- Autorzy:
-
Maueröder, Christian
Anders, Hans-Joachim
Hoffmann, Markus
Kołaczkowska, Elżbieta
Mitroulis, Ioannis
van der Vlag, Johan
Yousefi, Shida
Schauer, Christine
Daniel, Christoph
De Lorenzo, Rebecca
Knopf, Jasmin
Vitkov, Ljubomir
Kanthi, Yogendra
Schett, Georg
Ackermann, Maximilian
Vandenabeele, Peter
Radic, Marko Z.
Singh, Jeeshan
Stürzl, Michael
Kaplan, Mariana J.
Egeblad, Mikala
Schapher, Mirco
Mahajan, Aparna
Neeli, Indira
Rovere-Querini, Patrizia
Narasaraju, Teluguakula
Bowlin, Gary L.
Stark, Konstantin
Yanginlar, Cansu
Bilyy, Rostyslav
Hidalgo, Andrés
Herrmann, Martin
Henneck, Timo
Ritis, Konstantinos
Skendros, Panagiotis
Knight, Jason S.
Hohberger, Bettina
Simon, Hans-Uwe
Leppkes, Moritz
Naschberger, Elisabeth
Kubes, Paul
von Köckritz-Blickwede, Maren
Zarbock, Alexander
Maugeri, Norma
Manfredi, Angelo A.
Muñoz, Luis E.
Ng, Lai Guan - Opis:
- SARS-CoV-2 infection poses a major threat to the lungs and multiple other organs, occasionally causing death. Until effective vaccines are developed to curb the pandemic, it is paramount to define the mechanisms and develop protective therapies to prevent organ dysfunction in patients with COVID-19. Individuals that develop severe manifestations have signs of dysregulated innate and adaptive immune responses. Emerging evidence implicates neutrophils and the disbalance between neutrophil extracellular trap (NET) formation and degradation plays a central role in the pathophysiology of inflammation, coagulopathy, organ damage, and immunothrombosis that characterize severe cases of COVID-19. Here, we discuss the evidence supporting a role for NETs in COVID-19 manifestations and present putative mechanisms, by which NETs promote tissue injury and immunothrombosis. We present therapeutic strategies, which have been successful in the treatment of immunο-inflammatory disorders and which target dysregulated NET formation or degradation, as potential approaches that may benefit patients with severe COVID-19.
- Dostawca treści:
- Repozytorium Uniwersytetu Jagiellońskiego
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