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    Wyświetlanie 1-10 z 10
    Tytuł:
    Treatable traits in the European U-BIOPRED adult asthma cohorts
    Autorzy:
    Wagers, Scott S.
    Manta, A.
    Krug, N.
    Chung, Kian Fan
    Seibold, W.
    Fleming, L.J.
    Sousa, Ana R.
    Mazein, A.
    Vestbo, J.
    Hedlin, G.
    van Geest, M.
    Frey, U.
    Horvath, Ildiko
    James, A.J.
    Bates, S.
    Boedigheimer, M.J.
    Djukanovic, Ratko
    Burg, D.
    Bonnelykke, K.
    Postle, A.
    Ahmed, H.
    Simpson, Andrew J.
    Miralpeix, M.
    Baribaud, F.
    Fitch, N.
    Haughney, J.
    Corfield, J.
    Gahlemann, M.
    Higenbottam, T.
    Loza, M.J.
    Masefield, S.
    Dahlen, Sven-Erik
    Bigler, J.
    Sterk, P.J.
    Sun, K.
    Bisgaard, H.
    Erpenbeck, V.J.
    Guo, Y.
    Bansal, A.T.
    Adock, Ian M.
    Chaiboonchoe, A.
    Hohlfeld, J.M.
    Mores, N.
    Erzen, D.
    Caruso, M.
    Howarth, P.
    De Meulder, B.
    Pandis, Ioannis
    Lutter, R.
    Sigmund, R.
    Montuschi, P.
    Weiszhart, Z.
    Rowe, A.
    Rao, N.
    Powel, P.
    Geiser, T.
    Bush, A.
    Skipp, P.J.
    Wagers, S.S.
    Roberts, Graham
    Compton, C.H.
    Shaw, Dominick E.
    Shaw, D.E.
    Singer, Florian
    Formaggio, E.
    Pahus, L.
    Sandstrom, Thomas
    Hashimoto, S.
    Knowles, R.
    Montuschi, Paolo
    Dahlen, Barbro
    Matthews, J.G.
    Wagener, A.H.
    Musiał, Jacek
    Fowler, Stephen J.
    Hekking, P.W.
    Vissing, N.H.
    Bakke, Per S.
    Knox, A.J.
    Krung, Norbert
    van Aalderen, W.
    Riley, John H.
    D'Amico, A.
    Hekking, Pieter-Paul
    Meiser, A.
    Puig Valls, M.
    Middelveld, R.J.M.
    Auffray, C.
    Caruso, Massimo
    Roberts, A.
    Sun, Kai
    Bansal, Aruna T.
    Goss, V.
    Chanez, P.
    Murray, C.S.
    Sterk, Peter J.
    Schofield, J.P.R.
    Wheelock, C.E.
    Brinkman, P.
    Wilson, S.J.
    Bel, E.H.
    Pavlidis, S.
    Brandsma, J.
    Bucchioni, E.
    Bates, Stewart
    Selby, A.
    Fleming, Louise J.
    Lefaudeux, D.
    Fichtner, K.
    Singer, F.
    Myles, D.
    Pratico, G.
    Dostawca treści:
    Repozytorium Uniwersytetu Jagiellońskiego
    Artykuł
    Tytuł:
    Allergic Rhinitis and its Impact on Asthma (ARIA) : achievements in 10 years and future needs
    Autorzy:
    Aït-Khaled, N.
    Papadopoulos, N. G.
    Bush, A.
    Morais-Almeida, M.
    Howarth, P.
    Boner, A. L.
    El-Meziane, A.
    Canonica, G. W.
    Casale, T. B.
    Keith, P. K.
    Valero, A. L.
    Meltzer, E. O.
    Cruz, A. A.
    Bieber, T.
    Costa, D. J.
    Mullol, J.
    Keil, T.
    Kvedariene, V.
    Lodrup Carlsen, K. C.
    Custovic, A.
    Palkonen, S.
    Khayat, G.
    Bedbrook, A.
    Namazova-Baranova, L.
    Wang, D. Y.
    O'Hehir, R. E.
    Pali-Schöll, I.
    Makela, M. J.
    Kowalski, M. L.
    Berrissoul, F.
    Martinez, F. D.
    Pohl, W.
    Dolen, W. K.
    Vandenplas, O.
    Mazon, A.
    Mihaltan, F.
    Baena-Cagnani, C. E.
    Okubo, K.
    Roberts, R.
    Chen, Y. Z.
    Dokic, D.
    Zernotti, M. E.
    Dykewicz, M. S.
    Rottem, M.
    Mohammad, Y.
    Guzmán, M. A.
    Brightling, C. E.
    Masjedi, M. R.
    Naclerio, R.
    Demoly, P.
    Cesario, A.
    Rabe, K. F.
    Melen, E.
    Hellquist-Dahl, B.
    Emuzyte, R.
    Ouedraogo, S.
    Hourihane, J. O'B.
    Akdis, C. A.
    Niżankowska-Mogilnicka, Ewa
    van Wijk, R. Gerth
    Ansotegui, I. J.
    Reitamo, S.
    Potter, P.
    Humbert, M.
    Horak, F.
    Stoloff, S. W.
    Pawankar, R.
    Ratomaharo, J.
    Stein, R. T.
    Solé, D.
    Cepeda, A. M.
    Sunyer, J.
    Kaliner, M. A.
    Maurer, M.
    Zar, H. J.
    Togias, A.
    Jackson, C.
    Beghé, B.
    Chavannes, N. H.
    Annesi-Maesano, I.
    Carlsen, K. H.
    Carr, W.
    Muraro, A.
    Neou, A.
    van Weel, C.
    Bousquet, P. J.
    Darsow, U.
    Rosenwasser, L.
    Martin, F.
    Ring, J.
    Blaiss, M. S.
    Okamoto, Y.
    Kuna, P.
    El-Gamal, Y.
    Zhong, N.
    Marshall, G. D.
    Baiardini, I.
    Bonini, S.
    Passalacqua, G.
    Ivancevich, J. C.
    Chivato Pérez, T.
    Durham, S. R.
    Gotua, M.
    Douagui, H.
    Koppelman, G. H.
    Romano, A.
    Zuberbier, T.
    Agache, I.
    Braido, F.
    Hellings, P. W.
    Chiriac, A. M.
    Le, L. T.
    Spranger, O.
    Devillier, P.
    Niggemann, B.
    Todo-Bom, A.
    Popov, T. A.
    Boulet, L. P.
    Rosado-Pinto, J.
    Fokkens, W. J.
    Mendez, N. H.
    Van Cauwenberge, P.
    Postma, D. S.
    Calvo, M. A.
    Wöhrl, S.
    Bateman, E. D.
    Fukuda, T.
    Bouchard, J.
    Caballero, F.
    Bennoor, K. S.
    Nafti, S.
    Viegi, G.
    Samolinski, B.
    Fonseca, J. A.
    Yiallouros, P. K.
    Lockey, R. F.
    Just, J.
    Chkhartishvili, E.
    Merk, H.
    Dahl, R.
    Yusuf, O.M.
    Simons, F. E. R.
    Kalyoncu, A. F.
    Bergmann, K. C.
    Vichyanond, P.
    Schünemann, H. J.
    Orru, M. P.
    Ciprandi, G.
    Wickman, M.
    Nekam, K.
    Scadding, G. K.
    Bel, E. H.
    Gereda, J. E.
    Gamkrelidze, A.
    Khaltaev, N.
    Kim, Y. Y.
    Valeyre, D.
    Sooronbaev, T.
    Mavale-Manuel, S.
    González Diaz, S.
    Brozek, J. L.
    Williams, D.
    Pigearias, B.
    Yawn, B. P.
    Andrianarisoa, A.
    Fletcher, M.
    Roman Rodriguez, M.
    Haahtela, T.
    Sheikh, A.
    Ohta, K.
    Caraballo, L. R.
    Didi, T.
    Dubakiene, R.
    Lemière, C.
    Aberer, W.
    Deleanu, D.
    Kalayci, O.
    Ryan, D.
    Zidarn, M.
    Grouse, L.
    Kull, I.
    Valenta, R.
    Nyembue, T. D.
    Rogala, B.
    Toskala, E.
    Yorgancioglu, A.
    Beji, M.
    Bindslev Jensen, C.
    Bachert, C.
    Price, D.
    Calderon, M. A.
    Fiocchi, A.
    Lipworth, B.
    Sisul, J. C.
    Koffi N'Goran, B.
    De Blay, F.
    Adachi, M.
    Spicak, V.
    Cox, L.
    Li, J.
    Mahboub, B.
    Wright, J.
    Camargos, P. A. M.
    Park, H. S.
    Larenas-Linnemann, D.
    Valovirta, E.
    Ozdemir, C.
    Sanchez-Borges, M.
    Valiulis, A.
    Lieberman, P.
    Ben Kheder, A.
    Bousquet, J.
    Szczeklik, Andrzej
    Schmid-Grendelmeier, P.
    Panzner, P.
    Denburg, J. A.
    Tremblay, Y.
    Opis:
    Allergic rhinitis (AR) and asthma represent global health problems for all age groups. Asthma and rhinitis frequently coexist in the same subjects. Allergic Rhinitis and its Impact on Asthma (ARIA) was initiated during aWorld Health Organization workshop in 1999 (published in 2001). ARIA has reclassified AR as mild/moderate-severe and intermittent/persistent. This classification closely reflects patients’ needs and underlines the close relationship between rhinitis and asthma. Patients, clinicians, and other health care professionals are confronted with various treatment choices for the management of AR. This contributes to considerable variation in clinical practice, and worldwide, patients, clinicians, and other health care professionals are faced with uncertainty about the relative merits and downsides of the various treatment options. In its 2010 Revision, ARIA developed clinical practice guidelines for the management of AR and asthma comorbidities based on the Grading of Recommendation, Assessment, Development and Evaluation (GRADE) system. ARIA is disseminated and implemented in more than 50 countries of the world. Ten years after the publication of the ARIAWorld Health Organization workshop report, it is important to make a summary of its achievements and identify the still unmet clinical, research, and implementation needs to strengthen the 2011 European Union Priority on allergy and asthma in children.
    Dostawca treści:
    Repozytorium Uniwersytetu Jagiellońskiego
    Artykuł
    Tytuł:
    The role of inflammation in anxiety and depression in the European U-BIOPRED asthma cohorts
    Autorzy:
    Fan Chung, Kian
    Sanak, Marek
    Caruso, Massimo
    Cheng, Xiaojing
    Dahlen, Sven-Erik
    Adcock, Ian M.
    Sterk, Peter J.
    Sousa, Ana R.
    De Meulder, Bertrand
    Krug, Norbert
    Montuschi, Paolo
    Dahlen, Barbro
    Hou, Ruihua
    Fowler, Stephen J.
    Skipp, Paul J.
    Bakke, Per S.
    Sandström, Thomas
    Horváth, Ildikó
    Djukanovic, Ratko
    Ye, Gang
    Howarth, Peter H.
    Schofield, James P.R.
    Auffray, Charles
    Shaw, Dominic E.
    Opis:
    Background: Growing evidence indicates high comorbid anxiety and depression in patients with asthma. However, the mechanisms underlying this comorbid condition remain unclear. The aim of this study was to investigate the role of inflammation in comorbid anxiety and depression in three asthma patient cohorts of the Unbiased Biomarkers for the Prediction of Respiratory Disease Outcomes (U-BIOPRED) project. Methods: U-BIOPRED was conducted by a European Union consortium of 16 academic institutions in 11 European countries. A subset dataset from subjects with valid anxiety and depression measures and a large blood biomarker dataset were analysed, including 198 non-smoking patients with severe asthma (SAn), 65 smoking patients with severe asthma (SAs), 61 non-smoking patients with mild-to-moderate asthma (MMA), and 20 healthy non-smokers (HC). The Hospital Anxiety and Depression Scale was used to measure anxiety and depression and a series of inflammatory markers were analysed by the SomaScan v3 platform (SomaLogic, Boulder, Colo). ANOVA and the Kruskal-Wallis test were used for multiple-group comparisons as appropriate. Results: There were significant group effects on anxiety and depression among the four cohort groups (p < 0.05). Anxiety and depression of SAn and SAs groups were significantly higher than that of MMA and HC groups (p < 0.05. There were significant differences in serum IL6, MCP1, CCL18, CCL17, IL8, and Eotaxin among the four groups (p < 0.05). Depression was significantly associated with IL6, MCP1, CCL18 level, and CCL17; whereas anxiety was associated with CCL17 only (p < 0.05). Conclusions: The current study suggests that severe asthma patients are associated with higher levels of anxiety and depression, and inflammatory responses may underlie this comorbid condition.
    Dostawca treści:
    Repozytorium Uniwersytetu Jagiellońskiego
    Artykuł
    Tytuł:
    IL-17high asthma with features of a psoriasis immunophenotype
    Autorzy:
    Pandis, Ioannis
    Sousa, Ana R.
    Sanak, Marek
    Howarth, Peter
    Horvath, Ildiko
    Krug, Norbert
    Montuschi, Paolo
    Sandstrom, Thomas
    Bakke, Per S.
    Djukanovic, Ratko
    Bigler, Jeanette
    Auffray, Charles
    Östling, Jörgen
    Sterk, Peter J.
    Guo, Yike
    Schofield, James P. R.
    Fowler, Stephen J.
    Shaw, Dominick E.
    Jevnikar, Zala
    Sun, Kai
    Dahlen, Sven-Erik
    Caruso, Massimo
    Vaarala, Outi
    Lutter, Rene
    Ward, Jonathan
    van Geest, Marleen
    Wilson, Susan
    Skipp, Paul J.
    Chung, Kian Fan
    Adcock, Ian M.
    Opis:
    Background: The role of IL-17 immunity is well established in patients with inflammatory diseases, such as psoriasis and inflammatory bowel disease, but not in asthmatic patients, in whom further study is required. Objective: We sought to undertake a deep phenotyping study of asthmatic patients with upregulated IL-17 immunity. Methods: Whole-genome transcriptomic analysis was performed by using epithelial brushings, bronchial biopsy specimens (91 asthmatic patients and 46 healthy control subjects), and whole blood samples (n 5 498) from the Unbiased Biomarkers for the Prediction of Respiratory Disease Outcomes (U-BIOPRED) cohort. Gene signatures induced in vitro by IL-17 and IL-13 in bronchial epithelial cells were used to identify patients with IL-17–high and IL-13–high asthma phenotypes. Results: Twenty-two of 91 patients were identified with IL-17, and 9 patients were identified with IL-13 gene signatures. The patients with IL-17–high asthma were characterized by risk of frequent exacerbations, airway (sputum and mucosal) neutrophilia, decreased lung microbiota diversity, and urinary biomarker evidence of activation of the thromboxane B2 pathway. In pathway analysis the differentially expressed genes in patients with IL-17-high asthma were shared with those reported as altered in psoriasis lesions and included genes regulating epithelial barrier function and defense mechanisms, such as IL1B, IL6, IL8, and b-defensin. Conclusion: The IL-17–high asthma phenotype, characterized by bronchial epithelial dysfunction and upregulated antimicrobial and inflammatory response, resembles the immunophenotype of psoriasis, including activation of the thromboxane B2 pathway, which should be considered a biomarker for this phenotype in further studies, including clinical trials targeting IL-17.
    Dostawca treści:
    Repozytorium Uniwersytetu Jagiellońskiego
    Artykuł
    Tytuł:
    Stratification of asthma phenotypes by airway proteomic signatures
    Autorzy:
    Nicholas, Ben
    Lefaudeux, Diane
    Horvath, Ildiko
    Riley, John
    Dahlen, Sven-Erik
    Sun, Kai
    Sandstrom, Thomas
    Bakke, Per S.
    Bansal, Aruna T.
    Djukanovic, Ratko
    Sousa, Ana R.
    Montuschi, Paolo
    Sanak, Marek
    Chung, Kian Fan
    Lutter, Rene
    Krug, Norbert
    Auffray, Charles
    Caruso, Massimo
    Xian, Yang
    Staykova, Doroteya
    Shaw, Dominick E.
    Pandis, Ioannis
    Corfield, Julie
    De Meulder, Bertrand
    Folisi, Caterina
    Howarth, Peter
    Adcock, Ian M.
    Rowe, Anthony
    Sterk, Peter J.
    Wilson, Susan
    Guo, Yike
    Burg, Dominic
    Skipp, Paul J.
    Strazzeri, Fabio
    Ward, Jonathan
    Brandsma, Joost
    Schofield, James P.R.
    Fowler, Stephen J.
    Opis:
    neutrophils
    proteomics
    biomarkers
    asthma
    Background: Stratification by eosinophil and neutrophil counts increases our understanding of asthma and helps target therapy, but there is room for improvement in our accuracy in prediction of treatment responses and a need for better understanding of the underlying mechanisms. Objective: We sought to identify molecular subphenotypes of asthma defined by proteomic signatures for improved stratification. Methods: Unbiased label-free quantitative mass spectrometry and topological data analysis were used to analyze the proteomes of sputum supernatants from 246 participants (206 asthmatic patients) as a novel means of asthma stratification. Microarray analysis of sputum cells provided transcriptomics data additionally to inform on underlying mechanisms. Results: Analysis of the sputum proteome resulted in 10 clusters (ie, proteotypes) based on similarity in proteomic features, representing discrete molecular subphenotypes of asthma. Overlaying granulocyte counts onto the 10 clusters as metadata further defined 3 of these as highly eosinophilic, 3 as highly neutrophilic, and 2 as highly atopic with relatively low granulocytic inflammation. For each of these 3 phenotypes, logistic regression analysis identified candidate protein biomarkers, and matched transcriptomic data pointed to differentially activated underlying mechanisms. Conclusion: This study provides further stratification of asthma currently classified based on quantification of granulocytic inflammation and provided additional insight into their underlying mechanisms, which could become targets for novel therapies.
    eosinophils
    Dostawca treści:
    Repozytorium Uniwersytetu Jagiellońskiego
    Artykuł
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