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    Wyświetlanie 1-6 z 6
    Tytuł:
    BCG vaccination in patients with severe combined immunodeficiency: complications, risks, and
    Autorzy:
    Marciano, Beatriz E.
    Espinosa-Padilla, Sara E.
    Hernandez-Nieto, Leticia
    Huang, Chiung-Yu
    Kowalczyk, Danuta
    Fleishe, Thomas A.
    Yildiran, Alias
    Cipe, Funda
    Nuñez-Nuñez, M. Enriqueta
    Neven, Bénédicte
    Ohtsuka, Yoshitoshi
    Ariga, Tadashi
    Carvalho, Beatriz Costa
    Gennery, Andrew
    Esteves, Isabel
    Morio, Tomohiro
    Yamada, Masafumi
    Roxo, Persio
    Rezaei, Nima
    Bezrodnik, Liliana
    Slatte, Mary A.
    Nademi, Zohreh
    Sevciovic Grumach, Anete
    Lau, Yu-Lung
    Shcherbina, Anna
    Reda, Shereen M.
    Nishikomori, Ryuta
    Ikinciogullari, Aydan
    Elfeky, Reem A.
    Listello, Viviana
    Szaflarska, Anna
    Joshi, Gyan
    Toshio, Heike
    Pereira, Mar ía I.
    Thon, Vojtech
    Torres-Lozano, Carlos
    Rosenzweig, Sergio D.
    Gόmez Raccio, Andrea C.
    Al-Tamemi, Salem
    Formankova, Renata
    Porras, Oscar
    Pinto, Jorge A.
    Franco, Jose L.
    Al-Herz, Waleed
    Kiliç, Şebnem
    Liberatore, Diana
    Orellana, Julio C.
    Marques, Jose Gonçalo
    Dogu, Figen
    Gala, Nermeen
    Davies, Graham
    Espinosa-Rosales, Francisco
    Allwood, Zoe
    Opis:
    Background: Severe combined immunodeficiency (SCID) is a syndrome characterized by profound T-cell deficiency. BCG vaccine is contraindicated in patients with SCID. Because most countries encourage BCG vaccination at birth, a high percentage of patients with SCID are vaccinated before their immune defect is detected. Objectives: We sought to describe the complications and risks associated with BCG vaccination in patients with SCID. Methods: An extensive standardized questionnaire evaluating complications, therapeutics, and outcomes regarding BCG vaccination in patients given a diagnosis of SCID was widely distributed. Summary statistics and association analysis was performed. Results: Data on 349 BCG-vaccinated patients with SCID from 28 centers in 17 countries were analyzed. Fifty-one percent of the patients had BCG-associated complications, 34% disseminated and 17% localized (a 33,000- and 400-fold increase, respectively, over the general population). Patients receiving early vaccination (<_1 month) showed an increased prevalence of complications (P 5 .006) and death caused by BCG-associated complications (P < .0001). The odds of experiencing complications among patients with T-cell numbers of 250/mL or less at diagnosis was 2.1 times higher (95% CI, 1.4-3.4 times higher; P 5 .001) than among those with T-cell numbers of greater than 250/mL. BCG-associated complications were reported in 2 of 78 patients who received antimycobacterial therapy while asymptomatic, and no deaths caused by BCG-associated complications occurred in this group. In contrast, 46 BCG-associated deaths were reported among 160 patients treated with antimycobacterial therapy for a symptomatic BCG infection (P < .0001). Conclusions: BCG vaccine has a very high rate of complications in patients with SCID, which increase morbidity and mortality rates. Until safer and more efficient antituberculosis vaccines become available, delay in BCG vaccination should be considered to protect highly vulnerable populations from preventable complications. (
    Dostawca treści:
    Repozytorium Uniwersytetu Jagiellońskiego
    Artykuł
      Wyświetlanie 1-6 z 6

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