Autor: Konecki, Dariusz - Prolib Integro

Skocz do pozycji: 1.

Tytuł:: Correlation between findings of multislice helical computed tomography (CT), endoscopic examinations, endovascular procedures, and surgery in patients with symptoms of acute gastrointestinal bleeding
Autorzy:: Pacho, Ryszard
Grabowska-Derlatka, Laretta
Rowiński, Olgierd
Konecki, Dariusz
Opis:: Background: Endoscopic methods (gastroscopy and colonoscopy) are considered fundamental for the diagnosis of gastrointestinal bleeding. In recent years, multidetector computed tomography (MDCT) has also gained importance in diagnosing gastrointestinal bleeding, particularly in hemodynamically unstable patients and in cases with suspected lower gastrointestinal tract bleeding. CT can detect both the source and the cause of active gastrointestinal bleeding, thereby expediting treatment initiation. Material/Methods: The study group consisted of 16 patients with clinical symptoms of gastrointestinal bleeding in whom features of active bleeding were observed on CT. In all patients, bleeding was verified by means of other methods such as endoscopic examinations, endovascular procedures, or surgery. Results: The bleeding source was identified on CT in all 16 patients. In 14 cases (87.5%), bleeding was confirmed by other methods. Conclusions: CT is an efficient, fast, and readily available tool for detecting the location of acute gastrointestinal bleeding.
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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Skocz do pozycji: 2.

Tytuł:: Effectiveness and safety of CT-guided drainage of abdominal abscesses with small and extra-small-bore drains : a single-centre observational study
Autorzy:: Wnuk, Emilia
Konecki, Dariusz
Milczarek, Krzysztof
Franke, Jakub
Rosiak, Grzegorz
Opis:: Purpose: Computed tomography (CT)-guided percutaneous drainage is an established method for the treatment of abdominal abscesses. The purpose of this study is to evaluate the effectiveness and safety of drainage of abdominal abscesses with small-bore (6F and 9F) drains. Material and methods: The analysis of a prospectively maintained database included 135 consecutive patients from a single centre with abdominal or pelvic abscesses, who underwent CT-guided drainage. Procedures were performed using a one-step trocar technique with 6F (40 procedures) or 9F (95 procedures) catheters. Technical success was defined as insertion of the drain into the abscess cavity and aspiration of the fluid sample. Clinical success was defined as resolution of infection without surgical intervention or upsizing of the drain. Results: The mean size of abscesses was 77.0 ± 28.8 mm (32-220 mm). Thick fluid was aspirated from 129 collections; 6 collections contained thin fluid. Technical success was achieved in 100% of procedures. Clinical success was achieved in 94.8% of patients. Surgical drainage was necessary in 3.7% of patients and upsizing in 1.5% of patients. Complications of Clavien-Dindo grade III were noted in 2.2% of patients without grade IV or V adverse events. The mean radiation dose in terms of Dose Length Product was 617 ± 467 mGy x cm. The mean procedure time was 28.0 ± 11.3 min. Conclusions: CT-guided drainage of abdominal abscesses with small- and very small-bore drains is usually sufficient to obtain clinical success with a low complication rate in the case of thick fluid collections.
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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Skocz do pozycji: 3.

Autorzy:: Konecki, Dariusz
Milczarek, Krzysztof
Franke, Jakub
Rosiak, Grzegorz
Cieszanowski, Andrzej
Opis:: Colorectal cancer is a prevalent malignancy, with colorectal liver metastases (CLM) being a common and challenging clinical issue. Traditionally, surgical resection was the only curative treatment; however, percutaneous ablation (radiofrequency, microwave, and irreversible electroporation) has emerged as a treatment option for select patients. Early trials demonstrated the efficacy of thermal ablation, leading to its inclusion in international guidelines. Currently, for small tumours, it is considered a viable alternative to resection. Recent studies demonstrate the non-inferiority of thermal ablation compared to resection in select cases and emphasize the importance of achieving an adequate ablation margin. Advancements in imaging techniques, ablative modalities, the use of image fusion, as well as ablation confirmation software, allow for a more patient-tailored approach. Additionally, tumour biology, including genetic mutations, influences both overall survival and local control, highlighting the need for personalised treatment strategies. As randomised trials continue to provide more data, the role of ablation in CLM management is evolving. This paper aims to provide a narrative review of factors predicting local control and overall survival in patients treated with ablation. Future research focusing on molecular markers, advanced imaging, and ablation verification techniques may further refine patient selection, and optimise treatment outcomes and follow-up imaging.
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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Skocz do pozycji: 4.

Tytuł:: An X-ray lead screen may be used to reduce an interventional radiologists radiation exposure during CT-guided procedures
Autorzy:: Konecki, Dariusz
Milczarek, Krzysztof
Rowiński, Olgierd
Podgórska, Joanna
Rosiak, Grzegorz
Opis:: Purpose: The exposure of both patient and operator to radiation is one of the limitations of computed tomography (CT)-guided interventions, and it should be kept as low as reasonably possible. The purpose of the study was to evaluate the efficacy of a lead screen in reducing the radiation dose to an operator in the course of CT-guided interventions. Material and methods: This prospective study analysed data collected from 72 consecutive CT-guided procedures, all of which were performed with an X-ray protective lead screen placed between the scanner and the operator. Five dosimeters were placed in the CT scanning room, and accumulated radiation doses were measured for each dosimeter. Results: The dosimeter placed on the gantry side of the lead screen revealed highest levels of radiation (11.33 ± 1.93 mSv), which were significantly higher than those at all other dosimeters. The radiation dose behind the lead screen was almost the same when measured by dosimeters on the CT scanner gantry side and 3 metres away from it. The presence of the screen caused no discomfort for operators. Conclusions: A lead screen reduces an operator's radiation exposure significantly, while not posing any obstacles or causing any discomfort while CT-guided procedures are carried out.
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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Skocz do pozycji: 5.

Tytuł:: T1a renal cancer cryoablation : first experiences in Poland
Autorzy:: Demkow, Tomasz
Konecki, Dariusz
Gałązka, Zbigniew
Ostrowski, Tomasz
Milczarek, Krzysztof
Franke, Jakub
Nowakowski, Robert
Rosiak, Grzegorz
Opis:: Purpose: Cryoablation is one of the methods of treating patients with renal cancer with curative intent. This procedure is not widely available in Poland due to the lack of reimbursement until April 2023. The purpose of this study is to present the results of the first experiences in cryoablation of renal cell carcinoma in Poland. Material and methods: Patients with renal cell carcinoma in T1a stage (up to 4 cm in diameter) were treated with percutaneous cryoablation between December 2020 and December 2023. All patients were disqualified from surgical treatment due to age, comorbidities, or history of nephrectomy. Diagnosis was confirmed by computed tomography (CT)-guided core needle biopsy that was performed 2-4 weeks before cryoablation. Results: Twenty-five patients underwent CT-guided cryoablation of T1a renal cancer. The mean age of the patients as 77 years (43-91 years). The mean diameter of lesions was 27 mm (15-40 mm). None of the patients presented with local or distant recurrence within the mean 12-months of follow-up period (100% progression-free survival). Urine leak treated with a stent was detected in one patient. Four patients died within the follow-up period, but none of the deaths was directly related to the procedure. Conclusions: Cryoablation is an effective and safe procedure and should be available to more patients in Poland.
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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Skocz do pozycji: 6.

Tytuł:: Effect of chlorpheniramine and cimetidine, a histamine H1 and H2 antagonist on (3H)glucose uptake in the brain of adult rats lesioned with 5,7-dihydroxytryptamine as neonates
Wpływ chlorfeniraminy i cymetydyny, antagonistów receptorów histaminowych H1 i H2 na wychwyt (3H)glukozy w mózgu dorosłych szczurów po podaniu noworodkom 5,7-dihydroksytryptaminy
Autorzy:: Jośko, Jadwiga
Drab, Jacek
Nowak, Przemysław
Szkilnik, Ryszard
Boroń, Dariusz
Elwart, Marta
Konecki, Janusz
Brus, Halina
Brus, Ryszard
Tematy:: 5
7-dht
5-ht
5-hiaa
chlorpheniramine
cimetidine
6-3h-d-glucose
brain
rats
chlorfeniramina
cymetydyna
6-(3h)-d-glukoza
mózg
szczury; Pokaż więcej
Wydawca:: Śląski Uniwersytet Medyczny w Katowicach
Powiązania:: https://bibliotekanauki.pl/articles/1038674.pdf Link otwiera się w nowym oknie
Opis:: BACKGROUND The aim of the study was to examine eff ect of chlorpheniramine (hista- mine H1 receptor antagonist) and cimetidine (histamine H2 receptor an- tagonist) on (3H)glucose uptake in the brain of adult rats lesioned with 5,7-dihydroxytryptamine (neurotoxin for the central serotoninergic sys- tem) as neonates. MATERIAL AND METHODS Male 3-days old Wistar rats were injected with serotoninergic neurons neurotoxin 5,7-dihydroxytryptamine, 75 μg icv. Control rats were injected with saline 10 μg icv. At 8 weeks level of 5-HT and 5-HIAA was estimat- ed in the striatum, frontal cortex and hippocampus of the brain. Other 8 weeks old animals of control and 5,7-DHT lesioned as neonates were injected with S(+)chlorpheniramine (H1 receptor antagonist) 10.0 mg/kg ip or with cimetidine (H2 receptor antagonist) 5.0 mg/kg ip. Control rats were injected with saline 1.0 ml/kg ip. 60 minutes later 6-(3H)-D-glucose was applied in a dose of 500 μCi/kg ip and 15 minutes later all rats were decapitated and their brains were excised, placed on the ice and sample of frontal cortex, striatum, hippocampus, thalamus with hypothalamus, pons and cerebellum were separated and weighted. Then in the examined tissues radioactivity was measured in liquid scintillation counter and ex- pressed in DPM/100 mg of wet tissue. RESULTS 5,7-DHT decreased signifi cantly the level of 5-HT and 5-HIAA in all examined tissues in the brain of adult rats. In rats neonatally lesioned with 5,7-DHT radioactivity signifi cantly increased as compare to the control. Chlorpheniramine prevent signifi cantly that eff ect in the frontal cortex and cimetidine in the frontal cortex, hippocampus and cerebellum. CONCLUSION From above we conclude that in the brain of mammalians the metabolic link between histaminergic and serotoninergic system exist in regulation of energetic prcesses connected with glucose metabolism.
WSTĘP Celem pracy było zbadanie wpływu chlorfeniraminy, antagonisty receptora histaminowego H1 i cymetydyny, antagonisty receptora histaminowego H2 na wychwyt (3H)glukozy w mózgu dorosłych szczurów z lezją (zniszczenie) ośrodkowego układu serotoninergicznego wywołaną podaniem noworodkom neurotoksyny 5,7-dihydroksytryptaminy. MATERIAŁ I METODY Trzydniowe noworodki płci męskiej szczepu Wistar otrzymały do bocznej komory mózgu (icv) 75 μg 5,7-dihydroksytryptaminy (5,7-DHT), neurotoksynę układu serotoninergicznego. Zwierzęta kontrolne otrzymały icv 10 μl 0,9% roztworu NaCl. Po osiągnięciu 8 tygodni życia zwierzęta dekapitowano i w korze czołowej, prążkowiu oraz zakręcie hipokampa oznaczono zawartość 5-HT i 5-HIAA metodą HPLC/ED. Osobnej grupie badanej i kontrolnej podano S(+)chlorfeniraminę 10,0 mg/kg ip (antagonista receptora histaminowego H1) lub cymetydynę 5,0 mg/kg ip (antagonista receptora histaminowego H2). Zwierzęta kontrolne obu grup otrzymały 0,9% roztwór NaCl 1,0 ml/kg ip. Po 60 minutach wszystkie szczury otrzymały 6-(3H)-D-glukozę 500 μCi/kg ip. Po dalszych 15 minutach zwierzęta dekapitowano, wyjmowano z czaszki mózg, separowano z niego korę czołową, prążkowie, hipokamp, wzgórze z podwzgórzem, most i móżdżek, w których oznaczono radioaktywność przy użyciu licznika scyntylacyjnego. Wyniki wyrażono w DPM (Desintegrations Per Minute) na 100 mg świeżej tkanki. WYNIKI 5,7-DHT podany noworodkom znamiennie obniżył zawartość 5-HT i 5-HIAA w badanych fragmentach mózgu dorosłych szczurów. U zwierząt z lezją ośrodkowego układu serotoninergicznego we wszystkich badanych częściach mózgu wykazano znamienny wzrost wychwytu (3H)glukozy. Badani antagoniści receptorów histaminowych nie wpływali na wychwyt (3H)glukozy w mózgu zwierząt grupy kontrolnej, natomiast chlorfeniramina zapobiegała wychwytowi glukozy tylko w korze mózgowej, a cymetydyna w korze mózgowej, hipokampie i móżdżku zwierząt z lezją ośrodkowego układu serotoninergicznego wywołaną podaniem noworodkom 5,7-DHT. WNIOSKI Wyniki wskazują na metaboliczne powiązania w mózgu ssaków między układem serotoninergicznym i histaminergicznym.
Dostawca treści:: Biblioteka Nauki

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