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Wyszukujesz frazę "Liu, Song" wg kryterium: Autor


Tytuł:
Passenger’s routes planning in stochastic common-lines’ multi-modal transportation network through integrating Genetic Algorithm and Monte Carlo simulation
Autorzy:
Peng, Yong
Mo, Zhiyao
Liu, Song
Tematy:
stochastic networks
multimodal transportation
passengers’ route
genetic algorithm
Monte Carlo simulation
sieci stochastyczne
transport multimodalny
algorytm genetyczny
symulacja Monte Carlo
Pokaż więcej
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Powiązania:
https://bibliotekanauki.pl/articles/1955092.pdf  Link otwiera się w nowym oknie
Opis:
In the urban transportation network, most passengers choose public transportation to travel. However, bad weather, accidents, traffic jams and other factors lead to uncertainty in transportation network. Besides, transport vehicles running on the same segments of routes and belonging to different modes or routes make the transportation network more complicated. In order to improve the efficiency of passenger’s travel, this paper aim to introducing an approach for optimizing passenger travel routes. This approach takes the travel cost and the number of transfers as constraints to finding the shortest total travel duration of passenger in urban transportation network. The running duration and dwell duration of the vehicles in the network are uncertain, and the vehicles are running according to the timetables. As transportation modes, bus, rail transit and walk are considered. In terms of methodological contribution, this paper combines Genetic Algorithm (GA) and Monte Carlo simulation to deal with optimization problem under stochastic conditions. This paper uses Monte Carlo simulation to simulate the running duration and dwell time of vehicles in different scenarios to deal with the uncertainty of the network. The shortest path of passenger’s travel is solved by GA. Two kinds of population management strategies including single population management strategy and multiple population management strategy are designed to guide the solution population evolving process. The two kinds of population management strategies of GA are tested in numerical example. The satisfactory convergence performance and efficiency of the model and algorithm is verified by the numerical example. The numerical example also demonstrated that the multiple population management strategy of GA can get better results in a shorter CPU time. At the same time, the influences of some significant variables on solution are performed. This paper is able to provide a scientific quantitative support to the path scheme selection under the influence of common-lines and timetables of different modes of transportation in stochastic urban multimodal transportation network.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Reprogramming the tumor microenvironment leverages $CD8^{+}$ T cell responses to a shared tumor/self antigen in ovarian cancer
Autorzy:
Mistarz, Anna
Rokita, Hanna
McGray, A. J. Robert
Hutson, Alan
Winkler, Marta
Kozbor, Danuta
Gambotto, Andrea
Battaglia, Sebastiano
Liu, Song
Wang, Jianmin
Odunsi, Kunle O.
Singh, Prashant K.
Opis:
Tumor antigen-driven responses to weakly immunogenic self-antigens and neoantigens directly affect treatment efficacy following immunotherapy. Using orthotopically grown SV40 T $antigen^{+}$ ovarian carcinoma in antigen-naive wild-type or TgMISIIR-TAg-Low transgenic mice expressing SV40 T antigen as a self-antigen, we investigated the impact of CXCR4-antagonist-armed oncolytic virotherapy on tumor progression and antitumor immunity. Immunostaining and single-cell RNA sequencing analyses of the peritoneal tumor microenvironment of untreated tumors in syngeneic wild-type mice revealed the presence of SV40 T antigen-specific $CD8^{+}$ T cells, a balanced M1/M2 transcriptomic signature of tumor-associated macrophages, and immunostimulatory cancer-associated fibroblasts. This contrasted with polarized M2 tumor-associated macrophages, immunosuppressive cancer-associated fibroblasts, and poor immune activation in TgMISIIR-TAg-Low mice. Intraperitoneal delivery of CXCR4-antagonist-armed oncolytic vaccinia virus led to nearly complete depletion of cancer-associated fibroblasts, M1 polarization of macrophages, and generation of SV40 T antigen-specific CD8+ T cells in transgenic mice. Cell depletion studies revealed that the therapeutic effect of armed oncolytic virotherapy was dependent primarily on $CD8^{+}$ cells. These results demonstrate that targeting the interaction between immunosuppressive cancer-associated fibroblasts and macrophages in the tolerogenic tumor microenvironment by CXCR4-A-armed oncolytic virotherapy induces tumor/self-specific $CD8^{+}$ T cell responses and consequently increases therapeutic efficacy in an immunocompetent ovarian cancer model.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
CAMPTOTHECIN INHIBITS MIGRATION, INVASION AND CLONOGENIC PROPERTY OF LIVER CANCER CELLS BY MODULATING MICRORNA EXPRESSION
Autorzy:
Liu, Zhenzhong
Wu, Song
Li, Xiaoqian
Tematy:
Hepatocellular Carcinoma
cell proliferation
cell cycle
Camptothecin
miRNA
Pokaż więcej
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Powiązania:
https://bibliotekanauki.pl/articles/895460.pdf  Link otwiera się w nowym oknie
Opis:
Camptothecin (CPT), an alkaloid natural product, extracted from Camptotheca acuminata bark, has been reported to have potential antitumor activity in diverse cancers. MicroRNAs (MiRNAs) are a class of short, non-coding RNAs that plays a crucial role in the normal physiology by attenuating translation. Here, we showed that the CPT modulates the expression of miRNAs in hepatocellular carcinoma cells (HCC). Microarray analysis reveals that CPT modulates the expression of as many as 39 miRNAs in HCC cells (Huh7), 27 miRNAs were downregulated whereas 12 miRNAs were upregulated. miR-16 is the key miRNA upregulated by CPT and targets key prosurvival proteins (MMP-2, MMP-9 and cyclin D1). Our results demonstrate that CPT is inhibiting cell viability of HCC cells significantly when compared with the untreated cells. Wound healing and colony formation assay confirm inhibition of cell migration and clonogenic property of Huh7 cells respectively, upon the dose-dependent treatment of CPT. Furthermore, the Boyden chamber assay analysis revealed a significant inhibition of number of invasive cells in CPT treated cells with comparison to untreated Huh7 cells. Mechanistically, CPT upregulates miR-16 expression which targets MMP-2, MMP-9, cyclin D1 downregulation and subsequently upregulates the expression of E-cadherin, TIMP1, p21, and p27, thereby inhibits cell migration, invasion and clonogenic property of HCC cells. In summary, CPT treatment in Huh7 cells decreases cell viability and upregulates miR-16 expression, which results in inhibition of cell migration, invasion and clonogenic property of cells, by decreasing MMP-2, MMP-9, cyclin D1 and increasing the expression of cell cycle-regulated proteins p21 and p27.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Optical design of a short-wave infrared coded aperture snapshot spectral imager based on Offner–Wynne imaging spectrometer
Autorzy:
Song, Chong
Zhou, Liang
Liu, Zhaohui
Jiang, Kai
Liu, Kai
Tematy:
Offner-Wynne imaging spectrometer
CASSI
coded aperture snapshot spectral imager
short-wave infrared
optical design
Pokaż więcej
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Powiązania:
https://bibliotekanauki.pl/articles/2086755.pdf  Link otwiera się w nowym oknie
Opis:
A calculation model to obtain the optimal combination of Offner–Wynne imaging spectrometer parameters to balance the RMS spot radius of the chief ray over the entire field is established. On the basis of the calculation model, an Offner–Wynne imaging spectrometer is designed, and then it is applied in a short-wave infrared coded aperture snapshot spectral imager (CASSI). The optical system of the short-wave infrared CASSI is designed by a combination method of independent design and integrated optimization. The spectral smile and spectral keystone of the optical system which operates in the 900–1700 nm band are respectively less than half a pixel. The focal length of the optical system is 1200 mm, the total optical system length is 775mm, and its average spectral resolution is 16 nm. The optical system offers the advantages of excellent imaging quality, compact optical structure, high optical transmittance, reduced spectral smile and spectral keystone.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Controllable preparation of highly active horseradish peroxidase-gold nanoparticle bionanoconjugate
Autorzy:
Zhang, P.
Liu, Ch.
Song, S.
Peng, Ch.
Tematy:
horseradish peroxidase
gold nanoparticles
bionanoconjugate
Pokaż więcej
Wydawca:
Zachodniopomorski Uniwersytet Technologiczny w Szczecinie. Wydawnictwo Uczelniane ZUT w Szczecinie
Powiązania:
https://bibliotekanauki.pl/articles/778931.pdf  Link otwiera się w nowym oknie
Opis:
A novel method of immobilizing horse radish peroxidase enzyme (HRP) onto the surface of gold nanoparticles (GNPs) was developed. As a result, a high-activity bionanoconjugates was obtained through utilizing the biotin-streptavidin (SA) system. The HRP-SA-GNP bionanoconjugate with high activity was conveniently prepared through the biotin- avidin system. Compared with the HRP-GNP bioconjugate prepared through the traditional electrostatic absorption method, the enzyme activity per GNPs of this new bionanoconjugate was enhanced by 10 times. Moreover, the enzyme activity of this bionanoconjugate was controllable. The above method of bionanoconjugation preparation has promising applications In the fi elds including preparing highly active bio-nanoprobe and immobilized enzyme.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Improved dynamic control method for energy storage units in PV dominated microgrids
Autorzy:
Wang, Q.
Liu, Y.
Song, W.
Xuan, K.
Tematy:
current correction coefficient
load distribution
PV DC microgrid
secondary control
weighted calculation
Pokaż więcej
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Powiązania:
https://bibliotekanauki.pl/articles/141382.pdf  Link otwiera się w nowym oknie
Opis:
In a PV-dominant DC microgrid, the traditional energy distribution method based on the droop control method has problems such as output voltage drop, insufficient power distribution accuracy, etc. Meanwhile, different battery energy storage units usually have different parameters when the system is running. Therefore, this paper proposes an improved control method that introduces a reference current correction factor, and a weighted calculation method for load power distribution based on the parameters of battery energy storage units is proposed to achieve weighted allocation of load power. In addition, considering the variation of bus voltage at the time of load mutation, voltage secondary control is added to realize dynamic adjustment of DC bus voltage fluctuation. The proposed method can achieve balance and stable operation of energy storage units. The simulation results verified the effectiveness and stability of the proposed control strategy.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Study of inorganic powders used for preparation of waterproof coating to coal mine roadways
Badanie proszków nieorganicznych stosowanych do przygotowania wodoodpornych powłok jezdni w kopalniach węgla
Autorzy:
Song, H.
Liu, J.
Xue, F.
Cheng, F.
Tematy:
waterproof coating
coal mine roadway
adhesive
inorganic filler
powłoka wodoodporna
jezdnia w kopalni węgla
spoiwo
napełniacz nieorganiczny
Pokaż więcej
Wydawca:
Sieć Badawcza Łukasiewicz - Instytut Chemii Przemysłowej
Powiązania:
https://bibliotekanauki.pl/articles/947175.pdf  Link otwiera się w nowym oknie
Opis:
The new coatings based on styrene-acrylate copolymer with solid powder additives were prepared. Solid additives were one of three types of adhesives (white cement, Portland cement, and alumina cement) and one of four inorganic fillers (quartz powder, talcum powder, calcium carbonate powder, and fly ash). The coatings were tested by determination of surface drying time, hard drying time, tensile strength, and elongation at break. The ratio of water absorption after 7 days was also measured. The results showed that white cement was the best inorganic adhesive with optimal amount of 40–50 wt % in solid powder part. Quartz powder served as better inorganic filler compared with talcum powder and calcium carbonate powder. Fly ash could also be used as good inorganic filler but in amount lower than 10 wt %. Thus prepared coatings satisfy requirements for class III according to GB/T23445-2009 standard.
Przygotowano nowe powłoki na bazie kopolimeru styren-akrylan z dodatkiem proszków stałych. Dodatki stałe stanowiły jeden z trzech rodzajów spoiwa (cement biały, cement portlandzki i cement glinowy) oraz jeden z czterech napełniaczy nieorganicznych (kwarc w postaci proszku, talk, sproszkowany węglan wapnia oraz popiół lotny). Powłoki badano przez określanie czasu suszenia powierzchni, czasu całkowitego suszenia, wytrzymałości na rozciąganie i wydłużenia przy zerwaniu. Wyznaczano również współczynnik absorpcji wody po 7 dniach. Badania wykazały, że najlepszym spoiwem nieorganicznym jest cement biały wilości 40–50 % mas. Proszek kwarcowy jest lepszym napełniaczem nieorganicznym niż talk lub sproszkowany węglan wapnia. Stwierdzono również, że dobrym napełniaczem nieorganicznym są popioły lotne, ale mogą być stosowane tylko w ilości mniejszej niż 10 % mas. Tak przygotowane powłoki spełniają wymagania klasy III według normy GB/T 23445-2009.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Flame retardant properties of gas sealing materials used in coal mines
Uniepalniacze w materiałach zabezpieczających ściany w kopalniach węgla przed wypływem gazu
Autorzy:
Song, H.
Liu, J.
Xue, F.
Cheng, F.
Tematy:
flame retardant
coal mine
gas sealing materials
tensile strength
flame resistance properties
opóźniacz palenia
kopalnia węgla
materiały zabezpieczające przed wypływem gazu
wytrzymałość na rozciąganie
odporność na płomień
Pokaż więcej
Wydawca:
Sieć Badawcza Łukasiewicz - Instytut Chemii Przemysłowej
Powiązania:
https://bibliotekanauki.pl/articles/947389.pdf  Link otwiera się w nowym oknie
Opis:
Flame retardants are key ingredients for gas sealing materials used in the coal mine wall. In this paper, the types and doses of flame retardants are investigated. The results showed that a gas sealing material with 11 wt % complex flame retardants had a good performance when the complex flame retardants were composed of aluminum hydroxide and chlorinated paraffin at a ratio of 3:8. The flame resistant property of this gas sealing material conforms to the safety standards of coal mines (MT113-1995). Furthermore, their mechanical properties met the standard requirements of the polymer cement waterproof coatings (GB/T23445-2009). The costs are very low compared with similar products in current practical use.
Zbadano wpływ rodzaju oraz ilości uniepalniacza, dodanego do emulsji styrenowo-akrylowej napełnionej krzemionką i cementem, na palność otrzymanej kompozycji zabezpieczającej ściany w kopalni węgla przed wypływem gazu. Efekt opóźnienia palenia na poziomie przewidzianym w normach bezpieczeństwa kopalń węgla (MT113-1995) uzyskano w wypadku zastosowania materiału uszczelniającego, modyfikowanego dodatkiem 11 % mas. kompozycji uniepalniacza, stanowiącej mieszaninę wodorotlenku glinu i chlorowanej parafiny w stosunku masowym 3:8. Modyfikowane materiały uszczelniające spełniają również wymagania pod względem właściwości mechanicznych, dotyczące polimerowo-cementowych powłok wodochronnych (GB/T23445-2009), a koszt ich wytwarzania jest dużo niższy niż koszt wytwarzania stosowanych obecnie produktów.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Dissolution kinetics of malachite in ethylene diamine phosphate solutions
Autorzy:
Shen, Peilun
Liu, Ruizeng
Liu, Dianwen
Zhan, Xiaolin
Jia, Xiaodong
Song, Kaiwei
Tematy:
malachite
organic amine
ethylene diamine phosphate
dissolution
kinetic
Pokaż więcej
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Powiązania:
https://bibliotekanauki.pl/articles/110214.pdf  Link otwiera się w nowym oknie
Opis:
Ethylene diamine phosphate (EDP), as a synthetic organic reagent, was used for the first time to leach malachite, and a new method of using organic amine to leach copper oxide ore was developed. The effects of stirring speed, particle size, reagent concentration, and reaction temperature on EDP-dissolution malachite were investigated. Results showed that malachite rapidly dissolved in EDP solution. The malachite-dissolving rate also increased with increased reagent concentration, increased reaction temperature, and decreased particle size. Stirring speed exhibited nearly no effect on EDP-induced malachite dissolution. The leaching kinetics was found to follow the shrinking-core model, and dissolution was controlled by surface chemical reaction with an activation energy of 52.63kJ×mol−1. A semiempirical rate equation was obtained to describe the dissolution process expressed as 1-(1-XCu)1/3=0.0149(CEDP)0.7814 × (Pmalachite)−0.7982×exp(−6.3308/T) ×t.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effects of Metal Oxides on the Thermal Decomposition Kinetics and Mechanisms of HAN/PVA Based Propellants
Autorzy:
Hu, Song-qi
Liu, Xue-li
Liu, Lin-Lin
Kang, Bo
Zhang, Yan
Tematy:
HAN/PVA-based propellant
metal oxides
catalytic behaviour
kinetic parameters
Pokaż więcej
Wydawca:
Sieć Badawcza Łukasiewicz - Instytut Przemysłu Organicznego
Powiązania:
https://bibliotekanauki.pl/articles/27787991.pdf  Link otwiera się w nowym oknie
Opis:
The thermal decomposition processes of HAN/PVA-based propellants have been investigated using a simultaneous thermogravimetric analysis (TGA) – differential scanning calorimetry (DSC), coupled with Fourier-Transform Infrared Spectroscopy (FTIR) and Mass Spectrometry (MS) system. The activation energy (Ea), pre-exponential factor A and reaction mechanism function f(α) of the decomposition processes have been determined by non-isothermal and Malek methods. The results showed that the decomposition process of an HAN/PVA sample occurs mainly in the temperature range 202.2~220.1 °C, with a mass loss, heat release and Ea of about 84.8%, 1474.18 and 88.76 kJ·mol–1, respectively. Of the seven metal oxides studied as catalysts, Al2O3, V2O5 and Fe2O3 have significant catalytic effects on an HAN/PVA-based propellant, in lowering the decomposition temperature, with Ea changing from 88.8 to 83.7, 85.6 and 113.6 kJ·mol–1, respectively. The f(α) of both HAN/PVA and HAN/PVA/Al2O3 samples can be expressed as f(α) = (1 – α)2, whereas f(α) = α or f(α) = α/2 fit well for the HAN/PVA/V2O5 and HAN/PVA/Fe2O3 samples.
Dostawca treści:
Biblioteka Nauki
Artykuł

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