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Przejdź do strony domowej biblioteki Pedagogiczna Biblioteka Wojewódzka im. Komisji Edukacji Narodowej w Lublinie Link otwiera się w nowym oknie Logo biblioteki Prolib Integro - strona głównaPedagogiczna Biblioteka Wojewódzka im. Komisji Edukacji Narodowej w Lublinie
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Wyszukujesz frazę "Hancock, R." wg kryterium: Autor

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    Wyświetlanie 1-10 z 10
    Tytuł:
    Restraining quiescence release-related ageing in plant cells : a case study in carrot
    Autorzy:
    Verrall, Susan R.
    Foyer, Christine H.
    Schulz, Katie
    Kärkönen, Anna
    Machaj, Gabriela
    Knox, Paul
    Hancock, Robert D.
    Karpinska, Barbara
    Saranpää, Pekka
    Korpinen, Risto
    Opis:
    The blackening of cut carrots causes substantial economic losses to the food industry. Blackening was not observed in carrots that had been stored underground for less than a year, but the susceptibility to blackening increased with the age of the carrots that were stored underground for longer periods. Samples of black, border, and orange tissues from processed carrot batons and slices, prepared under industry standard conditions, were analyzed to identify the molecular and metabolic mechanisms underpinning processing-induced blackening. The black tissues showed substantial molecular and metabolic rewiring and large changes in the cell wall structure, with a decreased abundance of xyloglucan, pectins (homogalacturonan, rhamnogalacturonan-I, galactan and arabinan), and higher levels of lignin and other phenolic compounds when compared to orange tissues. Metabolite profiling analysis showed that there was a major shift from primary to secondary metabolism in the black tissues, which were depleted in sugars, amino acids, and tricarboxylic acid (TCA) cycle intermediates but were rich in phenolic compounds. These findings suggest that processing triggers a release from quiescence. Transcripts encoding proteins associated with secondary metabolism were less abundant in the black tissues, but there were no increases in transcripts associated with oxidative stress responses, programmed cell death, or senescence. We conclude that restraining quiescence release alters cell wall metabolism and composition, particularly regarding pectin composition, in a manner that increases susceptibility to blackening upon processing.
    Dostawca treści:
    Repozytorium Uniwersytetu Jagiellońskiego
    Artykuł
    Tytuł:
    Outcome after acute ischemic stroke is linked to sex-specific lesion patterns
    Autorzy:
    Dalca, Adrian V.
    Lindgren, Arne G.
    Söderholm, Martin
    Donatti, Amanda
    Benavente, Oscar R.
    Giese, Anne-Katrin
    Levi, Christopher R.
    Strbian, Daniel
    Brudfors, Mikael
    Sharma, Pankaj
    Thijs, Vincent
    Donahue, Kathleen L.
    Mocking, Steven J. T.
    Holmegaard, Lukas
    Schmidt, Reinhold
    Etherton, Mark R.
    Sacco, Ralph L.
    Vagal, Achala
    Hong, Sungmin
    Cole, John W.
    Rundek, Tatjana
    Maguire, Jane
    Jood, Katarina
    Jimenez-Conde, Jordi
    Sousa, Alessandro
    Bzdok, Danilo
    Nardin, Marco J.
    Stanne, Tara M.
    Ropele, Stefan
    Zand, Ramin
    Bevan, Stephen
    Lemmens, Robin
    Słowik, Agnieszka
    McIntosh, Elissa C.
    Rost, Natalia S.
    Roquer, Jaume
    Phuah, Chia-Ling
    Schirmer, Markus D.
    Regenhardt, Robert W.
    Griessenauer, Christoph J.
    Rosand, Jonathan
    Worrall, Bradford B.
    Wasselius, Johan
    Tatlisumak, Turgut
    Attia, John
    Woo, Daniel
    Bonkhoff, Anna K.
    Jern, Christina
    Hancock, Brandon L.
    Kittner, Steven J.
    McArdle, Patrick F.
    Bretzner, Martin
    Wu, Ona
    McDonough, Caitrin W.
    Meschia, James F.
    Rolfs, Arndt
    Heitsch, Laura
    Opis:
    Acute ischemic stroke affects men and women differently. In particular, women are often reported to experience higher acute stroke severity than men. We derived a low-dimensional representation of anatomical stroke lesions and designed a Bayesian hierarchical modeling framework tailored to estimate possible sex differences in lesion patterns linked to acute stroke severity (National Institute of Health Stroke Scale). This framework was developed in 555 patients (38% female). Findings were validated in an independent cohort (n = 503, 41% female). Here, we show brain lesions in regions subserving motor and language functions help explain stroke severity in both men and women, however more widespread lesion patterns are relevant in female patients. Higher stroke severity in women, but not men, is associated with left hemisphere lesions in the vicinity of the posterior circulation. Our results suggest there are sex-specific functional cerebral asymmetries that may be important for future investigations of sex-stratified approaches to management of acute ischemic stroke.
    Dostawca treści:
    Repozytorium Uniwersytetu Jagiellońskiego
    Artykuł
    Tytuł:
    PCSK9 genetic variants and risk of type 2 diabetes : a mendelian randomisation study
    Autorzy:
    Bots, Michiel L.
    Froguel, Philippe
    Hypponen, Elina
    Price, Jackie F.
    Smart, Melissa
    van Iperen, Erik
    Hakonarson, Hakon
    Lange, Leslie A.
    Ridker, Paul M.
    Moldovan, Max
    Kiechl, Stefan
    Kumari, Meena
    Husemoen, Lise Lotte Nystrup
    Liu, Tian
    Patel, Riyaz S.
    Mahajan, Anubha
    Larson, Eric B.
    Sanchez-Galvez, Adelaida
    Ritchie, Marylyn D.
    Pikhart, Hynek
    Kitchner, Terrie
    Willeit, Karin
    Demuth, Juri
    Verweij, Niek
    Balkau, Beverley
    Cariou, Bertrand
    de Andrade, Mariz
    Sacerdote, Carlotta
    Morris, Richard
    Matullo, Giuseppe
    Young, Robin
    Lerch, Markus M.
    Kubinova, Ruzena
    Christen, Tim
    Malyutina, Sofia
    Wareham, Nicholas J.
    Chasman, Daniel I.
    O' Donnell, Martin
    Fairhurst-Hunter, Zammy
    Uitterlinden, Andre
    Scott, Robert
    Hingorani, Aroon D.
    Whincup, Peter
    Power, Christine
    Hancock, Stephen
    Grarup, Niels
    van der Schouw, Yvonne T.
    Mason, Dan
    Pająk, Andrzej
    Tamosiunas, Abdonas
    Guarrera, Simonetta
    Mook-Kanamori, Dennis O.
    Dorr, Marcus
    Ward, Joey
    Pare, Guillaume
    Bobak, Martin
    Pell, Jill P.
    Hovingh, G. Kees
    Bertram, Lars
    Pedersen, Oluf
    Kirchner, H. Lester
    Gustafsson, Stefan
    Linneberg, Allan
    Carrell, David S.
    Snieder, Harold
    Baumeister, Sebastian
    Hartwig, Fernando Pires
    Ford, Ian
    Casas, Juan-Pablo
    Preiss, David
    Ben-Shlomo, Yoav
    Swerdlow, Daniel I.
    Willeit, Johann
    Fiorito, Giovanni
    Holmes, Michael V.
    Yusuf, Salim
    Volker, Uwe
    Denny, Joshua C.
    Meade, Tom
    Maitland-van der Zee, Anke H.
    Panayiotou, Andrie G.
    McLachlan, Stela
    Lyall, Donald M.
    Grobbee, Diederick E.
    Coassin, Stefan
    Wanamethee, Goya
    Volzke, Henry
    Kivimaki, Mika
    Wright, John
    Carty, Cara
    Nicolaides, Andrew
    Asselbergs, Folkert W.
    Eppinga, Ruben N.
    Langenberg, Claudia
    Attia, John
    Welch, Catherine
    Padmanabhan, Sandosh
    Brilliant, Murray
    Marques-Vidal, Pedro
    Bonnefond, Amélie
    Franco, Oscar
    Baranova, Ekaterina V.
    Reiner, Alex P.
    Teumer, Alexander
    Keating, Brendan J.
    Thuillier, Dorothee
    Horta, Bernardo Lessa
    Ingelsson, Erik
    Humphries, Steve E.
    Smith, Daniel J.
    Lind, Lars
    Hansen, Torben
    Holliday, Elizabeth
    van der Harst, Pim
    Schmidt, Amand F.
    Cooper, Jackie
    Steinhagen-Thiessen, Elisabeth
    Hofman, Albert
    Dehghan, Abbas
    Onland-Moret, N. Charlotte
    Demuth, Ilja
    Chong, Michael
    Roden, Dan M.
    Said, M. Abdullah
    McCarty, Catherine A.
    Crosslin, David R.
    Campbell, Archie
    Simonsen, Kenneth Starup
    Luan, Jian'an
    Bao, Yanchun
    Sattar, Naveed
    Pazoki, Raha
    Norman, Kristina
    Dostawca treści:
    Repozytorium Uniwersytetu Jagiellońskiego
    Artykuł
    Tytuł:
    Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9
    Autorzy:
    Denaxas, Spiros
    Lester, Kirchner H.
    Bondy, Melissa
    Casas, Juan P.
    Kitchner, Terrie
    Fiorito, Giovanni
    Roden, Dan M.
    Hovingh, Kees
    Swerdlow, Daniel I.
    Hemminki, Kari
    Nicolaides, Andrew
    Mahajan, Anubha
    Linneberg, Allan
    Lill, Christina M.
    Pazoki, Raha
    Wright, John
    Morris, Richard
    Pare, Guillaume
    Law, Philip
    Price, Jackie F.
    Welch, Catherine
    Hakonarson, Hakon
    Campbell, Archie
    Panayiotou, Andrie G.
    Eppinga, Ruben N.
    Uitterlinden, Andre
    Wareham, Nicholas J.
    Cooper, Jackie
    Malyutina, Sofia
    Valentine, Dennis
    Fairhurst-Hunter, Zammy
    Christen, Tim
    Ingelsson, Erik
    Hopewell, Jemma C.
    Lerch, Markus M.
    Franco, Oscar
    Costa, Rui Providencia E.
    Sanchez-Galvez, Adelaida
    Guarrera, Simonetta
    Kiechl, Stefan
    Asselbergs, Folkert W.
    Hancock, Stephen
    Speedy, Helen
    Scott, Robert A.
    Hansen, Torben
    Goldschmidt, Hartmut
    Meade, Tom
    Froguel, Philippe
    Brilliant, Murray
    Lange, Leslie A.
    Demuth, Ilja
    McLachlan, Stela
    Faraway, Rupert
    Grobbee, Diederick E.
    Bao, Yanchun
    Engert, Andreas
    Mason, Dan
    ODonnell, Martin
    Bertram, Lars
    Roussel, Ronan
    Luan, Jianan
    Crosslin, David R.
    Ward, Joey
    Hansson, Markus
    Hartwig, Fernando Pires
    Chong, Michael
    Dorr, Marcus
    Ritchie, Marylyn D.
    Pikhart, Hynek
    Holliday, Elizabeth
    Li, Ni
    Padmanabhan, Sandosh
    Houlston, Richard
    McCarty, Catherine A.
    Moldovan, Max
    Langenberg, Claudia
    Smart, Melissa
    Snieder, Harold
    Kinnersley, Ben
    Cornish, Alex J.
    Chasman, Daniel I.
    van Iperen, Erik
    Pell, Jill P.
    Schmidt, Amand F.
    Willeit, Johann
    Morgan, Gareth
    Humphries, Steve E.
    Young, Robin
    Whincup, Peter
    Bonnefond, Amelie
    Labreche, Karim
    Volzke, Henry
    Finan, Chris
    Ridker, Paul M.
    Wanamethee, Goya
    Dale, Caroline
    Went, Molly
    Attia, John
    Ben-Shlomo, Yoav
    Hingorani, Aroon D.
    Tamosiunas, Abdonas
    van der Schouw, Yvonne T.
    Seshadri, Sudha
    Kumari, Meena
    Carrell, David S.
    Denny, Joshua C.
    Maitland-van der Zee, Anke H.
    Matullo, Giuseppe
    Patel, Riyaz S.
    Sacerdote, Carlotta
    Sattar, Naveed
    Norman, Kristina
    Power, Christine
    Ford, Ian
    Pająk, Andrzej
    Lind, Lars
    Schofield, Peter
    Yusuf6, Salim
    Holmes, Michael V.
    Baumeister, Sebastian
    Volker, Uwe
    Christophersen, Ingrid E.
    Scott, Rodney
    Onland-Moret, N. Charlotte
    Allan, James
    Weinhold, Niels
    Nilsson, Bjorn
    Steinhagen-Thiessen, Elisabeth
    Preiss, David
    Verweij, Niek
    Coassin, Stefan
    Cariou, Bertrand
    Bobak, Martin
    Sanson, Marc
    Jess, Tine
    Baranova, Ekaterina V.
    Bots, Michiel L.
    Kivimaki, Mika
    Willeit, Karin
    Thuillier, Dorothee
    Sonneveld, Pieter
    Hofman, Albert
    Teumer, Alexander
    Hypponen, Elina
    Simon, Matthias
    Sud, Amit
    de Andrade, Mariza
    Larson, Eric B.
    Carty, Cara
    Grarup, Niels
    Reiner, Alex P.
    Said, M. Abdullah
    Marques-Vidal, Pedro
    Demuth, Juri
    Fatemifar, Ghazaleh
    Keating, Brendan J.
    Hemingway, Harry
    van der Harst, Pim
    Mook-Kanamori, D. O.
    Dobbins, Sara E.
    Kubinova, Ruzena
    Horta, Bernardo Lessa
    Dehghan, Abbas
    Pedersen, Oluf
    Dostawca treści:
    Repozytorium Uniwersytetu Jagiellońskiego
    Artykuł
      Wyświetlanie 1-10 z 10

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