuqing
Gudbjartsson, Daniel F.
Ohlsson, Claes
O’Donnell, Christopher J.
Silva, Claudia T.
Sinagra, Gianfranco
Sundstrom, Johan
Balkau, Beverley
Shah, Nabi
Bottinger , Erwin P.
Delgado, Graciela E.
de Mutsert, Renée
Meitinger , Thomas
Hansen, Torben
Morrison , Alanna C.
Tanaka, Toshiko
Froguel, Philippe
Yao, Jie
Rankinen, Tuomo
Tham, Yih-Chung
Lange, Leslie A.
Felix, Stephan B.
Wong, Tien-Yin
Taylor, Kent D.
Kaab, Stefan
Smith, J. Gustav
Lakatta, Edward L.M.
Salfati, Elias
Appel, Emil V.
Girotto, Giorgia
de Geus, Eco J. C.
Cocca, Massimiliano
Rao, Dabeeru C.
Tarasov, Kirill V.
Schraut, Katharina E.
Schurmann, Claudia
van Duijn, Cornelia M.
Mononen, Nina
Ring, Susan M.
Milaneschi, Yuri
Burgess, Stephen
Dorr, Marcus
Wilson, James F.
Padmanabhan, Sandosh
Franke, Andre
Tan, Nicholas
Vollenweider, Peter
Kooner, Jaspal S.
Lahti , Jari
Lehtimaki, Terho
Snieder, Harold
Wang , Lihua
Kardia, Sharon L. R.
Robino, Antonietta
Palmer, Colin N. A.
Nolte, Ilja M.
Boehnke, Michael
Gyllensten, Ulf
Weiss, Stefan
Stefansson, Kari
Li, Hengtong L.
Ferrucci, Luigi
Oldehinkel, Albertine J.
Marz, Winfried
Trompet, Stella
Pavani, Francesca
Kahonen, Mika
Porteous, David J.
Luan, Jian’an
van der Ende, M. Yldau
Hwang, ShihJen
Kraft, Peter
Psaty, Bruce M.
Raitakari, Olli T.
Noordam, Raymond
Mohlke, Karen L.
Brody, Jennifer A.
Witte, Daniel R.
den Hoed, Marcel
Chambers, John C.
Qi, Lu
Galesloot, Tessel E.
Pistis, Giorgio
Kiemeney, Lambertus A. L. M.
Melander, Olle
Auro, Kirsi
Pechlivanis, Sonali
de Vries, Paul S.
Holm, Hilma
Iribarren, Carlos
Lind, Lars
Zeng, Linyao
van der Most, Peter J.
Foco, Luisa
Hayward, Caroline
Timpson, Nicholas J.
Peters, Annette
Feitosa, Mary F.
Quek, Debra Q.
Strauch, Konstantin
Zhao, Jing
Rotter, Jerome I.
Degenhardt, Frauke
Verweij, Niek
Groop, Leif
Ingelsson, Martin
Schunkert, Heribert
Bouchard, Claude
Hagemeijer, Yanick P.
Joshi, Peter K.
Moebus, Susanne
Bandinelli, Stefania
Tai, E. Shyong
Mahendran, Yuvaraj
Erdmann, Jeanette
Jackson, Anne U.
Muller-Nurasyid, Martina
Zhang, Weihua
Eriksson, Johan G.
Tan, Vanessa Y.
Sim, Xueling S.
Sveinbjornsson, Gardar
van den Berg, Marten E.
Sotoodehnia, Nona
Mook-Kanamori, Dennis O.
Roselli, Carolina
Heckbert, Susan R.
Cornelis, Marilyn C.
Penninx, Brenda W. J. H.
Lieb, Wolfgang
Lyytikainen, Leo-Pekka
Cheng, Ching-Yu
Ladenvall, Claes
Correa, Adolfo
Eijgelsheim, Mark
Kolcic, Ivana
Waldenberger, Melanie
Isaacs, Aaron
Grarup, Niels
Jukema, J. Wouter
Faul, Jessica D.
Munroe, Patricia B.
Lin, Henry J.
de Graaf, Jacqueline
Loos, Ruth J. F.
Polasek, Ozren
Johansson, Åsa
Macfarlane, Peter W.
van der Harst, Pim
Salo, Perttu
Rueedi, Rico
Nethander, Maria
Cusi, Daniele
Sinner, Moritz F.
Weir, David R.
Peyser, Patricia A.
Arking, Dan E.
Said, M. Abdullah
Opis:: Resting heart rate is associated with cardiovascular diseases and mortality in observational and Mendelian randomization studies. The aims of this study are to extend the number of resting heart rate associated genetic variants and to obtain further insights in resting heart rate biology and its clinical consequences. A genome-wide meta-analysis of 100 studies in up to 835,465 individuals reveals 493 independent genetic variants in 352 loci, including 68 genetic variants outside previously identified resting heart rate associated loci. We prioritize 670 genes and in silico annotations point to their enrichment in cardiomyocytes and provide insights in their ECG signature. Two-sample Mendelian randomization analyses indicate that higher genetically predicted resting heart rate increases risk of dilated cardiomyopathy, but decreases risk of developing atrial fibrillation, ischemic stroke, and cardio-embolic stroke. We do not find evidence for a linear or non-linear genetic association between resting heart rate and all-cause mortality in contrast to our previous Mendelian randomization study. Systematic alteration of key differences between the current and previous Mendelian randomization study indicates that the most likely cause of the discrepancy between these studies arises from false positive findings in previous one-sample MR analyses caused by weak-instrument bias at lower P-value thresholds. The results extend our understanding of resting heart rate biology and give additional insights in its role in cardiovascular disease development.
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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