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Wyszukujesz frazę "Kaplanoglu, Muhammed" wg kryterium: Autor


Tytuł:
A cross-staged gantry for total-body PET and CT imaging
Autorzy:
Moskal, Paweł
Kaplanoglu, Muhammed
Opis:
Total-body Positron Emission Tomography (PET) scanning is a promising new method for rapidly acquiring comprehensive wide-volume metabolic data with a lower radiation dosage compared to discrete whole-body PET imaging. PET scanners are generally used with Computed Tomography (CT) scanners to precisely understand tumor location and composition with the help of anatomical images. However, PET/CT sequential imaging methods for simultaneous total-body imaging are impractical for claustrophobic patients due to the enclosed gantry design and require large examination rooms because of the need for an exceptionally long patient table. To address this challenge, the Jagiellonian-PET Tomography (J-PET) Total-body scanner employs an innovative approach: utilizing both PET and CT devices on the same patient table but from different axes. The motion system of the J-PET Total Body scanner requires custom linear stages to move both PET and CT gantries. In this study, a novel cross-staged linear guiding solution is proposed by combining scanners on intersecting separable stages. The proposed sliding system is a combination of different machine elements and will be produced for the J-PET Total-body PET/CT Scanner. Concept designs are shown, and the proposed system is described. The application of the system is discussed for the J-PET Total-body PET/CT scanner. The proposed solution is still in the development phase. The system holds the potential to achieve combining CT and PET scanners from different axes and enables motion artifact-free imaging for total-body imaging.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
Nonmaximal entanglement of photons from positron-electron annihilation demonstrated using a plastic PET scanner
Autorzy:
Curceanu, Catalina
Chug, Neha
Kapłon, Łukasz
Niedźwiecki, Szymon
Coussat, Aurélien
Czerwiński, Eryk
Gorgol, Marek
Skurzok, Magdalena
Tayefi Ardebili, Keyvan
Mryka, Wiktor
Kumar, Deepak
Beyene, Ermias Yitayew
Kacprzak, Krzysztof
Dulski, Kamil
Lisowski, Filip
Tanty, Pooja
Stępień, Ewa
Lisowski, Edward
Jasińska, Bożena
Das, Manish
Valsan Eliyan, Kavya
Parzych, Szymon
Sharma, Sushil
Kaplanoglu, Muhammed
Rädler, Martin
Moskal, Paweł
Kozik, Tomasz
Perez del Rio, Elena
Opis:
In state-of-the-art positron emission tomography (PET), information about annihilation photon polarization is unavailable. Here, we present a PET scanner built from plastic scintillators, where annihilation photons primarily interact via the Compton effect, providing information about both photon polarization and propagation direction. Using this plastic-based PET, we determined the distribution of the relative angle between polarization planes of photons from positron-electron annihilation in a porous polymer. The amplitude of the observed distribution is smaller than predicted for maximally quantum entangled two-photon states but larger than expected for separable photons. This result can be well explained by assuming that photons from pick-off annihilation are not entangled, while photons from direct and parapositronium annihilations are maximally entangled. Our result indicates that the degree of entanglement depends on the annihilation mechanism in matter, opening avenues for exploring polarization correlations in PET as a diagnostic indicator.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
Development of correction techniques for the J-PET Scanner
Autorzy:
Curceanu, Catalina
Khreptak, Aleksander
Niedźwiecki, Szymon
Chug, Neha
Mędrala-Sowa, Justyna
Sowa-Staszczak, Anna
Badawi, Ramsey
Czerwiński, Eryk
Skurzok, Magdalena
Głowa, Bogusław
Spencer, Benjamin A.
Tayefi Ardebili, Keyvan
Mryka, Wiktor
Kumar, Deepak
Beyene, Ermias Yitayew
Kacprzak, Krzysztof
Korcyl, Grzegorz
Kubat, Karol
Pandey, Piyush
Lisowski, Filip
Tanty, Pooja
Opalińska, Marta
Bayerlein, Reimund
Stępień, Ewa
Lisowski, Edward
Kunimmal Venadan, Anoop
Das, Manish
Valsan Eliyan, Kavya
Parzych, Szymon
Sharma, Sushil
Hubalewska-Dydejczyk, Alicja
Kaplanoglu, Muhammed
Moyo, Simbarashe
Kasperska, Kamila
Moskal, Paweł
Rädler, Martin
Opis:
Objective: Positron emission tomography (PET) is a widely used medical imaging technique that allows for non-invasive imaging of metabolic processes. However, traditional PET scanners rely on costly inorganic scintillators that limit their accessibility, especially in light of emerging long axial field-of-view devices. The modular J-PET scanner, an innovative alternative, uses 50-cm-long plastic scintillator strips, offering a cost-effective and modular solution. In this study we develop and assess the PET data correction techniques required for quantitative image reconstruction. Methods: We present methods for attenuation correction, random coincidence correction using the delayed time window (DTW) technique and scatter correction based on Monte Carlo simulations. Phantom studies using the NEMA IQ phantom were performed to qualitatively evaluate these corrections. Results: The results demonstrate that our implemented corrections for attenuation and random and scattered coincidences successfully improve the uniformity of tracer distribution in homogenous volumes and significantly reduce undesired activity in cold regions. Despite limitations in sensitivity and axial resolution, the applied correction techniques effectively enhance image quality, providing promising results for future applications. Conclusions: These findings highlight the potential of the modular J-PET system to offer affordable PET imaging and to pave the way for a total-body PET scanner based on plastic scintillators. Future work will focus on quantitative validation and the implementation of these corrections for human subject imaging.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
Discrete symmetries tested at 10$^{−4}$ precision using linear polarization of photons from positronium annihilations
Autorzy:
Curceanu, Catalina
Chug, Neha
Kapłon, Łukasz
Niedźwiecki, Szymon
Coussat, Aurélien
Konieczka, Paweł
Czerwiński, Eryk
Gorgol, Marek
Skurzok, Magdalena
Tayefi Ardebili, Keyvan
Mryka, Wiktor
Kumar, Deepak
Raj, Juhi
Beyene, Ermias Yitayew
Kacprzak, Krzysztof
Korcyl, Grzegorz
Hiesmayr, Beatrix C.
Shivani, Shivani
Dulski, Kamil
Dadgar, Meysam
Bass, Steven D.
Gajos, Aleksander
Eliyan, Kavya Valsan
Raczyński, Lech
Tanty, Pooja
Shopa, Roman Y.
Stępień, Ewa
Klimaszewski, Konrad
Jasińska, Bożena
Das, Manish
Wiślicki, Wojciech
Parzych, Szymon
Tayefi Ardebili, Faranak
Moyo, Simbarashe
Kaplanoglu, Muhammed
Sharma, Sushil
Moskal, Paweł
Krzemień, Wojciech
Silarski, Michał
Kozik, Tomasz
Perez del Rio, Elena
Opis:
Discrete symmetries play an important role in particle physics with violation of CP connected to the matter-antimatter imbalance in the Universe. We report the most precise test of P, T and CP invariance in decays of ortho-positronium, performed with methodology involving polarization of photons from these decays. Positronium, the simplest bound state of an electron and positron, is of recent interest with discrepancies reported between measured hyperfine energy structure and theory at the level of 10−4 signaling a need for better understanding of the positronium system at this level. We test discrete symmetries using photon polarizations determined via Compton scattering in the dedicated J-PET tomograph on an event-by-event basis and without the need to control the spin of the positronium with an external magnetic field, in contrast to previous experiments. Our result is consistent with QED expectations at the level of 0.0007 and one standard deviation.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
Studies of CPT symmetry in positronium decays with the 192 plastic strip J-PET detector
Autorzy:
Hajduga, J.
Bass, Steven D.
Khreptak, Aleksander
Tiwari, Satyam
Czerwiński, Eryk
Szumlak, T.
Stępień, Ewa
Chug, Neha
Curceanu, C.
Korcyl, Grzegorz
Valsan Eliyan, Kavya
Beyene, Ermias
Rädler, Martin
Kierys, A.
Mryka, Wiktor
Lisowski, E.
Pandey, Piyush
Kunimmal Venadan, Anoop
Mędrala-Sowa, Justyna
Kumar, Deepak
Niedźwiecki, Szymon
Tanty, Pooja
Gorgol, M.
Sienkiewicz, A.
Jasińska, B.
Kubat, Karol
Sharma, Sushil
Moskal, Paweł
Kapłon, Łukasz
Kacprzak, Krzysztof
Skurzok, Magdalena
Perez del Rio, Elena
Parzych, Szymon
Rachwał, B.
Lisowski, F.
Kasperska, Kamila
Jalali, Sharareh
Porcelli, Alessio
Tayefi Ardebili, Keyvan
Das, Manish
Moyo, Simbarashe
Kaplanoglu, Muhammed Tevfik
Kozik, Tomasz
Opis:
A direct test of the CPT symmetry is performed for the electromagnetic decays of ortho-positronium using the Jagiellonian positron emission tomograph (J-PET). We present the precise measurement of the CPT-sensitive angular correlation entailing the positronium spin and the momenta of its annihilation photons, surpassing previous studies utilizing the same detection system. Positrons originating from a $^{22}$Na source are emitted from the detector’s center and subsequently form positronium atoms within the spherical chamber covered with porous material. Reconstruction of annihilation locations using the 192-strip J-PET detector makes it possible to determine the positronium emission direction, which defines the quantization axis along which positronium is polarized, without the application of external magnetic fields. The measurements were performed in total for 356 days resulting in an identification of 47.8 $\times$ 10$^{6}$ events with ortho-positronium decays into three photons. The results are consistent with the exactness of CPT symmetry with measured asymmetry amplitude -0.00029 ± 0.00022 (stat.) and with statistical error four times smaller than the previous best measurement.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
Positronium image of the human brain in vivo
Autorzy:
Curceanu, Catalina
Chug, Neha
Kapłon, Łukasz
Niedźwiecki, Szymon
Perez del Rio, Elena
Czerwiński, Eryk
Skurzok, Magdalena
Bass, Steven
Tayefi Ardebili, Keyvan
Mryka, Wiktor
Kumar, Deepak
Królicki, Leszek
Moskal, Gabriel
Kacprzak, Krzysztof
Korcyl, Grzegorz
Kubat, Karol
Fronczewska, Katarzyna
Dulski, Kamil
Shivani, Shivani
Dadgar, Meysam
Baran, Jakub
Choiński, Jarosław
Gajos, Aleksander
Kajetanowicz, Marcin
Kobylecka, Małgorzata
Raczyński, Lech
Migdał, Wojciech
Tanty, Pooja
Shopa, Roman Y.
Stępień, Ewa
Mączewska, Joanna
Klimaszewski, Konrad
Das, Manish
Valsan Eliyan, Kavya
Wiślicki, Wojciech
Parzych, Szymon
Tayefi Ardebili, Faranak
Sharma, Sushil
Kaplanoglu, Muhammed
Moskal, Paweł
Krzemień, Wojciech
Silarski, Michał
Kozik, Tomasz
Kunikowska, Jolanta
Opis:
Positronium is abundantly produced within the molecular voids of a patient’s body during positron emission tomography (PET). Its properties dynamically respond to the submolecular architecture of the tissue and the partial pressure of oxygen. Current PET systems record only two annihilation photons and cannot provide information about the positronium lifetime. This study presents the in vivo images of positronium lifetime in a human, for a patient with a glioblastoma brain tumor, by using the dedicated Jagiellonian PET system enabling simultaneous detection of annihilation photons and prompt gamma emitted by a radionuclide. The prompt gamma provides information on the time of positronium formation. The photons from positronium annihilation are used to reconstruct the place and time of its decay. In the presented case study, the determined positron and positronium lifetimes in glioblastoma cells are shorter than those in salivary glands and those in healthy brain tissues, indicating that positronium imaging could be used to diagnose disease in vivo.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł

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