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Wyświetlanie 1-10 z 29
Tytuł:
Identification and prospective stability of electronic nose (eNose)-derived inflammatory phenotypes in patients with severe asthma
Autorzy:
Lefaudeux, D.
Wang, Y.
Vink, T.J.
Dahlén, S.E.
Caruso, M.
De Meulder, B.
Fowler, S.J.
Brinkman, P.
Shaw, D.E.
Bansal, A.T.
Montuschi, P.
Chanez, P.
Sun, K.
Knobel, H.H.
Maitland-van der Zee, A.H.
Pennazza, G.
Djukanovic, R.
Horvath, I.
Hekking, P.P.
D'Amico, A.
Santonico, M.
Sousa, A.R.
Krug, N.
Geiser, T.
Wagener, A.H.
Weda, H.
Bakke, P.S.
Corfield, J.
Musiał, Jacek
Rattray, N.J.
Sandstrom, T.
Chung, K.F.
Sterk, P.J.
Auffray, C.
Riley, J.H.
Opis:
Background: Severe asthma is a heterogeneous condition, as shown by independent cluster analyses based on demographic, clinical, and inflammatory characteristics. A next step is to identify molecularly driven phenotypes using ‘‘omics’’ technologies. Molecular fingerprints of exhaled breath are associated with inflammation and can qualify as noninvasive assessment of severe asthma phenotypes. Objectives: We aimed (1) to identify severe asthma phenotypes using exhaled metabolomic fingerprints obtained from a composite of electronic noses (eNoses) and (2) to assess the stability of eNose-derived phenotypes in relation to withinpatient clinical and inflammatory changes. Methods: In this longitudinal multicenter study exhaled breath samples were taken from an unselected subset of adults with severe asthma from the U-BIOPRED cohort. Exhaled metabolites were analyzed centrally by using an assembly of eNoses. Unsupervised Ward clustering enhanced by similarity profile analysis together with K-means clustering was performed. For internal validation, partitioning around medoids and topological data analysis were applied. Samples at 12 to 18 months of prospective follow-up were used to assess longitudinal within-patient stability. Results: Data were available for 78 subjects (age, 55 years [interquartile range, 45-64 years]; 41% male). Three eNosedriven clusters (n 5 26/33/19) were revealed, showing differences in circulating eosinophil (P 5 .045) and neutrophil (P 5 .017) percentages and ratios of patients using oral corticosteroids (P 5 .035). Longitudinal within-patient cluster stability was associated with changes in sputum eosinophil percentages (P 5 .045). Conclusions: We have identified and followed up exhaled molecular phenotypes of severe asthma, which were associated with changing inflammatory profile and oral steroid use. This suggests that breath analysis can contribute to the management of severe asthma.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
Applied radiotracer techniques for studying pollutant bioaccumulation in selected marine organisms (jellyfish, crabs and sea stars)
Autorzy:
Fowler, S.
Teyssié, J.
Cotret, O.
Danis, B.
Rouleau, C.
Warnau, M.
Tematy:
radiotracers
bioaccumulation
metals
radionuclides
PCB
marine invertebrates
Pokaż więcej
Wydawca:
Instytut Chemii i Techniki Jądrowej
Powiązania:
https://bibliotekanauki.pl/articles/147253.pdf  Link otwiera się w nowym oknie
Opis:
Obtaining specific information on contaminant biokinetics in marine biota is often necessary for properly interpreting monitoring data on trace contaminant levels in bioindicator species living under varying environmental conditions. Radiotracers have been employed in laboratory experiments to assess the uptake, distribution and retention of selected heavy metals and PCB congeners in three potential marine bioindicators occupying different ecological niches in the coastal zone. Pelagic and benthic jellyfish readily accumulated Co, Ag, Zn, Cd, 137Cs and 241Am from both water and food and retained them with biological half-lives (Tb1/2) ranging from a few days to several weeks. Zinc and silver were accumulated to the greatest degree (CF ~ 4 ´ 102), with benthic jellyfish having a greater affinity for metals than the pelagic species. Results from light–dark experiments indicate that the enhanced metal uptake in the benthic jellyfish is due to the presence of endosymbiotic photosynthetic zooxanthellae situated in the arms of organisms. Shore crabs ingesting Ag, a sewage-related contaminant, readily accumulated the metal with male crabs assimilating some 71% and female crabs 51% of the Ag from their food. Moreover, the assimilated fraction of Ag remained virtually immobile in their tissues as evidenced by an extremely long Tb1/2 for depuration of 7.3 years. Sea stars exposed to 14C-labelled PCB congener #153 in sea water accumulated the congener mainly in the body wall and podia reaching lipid weight CFs that ranged between approximately 2 x 10 5 to 4 x 10 5. In contrast, following exposure in radio-labelled sediments, the corresponding PCB transfer factors in the same tissues were much lower, viz., 3 x 10 2 to 5 x 10 2. Nevertheless, regardless of the exposure mode, CFs of PCB in the other tissues (digestive system, gonads, pyloric and rectal caeca) were consistently one to two orders of magnitude lower, an observation which suggests that sea star body wall and podia could serve as target tissues in biomonitoring studies assessing these toxic compounds.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Stochastic Carrier Dynamics in Semiconductor Superlattices
Autorzy:
Fromhold, T. M.
Bujkiewicz, S.
Patanè, A.
Stapleton, S. P.
Sherwood, D.
Fowler, D.
Cooper, J.
Eaves, L.
Belyaev, A. E.
Krokhin, A. A.
Neumann, A.
Wilkinson, P. B.
Sankeshwar, N. S.
Henini, M.
Sheard, F. W.
Tematy:
73.20.At
73.21.Cd
Pokaż więcej
Wydawca:
Polska Akademia Nauk. Instytut Fizyki PAN
Powiązania:
https://bibliotekanauki.pl/articles/2044604.pdf  Link otwiera się w nowym oknie
Opis:
We explore a new regime of hot carrier dynamics, in which electrons in a superlattice miniband exhibit a unique type of stochastic motion when a magnetic field is tilted at an angle θ to the superlattice axis. Remarkably, the dynamics of a miniband electron in a tilted magnetic field reduce to a one-dimensional simple harmonic oscillator, of angular frequency ω$\text{}_{C}$ cos θ, where ω$\text{}_{C}$ is the cyclotron frequency, driven by a time-dependent plane wave whose angular frequency equals the Bloch frequency ω$\text{}_{B}$. At bias voltages for which ω$\text{}_{B}$=nω$\text{}_{C}$ cos θ, where n is an integer, the electron orbits change from localised Bloch-like trajectories to unbounded stochastic orbits, which diffuse rapidly through intricate web patterns in phase space. To quantify how these webs affect electron transport, we make drift-diffusion calculations of the current-voltage curves including the effects of space-charge build up. When the magnetic field is tilted, our simulations reveal a large resonant peak, which originates from stochastic delocalisation of the electron orbits. We show that the corresponding quantised eigenstates change discontinuously from a highly localised character when the system is off resonance to a fully delocalised form when the resonance condition is satisfied.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Treatable traits in the European U-BIOPRED adult asthma cohorts
Autorzy:
Wagers, Scott S.
Manta, A.
Krug, N.
Chung, Kian Fan
Seibold, W.
Fleming, L.J.
Sousa, Ana R.
Mazein, A.
Vestbo, J.
Hedlin, G.
van Geest, M.
Frey, U.
Horvath, Ildiko
James, A.J.
Bates, S.
Boedigheimer, M.J.
Djukanovic, Ratko
Burg, D.
Bonnelykke, K.
Postle, A.
Ahmed, H.
Simpson, Andrew J.
Miralpeix, M.
Baribaud, F.
Fitch, N.
Haughney, J.
Corfield, J.
Gahlemann, M.
Higenbottam, T.
Loza, M.J.
Masefield, S.
Dahlen, Sven-Erik
Bigler, J.
Sterk, P.J.
Sun, K.
Bisgaard, H.
Erpenbeck, V.J.
Guo, Y.
Bansal, A.T.
Adock, Ian M.
Chaiboonchoe, A.
Hohlfeld, J.M.
Mores, N.
Erzen, D.
Caruso, M.
Howarth, P.
De Meulder, B.
Pandis, Ioannis
Lutter, R.
Sigmund, R.
Montuschi, P.
Weiszhart, Z.
Rowe, A.
Rao, N.
Powel, P.
Geiser, T.
Bush, A.
Skipp, P.J.
Wagers, S.S.
Roberts, Graham
Compton, C.H.
Shaw, Dominick E.
Shaw, D.E.
Singer, Florian
Formaggio, E.
Pahus, L.
Sandstrom, Thomas
Hashimoto, S.
Knowles, R.
Montuschi, Paolo
Dahlen, Barbro
Matthews, J.G.
Wagener, A.H.
Musiał, Jacek
Fowler, Stephen J.
Hekking, P.W.
Vissing, N.H.
Bakke, Per S.
Knox, A.J.
Krung, Norbert
van Aalderen, W.
Riley, John H.
D'Amico, A.
Hekking, Pieter-Paul
Meiser, A.
Puig Valls, M.
Middelveld, R.J.M.
Auffray, C.
Caruso, Massimo
Roberts, A.
Sun, Kai
Bansal, Aruna T.
Goss, V.
Chanez, P.
Murray, C.S.
Sterk, Peter J.
Schofield, J.P.R.
Wheelock, C.E.
Brinkman, P.
Wilson, S.J.
Bel, E.H.
Pavlidis, S.
Brandsma, J.
Bucchioni, E.
Bates, Stewart
Selby, A.
Fleming, Louise J.
Lefaudeux, D.
Fichtner, K.
Singer, F.
Myles, D.
Pratico, G.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
The role of inflammation in anxiety and depression in the European U-BIOPRED asthma cohorts
Autorzy:
Fan Chung, Kian
Sanak, Marek
Caruso, Massimo
Cheng, Xiaojing
Dahlen, Sven-Erik
Adcock, Ian M.
Sterk, Peter J.
Sousa, Ana R.
De Meulder, Bertrand
Krug, Norbert
Montuschi, Paolo
Dahlen, Barbro
Hou, Ruihua
Fowler, Stephen J.
Skipp, Paul J.
Bakke, Per S.
Sandström, Thomas
Horváth, Ildikó
Djukanovic, Ratko
Ye, Gang
Howarth, Peter H.
Schofield, James P.R.
Auffray, Charles
Shaw, Dominic E.
Opis:
Background: Growing evidence indicates high comorbid anxiety and depression in patients with asthma. However, the mechanisms underlying this comorbid condition remain unclear. The aim of this study was to investigate the role of inflammation in comorbid anxiety and depression in three asthma patient cohorts of the Unbiased Biomarkers for the Prediction of Respiratory Disease Outcomes (U-BIOPRED) project. Methods: U-BIOPRED was conducted by a European Union consortium of 16 academic institutions in 11 European countries. A subset dataset from subjects with valid anxiety and depression measures and a large blood biomarker dataset were analysed, including 198 non-smoking patients with severe asthma (SAn), 65 smoking patients with severe asthma (SAs), 61 non-smoking patients with mild-to-moderate asthma (MMA), and 20 healthy non-smokers (HC). The Hospital Anxiety and Depression Scale was used to measure anxiety and depression and a series of inflammatory markers were analysed by the SomaScan v3 platform (SomaLogic, Boulder, Colo). ANOVA and the Kruskal-Wallis test were used for multiple-group comparisons as appropriate. Results: There were significant group effects on anxiety and depression among the four cohort groups (p < 0.05). Anxiety and depression of SAn and SAs groups were significantly higher than that of MMA and HC groups (p < 0.05. There were significant differences in serum IL6, MCP1, CCL18, CCL17, IL8, and Eotaxin among the four groups (p < 0.05). Depression was significantly associated with IL6, MCP1, CCL18 level, and CCL17; whereas anxiety was associated with CCL17 only (p < 0.05). Conclusions: The current study suggests that severe asthma patients are associated with higher levels of anxiety and depression, and inflammatory responses may underlie this comorbid condition.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Wyświetlanie 1-10 z 29

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