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Wyświetlanie 1-10 z 13
Tytuł:
Pulsed Power and Power Conditioning Capacitors
Autorzy:
Macdougall, F.
Jow, T.
Ennis, J.
Yang, X.
Yen, S.
Cooper, R.
Gilbert, J.
Schneider, M.
Naruo, C.
Bates, J.
Tematy:
84.32.Tt
84.60.Ve
Pokaż więcej
Wydawca:
Polska Akademia Nauk. Instytut Fizyki PAN
Powiązania:
https://bibliotekanauki.pl/articles/1807873.pdf  Link otwiera się w nowym oknie
Opis:
A capacitor development effort focused on capacitors used in pulsed power and power conversion applications underwent at General Atomics Electronic Systems Inc. (GA-ESI) for decades. In recent years, funding for these efforts has accelerated the rate of development progress to the point where the time it takes to decrease the size of a capacitor by half has dropped from 10 years to 4 years. This progress made in pulsed power and power conversion capacitors will be described along with the performance characteristics of today's capacitors.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A different path to the summit of Fusarium Head Blight resistance in wheat: developing germplasm with a systemic approach.
Autorzy:
Comeau, A.
Langevin, F.
Caetano, V.R
Haber, S.
Savard, M.E.
Voldeng, H.
Fedak, G.
Dion, Y.
Rioux, S.
Gilbert, J.
Martin, R.A.
Eudes, F.
Scheeren, P.L.
Tematy:
barley yellow dwarf virus (BYDV)
biotic and abiotic stresses
Fusarium Head Blighy (FHB)
genotypes
resistance
traits interaction
Pokaż więcej
Wydawca:
Instytut Hodowli i Aklimatyzacji Roślin
Powiązania:
https://bibliotekanauki.pl/articles/2199597.pdf  Link otwiera się w nowym oknie
Opis:
In pursuing FHB resistance in wheat, 30 years of conventional breeding efforts in Eastern Canada have brought some progress. Substantial investment and the application in recent years of marker-assisted selection have to date, however, failed to produce agronomic lines that resist FHB as well as Sumai 3. We present here an alternative path, described as the systemic approach. Rather than seeking to introgress specific putative resistance genes, it subjects target germplasm to regimes of repeated cycles of multiple, interacting (biotic and abiotic) stresses in which desirable traits – not always adequately expressed in parental lines – are identified and selected. How can such a seemingly counterintuitive process work? The systemic approach views desired resistance as arising from the interactions of complex regulation mechanisms mediating how a host responds when a pathogen attacks. These constituents of resistance should thus not always be understood simply as discrete Mendelian units. In repeated rounds of selection, the systemic approach captures those rare individuals that embody optimal interactions of traits, and advances them as founders of lines that resist FHB more effectively than if selection focused on FHB alone. In Quebec, we have chosen to select wheat populations under combined pressure from barley yellow dwarf virus (BYDV) infection and FHB. Resistance to FHB and tolerance of BYDV are quantitative traits that interact. BYD increases both the direct losses from FHB and the production of mycotoxins. Selection under virus pressure, therefore, helps identify those individuals which express FHB resistance more effectively. Moreover, the correlates of virus tolerance (physiological efficiency, generalized stress tolerance and yield) point to those plants with better root traits, ability to produce biomass and yield stability. Together with numerous secondary criteria, such selection eliminates all but a few ‘winners’ in each round. Seen from a systemic perspective, the difficulty of identifying good progeny among descendants of crosses with Sumai 3 does not surprise. Deleterious linkages, pleiotropy and epistasis will usually combine in far from optimal expressions of the assembled genetic information. The systemic approach, by contrast, identifies in repeated cycles increasingly optimized expressions of genes, allowing all potential sources of resistance to be explored. Thus resistant lines can readily be derived from the crosses of susceptible parents, an objective rarely sought in conventional, focused approaches. Moreover, wheat plants respond to the systemic approach’s powerful stresses with enhanced epigenetic variation, raw material from which broader ranges of heritable traits can be selected. Germplasm that expresses a full range of attractive traits while resisting FHB as effectively as Sumai 3 can now be shown to be much more abundant than previously imagined. Perhaps this promise will entice more wheat workers to try a systemic approach...
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A different path to the summit of Fusarium Head Blight resistance in wheat: developing germplasm with a systemic approach.
Autorzy:
Comeau, A.
Langevin, F.
Caetano, V.R
Haber, S.
Savard, M.E.
Voldeng, H.
Fedak, G.
Dion, Y.
Rioux, S.
Gilbert, J.
Martin, R.A.
Eudes, F.
Scheeren, P.L.
Tematy:
barley yellow dwarf virus (BYDV)
biotic and abiotic stresses
Fusarium Head Blighy (FHB)
genotypes
resistance
traits interaction
Pokaż więcej
Wydawca:
Instytut Hodowli i Aklimatyzacji Roślin
Powiązania:
https://bibliotekanauki.pl/articles/55928392.pdf  Link otwiera się w nowym oknie
Opis:
In pursuing FHB resistance in wheat, 30 years of conventional breeding efforts in Eastern Canada have brought some progress. Substantial investment and the application in recent years of marker-assisted selection have to date, however, failed to produce agronomic lines that resist FHB as well as Sumai 3. We present here an alternative path, described as the systemic approach. Rather than seeking to introgress specific putative resistance genes, it subjects target germplasm to regimes of repeated cycles of multiple, interacting (biotic and abiotic) stresses in which desirable traits – not always adequately expressed in parental lines – are identified and selected. How can such a seemingly counterintuitive process work? The systemic approach views desired resistance as arising from the interactions of complex regulation mechanisms mediating how a host responds when a pathogen attacks. These constituents of resistance should thus not always be understood simply as discrete Mendelian units. In repeated rounds of selection, the systemic approach captures those rare individuals that embody optimal interactions of traits, and advances them as founders of lines that resist FHB more effectively than if selection focused on FHB alone. In Quebec, we have chosen to select wheat populations under combined pressure from barley yellow dwarf virus (BYDV) infection and FHB. Resistance to FHB and tolerance of BYDV are quantitative traits that interact. BYD increases both the direct losses from FHB and the production of mycotoxins. Selection under virus pressure, therefore, helps identify those individuals which express FHB resistance more effectively. Moreover, the correlates of virus tolerance (physiological efficiency, generalized stress tolerance and yield) point to those plants with better root traits, ability to produce biomass and yield stability. Together with numerous secondary criteria, such selection eliminates all but a few ‘winners’ in each round. Seen from a systemic perspective, the difficulty of identifying good progeny among descendants of crosses with Sumai 3 does not surprise. Deleterious linkages, pleiotropy and epistasis will usually combine in far from optimal expressions of the assembled genetic information. The systemic approach, by contrast, identifies in repeated cycles increasingly optimized expressions of genes, allowing all potential sources of resistance to be explored. Thus resistant lines can readily be derived from the crosses of susceptible parents, an objective rarely sought in conventional, focused approaches. Moreover, wheat plants respond to the systemic approach’s powerful stresses with enhanced epigenetic variation, raw material from which broader ranges of heritable traits can be selected. Germplasm that expresses a full range of attractive traits while resisting FHB as effectively as Sumai 3 can now be shown to be much more abundant than previously imagined. Perhaps this promise will entice more wheat workers to try a systemic approach...
Dostawca treści:
Biblioteka Nauki
Artykuł
Autorzy:
Chahla, Jorge
Kennedy, Nicholas I.
Moatshe, Gilbert
DePhillipo, Nicholas N.
Kennedy, Mitchell I.
Tollefson, Luke V.
Malinowski, Konrad
Tagliero, Adam J.
LaPrade, Robert F.
Opis:
Background and Objective: Knee surgery attempts to restore the native biomechanics of the knee, improve stability, and decrease the progression of osteoarthritis (OA). However, despite improvements in surgical techniques, tissue degradation and OA are common after knee surgery, occurring in higher rates in surgical knees compared to non-surgical knees. The aim of this study is to analyze previous literature to determine which synovial fluid biomarkers contribute to knee tissue degradation and decrease patient outcomes in the post-surgical setting of the knee. Methods: A narrative review of relevant literature was performed in July 2023. Studies reporting on synovial biomarkers associated with the post-surgical knee were included. Key Content and Findings: The literature reported that proinflammatory synovial biomarkers cause cartilage degradation and turnover which eventually leads to OA. The associated biomarkers are typically present prior to physical symptoms so understanding which one’s correlate to OA is important for potential therapeutic treatments in the future. Studying the preoperative, early postoperative, and late postoperative synovial biomarkers will allow physicians to develop an improved understanding of how these biomarkers progress and correlate to knee tissue degradation and OA. This understanding could lead to further developments into potential treatment options. Research into inhibiting or reversing these inflammatory biomarkers to slow the progression of knee tissue degradation has already begun and has reported some promising results but is currently limited in scope. Conclusions: Synovial fluid biomarkers in the post-surgical knee setting may contribute to decreased patient outcomes and the progression of knee tissue degradation. There is no current consensus on which of these biomarkers are the most detrimental or associated with decreased patient outcomes. With an improved understanding of the individual biomarkers, potential personalized therapeutic treatment could be used by physicians in the future to improve patient outcomes after surgery.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
Crystallographic characterisation and development of bi-substrate inhibitors of coronavirus nsp14 methyltransferase
Autorzy:
Ahmad, Shamshad A.
Scott, Duncan E.
Saikatendu, Kumar Singh
See, Kexin
Urakova, Nadya
Wanningen, Patrick
Kresik, Leanid
Snijder, Eric J.
O'Neill, Sandra
Czarna, Anna
Gilbert, Ian H.
Grygier, Przemysław
Delpal, Adrien
Post, John M.
Eadsforth, Thomas
Norval, Suzanne
O'Byrne, Sean N.
Pyrć, Krzysztof
Wierzbicka, Kinga
Smith, Craig D.
Decroly, Etienne
Matsuda, Alex
Georgiou, Irene
Groenewold, Mirjam
Chang, Edcon
Plewka, Jacek
Robinson, Colin
Opis:
SARS-CoV-2 non-structural protein 14 (nsp14) is essential for viral mRNA cap guanine-N7 methylation and represents a promising but underexplored antiviral target. Herein we describe a structure-guided campaign based on a hit from a focussed SAM mimetic library. Systematic SAR exploration guided by six X-ray co-crystal structures in complex with SARS-CoV-2 led to compound 26, a bi-substrate inhibitor that bridges the SAM and RNA cap binding sites. Compound 26 achieved nanomolar potency against nsp14 from SARS-CoV-2 ($IC_{50}$ = 53 nM), SARS-CoV-1, and two alphacoronaviruses, with excellent selectivity over human RNMT and flaviviral MTase. In general, the compounds demonstrated favourable metabolic stability, passive permeability, and no HepG2 cytotoxicity. However, cellular antiviral activity was limited, revealing disconnects between enzyme inhibition and phenotypic response. These findings provide a structural framework for optimizing bi-substrate methyltransferase inhibitors against coronaviruses with a view for pan-coronaviral activity.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
Nuclear astrophysics with radioactive ions at FAIR
Autorzy:
Trautmann, W.
Csatlós, M.
Dupont, E.
Litvinov, Y.
Neumann-Cosel, P. von
Labiche, M.
Spieker, M.
Rigollet, C.
Wagner, A.
Déchery, F.
Pandit, S.
Morcelle, V.
Reifarth, R.
Sohler, D.
Dueñas, J.
Ornelas, A.
Kulessa, Reinhard
Endres, J.
Körner, G.
Zerguerras, T.
Fernandez-Dominguez, B.
Uvarov, L.
Borge, M. G.
Naqvi, F.
Heftrich, T.
Lederer, C.
Savran, D.
Timar, J.
Jonson, B.
Schmitt, C.
Zgura, M.
Al-Khalili, J.
Zartova, I.
Uesaka, T.
Bertulani, C.
Körper, D.
Grigorenko, L.
Mahata, K.
Kratz, J.
Nikolski, E.
Stuhl, L.
Weick, H.
Pietri, S.
Ignatyuk, A.
Sümmerer, K.
Cherciu, M.
Herzberg, R.
Nociforo, C.
Jakobsson, B.
Gulyas, J.
Söderström, P.
Iwasa, N.
Nacher, E.
Casarejos, E.
Streicher, B.
Wieland, O.
Lazarus, I.
Bagchi, S.
Trivedi, T.
Cederkall, J.
Brambilla, S.
Catford, W.
Tengblad, O.
Pietralla, N.
Detistov, P.
Stan, E.
Taylor, J.
Tostevin, J.
Benlliure, J.
Kröll, T.
Petrache, C.
Boutachkov, P.
Fernandez, P. Diaz
Langanke, K.
Monago, J. Briz
Hammache, F.
Alkhomashi, N.
Heil, M.
Cresswell, J.
Johansson, H.
Davids, B.
Thornhill, J.
Khan, E.
Rauscher, T.
Panin, V.
Pivovarov, Y.
Derya, V.
Stevenson, P.
Rosado, J. Sánchez
Kuzmin, E.
Pawłowski, P.
Thoennessen, M.
Beceiro, S.
Maev, E.
Liberati, V.
Tornyi, T.
Parkar, V.
Schrock, P.
Gasparic, I.
Avdeichikov, V.
Gastineau, B.
Volknandt, M.
Elekes, Z.
Lemmon, R.
Jurado, B.
Romig, C.
Cederwall, B.
Zhukov, M.
Sanchez, J.
Terashima, S.
Aksouh, F.
Alvarez-Rodriguez, R.
Rastrepina, G.
Thungstrom, G.
Taieb, J.
Ilieva, S.
Shrivastava, A.
Schwengner, R.
Kelic-Heil, A.
Koloczek, A.
Woods, P.
Ritter, C.
Egelhof, P.
Togano, Y.
Saez, del Rio
Wimmer, C.
Sauerwein, A.
Dmitry, S.
Townsley, C.
Ershova, O.
Aumann, T.
Stanoiu, M.
Schmid, M. von
Bertini, D.
Gilbert, M.
Davinson, T.
Wells, D.
Udias, J.
Mengoni, D.
Paradela, C.
Bleis, T. Le
Boztosun, I.
Kogimtzis, M.
Yakorev, D.
Redondo, D. Galaviz
Garg, U.
Kräckmann, S.
Egorova, I.
Sakuta, S.
Belier, G.
Palit, R.
Scheit, H.
Roussel-Chomaz, P.
Röder, M.
Chartier, M.
Geissel, H.
Coleman-Smith, P.
Suda, T.
Velho, P.
Machado, J.
Stepantsov, S.
Najafi, M.
Mancusi, D.
Sidorchuk, S.
Ricciardi, M.
Heine, M.
Cardona, J. Zamora
Ershov, S.
Fiori, E.
Haiduc, M.
Gernhäuser, R.
Gannon, S.
Holl, M.
Salsac, M.
Tomohiro, U.
Junghans, A.
Nyman, G.
Movsesyan, A.
Doré, D.
Andreev, V.
Pereira, J.
Perea, A.
Tanihata, I.
Frutos, T. Rodriguez
Bishop, S.
Slobodan, D.
Pohl, M.
Schnorrenberger, L.
Münzenberg, G.
Camera, F.
Pickstone, S.
Singh, P.
Winfield, J. S.
Andrei, B.
Atar, L.
Fomichev, A.
Chatillon, A.
Typel, S.
Weigand, M.
Kurz, N.
Ivanov, M.
Gorshkov, A.
Paschalis, S.
Crespi, F.
Kalantar, N.
Kanungo, R.
Sampson, J.
Fetisov, A.
Barbieri, C.
Bendel, M.
Gourishetty, A.
Wimmer, K.
Ghosh, T.
Kiselev, O.
Berjillos, R.
Blumenfeld, Y.
Nilsson, T.
AlGhamdi, S.
Krupko, S.
Marganiec, J.
Bracco, A.
Enders, J.
Vikhrov, V.
Altstadt, S.
Nolan, P.
Sarriguren, P.
Ignatov, A.
Thomas, T.
Lemasson, A.
Marusov, V.
Langer, C.
Cortina-Gil, D.
Schmidt, S.
Boretzky, K.
Simpson, E.
Teubig, P.
Joshi, P.
Kumar, S.
Ribeiro, G.
Sonnabend, K.
Khanzadeev, A.
Simon, H.
Glorius, J.
Krücken, R.
Bonaccorso, A.
Sanjari, S.
Zuber, K.
Fonseca, M.
Gasques, L.
Friese, J.
Riisager, K.
Adachi, T.
Seddon, D.
Scheidenberger, C.
Silva, J.
Richter, A.
Wyss, R.
Strieder, F.
Perez, M. Martinez
Wiescher, M.
Chulkov, L.
Fraile, L.
Hass, M.
Vignote, J. Rodriguez
Vajta, Z.
Westerberg, L.
Stach, D.
Potlog, P.
AlGarawi, M.
Moreno, O.
Ter-Akopian, G.
Volkov, V.
Henriques, A.
Crespo, R.
Sherrill, B.
Herraiz, J. Lopez
Nakamura, T.
Uberseder, E.
Rout, P.
Krings, T.
Sarkar, M. Saha
Bloch, T.
Blasi, N.
Zieblinski, M.
Zilges, A.
Alkhazov, G.
Roy, S.
Botvina, A.
Winkel, M.
Bemmerer, D.
Hennig, A.
Million, B.
Löher, B.
Kresan, D.
Harakeh, M.
Bacri, C.
Beinrucker, C.
Petri, M.
Freer, M.
Alvarez-Pol, H.
Prokofiev, A.
Krumbholz, A.
Plag, R.
Benzoni, G.
Caesar, C.
Göbel, K.
Golubev, P.
Yavor, M.
Beck, C.
Zhdanov, A.
Caamano, M.
Wamers, F.
Novatsky, B.
Thies, R.
Boudard, A.
Rossi, D.
Rios, A.
Krasznahorkay, A.
DiJulio, D.
Takechi, M.
Kezzar, K.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
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Wyświetlanie 1-10 z 13

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