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Wyświetlanie 1-10 z 21
Tytuł:
Myocardial remodeling in rats with metabolic syndrome: role of Rho-kinase mediated insulin resistance
Autorzy:
Li, Chuan-Bao
Li, Xiao-Xing
Chen, Yu-Guo
Gao, Hai-Qing
Bao, Cheng-Mei
Liu, Xiang-Qun
Bu, Pei-Li
Zhang, Juan
Zhang, Yun
Ji, Xiao-Ping
Tematy:
Rat
Metabolism
Myocardium
Phosphorylation
Insulin resistance
Pokaż więcej
Wydawca:
Polskie Towarzystwo Biochemiczne
Powiązania:
https://bibliotekanauki.pl/articles/1039743.pdf  Link otwiera się w nowym oknie
Opis:
Insulin resistance (IR) plays a critical role in metabolic syndrome (MS). Previous studies have demonstrated that activated ROCK is increased in MS patients. However, the effect of Rho-kinase (ROCK) on IR has not been definitely determined. Thus, the aims of the present study were to determine whether ROCK activation induces IR or affects myocardial structure and function, as well as the possible mechanisms underlying this process. Wistar rats fed high fat, high glucose and high salt diet sewed as model of MS and we used transmission electron microscopy, echocardiogram technology, and terminal deoxynucleotidyl transferase-mediated DNA nick-end labeling staining to identify any myocardial damage. The protein levels of MYPT-1 (characteristic of ROCK activation), IRS-1 and AKT were analyzed by immunohistochemistry and Western blotting. In hearts from MS rats, we found increased protein levels of phospho-MYPT-1 and phospho-IRS-1 (Ser307) and decreased phospho-AKT compared to levels in normal rats. In conclusion, the results suggest that ROCK-mediated IR is involved in the development of myocardial impairments in MS rats and that this effect is mediated probably via the IRS-1/PI3-kinase/AKT pathway.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A multiscale methodology for CFD simulation of catalytic distillation bale packings
Autorzy:
Ding, H.
Xiang, W.
Liu, Ch.
Tematy:
multiscale model
CFD
reactive distillation
Pokaż więcej
Wydawca:
Zachodniopomorski Uniwersytet Technologiczny w Szczecinie. Wydawnictwo Uczelniane ZUT w Szczecinie
Powiązania:
https://bibliotekanauki.pl/articles/780059.pdf  Link otwiera się w nowym oknie
Opis:
A multiscale model for simulating the hydrodynamic behavior of catalytic bale packings has been proposed. This model combines computational fluid dynamics (CFD) and macroscopic calculation. At small scale calculation, the CFD model includes 3-D volume-of-fluid (VOF) simulation within representative elementary unit (REU) under unsteady-state conditions. The REU constitutes gauze and catalyst domain, and porous media model is applied. At large scale calculation, a new mechanistic model deduced from the unit network model is employed. Based on liquid split proportion from small scale calculation, liquid distribution of the entire bale packing can be predicted. To evaluate different packing design, three common bale arrangements, i.e. one-bale, nine-bales and seven-bales, are compared. The area-weighted Christiansen uniformity coefficient is introduced to assess the distribution performance. A comparison between simulation and experimental results is made to validate the multiscale model. The present methodology is proved to be effective to analysis and design of catalytic distillation columns.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Influence of optical Airy transform on non-diffracting propagation distance of finite energy Airy beams
Autorzy:
Chu, Xingchun
Liu, Rongjiang
Wang, Xiang
Han, Zhongxiang
Ni, Yanhui
Tematy:
physics optics
non-diffracting beam
finite energy Airy beam
non-diffracting propagation distance
optical Airy transform
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Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Powiązania:
https://bibliotekanauki.pl/articles/2033885.pdf  Link otwiera się w nowym oknie
Opis:
Finite energy Airy beams (FEAB) generated in laboratory have a short non-diffracting propagation distance (NDPD), which restricts its application in laser communication, laser detection and other fields. Effects of optical Airy transform (OAT) on NDPD of FEAB is analyzed. By comparing the theoretical formulas of the FEAB before and after the OAT, we find that when the transform parameter α of the OAT is larger than zero, the transverse scaling factor of the transformed FEAB is greater than that before the transformation, while the transformed exponential decay factor is smaller than that before the transformation. Using the Huygens–Fresnel diffractive integral, we derive the propagation formula of the transformed FEAB. Initial intensity distribution of FEAB before and after the OAT is compared. Propagation dynamics of the transformed FEAB with different α is numerically simulated and its NDPD is quantitatively evaluated. Results show that: with the increase of α, side lobes of the transformed FEAB increase, its main lobe and side lobes become wider than that before the transformation, and the inclination of the propagation trajectory decreases. When α is greater than half of the transverse scaling factor, the NDPD of the transformed FEAB increases rapidly.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Diversity of scoring, ingenuity of striking, art of flying - conceptual and systematical identification of soccer scoring techniques
Autorzy:
Zhang, Xiang
Shan, Gongbing
Liu, Feng
Yang, Shenglai
Meng, Mingliang
Tematy:
scientific-based training system
biomechanics
anatomy
goal repeatability
aerial shots
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Wydawca:
PPHU Projack Jacek Wąsik
Powiązania:
https://bibliotekanauki.pl/articles/1933083.pdf  Link otwiera się w nowym oknie
Opis:
The terms of soccer scoring techniques (SSTs) used in practice and research have been remaining confusing; even dramatic, we still do not know how many SSTs available for the game. This scenario hinders not only the scientific studies on some unique SSTs but also the development of novel coaching methods for learning these SSTs. The current paper aims to bridge the gap by establishing a SST terminology system. The system is built based on goal repeatability, selected anatomical & biomechanical parameters, and analyses of 579 attractive goals from international professional tournaments. The results have revealed that there are 43 SSTs existed in current soccer practice. Some SSTs can be identified by preliminary parameters (i.e. anatomical parameters, the ball vertical position at the shot and the hit-point on the ball), but most of them need additional biomechanical examination on the movement control in frontal & transverse planes, jumping control, and trunk orientation at shots in order to identify uniquely. Further, the new SST terminology has disclosed that soccer attractiveness is linked to the diversity, ingenuity and artistry of shots. The most attractive type of scoring awaited by millions of spectators is aerial shots. Lastly, the most important contribution of the new SST terminology system is to help researchers and practitioners launch target-orientated studies that would provide a practical and convincing scientific coach-method, clear definitions, and means to reevaluate and improve SSTs in practice.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Influence of Wave-Absorbing Functional Particles on the Electromagnetic Properties and Mechanical Properties of Coated Composites for Nickel Powders
Wpływ absorbujących fale cząstek funkcyjnych na właściwości elektromagnetyczne i mechaniczne kompozytów powlekanych żywicą poliuretanową zawierającą proszek niklu
Autorzy:
Liu, Yuanjun
Wang, Yi
Wu, Xiang
Zhang, Lulu
Niu, Jiarong
Tematy:
nickel powder
single-layer coating
electromagnetic shielding
dielectric properties
proszek niklowy
powłoka jednowarstwowa
ekranowanie elektromagnetyczne
właściwości dielektryczne
Pokaż więcej
Wydawca:
Sieć Badawcza Łukasiewicz - Instytut Biopolimerów i Włókien Chemicznych
Powiązania:
https://bibliotekanauki.pl/articles/233612.pdf  Link otwiera się w nowym oknie
Opis:
In this subject, a single-layer coated composite for nickel powders was prepared using PU2540 polyurethane as the matrix, nickel powder as the wave-absorbing functional particle, and coating technology on plain cotton fabric. The influence of wave-absorbing functional particles on the dielectric, shielding effectiveness and mechanical properties of the single-layer coated composite for nickel powders was mainly analysed and compared. Results showed that the real and imaginary parts and loss tangent of the dielectric constant were all the largest when the iron powder was mixed with the nickel powder, and its polarizing ability, loss ability and attenuation ability with respect to electromagnetic waves were all the maximum. When the graphene was mixed with the nickel powder, the shielding attenuation ability with respect to electromagnetic waves was the best.
W ramach pracy przygotowano jednowarstwowy kompozyt powlekany żywicą poliuretanową zawierającą proszek niklu. Do przygotowania kompozytów użyto poliuretanu PU2540 jako matrycy i proszku niklu jako absorbującej fale cząstki funkcjonalnej oraz zastosowano technologię powlekania na gładkiej tkaninie bawełnianej. Przeanalizowano i porównano głównie wpływ absorbujących fale funkcjonalnych cząstek na dielektryk, skuteczność ekranowania i właściwości mechaniczne jednowarstwowego powlekanego kompozytu. Wyniki pokazały, że rzeczywiste i urojone części oraz styczna strat stałej dielektrycznej były największe, gdy proszek żelaza został zmieszany z proszkiem niklu, a jego zdolność polaryzacyjna, zdolność do strat i zdolność tłumienia fal elektromagnetycznych były maksymalne. Gdy grafen został zmieszany z proszkiem niklu, zdolność tłumienia ekranowania fal elektromagnetycznych była najlepsza.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Image compression and encryption algorithm based on advanced encryption standard and hyper-chaotic system
Autorzy:
Nie, Zhe
Liu, Zheng-Xin
He, Xiang-Tao
Gong, Li-Hua
Tematy:
hyper-chaotic system
advanced encryption standard
discrete cosine transform
image encryption
image compression
Pokaż więcej
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Powiązania:
https://bibliotekanauki.pl/articles/174108.pdf  Link otwiera się w nowym oknie
Opis:
An image compression and encryption algorithm by combining the advanced encryption standard (AES) with the hyper-chaotic system is designed, in which Arnold map is employed to eliminate part of the block effect in the image compression process. The original image is compressed with the assistance of a discrete cosine transform and then its transform coefficients are encrypted with the AES algorithm. Besides, the hyper-chaotic system is adopted to introduce the nonlinear processfor image encryption. Numerical simulations and theoretical analyses demonstrate that the proposed image compression and encryption algorithm is of high security and good compression performance.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Lipopolysaccharide accelerates fine particulate matter-induced cell apoptosis in human lung bronchial epithelial cells
Autorzy:
Ru, Qin
Xiong, Qi
Chen, Lin
Tian, Xiang
Yue, Kai
Ma, Baomiao
Liu, Lu
Wu, Rihui
Xu, Congyue
Pi, Mingshan
Li, Chaoying
Tematy:
Apoptosis
cytotoxicity
inflammation
fine particulate matter
free radicals
bronchial epithelial cells
Pokaż więcej
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Powiązania:
https://bibliotekanauki.pl/articles/2161782.pdf  Link otwiera się w nowym oknie
Opis:
Objectives The aim of the study has been to investigate the effect of the Standard Reference Material of fine particulate matter (SRM 2786) on cytotoxicity and apoptosis in human lung bronchial epithelial cells (16HBE cells). Whether the lipopolysaccharide (LPS)-induced inflammation could further accelerate cell apoptosis induced by SRM 2786 stimulation has also been determined. Material and Methods 16HBE cells were exposed to various doses of SRM 2786 with or without LPS. The following parameters: cytotoxicity, apoptotic rate, Bax/Bcl-2 expression, nitric oxide (NO) production, and reactive oxygen species (ROS) generation were measured. Results The results have shown that SRM 2786 induces cell damage and apoptosis of 16HBE cells as demonstrated by significant decrease in expression of Bcl-2 and increase in expression of Bax. When compared with the control cells, the apoptotic rate of cells treated by 500 μg/ml of SRM 2786 increased from 2.43±0.21% to 43.96±2.95% (p < 0.01). Further, there was an elevated production of NO and ROS post SRM 2786 treatment. The level of NO in cells treated with 500 μg/ml of SRM 2786 was 18.33±1.02 μmol/l whereas that of control cells was 1.58±0.31 μmol/l (p < 0.01). When compared with the control group, the level of intracellular ROS increased by 24% after treatment with 500 μg/ml of SRM 2786 (p < 0.05). In addition, LPS pre-treatment may accelerate cell apoptosis by increasing generation of NO and ROS followed by SRM 2786 stimulation. When compared to cells treated with 125 μg/ml of SRM 2786 alone, the levels of NO and ROS in cells pretreated with LPS increased by 28% and 11.6%, respectively (p < 0.05), and the apoptotic rate increased from 34.62±4.44% to 54.11±3.34% (p < 0.01). Conclusions These findings have suggested that in vitro exposure to SRM 2786 could induce 16HBE cells apoptosis probably by means of the mechanism involving the generation of free radicals, while the degree of apoptosis would be further aggravated under inflammation condition. Int J Occup Med Environ Health 2018;31(2):173–183
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Evaluation of differential serum expression of three factors and pulmonary function in patients with silicosis
Autorzy:
Zhu, Ying
Duan, Xia Yu
Cheng, Yun Qi
Yao, Xin Jing
Xu, Hong
Zhang, Kui Sheng
Li, Feng Shi
Yang, Fang
Liu, Liang He
Yuan, Xiang Ju
Tematy:
silicosis
pulmonary function
early diagnosis
ROC
PTPN2
factor B
Pokaż więcej
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Powiązania:
https://bibliotekanauki.pl/articles/2086531.pdf  Link otwiera się w nowym oknie
Opis:
ObjectivesSilicosis is a chronic occupational lung disease. As was previously found by the authors, some proteins increased in the lung tissue of activated rats, and protein tyrosine phosphatase non-receptor type 2 (PTPN2), factor B, and vaccinia-related kinase 1 (VRK1) showed highly differential expressions.Material and MethodsIn this study, serum and bronchoalveolar lavage fluid samples were collected from patients with silicosis and healthy people to verify the expression of PTPN2, factor B, and VRK1. The diagnostic value of differentially expressed proteins for silicosis was judged.ResultsThe expression levels of serum PTPN2, VRK1, and factor B in patients with silicosis were significantly higher than those in the control group (p < 0.01). Higher serum PTPN2 and factor B concentrations significantly and negatively correlated with the ratio of forced expiratory volume in 1 s to forced vital capacity (FEV1/FVC), maximum vital capacity (VCmax), FEV1, and FVC, suggesting that the high expression of PTPN2 and factor B is associated with decreased pulmonary ventilation function and restrictive ventilatory impairment in patients with silicosis. All area under curve (AUC) measurements generated from single detection events were >0.744, with PTPN2 reaching the highest value (0.858). The AUC, sensitivity, and specificity for the combined diagnosis using factor B and PTPN2 were 0.907, 86.91% and 85.07%, respectively, for factor B and PTPN2. The 3 differentially expressed proteins are potential classes of predictive biomarkers for silicosis.ConclusionsRegarding the economy and test practicality, the best diagnostic combination is factor B and PTPN2 for the analysis of AUC, sensitivity and specificity.
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-10 z 21

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