- Tytuł:
- Contribution of the intra- and intermolecular routes in autocatalytic zymogen activation: application to pepsinogen activation
- Autorzy:
-
Varón, Ramón
Fuentes, Matilde
García-Moreno, Manuela
Garcìa-Sevilla, Francisco
Arias, Enrique
Valero, Edelmira
Arribas, Enrique - Tematy:
-
intermolecular activation
intramolecular activation
autocatalysis
enzyme kinetics
proenzyme activation - Pokaż więcej
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Powiązania:
- https://bibliotekanauki.pl/articles/1041258.pdf Link otwiera się w nowym oknie
- Opis:
- Taking as the starting point a recently suggested reaction scheme for zymogen activation involving intra- and intermolecular routes and the enzyme-zymogen complex, we carry out a complete analysis of the relative contribution of both routes in the process. This analysis suggests the definition of new dimensionless parameters allowing the elaboration, from the values of the rate constants and initial conditions, of the time course of the contribution of the two routes. The procedure mentioned above related to a concrete reaction scheme is extrapolated to any other model of autocatalytic zymogen activation involving intra- and intermolecular routes. Finally, we discuss the contribution of both of the activating routes in pepsinogen activation into pepsin using the values of the kinetic parameters given in the literature.
- Dostawca treści:
- Biblioteka Nauki
Artykuł