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Wyszukujesz frazę "Huber-Huber, Christoph" wg kryterium: Autor


Tytuł:
#EEGManyLabs : investigating the replicability of influential EEG experiments
Autorzy:
Mudrik, Liad
Muthuraman, Muthuraman
Zakharov, Ilya
Arvaneh, Mahnaz
Kalenkovich, Evgenii
Vloeberghs, Robin
Bradford, Daniel E.
Welke, Dominik
Hinojosa, Jose A.
Pavlov, Yuri G.
Ehinger, Benedikt
Liesefeld, Heinrich R.
Nilsonne, Gustav
Busch, Niko A.
Ganis, Giorgio
Bland, Amy R.
Bublatzky, Florian
Senderecka, Magdalena
Ladouceur, Cecile D.
Dumas, Guillaume
Johannesson, Magnus
Langer, Nicolas
Beste, Christian
Clayson, Peter E.
Niso, Guiomar
Tognoli, Emmanuelle
Huber-Huber, Christoph
Wessel, Jan R.
Sass, Sarah M.
Adamian, Nika
Appelhoff, Stefan
Dreber, Anna
Karimi-Rouzbahani, Hamid
Pourtois, Gilles
Ruzzoli, Manuela
Oostenveld, Robert
Ocklenburg, Sebastian
Snyder, Joel S.
Verona, Edelyn
MacNamara, Annmarie
van Vugt, Marieke K.
Pernet, Cyril R.
Kulke, Louisa
Neal, Lauren B.
Cruse, Damian
Benwell, Christopher S.Y.
He, Xun
Keil, Andreas
Schaefer, Alexandre
Jack, Bradley N.
Jones, Rhiannon
Tamnes, Christian K.
Czeszumski, Artur
Inzlicht, Michael
Mushtaq, Faisal
Kaltwasser, Laura
Konig, Peter
Luque, David
Kouara, Layla
Opis:
There is growing awareness across the neuroscience community that the replicability offindings about the relationship between brain activity and cognitive phenomena can beimproved by conducting studies with high statistical power that adhere to well-defined and standardised analysis pipelines. Inspired by recent efforts from the psychological sciences,and with the desire to examine some of the foundational findings using electroencephalog-raphy (EEG), we have launched #EEGManyLabs, a large-scale international collaborativereplication effort. Since its discovery in the early 20th century, EEG has had a profound in-fluence on our understanding of human cognition, but there is limited evidence on thereplicability of some of the most highly cited discoveries. After a systematic search and selection process, we have identified 27 of the most influential and continually cited studies inthe field. We plan to directly test the replicability of key findings from 20 of these studies inteams of at least three independent laboratories. The design and protocol of each replicationeffort will be submitted as a Registered Report and peer-reviewed prior to data collection.Prediction markets, open to all EEG researchers, will be used as a forecasting tool to examinewhich findings the community expects to replicate. This project will update our confidence insome of the most influential EEG findings and generate a large open access database that canbe used to inform future research practices. Finally, through this international effort, we hopeto create a cultural shift towards inclusive, high-powered multi-laboratory collaborations.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
Nano bio-responsive systems avoiding methicillin resistant Staphylococcus aureus colonization on an implant surface
Autorzy:
Magauer, Thomas
Bernkop-Schnürch, Andreas
Knoll, Annabelle
Griesser, Christoph
Molnar, Lana
Diaz-Coello, Sergio
Grobelny, Anna
Steixner, Stephan
Kunze-Liebhäuser, Julia
Zapotoczny, Szczepan
Badart, Michael
Meile, Susanne
Loessner, Martin J.
Schmelcher, Mathias
Coraça-Huber, Débora C.
Blanco Massani, Mariana
Opis:
Biomaterial-associated infections caused by Staphylococcus aureus represent a race between bacterial colonization and mammalian cell integration on implant surfaces. If bacteria win, biofilm forms, often causing persistent infection. To favor host cells, we developed a nano bio-responsive system (NanoBioRS) with two synergistic defense lines. The first is a bio-adhesive surface with polymer brushes that recruit mammalian cells. The second is a nano-bioactive coating of polyphosphate-encapsulated chimeric phage endolysin nanoparticles (M23-PP), activated by alkaline phosphatase—an enzyme vital for bone development and biofilm life cycle. Using metal-free surface-initiated atom transfer radical polymerization, we synthesized poly(polyethylene glycol methacrylate) (PPEGMA), poly(glycidyl methacrylate) (PGMA), and their block copolymer polymer brushes. These brushes were characterized via ellipsometry, FTIR, contact angle, and XPS. Functionalization with Arg-Gly-Asp (RGD) peptide enhanced MC3T3-E1 preosteoblast recruitment, as confirmed by fluorescence microscopy. Further bioactivation with M23-PP nanoparticles provided targeted antibacterial action. NanoBioRS was biocompatible and its efficacy was validated through competitive colonization assays with methicillin sensitive or resistant S. aureus, together with MC3T3-E1 cells. This biocompatible platform shows strong potential to prevent bacterial colonization of implants.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł

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