Autor: Lin, Li-Zi - Prolib Integro

Skocz do pozycji: 1.

Tytuł:: Urban greenspace under a changing climate : benefit or harm for allergies and respiratory health?
Autorzy:: Yang, Bo-Yi
Singh, Nitika
Dong, Guang-Hui
Alashhab, Samer
Baumbach, Clemens
Buters, Jeroen
Brauer, Michael
Lin, Li-Zi
Ritz, Beate
Fuertes, Elaine
Zeng, Xiao-Wen
Tham, Rachel
Gui, Zhao-Huan
Nowak, Dennis
Idrose, Nur Sabrina
Fulman, Nir
Heinrich, Joachim
Sadeh, Maya
Zhao, Tianyu
Markevych, Iana
Opis:: An increasing proportion of the world’s population lives in urban settings that have limited greenspace. Urbanization puts pressure on existing greenspace and reduces its access. Climate impacts, including increased temperature and extreme weather events, challenge the maintenance of urban vegetation, reducing its ecosystem services and benefits for human health. Although urban greenspace has been positively associated with numerous health indicators, the evidence for allergies and respiratory health is much less clear and mixed. To address these uncertainties, a workshop with 20 global participants was held in Munich, Germany, in May 2024, focusing on the impact of greenspace-related co-exposures on allergies and respiratory health. This narrative review captures key insights from the workshop, including the roles of urban greenspace in (1) climate change mitigation, (2) interactions with pollen, and (3) emissions of biogenic volatile organic compounds and their byproducts, such as ozone. Additionally, it presents research and stakeholder recommendations from the workshop. Future studies that integrate advanced greenspace exposure assessments and consider the interplay of greenspace with pollen and biogenic volatile organic compounds, along with their relevant byproducts are needed. Increased public awareness and policy actions will also be essential for developing urban greenspace that maximizes health benefits, minimizes risks, and ensures resilience amid a changing climate and rapid urbanization.
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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Skocz do pozycji: 2.

Tytuł:: Amino acid substitutions of His296 alter the catalytic properties of Zymomonas mobilis 10232 levansucrase
Autorzy:: Li, Shu
Chen, Ming
Li, Gang
Yan, Yong
Yu, Hai
Zhan, Yu
Peng, Zi
Wang, Jin
Lin, Min
Tematy:: Zymomonas mobilis
His296
levansucrase
levan
transfructosylation activity
hydrolysis activity; Pokaż więcej
Wydawca:: Polskie Towarzystwo Biochemiczne
Powiązania:: https://bibliotekanauki.pl/articles/1040841.pdf Link otwiera się w nowym oknie
Opis:: His296 of Zymomonas mobilis levansucrase (EC 2.4.1.10) is crucial for the catalysis of the transfructosylation reaction. The three-dimensional structures of levansucrases revealed the His296 is involved in the substrate recognition and binding. In this study, nine mutants were created by site-directed mutagenesis, in which His296 was substituted with amino acids of different polarity, charge and length. The substitutions of His296 with Arg or Trp retained partial hydrolysis and transfructosylation activities. The positively charged Lys substitution resulted in a 2.5-fold increase of sucrose hydrolysis. Substitutions with short (Cys or Ser), negatively charged (Glu) or polar (Tyr) amino acids virtually abolished both the activities. Analysis of transfructosylation products indicated that the mutants synthesized different oligosaccharides, suggesting that amino acid substitutions of His296 strongly affected both the enzyme activity and transfructosylation products.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: Intervention effects of greenspace exposure on human microbiota : a randomized controlled trial in Chinese young adults
Autorzy:: Dong, Guang-Hui
Huang, Ji-Lin
Markevych, Iana
Dadvand, Payam
Yang, Bo-Yi
Heinrich, Joachim
Li, Jun-Yi
Chen, Chen
Browing, Matthew H.E.M.
Li, Chuang
Zheng, Zi-Han
Jiang, Jian-Cheng
Zhao, Tian-Yu
Zhu, Xiao-Qi
Wang, Zhi
Wang, Lu
Opis:: Enriching human microbiota has been proposed as a mechanism by which greenspace exposure improves human health. The existing evidence is scarce with few studies able to evaluate causality. We conducted a randomized controlled trial of 30 healthy undergraduate students to explore the intervention effects of greenspace on human gut and oral microbiota alpha-diversity, composition, differential genera and functional pathways. The study participants were divided into three groups, including outdoor greenspace (GS) group, outdoor non-greenspace (NGS) group, and indoor group, who visited a park, an open space without vegetation, and a classroom, respectively, for two hours per day over seven days. Differences in microbial alpha-diversity and composition across various groups were tested using Wilcoxon test and permutational multivariate analysis of variance, respectively. Linear discriminant analysis effect size analysis was performed to test differences in genera and functional pathways. Greenspace intervention significantly increased gut microbiota alpha-diversity, especially the observed Amplicon Sequence variant indexes and the Faith indexes (both p <0.05). In addition, the intervention substantially changed the composition of gut microbiota, of which the relative abundances of potentially beneficial bacteria increased. Further, the greenspace intervention affected several functional pathways of gut microbiota, including "substance dependence", "specific types of cancer", and "viral infectious diseases". However, we did not find any significant effect of greenspace intervention on oral microbiota. Our results suggest that greenspace intervention diversifies the gut microbiota and alters its composition. These findings could help to reinforce the potential of increasing people’s access to greenspace as a public health intervention.
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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Skocz do pozycji: 4.

Tytuł:: Is PM1 similar to PM2.5? : a new insight into the association of PM1 and PM2.5 with childrens lung function
Autorzy:: Xiao-Wen, Zeng
Li-Wen, Hu
Knibbs, Luke D
Bloom, Michael S.
Guang-Hui, Dong
Guo, Yu-Ming
Mika, Komppula
Dharmage, Shyamali C.
Qi-Hua, Guan
Jalaludin, Bin
Heinrich, Joachim
Hong-Yao, Yu
Pasi, Jalava
Shao, Lin
Bo-Yi, Yang
Mo, Yang
Maija-Riitta, Hirvonen
Zi-Mian, Liang
Lan, Steve Hung
Marjut, Roponen
Markevych, Iana
Morawska, Lidia
Opis:: Experimental data suggests that PM1 is more toxic than PM2.5 although the epidemiologic evidence suggests that the health associations are similar. However, few objective exposure data are available to compare the associations of PM1 and PM2.5 with children lung function. Our objectives are a) to evaluate associations between long-term exposure to PM1, PM2.5 and children’s lung function, and b) to compare the associations between PM1 and PM2.5. From 2012 to 2013, we enrolled 6,740 children (7-14 years), randomly recruited from primary and middle schools located in seven cities in northeast China. We measured lung function including forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), peak expiratory flow (PEF), and maximal mid-expiratory flow (MMEF) utilizing two portable electronic spirometers. We dichotomized continuous lung function measures according the expected values for gender and age. The spatial resolution at which PM1 and PM2.5 estimated were estimated using a machine learning method and the temporal average concentrations were averaged from 2009 to 2012. A multilevel regression model was used to estimate the associations of PM1, PM2.5 exposure and lung function measures, adjusted for confounding factors. Associations with lower lung function were consistently larger for PM1 than for PM2.5. Adjusted odds ratios (OR) per interquartile range greater PM1 ranged from 1.53 for MMEF (95% confidence interval [CI]: 1.20-1.96) to 2.14 for FEV1 (95% CI: 1.66-2.76) and ORs for PM2.5 ranged from 1.36 for MMEF (95%CI: 1.12–1.66) to 1.82 for FEV1 (95%CI: 1.49-2.22), respectively. PM1 and PM2.5 had.
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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