Autor: Gryko, D. - Prolib Integro

Skocz do pozycji: 1.

Tytuł:: Fluorescence Microscopy of Corrole-Single Silver Nanowire Hybrid Nanostructures
Autorzy:: Czechowski, N.
Olejnik, M.
Nowak-Król, A.
Piątkowski, D.
Heiss, W.
Gryko, D.
Mackowski, S.
Tematy:: 33.50.-j
78.67.Uh
73.20.Mf
81.07.Pr
81.07.-b; Pokaż więcej
Wydawca:: Polska Akademia Nauk. Instytut Fizyki PAN
Powiązania:: https://bibliotekanauki.pl/articles/1419537.pdf Link otwiera się w nowym oknie
Opis:: We report on confocal microscopy imaging of hybrid nanostructures composed of silver nanowires and corroles. Both nanomaterials were separated by a 30 nm thick $SiO_2$ spacer in order to inhibit fluorescence quenching. The results show that for such a hybrid nanostructure the average enhancement of the fluorescence intensity reached 2.5. Importantly, the coupling to plasmon excitations in metallic nanowires leaves no effect on the fluorescence spectrum of the organic molecules.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Pedometer assessed physical activity of people with metabolic syndrome in Poland
Autorzy:: Owlasiuk, A.
Chlabicz, S.
Gryko, A.
Litwiejko, A.
Malyszko, J.
Bielska, D.
Wydawca:: Instytut Medycyny Wsi
Powiązania:: https://bibliotekanauki.pl/articles/50429.pdf Link otwiera się w nowym oknie
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: Hiatus hernia – Late complication after gastrectomy followed by double tract reconstruction (DTR): a case report
Autorzy:: Bandurski, R.
Gryko, M.
Dawidziuk, T.
Zaręba, K.
Cepowicz, D.
Kędra, B.
Tematy:: gastric cancer
hiatus hernia
late complication
surgery; Pokaż więcej
Wydawca:: Uniwersytet Medyczny w Białymstoku
Powiązania:: https://bibliotekanauki.pl/articles/1916509.pdf Link otwiera się w nowym oknie
Opis:: In patients with dyspeptic symptoms who have been treated for gastric cancer, other medical conditions apart from cancer recurrence should be considered. A long small-bowel loop left after esophagogastric anastomosis, flaccid diaphragmatic crura, and several external factors such as hard physical exertion can promote the development of postoperative hiatus hernia. The authors of this paper present a rare case of hiatus hernia considered a late complication of primary surgery performed due to gastric cancer. The 63-year-old patient had undergone total gastrectomy with double tract reconstruction (DTR) six years earlier. Gastrectomy was performed with extended lymphadenectomy (>D2). Histopathologic examination of tumor specimens showed mucinous adenocarcinoma with no lymph node metastasis and no distant metastases (pathologic staging: pT2, pN0, pM0). After six years, the patient was admitted to the 2nd Department of General and Gastroenterologic Surgery with abdominal pains, malaise, weight loss and feeling of fullness after small meals. Diagnostic procedures performed showed the presence of hiatus hernia, a very rare complication after this particular surgery, with no features of cancer recurrence. The patient was underwent surgery and the hernia was successfully repaired.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 4.

Tytuł:: Cancer of the gallbladder – own experience
Autorzy:: Gryko, M.
Dawidziuk, T.
Sawicka, E.
Cepowicz, D.
Kamocki, Zb.
Masiulaniec, P.
Kędra, B.
Tematy:: gallbladder cancer
survival
surgery
gallstones
cholecystectomy; Pokaż więcej
Wydawca:: Uniwersytet Medyczny w Białymstoku
Powiązania:: https://bibliotekanauki.pl/articles/1916507.pdf Link otwiera się w nowym oknie
Opis:: Gallbladder cancer is a relatively rare cancer of the gastrointestinal tract, most commonly detected (approximately 95% of cases) in the most advanced clinical stage IV and burdened with high mortality rate. This is mainly due to the nonspecific symptoms in the early stages of the disease. The remaining cases of gallbladder cancer are usually detected after surgery due to gallstone disease. Gallstones, their size and pancreatic juice reflux into the gallbladder are risk factors in the development of gallbladder cancer. In this paper the authors carried out a retrospective research based on an evaluation of a group of 38 patients treated surgically due to the gallbladder cancer in the years 2005-2012 in the Second Department of General and Gastroenterological Surgery in Białystok Medical University Hospital. In this group there were 29 women and 9 men, in age between 48-86 years. Although women suffered from gallbladder cancer more often than men, their survival rate was significantly better after the surgery. The research showed some benefits of extended surgical procedures even in patients with advanced stages of the disease, while the effectiveness of surgical treatment depends mainly on the possibility of radical resection of the primary lesion and, eventually, the resection of lymph nodes and other infiltrated tissues.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 5.

Tytuł:: N-Aryl substituents have an influence on the photophysics of tetraaryl-pyrrolo[3,2-b]pyrroles
Autorzy:: Banasiewicz, Marzena
Petrykowski, Wojciech D.
Morawski, Olaf
Kałuża, Zbigniew
Gryko, Daniel T.
Barboza, Cristina A.
Wydawca:: Royal Society of Chemistry
Cytata wydawnicza:: Phys. Chem. Chem. Phys., 2026, 28, 2344-2352 // https://doi.org/10.1039/D5CP03474D
Opis:: The photophysics of two series of 1,4-dihydro-tetraaryl-pyrrolo[3,2-b]pyrroles possessing N-aryl substituents with various electronic characteristics was investigated systematically. The molecular structure of these compounds was designed so that their solubility enabled us to study their absorption and emission in a broad range of solvents. The presence of N-4-nitrophenyl substituents is responsible for a weak charge-transfer absorption band and shifts the emission band hypsochromically. At the same time, their presence quenches fluorescence; although if electron-withdrawing substituents are present at positions 2 and 5, this effect is reduced by an order of magnitude. In the case of less electron-withdrawing N-4-cyanophenyl and N-3-cyanophenyl groups, strong emission is present only if the electron-withdrawing groups are located at positions 2 and 5. The combined experimental and computational study points out the existence of a barrier between au (bright) and ag (dark) CT states, the height of which is the key factor governing the fate of these molecules in the excited state. Weaker electronic communication at positions 1 and 4 of the DHPP core is responsible for strong charge separation. Polar solvents favor the formation of transient dipole moments due to excited-state symmetry-breaking, which amplifies the nonradiative deactivation of nitro-TAPPs. A large increase in fluorescence intensity at 77 K suggests that internal conversion is a key channel for non-radiative electronic relaxation. Conversely, moderate to weak electron-donating groups favor strong LE emission.
European Union’s Horizon 2020 Research and Innovation Programunder the Marie Skłodowska-Curie grant agreement no. 101007804; European Research Council (ARCHIMEDES, 101097337); Polish National Science Centre (OPUS 2020/37/B/ST4/00017); Polish high-performance computing infrastructure PLGrid (HPC Center: ACK Cyfronet AGH) grant no. PLG/2024/017465.
Dostawca treści:: Repozytorium Centrum Otwartej Nauki

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Skocz do pozycji: 6.

Tytuł:: Comparison of expression of selected proteins in the cells of intestinal and diffuse type gastric cancer – immunohistochemical analysis
Autorzy:: Gryko, M.
Prycznicz, A.
Dawidziuk, T.
Zińczuk, J.
Cepowicz, D.
Kamocki, Zb.
Kedra, B.
Guzińska-Ustymowicz, K.
Tematy:: gastric cancer
apoptosis
Lauren classification
E-cadherin
apoptotic pathways; Pokaż więcej
Wydawca:: Uniwersytet Medyczny w Białymstoku
Powiązania:: https://bibliotekanauki.pl/articles/1916399.pdf Link otwiera się w nowym oknie
Opis:: Introduction: Despite the progress in gaining knowledge about carcinogenesis, it is still unclear what processes are directly responsible for the differentiation of gastric cancer into its intestinal or diffuse form. Dividing of these two forms is based on one of the oldest, yet still commonly used classifications – the classification of Lauren. There are many factors that may influence the formation of gastric tumors of various aggressiveness. Purpose: To evaluate the expression of proteins: fragile histidine triad (FHIT), E-cadherin, α-catenin, γ-catenin, cathepsin B, epidermal growth factor (EGF), HER-2, MMP-9, MCM-2, Bak, Bax, BID, Bcl-XL, p53, FasL, Bcl-2, caspase-8, procaspase-3 in gastric cancer cells, depending on the type of tumor by Lauren classification. Materials and methods: Study group consisted of 91 patients treated surgically for gastric cancer in the Second Department of General and Gastroenterological Surgery, Medical University of Bialystok in years between 2000 and 2006. Results: It is shown, that the expression of E-cadherin was significantly higher in the Lauren I gastric cancer cells than in Lauren II. In case of caspase-8 there has been significantly less frequent expression of this protein in Lauren I gastric cancer cells compared to Lauren II. The authors describe no statistically significant differences in the expression of other proteins taken into consideration. Conclusions: These results suggest the role of adhesion and apoptosis-related proteins in the development of two different types of gastric cancer according to Lauren’s classification.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 7.

Tytuł:: All-Polymer Microcavities for the Fluorescence Radiative Rate Modification of a Diketopyrrolopyrrole Derivative
Autorzy:: Lanfranchi, Andrea
Patrini, Maddalena
Gryko, Daniel T.
Koszarna, Beata
D'Andrea, Cosimo
Lova, Paola
Sardar, Samim
Megahd, Heba
Comoretto, Davide
Wydawca:: American Chemical Society
Cytata wydawnicza:: ACS Omega 2022, 7, 15499−15506 ; https://doi.org/10.1021/acsomega.2c00167
Opis:: University of Genova (FRA 2019–2020) Ministry of the Instruction, University and Research, PRIN2020 (2020TS9LXS) Foundation for Polish Science (TEAM POIR.04.04.00-00-3CF4/16-00)
Controlling the radiative rate of emitters with macromolecular photonic structures promises flexible devices with enhanced performances that are easy to scale up. For instance, radiative rate enhancement empowers low-threshold lasers, while rate suppression affects recombination in photovoltaic and photochemical processes. However, claims of the Purcell effect with polymer structures are controversial, as the low dielectric contrast typical of suitable polymers is commonly not enough to provide the necessary confinement. Here we show all-polymer planar microcavities with photonic band gaps tuned to the photoluminescence of a diketopyrrolopyrrole derivative, which allows a change in the fluorescence lifetime. Radiative and nonradiative rates were disentangled systematically by measuring the external quantum efficiencies and comparing the planar microcavities with a series of references designed to exclude any extrinsic effects. For the first time, this analysis shows unambiguously the dye radiative emission rate variations obtained with macromolecular dielectric mirrors. When different waveguides, chemical environments, and effective refractive index effects in the structure were accounted for, the change in the radiative lifetime was assigned to the Purcell effect. This was possible through the exploitation of photonic structures made of polyvinylcarbazole as a high-index material and the perfluorinated Aquivion as a low-index one, which produced the largest dielectric contrast ever obtained in planar polymer cavities. This characteristic induces the high confinement of the radiation electric field within the cavity layer, causing a record intensity enhancement and steering the radiative rate. Current limits and requirements to achieve the full control of radiative rates with polymer planar microcavities are also addressed.
Dostawca treści:: Repozytorium Centrum Otwartej Nauki

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Skocz do pozycji: 8.

Tytuł:: The expression of apoptosis-related proteins in patients with ulcerative colitis
Autorzy:: Niewiarowska, K.
Lebelt, A.
Gryko, M.
Pryczynicz, A.
Famulski, W.
Czyżewska, J.
Kemona, A.
Piekarska-Dymicka, V.
Jagodzińska, D.
Guzińska-Ustymowicz, K.
Tematy:: Ulcerative colitis
Bcl-xl
Bax
Bid
Bcl-2; Pokaż więcej
Wydawca:: Uniwersytet Medyczny w Białymstoku
Powiązania:: https://bibliotekanauki.pl/articles/1916338.pdf Link otwiera się w nowym oknie
Opis:: Purpose: Recent literature data indicate a key role of apoptosis in the pathogenesis of inflammatory bowel disease. The aim of the study was to evaluate the expression of Bax, Bid, Bcl-2 and Bcl-xl in non-dysplastic and dysplastic epithelium in inflamated mucosa of patients with ulcerative colitis. Methods: The study consists of 18 patients with diagnosed ulcerative colitis. The expression of proteins was determined immunohistochemically. Results: Lack of Bax expression in normal epithelium of the inflamed intestinal mucosa (94.4%) and a weak expression of this protein were found in dysplastic glandular cells (67%). The Bax expression of dysplastic epithelium correlates with reduced severity of chronic inflammation (p<0.005). Bid expression in non-dysplastic glands was found in 67% of cases vs. 16% in dysplastic epithelium that was associated with the occurrence of epithelial erosions or ulcers (p<0.05). Moderate cytoplasmic expression of Bcl-xl was noted in 27.7% of patients in normal epithelium and in 66.1% within dysplastic lesions. Bcl-xl expression in dysplastic glandular cells correlated with the presence of neutrophils in the lamina propria (p <0.05). Conclusions: The immunohistochemical expressions of Bax, Bcl-2 and Bcl-xl increase and Bid protein expression decreases in dysplastic glandular tubes as compared to non-dysplastic intestinal epithelium in inflamed mucosa, which may suggest an imbalance of controlled cell death in ulcerative colitis.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 9.

Tytuł:: Double helicene possessing B–N dative bonds built on 1,4-dihydropyrrolo[3,2-b]pyrrole core
Autorzy:: Petrykowski, Wojciech D.
Poronik, Yevgen M.
Bertocchi, Francesco
Naim, Carmelo
Ciesielski, Arkadiusz
Terenziani, Francesca
Gryko, Daniel T.
Jacquemin, Denis
Cyrański, Michał K.
Vanthuyne, Nicolas
Wydawca:: Royal Society of Chemistry
Cytata wydawnicza:: Chem. Sci., 2025, 16, 8338–8345 // https://doi.org/10.1039/D5SC00540J
Opis:: European Union's Horizon 2020 Research and Innovation Program under the Marie Skłodowska-Curie grant agreement no. 10100780; European Research Council (ARCHIMEDES, 101097337); Polish National Science Centre, Poland (OPUS 2020/37/B/ST4/00017); COMP-HUB and COMP-R initiatives, funded by the “Departments of Excellence” program of the Italian Ministry for University and Research (MIUR, 2018-2022 and MUR, 2023-2027); French Agence Nationale de la Recherche (ANR) under contract ANR-21-CE07-0058-2 (CONDOR); GLiCID Computing Facility (Ligerien Group for Intensive Distributed Computing, 10.60487/glicid, Pays de la Loire, France.
Just four steps are required to transform 2-nitrobenzaldehyde into centrosymmetric, quadrupolar N,B-doped nanographenes possessing two nitrogen–boron dative bonds. A convergent fragment coupling strategy allowed rapid access to key intermediates bearing the 1,4-dihydropyrrolo[3,2-b]pyrrole core. 2,6-Di-tert-butylpyridine turned out to be the best base for the formation of B←N bonds. This synthetic strategy can be extended to encompass double helicenes possessing two [7]helicene units bearing four five-membered rings. The size of the peripheral arm influences the reaction output: in the case of replacing benzene with dibenzothiophene, the yield decreases from 75% to 16%. Interestingly only two enantiomers and not meso form are formed in the latter case. The obtained double helicene containing 14 fused rings, exhibits green emission characterized by reasonable fluorescence quantum yield reaching 0.38. This dye has average circularly polarized luminescence brightness (BCPL) of about 15 M−1 cm−1. The analysis of the electronic structure of the dyes with quantum chemical methods reveals highly-delocalized excited states with the core of the dye acting as a electron-donating moiety.
Dostawca treści:: Repozytorium Centrum Otwartej Nauki

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Skocz do pozycji: 10.

Tytuł:: Neutral rhodol-based dyes expressing localization in mitochondria
Autorzy:: Ferraboschi, Ilaria
Szewczyk, Adam
Belfield, Kevin D.
Ovčar, Juraj
Vygranenko, Kateryna V.
Minervino, Alfonso
Rozza, Riccardo
Gryko, Daniel T.
Yu, Shupei
Wrzosek, Antoni
Sissa, Cristina
Magistrato, Alessandra
Grisanti, Luca
Wydawca:: Royal Society of Chemistry
Cytata wydawnicza:: Org. Biomol. Chem., 2024, 22, 5886–5890 ; https://doi.org/10.1039/D4OB00252K
Opis:: Neutral rhodol-based red emitters are shown to efficiently localize in mitochondria, as demonstrated by confocal microscopy and co-localization studies. A simple model is proposed to explain the localization mechanism of neutral molecules. The model takes into account the strong coupling between the molecular dipole moment and the electric field of the inner mitochondrial membrane.
European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 101007804-Micro4Nano; PhD fellowship financed by PON R&I 2014–2020 (FSEREACT EU fundings); Departments of Excellence’ program of the Italian Ministry for University and Research (MIUR, 2018–2022 and MUR, 2023–2027).
Dostawca treści:: Repozytorium Centrum Otwartej Nauki

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