Autor: Long, Jacquelyn - Prolib Integro

Skocz do pozycji: 1.

Tytuł:: Targeting the cancer initiating cell : the Achilles’ heel of cancer
Autorzy:: McCubrey, James A.
Steelman, Linda S.
Laidler, Piotr
Chappell, William H.
Abrams, Stephen L.
Sattler, Jennifer A.
Long, Jacquelyn M.
Kempf, C. Ruth
Franklin, Richard A.
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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Autorzy:: Tafuri, Agostino
Nicoletti, Ferdinando
Cocco, Lucio
McCubrey, James A.
Malaponte, Graziella
Chappell, William H.
Kempf C., Ruth
Mazzarino, Maria C.
Steelman, Linda S.
Bonati, Antonio
Milella, Michele
Stivala, Franca
Bäsecke, Jörg
Donia, Marco
Laidler, Piotr
Abrams, Stephen L.
Libra, Massimo
Montalto, Giuseppe
Maksimovic‐Ivanic, Danijela
Fagone, Paolo
Evangelisti, Camilla
Long, Jacquelyn
Mijatovic, Sanja
Cervello, Melchiorre
Martelli, Alberto M.
Opis:: Dysregulated signaling through the Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways is often the result of genetic alterations in critical components in these pathways or upstream activators. Unrestricted cellular proliferation and decreased sensitivity to apoptotic‐inducing agents are typically associated with activation of these pro survival pathways. This review discusses the functions these pathways have in normal and neoplastic tissue growth and how they contribute to resistance to apoptotic stimuli. Crosstalk and commonly identified mutations that occur within these pathways that contribute to abnormal activation and cancer growth will also be addressed. Finally the recently described roles of these pathways in cancer stem cells, cellular senescence and aging will be evaluated. Controlling the expression of these pathways could ameliorate human health.
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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Skocz do pozycji: 3.

Tytuł:: Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR inhibitors : rationale and importance to inhibiting these pathways in human health
Autorzy:: Bonati, Antonio
Tafuri, Agostino
Laidler, Piotr
Donia, Marco
Mazzarino, Maria C.
Kempf, Ruth C.
Mijatovic, Sanja
Martelli, Alberto M.
Steelman, Linda S.
Libra, Massimo
Chappell, William H.
Malaponte, Graziella
Abrams, Stephen L.
Maksimovic-Ivanic, Danijela
Montalto, Giuseppe
Long, Jacquelyn M.
Cervello, Melchiorre
Bäsecke, Jörg
Cocco, Lucio
Fagone, Paolo
Stivala, Franca
Franklin, Richard A.
Milella, Michele
McCubrey, James A.
Evangelisti, Camilla
Nicoletti, Ferdinando
Opis:: The Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades are often activated by genetic alterations in upstream signaling molecules such as receptor tyrosine kinases (RTK). Integral components of these pathways, Ras, B-Raf, PI3K, and PTEN are also activated/inactivated by mutations. These pathways have profound effects on proliferative, apoptotic and differentiation pathways. Dysregulation of these pathways can contribute to chemotherapeutic drug resistance, proliferation of cancer initiating cells (CICs) and premature aging. This review will evaluate more recently described potential uses of MEK, PI3K, Akt and mTOR inhibitors in the proliferation of malignant cells, suppression of CICs, cellular senescence and prevention of aging. Ras/Raf/ MEK/ERK and Ras/PI3K/PTEN/Akt/mTOR pathways play key roles in the regulation of normal and malignant cell growth. Inhibitors targeting these pathways have many potential uses from suppression of cancer, proliferative diseases as well as aging.
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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