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Tytuł:
The role of inflammation in anxiety and depression in the European U-BIOPRED asthma cohorts
Autorzy:
Fan Chung, Kian
Sanak, Marek
Caruso, Massimo
Cheng, Xiaojing
Dahlen, Sven-Erik
Adcock, Ian M.
Sterk, Peter J.
Sousa, Ana R.
De Meulder, Bertrand
Krug, Norbert
Montuschi, Paolo
Dahlen, Barbro
Hou, Ruihua
Fowler, Stephen J.
Skipp, Paul J.
Bakke, Per S.
Sandström, Thomas
Horváth, Ildikó
Djukanovic, Ratko
Ye, Gang
Howarth, Peter H.
Schofield, James P.R.
Auffray, Charles
Shaw, Dominic E.
Opis:
Background: Growing evidence indicates high comorbid anxiety and depression in patients with asthma. However, the mechanisms underlying this comorbid condition remain unclear. The aim of this study was to investigate the role of inflammation in comorbid anxiety and depression in three asthma patient cohorts of the Unbiased Biomarkers for the Prediction of Respiratory Disease Outcomes (U-BIOPRED) project. Methods: U-BIOPRED was conducted by a European Union consortium of 16 academic institutions in 11 European countries. A subset dataset from subjects with valid anxiety and depression measures and a large blood biomarker dataset were analysed, including 198 non-smoking patients with severe asthma (SAn), 65 smoking patients with severe asthma (SAs), 61 non-smoking patients with mild-to-moderate asthma (MMA), and 20 healthy non-smokers (HC). The Hospital Anxiety and Depression Scale was used to measure anxiety and depression and a series of inflammatory markers were analysed by the SomaScan v3 platform (SomaLogic, Boulder, Colo). ANOVA and the Kruskal-Wallis test were used for multiple-group comparisons as appropriate. Results: There were significant group effects on anxiety and depression among the four cohort groups (p < 0.05). Anxiety and depression of SAn and SAs groups were significantly higher than that of MMA and HC groups (p < 0.05. There were significant differences in serum IL6, MCP1, CCL18, CCL17, IL8, and Eotaxin among the four groups (p < 0.05). Depression was significantly associated with IL6, MCP1, CCL18 level, and CCL17; whereas anxiety was associated with CCL17 only (p < 0.05). Conclusions: The current study suggests that severe asthma patients are associated with higher levels of anxiety and depression, and inflammatory responses may underlie this comorbid condition.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
IL-17high asthma with features of a psoriasis immunophenotype
Autorzy:
Pandis, Ioannis
Sousa, Ana R.
Sanak, Marek
Howarth, Peter
Horvath, Ildiko
Krug, Norbert
Montuschi, Paolo
Sandstrom, Thomas
Bakke, Per S.
Djukanovic, Ratko
Bigler, Jeanette
Auffray, Charles
Östling, Jörgen
Sterk, Peter J.
Guo, Yike
Schofield, James P. R.
Fowler, Stephen J.
Shaw, Dominick E.
Jevnikar, Zala
Sun, Kai
Dahlen, Sven-Erik
Caruso, Massimo
Vaarala, Outi
Lutter, Rene
Ward, Jonathan
van Geest, Marleen
Wilson, Susan
Skipp, Paul J.
Chung, Kian Fan
Adcock, Ian M.
Opis:
Background: The role of IL-17 immunity is well established in patients with inflammatory diseases, such as psoriasis and inflammatory bowel disease, but not in asthmatic patients, in whom further study is required. Objective: We sought to undertake a deep phenotyping study of asthmatic patients with upregulated IL-17 immunity. Methods: Whole-genome transcriptomic analysis was performed by using epithelial brushings, bronchial biopsy specimens (91 asthmatic patients and 46 healthy control subjects), and whole blood samples (n 5 498) from the Unbiased Biomarkers for the Prediction of Respiratory Disease Outcomes (U-BIOPRED) cohort. Gene signatures induced in vitro by IL-17 and IL-13 in bronchial epithelial cells were used to identify patients with IL-17–high and IL-13–high asthma phenotypes. Results: Twenty-two of 91 patients were identified with IL-17, and 9 patients were identified with IL-13 gene signatures. The patients with IL-17–high asthma were characterized by risk of frequent exacerbations, airway (sputum and mucosal) neutrophilia, decreased lung microbiota diversity, and urinary biomarker evidence of activation of the thromboxane B2 pathway. In pathway analysis the differentially expressed genes in patients with IL-17-high asthma were shared with those reported as altered in psoriasis lesions and included genes regulating epithelial barrier function and defense mechanisms, such as IL1B, IL6, IL8, and b-defensin. Conclusion: The IL-17–high asthma phenotype, characterized by bronchial epithelial dysfunction and upregulated antimicrobial and inflammatory response, resembles the immunophenotype of psoriasis, including activation of the thromboxane B2 pathway, which should be considered a biomarker for this phenotype in further studies, including clinical trials targeting IL-17.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Wyświetlanie 1-10 z 25

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