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Tytuł:
An extensive quality control and quality assurance (QC/QA) program significantly improves inter-laboratory concordance rates of flow-cytometric minimal residual disease assessment in acute lymphoblastic leukemia : an I-BFM-FLOW-Network report
Autorzy:
Scarparo, Pamela
Groeneveld-Krentz, Stefanie
Dubravcic, Klara
Moller, Claudia
Ratei, Richard
Rodriguez, Cecilia
Kloboves Prevodnik, Veronika
Popov, Alexander
Giordano, Hugo
Svec, Peter
Palazzi, Jorge
Anastasiou-Grenzelia, Theodora
Mejstrikova, Ester
Hrusak, Ondrej
Barcala, Virna
Szczepański, Tomasz
Deniz, Gunnur
Malusardi, Cecilia
Kiss, Csongor
Buldini, Barbara
Martin, Bibiana Maria
Gaipa, Giuseppe
Batinic, Drago
Campbell, Myriam
Paterakis, Georgios
Varotto, Elena
Barna, Gabor
Biondi, Andrea
Bruggemann, Monika
Dworzak, Michael N.
Gaillard, Marie Isabel
Slavkovic, Bojana
Basso, Giuseppe
Sala, Simona
Kohlscheen, Saskia
Sartor, Mary
Sędek, Łukasz
Burnusuzov, Hasan
Vernitsky, Helly
Bourquin, Jean-Pierre
Conter, Valentino
Felice, Marisa
Nikulshin, Sergey
Schumich, Angela
Rossi, Jorge
Suzan, Adin Cinar
Gonzalez, Alejandro
Torrebadell, Montserrat
Attarbaschi, Andishe
Bukowska-Straková, Karolina
Iarossi, Maria Belen
Feuerstein, Tamar
Tzanoudaki, Marianna
Kappelmayer, Janos
Kreminska, Elena
Solari, Liliana
Carelli, Daniela
Schrappe, Martin
Jakso, Pal
Agriello, Evangelina
Maglia, Oscar
Karawajew, Leonid
Galeano, Adriana
Marinov, Neda
Samardzija, Gordana
Taparkou, Anna
Maurer-Granofszky, Margarita
Sajaroff, Elisa Olga
Hevessy, Zsuzsanna
Opis:
Monitoring of minimal residual disease (MRD) by flow cytometry (FCM) is a powerful prognostic tool for predicting outcomes in acute lymphoblastic leukemia (ALL). To apply FCM-MRD in large, collaborative trials, dedicated laboratory staff must be educated to concordantly high levels of expertise and their performance quality should be continuously monitored. We sought to install a unique and comprehensive training and quality control (QC) program involving a large number of reference laboratories within the international Berlin-Frankfurt-Münster (I-BFM) consortium, in order to complement the standardization of the methodology with an educational component and persistent quality control measures. Our QC and quality assurance (QA) program is based on four major cornerstones: (i) a twinning maturation program, (ii) obligatory participation in external QA programs (spiked sample send around, United Kingdom National External Quality Assessment Service (UK NEQAS)), (iii) regular participation in list-mode-data (LMD) file ring trials (FCM data file send arounds), and (iv) surveys of independent data derived from trial results. We demonstrate that the training of laboratories using experienced twinning partners, along with continuous educational feedback significantly improves the performance of laboratories in detecting and quantifying MRD in pediatric ALL patients. Overall, our extensive education and quality control program improved inter-laboratory concordance rates of FCM-MRD assessments and ultimately led to a very high conformity of risk estimates in independent patient cohorts.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
Rare single nucleotide and copy number variants and the etiology of congenital obstructive uropathy : implications for genetic diagnosis
Autorzy:
Montini, Giovanni
Lin, Fangming
Szmigielska, Agnieszka
Mane, Shrikant
Alberti, Daniele
Guarino, Stefano
Appel, Gerald B.
Tasic, Velibor
Sanna-Cherchi, Simone
Gnutti, Barbara
Gesualdo, Loreto
Martino, Marida
Caliskan, Yasar
Nestor, Jordan G.
Capone, Valentina P.
Saraga, Marijan
Gucev, Zoran
Masnata, Giuseppe
Jin, Gina
Miklaszewska, Monika
Lim, Tze Y.
Lozanovski, Vladimir J.
Cocchi, Enrico
Scolari, Francesco
Marasa, Maddalena
Arapović, Adela
Lifton, Richard P.
Westland, Rik
Izzi, Claudia
Pezzutto, Alessandro
Zaniew, Marcin
Verbitsky, Miguel
McKiernan, James
Kiryluk, Krzysztof
Bonomini, Mario
Uy, Natalie S.
Ke, Juntao
Canetta, Pietro A.
Bomback, Andrew S.
Morello, William
La Scola, Claudio
Hays, Thomas
Bodria, Monica
Szczepańska, Maria
Ahram, Dina F.
Jamry-Dziurla, Anna
Conti, Giovanni
Latos-Bielenska, Anna
Cohen, David J.
Alam, Shumyle
Radhakrishnan, Jai
Manca, Valeria
Caridi, Gianluca
Mitrotti, Adele
Chatterjee, Debanjana
Lambert, Sarah
Finale, Carolina
Savoldi, Gianfranco
Krzemień, Grażyna
Ghiggeri, Gian Marco
Tondolo, Francesco
Rao, Mangala
Giordano, Mario
Drożdż, Dorota
Zhang, Jun Y.
Gharavi, Ali G.
Baraldi, Olga
van Wijk, Joanna A.E.
Kil, Byum Hee
Ranghino, Andrea
Piva, Stacy E.
Sikora, Przemysław
Esposito, Pasquale
Marzuillo, Pierluigi
Mizerska-Wasiak, Malgorzata
Zibar, Lada
La Manna, Gaetano
Santoro, Domenico
Materna-Kiryluk, Anna
Fiaccadori, Enrico
Pisani, Isabella
Di Renzo, Dacia
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
Contrast-associated acute kidney injury after thrombectomy for ischemic stroke
Autorzy:
Ciacciarelli, Antonio
Delibas, Sennur
Seweryn, Maksymilian
Strambo, Davide
Theodorou, Aikaterini
Kotas, Szymonn
Lin, Eugene
Samman Tahhan, Imad
Tsivgoulis, Georgios
Fuentes, Blanca
Tarletti, Roberto
Kovar, Martin
Filizzolo, Marco
Rigual, Ricardo
Pascarella, Rosario
Sanna, Alessandra
Hervas-Testal, Carlos
Common, Matthew R.
Radu, Razvan Alexandru
Zaccagnino, Matteo
Sobieszak-Skura, Paulina
Ferrao, Jorge
Hassan, Ameer E.
Barkley, Tiffany
Bravo, Alexandra Sevilla
Meloni, Rossella
Knoflach, Michael
Sheth, Sunil
Ferraro, Chiara
Verdam, Martijn
Bandzarewicz-Samcik, Anna Maria
De Raedt, Sylvie
Tollot, Saverio
Piano, Mariangela
Roubec, Martin
Nunes, Ana Paiva
Min, Jiangyong
Diomedi, Marina
Mele, Angelica
Morais, Marta
Bernardo, Francisco
Arnold, Marcel
Al Kasab, Sami
Lakatos, Lehel-Barna
Avola, Giulia
Panea, Cristina Aura
Vodret, Francesca
Tassi, Rossana
Wiacek, Marcin
Curro, Carmelo Tiberio
Barrile, Elena
Nowakowska-Kotas, Marta
Tiu, Vlad
Marcheselli, Simona
HajAissa, Naser
Saliou, Guillaume
Valcamonica, Gloria
Grimaldi, Silvia
Dilmen, Yavuz
Ekizoglu, Esme
Caramma, Andrea Salvatore
Macera, Antonio
Scarcia, Luca
Roszak, Mateusz Łukasz
Blazer Costa, Jose
Sanna, Antioco
De Michele, Manuela
Karwacki, Grzegorz M.
Francisco, Leonor
Acampa, Maurizio
Sezgin, Mine
Pezzini, Alessandro
Cella, Arianna
Doheim, Mohamed F.
Pereira, Liliana
Simonetti, Luigi
Ostos, Fernando
Moci, Marco
Tassinari, Tiziana
Zini, Andrea
Lesko, Norbert
Pedro Marto, Joao
Loizzo, Nicola D.
Viaro, Federica
Bartosik-Psujek, Halina
Zedde, Marialuisa
Labuz-Roszak, Beata
Školoudík, David
Mayer-Suess, Lukas
Pero, Guglielmo C.
Fedorko, Jakub
Maes, Louise
Ambler, Gareth
Wouters, Anke
Rapillo, Costanza Maria
Schwarz, Ghil
Bartoš, Josef
Marrone, Nicola
Pudło, Paulina
Cervo, Amedeo
Bellavia, Simone
Maurea, Carlo
Cassarino, Serena Gallo
Molina-Nuevo, Juan David
Demeestere, Jelle
Tetaria, Carl Manuata
Sramek, Martin
Qdais, Ahmad Abu
Gizewski, Elke R.
Pantoni, Leonardo
Petrescu, Simona
Petruzzellis, Marco
Terruso, Valeria
Nogueira, Raul G.
Al-Bayati, Alhamza R.
Pakizer, David
Perez-Sanchez, Soledad
Luchowski, Piotr
Vandervorst, Fenne
Beyeler, Morin
Maimone, Davide
Cruz-Culebras, Antonio
Khasawneh, Mohammad W.
Saia, Valentina
Valente, Mariarosaria
Ornello, Raffaele
Słowik, Agnieszka
Abdalkader, Mohamad
Power, Sarah
Klein, Piers
Vojik, Jan
Ayo-Martin, Oscar
Meder, Grzegorz
Wrona, Paweł
Farhat, Firas
Quilici, Luca
Rosini, Francesca
Tiu, Cristina
Alimonti, Dario
Moszko, Karolina
Kalsoum, Erwah
Paolucci, Matteo
Mazzoleni, Valentina
DęBiec, Aleksander
Stepien, Adam
Seoane, David
Mangiardi, Marilena
Moller, Jessica
Poretto, Valentina
Vittorini, Maria Grazia
Baracchini, Claudio
Anticoli, Sabrina
Vera Lechuga, Rocio
Cascio Rizzo, Angelo
Alessiani, Michele
Nicholson, Patrick
Bolognese, Manuel
Houghton, Margaret
Nguyen, Thanh N.
Hall, Emily
Scala, Irene
Meira, Torcato
Calleja, Patricia
Monteforte, Gabriella
Andreone, Vincenzo
Montaner, Joan
Bauknight, Wayne Martin
Eswaradass, Prasanna
Puła, Michal
Jaros, Adam
Mujanovic, Adnan
Miller, Samantha
Ali, Amir
Candelaresi, Paolo
Dorobek, Malgorzata
Merlino, Giovanni
Garcia-Madrona, Sebastian
Bilik, Marta
Zielińska-Turek, Justyna
Tonello, Simone
Toni, Danilo
Rodrigues, Miguel
Staszewski, Jacek
Ferreira, Patricia
Mannino, Marina
Zaidat, Osama O.
Almajali, Mohammad
Rizzo, Pier Andrea
Rejdak, Konrad
Cardillo, Alessandra
Sacco, Simona
Scopelliti, Giuseppe
Paya, Maria
Maestrini, Ilaria
Negrila, Anca
Sessa, Maria
Świtońska, Milena
Gdovinova, Zuzana
Lacidogna, Giordano
Guzinski, Maciej
Romi, Andrea
Pampana, Enrico
Roffe, Christine
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
GERDA results and the future perspectives for the neutrinoless double beta decay search using ^{76}Ge
Autorzy:
Laubenstein, M.
Gusev, K.
Baudis, L.
Egorov, V.
Wójcik, Marcin
Lubashevskiy, A.
Kazalov, V.
von Sturm, K.
Cattadori, C.
Comellato, T.
Bezrukov, L.
Kihm, T.
Kirsch, A.
Inzhechik, L. V.
Bellotti, E.
Hult, M.
Riboldi, S.
Domula, A.
Nemchenok, I.
Agostini, M.
Wegmann, A.
Zhukov, S. V.
Lubsandorzhiev, B.
Rumyantseva, N.
Demidova, E. V.
Pertoldi, L.
Zuber, K.
Lindner, M.
Grabmayr, P.
Lutter, G.
Garfagnini, A.
Zsigmond, A. J.
Heisel, M.
Barabanov, I.
Selivanenko, O.
Zhitnikov, I.
Hofmann, W.
Di Marco, N.
Belogurov, S.
Pullia, A.
Schulz, O.
Kirpichnikov, I. V.
Shirchenko, M.
Macolino, C.
Simgen, H.
Schönert, S.
Brugnera, R.
Chernogorov, A.
Kermaidic, Y.
Shevchik, E.
Pandola, L.
Vasenko, A. A.
Smolnikov, A.
Miloradovic, M.
Klimenko, A.
Stanco, L.
Kuzminov, V. V.
Bode, T.
Bakalyarov, A. M.
Kneißl, R.
D’Andrea, V.
Vanhoefer, L.
Ransom, C.
Schreiner, J.
Giordano, M.
Jochum, J.
Balata, M.
Pelczar, K.
Schneider, B.
Knöpfle, K. T.
Biernat, Jacek
Junker, M.
Bauer, C.
Misiaszek, Marcin
Wester, T.
Panas, Krzysztof
Lazzaro, A.
Borowicz, D.
Hiller, R.
Gurentsov, V.
Sada, C.
Yanovich, E.
Zinatulina, D.
Doroshkevich, E.
Wagner, V.
Zschocke, A.
Schwingenheuer, B.
Gangapshev, A.
Lippi, I.
Zuzel, Grzegorz
Moseev, P.
Mingazheva, R.
Wiesinger, C.
Brudanin, V.
Bettini, A.
Kochetov, O.
Maneschg, W.
Hemmer, S.
Majorovits, B.
Schütz, A.-K.
Veresnikova, A.
Hakenmüller, J.
Janicskó Csáthy, J.
Kornoukhov, V. N.
Caldwell, A.
Salamida, F.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
Probing Majorana neutrinos with double-$\beta$ decay
Autorzy:
Rumyantseva, N.
Nemchenok, I.
Krause, P.
Chernogorov, A.
Junker, M.
Schneider, B.
Lindner, M.
Schwarz, M.
Janicskó Csáthy, J.
Vanhoefer, L.
Zinatulina, D.
Egorov, V.
von Sturm, K.
Bezrukov, L.
Piseri, P.
Smolnikov, A.
Gusev, K.
Ransom, C.
Comellato, T.
Misiaszek, Marcin
Sada, C.
Zuber, K.
Veresnikova, A.
Baudis, L.
Bakalyarov, A. M.
Kirpichnikov, I. V.
Zsigmond, A. J.
Schwingenheuer, B.
Hegai, A.
Schütz, A.-K.
Schmitt, C.
Hult, M.
Stanco, L.
Brugnera, R.
Pertoldi, L.
Macolino, C.
Kihm, T.
Gurentsov, V.
Miloradovic, M.
Wiesinger, C.
Knöpfle, K. T.
Doroshkevich, E.
Heisel, M.
Mingazheva, R.
Di Marco, N.
Hiller, R.
Domula, A.
Shevchik, E.
Bauer, C.
Sala, E.
Kochetov, O.
Bellotti, E.
Wegmann, A.
Hakenmüller, J.
Zuzel, Grzegorz
Agostini, M.
Simgen, H.
Belogurov, S.
Shirchenko, M.
Kneißl, R.
Lippi, I.
Kuzminov, V. V.
Giordano, M.
Fomina, M.
Zschocke, A.
Grabmayr, P.
Pelczar, Krzysztof
Balata, M.
Salamida, F.
Lubashevskiy, A.
Selivanenko, O.
Garfagnini, A.
Kornoukhov, V. N.
Cattadori, C.
Jochum, J.
Stukov, D.
Hemmer, S.
Hofmann, W.
Schönert, S.
Pandola, L.
Schulz, O.
Lutter, G.
Lubsandorzhiev, B.
Vasenko, A. A.
Lazzaro, A.
Wagner, V.
Kish, A.
Barabanov, I.
Gangapshev, A.
Kazalov, V.
Inzhechik, L. V.
Klimenko, A.
Yanovich, E.
Caldwell, A.
Laubenstein, M.
Wester, T.
Borowicz, Dariusz
D’Andrea, V.
Panas, Krzysztof
Bettini, A.
Brudanin, V.
Demidova, E. V.
Moseev, P.
Falkenstein, R.
Kirsch, A.
Majorovits, B.
Zhitnikov, I.
Zhukov, S. V.
Maneschg, W.
Pullia, A.
Riboldi, S.
Wójcik, Marcin
Kermaïdic, Y.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
The ChoCO-W prospective observational global study : Does COVID-19 increase gangrenous cholecystitis?
Autorzy:
Lasithiotakis, Konstantinos
Kolla, Chrysoula-Christina
Bayhan, Zulfu
Sotiropoulou, Maria
Verras, Georgios Ioannis
Fabri, Nicolo
Lopez-Ruiz, Jose Antonio
Liman, Rumeysa Kevser
Massani, Marco
Azizan, Nornazirah
Capelli, Patrizio
Dogjani, Agron
Bouliaris, Konstantinos
Veroux, Massimiliano
Ibrahim, Mohamed
Abu-Zidan, Fikri M.
Occhionorelli, Savino
Andreuccetti, Jacopo
Ercolani, Giorgio
Atanasov, Boyko
Biffl, Walter L.
Lacavalla, Domenico
Nardello, Oreste
Agostinelli, Laura
Kwiatkowski, Andrzej
Colak, Elif
Palmieri Hernandez, Adriana Maria
Major, Piotr
Cappellacci, Federico
Uriguen-Etxeberria, Ana
Manatakis, Dimitrios K.
Palini, Gian Marco
Lupi, Davide
Gupta, Sanjay
Loutzidou, Lydia
Spolini, Alessandro
Litvin, Andrey
Capuzzolo, Sabino
Mendoza-Moreno, Fernando
Muzio, Elena
Olmi, Stefano
Khokha, Vladimir
Casoni Pattacini, Gianmaria
Tedesco, Silvia
Dumitrescu, Theodor Viorel
Roscio, Francesco
Abato, Emmanuele
Sartelli, Massimo
Triantafyllou, Tania
Hernandez Amín, Luz Adriana
Strzałka, Marcin
Massalou, Damien
Medas, Fabio
Andreotti, Dario
Miller, Kelsey
Aref, Hager
Maltinti, Gherardo
Podda, Mauro
Ietto, Giuseppe
Callari, Cosimo
Tvaladze, Ana
Al Bahri, Shadi
Abdullaev, Abakar
Campanile, Fabio Cesare
Ciorbagiu, Mihai Calin
Di Saverio, Salomone
Bayrak, Mehmet
Trigiante, Giuseppe
Gambarini, Fabrizio
Slavchev, Mihail
Azman, Azlanudin
Grassia, Sebastiano
Sellappan, Harivinthan
Palmieri Luna, Alfonso
Bonavina, Luigi
Negoi, Ionut
de Angelis, Nicola
Piccolo, Gaetano
Rossi, Stefano
Carcano, Giulio
Acheimastos, Vasileios
Agnoletti, Vanni
Matias-Garcia, Belen
Nikolopoulos, Ioannis
Zanus, Giacomo
Gonullu, Emre
Zulkifli, Anis Suraya M.
Delibegovic, Samir
Kojima, Mitsuaki
Quiroga-Valcarcel, Ana
Dalessio, Rossella
de Luca, Maurizio
Kumaz, Eray
Trinh, Anna
Bottari, Andrea
Meric, Serhat
Theodorou, Dimitrios
Kapiris, Stylianos
Akbar, Ali
Aliakbarian, Mohsen
Schizas, Dimitrios
Machain Vega, Gustavo
Canu, Gian Luigi
Moric, Trpimir
Ruggieri, Annamaria
Pisanu, Adolfo
Ozkan, Zeynep
Bagolini, Francesco
Norrey, Marcus
Tosi, Lorenzo
Vederaki, Styliani-Aikaterini
Xin Yi, Rebecca Choy
Aktimur, Yunus Emre
Asghar, Mohammad Sohail
Dorovinis, Panagiotis
Restini, Enrico
Armellino, Mariano Fortunato
Jung, Sung Won
Franchi, Caterina
Delis, Spiros G.
Moore, Ernest E.
de Lima Bertu, Jackson Vinicius
Licari, Leo
Bianco, Francesco
Vagios, Ilias
Abdel-Elsalam, Sherief
Lepiane, Pasquale
Moug, Susan J.
de Sa, Tiago Correia
Abdel-Elsalam, Wafaa
Ojeda, Leonardo
Munoz-Cruzado, Virginia Duran
Phooi Khei, Victoria Tan
Syllaios, Athanasios
Casati, Massimiliano
Volpicelli, Alessio
Vecchioni, Ilaria
Bains, Lovenish
Staderini, Fabio
Martines, Gennaro
Iftoda, Oksana
Gachabayov, Mahir
Nakamoto, Raira
Gabellini, Linda
Othman, Muhammad Asyraf
Bonaldi, Marta
Gumbs, Andrew A.
Dacapito, Fabrizio
Hedi Ghalloussi, Mohamed
Bonilauri, Stefano
Sidiropoulos, Theodoros A.
Galleano, Raffaele
Froiio, Caterina
Campagnacci, Roberto
Demirbas, Iskender Eren
Gurung, Rekha
Yalkin, Omer
Aparicio-Sanchez, Daniel
Pecchini, Francesca
Plehutsa, Oleksandr
Picardi, Biagio
Bondurri, Andrea
Vita, Domenico
Ioannidis, Orestis
Sartori, Alberto
Hamid, Hytham K.S.
Vacante, Marco
Pintar, Tadeja
Pujante, Antonio
Sin, Boo Han
Fransvea, Pietro
Damaskos, Dimitrios
Taddei, Antonio
Petronio, Barbara
Rahim, Razrim
Cavallaro, Andrea
Tasis, Nikolaos
Symeonidis, Savvas
Elbahnasawy, Mohamed
Michalopoulos, Nikolaos V.
Anastasi, Alessandro
Pesce, Antonio
Garulli, Gianluca
Baraket, Oussama
Misiakos, Evangelos P.
Costanzi, Andrea
Isik, Arda
Fortuna, Laura
Livadoti, Giada
Fleres, Francesco
Gomes, Felipe Couto
Gureh, Monika
Toma, Elena Adelina
Gelmini, Roberta
Pantalone, Desire
Veneroni, Simone
Balla, Andrea
Argenio, Giulio
Kirkpatrick, Andrew
Demetrashvili, Zaza
Dios Barbeito, Sandra
Sarnari, Jlenia
Ammerata, Giorgio
Deserra, Antonello
Curro, Giuseppe
Romero-Vargas, Estela
Chouillard, Elie
Conti, Luigi
Hirano, Elcio Shiyoiti
Pararas, Nikolaos
Serra, Francesco
Lekiashvili, Nika
Ansaloni, Luca
Romic, Ivan
Sydorchuk, Larysa
Shabana, Amanda
Rahman, Karim Abdul
Altintoprak, Fatih
Polat, Suleyman
Riva, Carlo
Poillucci, Gaetano
Das, Koray
Knut, Ruslan
Zanghi, Antonio
Jusoh, Asri Che
Catena, Fausto
Jedamzik, Julia
Rispoli, Michele
Kurtenkov, Mikhail
Cattaneo, Gaetano Maria
Kim, Jae Il
Nita, Gabriela
Doria, Emanuele
Gil-Olarte, Angeles
Maffioli, Anna
Gourgiotis, Stavros
Nagorni, Eleni-Aikaterini
Uzunoglu, Mustafa Yener
Ferrara, Francesco
Sani, Mohamad Ikhwan
Dai, Nick
Giordano, Alessio
Clarizia, Guglielmo
Cianchi, Fabio
Solaini, Leonardo
Giraudo, Giorgio
Chrysos, Emmanuel
Visconti, Diego
Czyżykowski, Łukasz
Dalili, Amin
Cappellani, Alessandro
Piccoli, Micaela
Gioco, Rossella
Rocha, Monica
Ammendola, Michele
Akin, Emrah
Grossi, Ugo
Pereira Fraga, Gustavo
Pikoulis, Emmanouil
Natkaniec, Michał
Landaluce-Olavarria, Aitor
Marinis, Athanasios
Atici, Semra Demirli
Zuhdi, Zamri
Tuncer, Gizem Kilinc
Seker, Ahmet
Altintas, Yasemin
Romano, Roberto
Kader, Saleh Abdel
Balogh, Zsolt J.
Rodriguez Gonzalez, Agustin
Azamat, Ibrahim
Zanzi, Federico
Estraviz-Mateos, Begona
Keramida, Myrto D.
Malerba, Michele
Biondi, Antonio
Shoko, Tomohisa
Borghi, Felice
Koylu, Zehra Alan
Kenig, Jakub
Capoglu, Recayi
Laface, Letizia
Koukoulis, George
Walędziak, Maciej
Dzulkarnaen, Zakaria Andee
Kluger, Yoram
Coccolini, Federico
Gendrikson, George
Felsenreich, Daniel M.
Cappato, Stefano
Santarelli, Mauro
Kaya, Tayfun
Guariniello, Anna
Matyja, Maciej
Lucchi, Andrea
Cillara, Nicola
Zainudin, Syaza
Anania, Gabriele
Cannavera, Alessandro
del Monte, Simone Rossi
Guagni, Tommaso
Papadoliopoulou, Maria
Iflazoglu, Nidal
Bombardini, Cristina
Machairas, Nikolaos
Negro, Giulia
Sawyer, Robert G.
Feo, Carlo Vittorio
Griggio, Giulia
Gomes, Carlos Augusto
Brisinda, Giuseppe
Ozer, Nazmi
Sydorchuk, Andrii
Mesina, Cristian
Papaconstantinou, Dimitrios
Canonico, Giuseppe
Omarov, Nail
Lostoridis, Eftychios
de Simone, Belinda
Bernardi, Daniele
Valenti, Maria Rosaria
Augustin, Goran
Cardinali, Luca
Afzal, Ameer
Ayed, Karim
Bala, Miklosh
Monteleone, Michela
Salobir, Jure
Patias, Parmenion
Pignata, Giusto
Martinotti, Mario
Sebastiani, Elisa
Piatto, Giacomo
Maurizi, Angela
Skorus, Urszula
Saeidi, Sara
Razat, Sulce
Yigit, Direnc
Rossi, Elena Giulia
Nardi, Matteo
Kedar, Asaf
Bisetto, Giovanni
Enciu, Octavian
Sasia, Diego
Martino, Costanza
Costanzo, Federico
Babiker, Ahmed
Guerci, Claudio
Tutino, Roberta
Mulita, Francesk
Ghoneim, Basma
Di Vita, Maria Domenica Pia
Vailas, Michail
Uymaz, Derya Salim
Andolfi, Enrico
Shin, Yong Chan
Altinel, Yuksel
Viola, Simona
Agresta, Ferdinando
Sydorchuk, Ruslan
Mousa, Hussam
Saramuzzo, Rosa
Hayati, Firdaus
Uccelli, Matteo
Filippo, Rosalinda
Kesetovic, Amar
Mantoglu, Baris
Ntokos, Georgios
Cianci, Pasquale
Kara, Yasin
Nikolo, Taxiarchis Konstantinos
Chuklin, Serhii
Clerici, Federico
Travaglini, Grazia
Agostini, Carlotta
Opis:
Background: The incidence of the highly morbid and potentially lethal gangrenous cholecystitis was reportedly increased during the COVID-19 pandemic. The aim of the ChoCO-W study was to compare the clinical findings and outcomes of acute cholecystitis in patients who had COVID-19 disease with those who did not. Methods: Data were prospectively collected over 6 months (October 1, 2020, to April 30, 2021) with 1-month follow-up. In October 2020, Delta variant of SARS CoV-2 was isolated for the first time. Demographic and clinical data were analyzed and reported according to the STROBE guidelines. Baseline characteristics and clinical outcomes of patients who had COVID-19 were compared with those who did not. Results: A total of 2893 patients, from 42 countries, 218 centers, involved, with a median age of 61.3 (SD: 17.39) years were prospectively enrolled in this study; 1481 (51%) patients were males. One hundred and eighty (6.9%) patients were COVID-19 positive, while 2412 (93.1%) were negative. Concomitant preexisting diseases including cardiovascular diseases (p < 0.0001), diabetes (p < 0.0001), and severe chronic obstructive airway disease (p = 0.005) were significantly more frequent in the COVID-19 group. Markers of sepsis severity including ARDS (p < 0.0001), PIPAS score (p < 0.0001), WSES sepsis score (p < 0.0001), qSOFA (p < 0.0001), and Tokyo classification of severity of acute cholecystitis (p < 0.0001) were significantly higher in the COVID-19 group. The COVID-19 group had significantly higher postoperative complications (32.2% compared with 11.7%, p < 0.0001), longer mean hospital stay (13.21 compared with 6.51 days, p < 0.0001), and mortality rate (13.4% compared with 1.7%, p < 0.0001). The incidence of gangrenous cholecystitis was doubled in the COVID-19 group (40.7% compared with 22.3%). The mean wall thickness of the gallbladder was significantly higher in the COVID-19 group [6.32 (SD: 2.44) mm compared with 5.4 (SD: 3.45) mm; p < 0.0001]. Conclusions: The incidence of gangrenous cholecystitis is higher in COVID patients compared with non-COVID patients admitted to the emergency department with acute cholecystitis. Gangrenous cholecystitis in COVID patients is associated with high-grade Clavien-Dindo postoperative complications, longer hospital stay and higher mortality rate. The open cholecystectomy rate is higher in COVID compared with non -COVID patients. It is recommended to delay the surgical treatment in COVID patients, when it is possible, to decrease morbidity and mortality rates. COVID-19 infection and gangrenous cholecystistis are not absolute contraindications to perform laparoscopic cholecystectomy, in a case by case evaluation, in expert hands.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Wyświetlanie 1-10 z 14

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