Autor: Herman, Roma - Prolib Integro

Skocz do pozycji: 1.

Autorzy:: Fyderek, Krzysztof
Herman, Roma B.
Dumnicka, Paulina
Opis:: Magnetic resonance enterography (MRE) is a commonly used method for non-invasive diagnosing and following of inflammatory bowel disease (IBD). Numerous reviews that compare and discuss MRE-based Crohn’s disease (CD) activity indices for adults have been published; however, no reviews of this kind have been published for children. Following a PubMed database literature search (January 2008 – November 2021), out of 316 research papers, 10 original papers about MRE-CD activity indices were included in the analysis. Four MRE-based scoring systems were discussed: Magnetic Resonance Index of Activity (MARIA), the Crohn’s Disease Magnetic Resonance Imaging Index (CDMI), the Magnetic Resonance Enterography Global Score (MEGS) and the Visual Analogue Scale (VAS). This review revealed that in the last 13 years, studies have proven that MRE-based CD activity indices correspond with endoscopic findings and clinical scores of CD activity.
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

Artykuł

na półce

Skocz do pozycji: 2.

Tytuł:: Induction of remission in pediatric Crohns disease patients assessed by the mucosal inflammation noninvasive index
Autorzy:: Pieczarkowski, Stanisław
Fyderek, Krzysztof
Herman, Roma
Dumnicka, Paulina
Opis:: In children with active luminal Crohn’s disease (CD), therapy with exclusive enteral nutrition (EEN) is recommended as the first line for induction of remission [1]. EEN is defined as feeding with complete liquid formula as the sole source of food [1]. Early complete mucosal healing (MH) after EEN induction in children predicts sustained remission [2]. If EEN is insufficiently effective after 2–4 weeks of good compliance, systemic corticosteroids (CS) may be considered for inducing remission [1]. There are no evidence-based guidelines of when best to re-evaluate disease activity after initiation of induction therapy. The use of endoscopic evaluation to assess MH after induction of remission in the pediatric population is impractical and has several limitations. Since clinical scores alone, such as Pediatric Crohn’s Disease Activity Index (PCDAI) or the weighted PCDAI (wPCDAI) [3], do not adequately reflect mucosal healing, fecal calprotectin (FC) is used as a superior measure of mucosal inflammation despite the fact that treatment modification based solely on fecal calprotectin is not recommended [1,3]. The recently published Mucosal Inflammation Noninvasive index (MINI) [4] is a simple and intuitive clinimetric tool developed to discriminate MH from mucosal inflammation. The authors of MINI revealed that the index was significantly more accurate than FC (p = 0.013) in assessing MH, which can be relevant especially in children with lower ranges of FC (100–599 µg/g) [4]. This study aims to assess the usefulness of MINI in evaluating the clinical response to induction of remission started with EEN in the pediatric population. We hypothesized that MINI allows for simple, noninvasive and adequate estimation of the effectiveness of induction treatment in children with CD.
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

Artykuł

na półce

Skocz do pozycji: 3.

Tytuł:: Is mean platelet volume a good predictor of sustained response to one year infliximab therapy in pediatric patients with Crohns disease?
Autorzy:: Dumnicka, Paulina
Sładek, Małgorzata
Herman, Roma
Fyderek, Krzysztof
Pieczarkowski, Stanisław
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

Artykuł

na półce

Skocz do pozycji: 4.

Tytuł:: Clinical usefulness of the Mucosal Inflammation Noninvasive Index in newly diagnosed paediatric Crohns disease patients
Autorzy:: Pieczarkowski, Stanisław
Herman, Roma B.
Wyżgowska, Agnieszka
Fyderek, Krzysztof
Dumnicka, Paulina
Opis:: Introduction: Mucosal healing (MH) has become a therapeutic goal in Crohn’s Disease (CD), but its frequent evaluation in endoscopic examination is fraught with several limitations. There is an increasing demand to replace invasive procedures with noninvasive markers of CD. Aim: To assess the clinical importance of the recently developed Mucosal Inflammation Noninvasive Index (MINI) in newly diagnosed paediatric Crohn’s Disease patients. Material and methods: Out of 60 consecutive newly diagnosed paediatric CD patients, 55 were enrolled in the study. The study examined the relationship between Simple Endoscopic Score for CD (SES-CD), Paediatric Crohn’s Disease Activity Index (PCDAI), laboratory findings and the newly developed MINI index. Results: Out of the 55 paediatric patients involved in the study, ileocolonoscopy was successful in 42 patients. In this group there was a strong positive correlation between MINI and PCDAI (R = 0.61; p < 0.001) and a moderate positive correlation between MINI and SES-CD (R = 0.39; p = 0.011). MINI score of 17 points or more indicated severe CD (defined as SES-CD ≥ 16 points) with a diagnostic sensitivity of 90% but with a low specificity of 50%. There were 13 (23%) patients in whom ileocecal valve intubation was not achieved, and in this group the correlation between MINI and PCDAI was also strong (R = 0.66; p = 0.014). Conclusions: The newly developed MINI index is a simple and intuitive clinimetric score that can be considered a useful tool in assessing mucosal inflammation among newly diagnosed paediatric CD patients.
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

Artykuł

na półce

Informacja

Wyszukujesz frazę "Herman, Roma" wg kryterium: Autor